Published in Cell on July 18, 2013
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell (2013) 3.26
The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse. Nucleic Acids Res (2013) 2.68
Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife (2013) 2.66
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res (2013) 2.20
A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell (2014) 2.03
Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families. Nat Genet (2015) 1.67
Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen. Cell Host Microbe (2014) 1.66
Measuring error rates in genomic perturbation screens: gold standards for human functional genomics. Mol Syst Biol (2014) 1.64
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet (2015) 1.38
Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech (2014) 1.30
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery. Genes Dev (2013) 1.27
Phenotype ontologies and cross-species analysis for translational research. PLoS Genet (2014) 1.19
Mouse genome database 2016. Nucleic Acids Res (2015) 1.11
High-throughput discovery of novel developmental phenotypes. Nature (2016) 1.10
Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells. Nat Biotechnol (2015) 1.04
Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote. Dev Cell (2014) 1.04
Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities. Biochim Biophys Acta (2014) 1.02
PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data. PLoS One (2015) 1.00
ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells. Hum Mol Genet (2014) 0.99
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res (2014) 0.98
Large-scale identification of chemically induced mutations in Drosophila melanogaster. Genome Res (2014) 0.98
Evolution by gene loss. Nat Rev Genet (2016) 0.96
Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome (2013) 0.96
Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model. PLoS One (2013) 0.95
An estimate of the average number of recessive lethal mutations carried by humans. Genetics (2015) 0.91
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet (2017) 0.89
The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron (2014) 0.87
Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun (2014) 0.87
Analysis of stop-gain and frameshift variants in human innate immunity genes. PLoS Comput Biol (2014) 0.87
Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. PLoS Genet (2014) 0.87
Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. PLoS Genet (2014) 0.87
A lacZ reporter gene expression atlas for 313 adult KOMP mutant mouse lines. Genome Res (2015) 0.86
Impact of temporal variation on design and analysis of mouse knockout phenotyping studies. PLoS One (2014) 0.86
A plethora of pleiotropy across complex traits. Nat Genet (2016) 0.86
Influence networks based on coexpression improve drug target discovery for the development of novel cancer therapeutics. BMC Syst Biol (2014) 0.85
A high-throughput in vivo micronucleus assay for genome instability screening in mice. Nat Protoc (2014) 0.85
CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa. Mol Ther (2016) 0.85
Quantitative assessment of the multiple processes responsible for bilirubin homeostasis in health and disease. Clin Exp Gastroenterol (2014) 0.85
Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene. PLoS One (2014) 0.85
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat Commun (2017) 0.84
Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson's disease. AMIA Annu Symp Proc (2015) 0.84
PhenoImageShare: an image annotation and query infrastructure. J Biomed Semantics (2016) 0.84
The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis. PLoS One (2015) 0.83
Utilising the resources of the International Knockout Mouse Consortium: the Australian experience. Mamm Genome (2015) 0.83
A gene expression resource generated by genome-wide lacZ profiling in the mouse. Dis Model Mech (2015) 0.83
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature (2017) 0.83
Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes. Mamm Genome (2015) 0.82
Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation. PLoS One (2015) 0.82
The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome. PLoS Comput Biol (2015) 0.82
Talking welfare: the importance of a common language. Mamm Genome (2015) 0.82
Reporting phenotypes in mouse models when considering body size as a potential confounder. J Biomed Semantics (2016) 0.82
Linking tissues to phenotypes using gene expression profiles. Database (Oxford) (2014) 0.82
Persistent Chromatin Modifications Induced by High Fat Diet. J Biol Chem (2016) 0.81
Mouse Genome Informatics (MGI): reflecting on 25 years. Mamm Genome (2015) 0.81
Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet (2014) 0.80
Rapid conversion of EUCOMM/KOMP-CSD alleles in mouse embryos using a cell-permeable Cre recombinase. Transgenic Res (2013) 0.79
The functional diversity of essential genes required for mammalian cardiac development. Genesis (2014) 0.79
Alteration of NCoR corepressor splicing in mice causes increased body weight and hepatosteatosis without glucose intolerance. Mol Cell Biol (2014) 0.79
Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study. Front Endocrinol (Lausanne) (2015) 0.79
Systematic analysis of gene properties influencing organ system phenotypes in mammalian perturbations. Bioinformatics (2014) 0.79
A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. G3 (Bethesda) (2015) 0.79
Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Neuron (2015) 0.78
Functional significance of the sex chromosomes during spermatogenesis. Reproduction (2015) 0.78
Parallel reverse genetic screening in mutant human cells using transcriptomics. Mol Syst Biol (2016) 0.78
Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia. Exp Hematol (2014) 0.78
Contributions of Mammalian Chimeras to Pluripotent Stem Cell Research. Cell Stem Cell (2016) 0.77
Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression. PLoS One (2016) 0.77
Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations. PLoS One (2014) 0.77
Allelome.PRO, a pipeline to define allele-specific genomic features from high-throughput sequencing data. Nucleic Acids Res (2015) 0.77
The digital revolution in phenotyping. Brief Bioinform (2015) 0.77
The Salmonella effector protein SifA plays a dual role in virulence. Sci Rep (2015) 0.77
Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation. J Immunol (2015) 0.77
Dissecting mammalian immunity through mutation. Immunol Cell Biol (2014) 0.77
Using association rule mining to determine promising secondary phenotyping hypotheses. Bioinformatics (2014) 0.77
Structural basis of substrate selectivity of E. coli prolidase. PLoS One (2014) 0.77
Alterations in Fibronectin Type III Domain Containing 1 Protein Gene Are Associated with Hypertension. PLoS One (2016) 0.77
Right Ventricular Epicardial Fibrosis in Mice With Sternal Segment Dislocation. Vet Pathol (2014) 0.76
Systems biology for hepatologists. Hepatology (2014) 0.76
Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms. Hum Mol Genet (2016) 0.76
Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach. Transgenic Res (2015) 0.76
A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 (Bethesda) (2016) 0.76
Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. EMBO Mol Med (2016) 0.76
Overview of genetic tools and techniques to study Notch signaling in mice. Methods Mol Biol (2014) 0.76
Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression. PLoS Genet (2016) 0.76
Organ system heterogeneity DB: a database for the visualization of phenotypes at the organ system level. Nucleic Acids Res (2014) 0.76
Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains. PLoS One (2015) 0.76
Quantitative X-ray microradiography for high-throughput phenotyping of osteoarthritis in mice. Osteoarthritis Cartilage (2014) 0.76
Mouse slc9a8 mutants exhibit retinal defects due to retinal pigmented epithelium dysfunction. Invest Ophthalmol Vis Sci (2015) 0.76
Genetics: finding genes for schizophrenia. Curr Biol (2014) 0.76
Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure. J Pathol (2016) 0.76
Developmental regulation of planar cell polarity and hair-bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics. Wiley Interdiscip Rev Dev Biol (2015) 0.76
Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Cell (2017) 0.76
Network Modules of the Cross-Species Genotype-Phenotype Map Reflect the Clinical Severity of Human Diseases. PLoS One (2015) 0.75
The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9. Leukemia (2016) 0.75
Genes Regulated by Vitamin D in Bone Cells Are Positively Selected in East Asians. PLoS One (2015) 0.75
Germline Modification and Engineering in Avian Species. Mol Cells (2015) 0.75
Genome-wide association studies and contribution to cardiovascular physiology. Physiol Genomics (2015) 0.75
Detection and preliminary screening of the human gene expression profile for Hirschsprung's disease. Mol Med Rep (2015) 0.75
Scaling up phenotyping studies. Nat Biotechnol (2015) 0.75
GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics (2004) 20.23
A combined transmembrane topology and signal peptide prediction method. J Mol Biol (2004) 15.77
Ensembl 2011. Nucleic Acids Res (2010) 14.68
A systematic survey of loss-of-function variants in human protein-coding genes. Science (2012) 12.25
A conditional knockout resource for the genome-wide study of mouse gene function. Nature (2011) 9.93
REVIGO summarizes and visualizes long lists of gene ontology terms. PLoS One (2011) 8.65
Role of duplicate genes in genetic robustness against null mutations. Nature (2003) 7.81
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol (2003) 7.47
Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet (2001) 5.67
Human disease genes. Nature (2001) 5.31
CORUM: the comprehensive resource of mammalian protein complexes--2009. Nucleic Acids Res (2009) 4.71
Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation. Am J Hum Genet (2007) 4.20
DBD--taxonomically broad transcription factor predictions: new content and functionality. Nucleic Acids Res (2007) 3.18
A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol (2010) 3.09
Next generation software for functional trend analysis. Bioinformatics (2009) 3.01
Too many roads not taken. Nature (2011) 2.93
Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium. Dis Model Mech (2012) 2.73
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. Nat Genet (2011) 2.72
A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles. Genesis (2004) 2.65
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12
Mouse duplicate genes are as essential as singletons. Trends Genet (2007) 2.12
Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans. Proc Biol Sci (2004) 1.94
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood (2009) 1.90
Gene essentiality, gene duplicability and protein connectivity in human and mouse. Trends Genet (2007) 1.89
The complex relationship of gene duplication and essentiality. Trends Genet (2009) 1.76
Genome-wide association studies in mice. Nat Rev Genet (2012) 1.75
Reduced body weight is a common effect of gene knockout in mice. BMC Genet (2008) 1.72
Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature. Am J Hum Genet (2011) 1.70
A resource for the conditional ablation of microRNAs in the mouse. Cell Rep (2012) 1.66
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models. Open Biol (2012) 1.65
Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell (2012) 1.57
Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits. Cell (2012) 1.48
X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet (2003) 1.45
Adaptor protein complex-4 (AP-4) deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disability. J Med Genet (2010) 1.43
A resource of vectors and ES cells for targeted deletion of microRNAs in mice. Nat Biotechnol (2011) 1.36
Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol (2006) 1.33
CBX7 is a tumor suppressor in mice and humans. J Clin Invest (2012) 1.24
The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol (2012) 1.20
Introduction to the Japan Mouse Clinic at the RIKEN BioResource Center. Exp Anim (2009) 1.14
Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm Genome (2012) 1.09
Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails. J Invest Dermatol (2011) 1.07
Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation. Mol Cell Biol (2001) 1.06
Immunological development and cardiovascular function are normal in annexin VI null mutant mice. Mol Cell Biol (1999) 1.05
The expression of Usp42 during embryogenesis and spermatogenesis in mouse. Gene Expr Patterns (2006) 0.96
Anxiety-like behaviors in mice lacking GIT2. Neurosci Lett (2008) 0.92
2E4/Kaptin (KPTN)--a candidate gene for the hearing loss locus, DFNA4. Ann Hum Genet (2000) 0.90
NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping. Mamm Genome (2012) 0.87
Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi. Nat Genet (2008) 19.97
A large and persistent carbon sink in the world's forests. Science (2011) 17.84
Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63
Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci (2013) 13.37
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Typhoid fever. N Engl J Med (2002) 12.96
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05
A conditional knockout resource for the genome-wide study of mouse gene function. Nature (2011) 9.93
Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet (2006) 9.87
Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature (2006) 9.30
Rapid pneumococcal evolution in response to clinical interventions. Science (2011) 9.09
Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet (2006) 8.02
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
The knockout mouse project. Nat Genet (2004) 7.80
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol (2007) 7.58
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol (2003) 7.47
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72
Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak. N Engl J Med (2012) 6.36
Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med (2003) 6.00
Multidrug-resistant Salmonella enterica serovar paratyphi A harbors IncHI1 plasmids similar to those found in serovar typhi. J Bacteriol (2007) 5.88
Evidence for several waves of global transmission in the seventh cholera pandemic. Nature (2011) 5.62
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell (2011) 5.19
Evolutionary history of Salmonella typhi. Science (2006) 5.00
Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2008) 4.98
Salmonella typhi, the causative agent of typhoid fever, is approximately 50,000 years old. Infect Genet Evol (2002) 4.96
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res (2003) 4.83
Citrobacter rodentium of mice and man. Cell Microbiol (2005) 4.76
Meta-analysis of genetic association studies. Trends Genet (2004) 4.72
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A (2003) 4.70
Routine use of microbial whole genome sequencing in diagnostic and public health microbiology. PLoS Pathog (2012) 4.69
IFITM3 restricts the morbidity and mortality associated with influenza. Nature (2012) 4.66
Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem (2013) 4.61
A high-resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biol (2006) 4.57
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 4.27
Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants. Genome Res (2009) 4.12
Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat Genet (2012) 4.10
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A (2004) 4.06
Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa. Lancet (2012) 4.02
Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. Genome Res (2009) 3.99
A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
Extracellular-matrix tethering regulates stem-cell fate. Nat Mater (2012) 3.94
The molecular clock mediates leptin-regulated bone formation. Cell (2005) 3.88
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development (2003) 3.84
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet (2004) 3.83
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog (2012) 3.81
Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry (2008) 3.80
Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet (2009) 3.72
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods (2009) 3.68
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biol (2009) 3.66
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell (2010) 3.60
Sox2 is required for sensory organ development in the mammalian inner ear. Nature (2005) 3.58
Identification of protein pheromones that promote aggressive behaviour. Nature (2007) 3.55
Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways. Genome Res (2008) 3.54
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53
Sequence-based characterization of structural variation in the mouse genome. Nature (2011) 3.48
Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell (2009) 3.45
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell (2009) 3.44
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40
Circadian orchestration of the hepatic proteome. Curr Biol (2006) 3.37
Multilocus sequence typing as a replacement for serotyping in Salmonella enterica. PLoS Pathog (2012) 3.37
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun (2009) 3.36
Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet (2008) 3.33
Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol (2010) 3.33
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLoS Genet (2006) 3.33
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol (2003) 3.31
Genetic and environmental effects on complex traits in mice. Genetics (2006) 3.27
Stem cell depletion through epidermal deletion of Rac1. Science (2005) 3.26
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25
Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development (2004) 3.24
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23
The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium. Nucleic Acids Res (2010) 3.23
Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe. Nat Genet (2012) 3.22
Evolutionary dynamics of Clostridium difficile over short and long time scales. Proc Natl Acad Sci U S A (2010) 3.18
ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A (2008) 3.15
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. Genes Dev (2002) 3.14
F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat Biotechnol (2006) 3.13
High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease. BMC Microbiol (2011) 3.11