Published in Proc Natl Acad Sci U S A on January 21, 2005
Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin. Mol Cell Biol (2006) 1.95
Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients' survival. Dig Dis Sci (2007) 1.64
Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. J Clin Invest (2011) 1.60
Vitamin D receptor is essential for normal keratinocyte stem cell function. Proc Natl Acad Sci U S A (2007) 1.42
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology (2006) 1.36
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A (2010) 1.29
Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk. Genes Cancer (2013) 1.28
Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts. Exp Lung Res (2010) 1.08
Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance. J Biol Chem (2010) 1.08
Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway. Exp Cell Res (2010) 1.02
Repression of beta-catenin signaling by PPAR gamma ligands. Eur J Pharmacol (2010) 1.01
PPAR gamma, bioactive lipids, and cancer progression. Front Biosci (Landmark Ed) (2012) 1.01
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. Mol Carcinog (2009) 0.98
The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. Nutr J (2007) 0.96
Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines. PLoS One (2009) 0.96
Small interfering RNA-mediated downregulation of beta-catenin inhibits invasion and migration of colon cancer cells in vitro. Med Sci Monit (2012) 0.94
Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer. Mol Carcinog (2011) 0.93
PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling. J Cell Mol Med (2007) 0.93
A Role for the PPARgamma in Cancer Therapy. PPAR Res (2008) 0.89
Clock genes: their role in colorectal cancer. World J Gastroenterol (2014) 0.86
PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. Invest New Drugs (2007) 0.85
Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction. Front Physiol (2014) 0.85
Emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer. World J Gastroenterol (2014) 0.84
Molecular basis of the potential of mesalazine to prevent colorectal cancer. World J Gastroenterol (2008) 0.83
TGFβ can stimulate the p(38)/β-catenin/PPARγ signaling pathway to promote the EMT, invasion and migration of non-small cell lung cancer (H460 cells). Clin Exp Metastasis (2014) 0.83
MicroRNA-130b promotes cell proliferation and invasion by inhibiting peroxisome proliferator-activated receptor-γ in human glioma cells. Int J Mol Med (2016) 0.81
Effects of gastrin 17 on beta-catenin/Tcf-4 pathway in Colo320WT colon cancer cells. World J Gastroenterol (2006) 0.81
Insulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. PLoS One (2013) 0.80
Multi-level interactions between the nuclear receptor TRα1 and the WNT effectors β-catenin/Tcf4 in the intestinal epithelium. PLoS One (2012) 0.79
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma. Front Neurosci (2016) 0.79
Adaptive elastic-net sparse principal component analysis for pathway association testing. Stat Appl Genet Mol Biol (2011) 0.78
Canonical Wnt signaling activity in early stages of chick lung development. PLoS One (2014) 0.77
Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation. Genome Med (2016) 0.77
Opposite Interplay between PPAR Gamma and Canonical Wnt/Beta-Catenin Pathway in Amyotrophic Lateral Sclerosis. Front Neurol (2016) 0.76
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PPAR Res (2017) 0.75
Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance. FASEB J (2015) 0.75
Peroxisome proliferator activated receptor-γ and the ubiquitin-proteasome system in colorectal cancer. World J Gastrointest Oncol (2010) 0.75
Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines. Front Genet (2016) 0.75
Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway. Cell Death Dis (2017) 0.75
LiCl Treatment Induces Programmed Cell Death of Schwannoma Cells through AKT- and MTOR-Mediated Necroptosis. Neurochem Res (2017) 0.75
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell (1994) 17.58
Identification and characterization of the familial adenomatous polyposis coli gene. Cell (1991) 14.46
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem (1995) 13.34
The RXR heterodimers and orphan receptors. Cell (1995) 12.33
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A (1999) 10.75
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science (1990) 9.90
APC mutations occur early during colorectal tumorigenesis. Nature (1992) 9.50
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol (1996) 6.88
Identification of deletion mutations and three new genes at the familial polyposis locus. Cell (1991) 5.42
Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med (1998) 5.16
Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. Mol Cell Biol (1998) 3.79
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol (2001) 3.44
Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med (1998) 3.13
Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat Med (1998) 2.90
Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology (2003) 2.65
The Yin-Yang of TCF/beta-catenin signaling. Adv Cancer Res (2000) 2.62
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology (2003) 2.59
Beta-catenin affects androgen receptor transcriptional activity and ligand specificity. Cancer Res (2000) 2.44
APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A (2002) 1.89
A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis. J Biol Chem (2000) 1.87
Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res (2001) 1.80
The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. Carcinogenesis (1998) 1.59
Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues. Carcinogenesis (2000) 1.52
Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells. J Biol Chem (2001) 1.48
Wnt signaling during development of the gastrointestinal tract. Dev Biol (2003) 1.44
The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J Mol Med (Berl) (2001) 1.36
Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway. J Biol Chem (2004) 1.36
Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells. J Endocrinol (1999) 1.35
Expression of the peroxisome proliferator-activated receptor (PPAR) in the mouse colonic mucosa. Biochem Biophys Res Commun (1996) 1.34
Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells. J Biol Chem (2002) 1.28
Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3' enhancer. Nucleic Acids Res (1992) 1.17
Beta-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res (2001) 1.17
A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4. J Biol Chem (2003) 1.16
Localized gene action controlling intestinal neoplasia in mice. Proc Natl Acad Sci U S A (1997) 1.02
PPARgamma and colorectal carcinoma: conflicts in a nuclear family. Nat Med (1998) 0.90
The role of PPARgamma in colon cancer: is it as simple as APC? Gastroenterology (2003) 0.77
PPARgamma, an X-ceptor for Xs. Ann N Y Acad Sci (2002) 0.77
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med (2007) 12.24
The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity (2009) 8.95
Host-gut microbiota metabolic interactions. Science (2012) 7.73
Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A (2011) 6.16
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol (2003) 5.87
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology (2003) 2.59
Predominant role of host genetics in controlling the composition of gut microbiota. PLoS One (2008) 2.33
Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging. Proc Natl Acad Sci U S A (2010) 2.14
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci U S A (2011) 1.89
A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc Natl Acad Sci U S A (2002) 1.82
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. Am J Pathol (2006) 1.77
Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem (2012) 1.76
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A (2008) 1.74
Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell (2009) 1.68
Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge. J Allergy Clin Immunol (2009) 1.68
Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine. Cell Microbiol (2007) 1.55
Over-expression of a modified bifunctional apoptosis regulator protects against cardiac injury and doxorubicin-induced cardiotoxicity in transgenic mice. Cardiovasc Res (2008) 1.52
Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet (2002) 1.50
Intestinal microbiota regulate xenobiotic metabolism in the liver. PLoS One (2009) 1.49
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development (2014) 1.49
The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp Cell Res (2006) 1.46
Therapeutic modulation of microbiota-host metabolic interactions. Sci Transl Med (2012) 1.45
Environmentally-acquired bacteria influence microbial diversity and natural innate immune responses at gut surfaces. BMC Biol (2009) 1.45
Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLoS One (2010) 1.43
Isolation of flagellated bacteria implicated in Crohn's disease. Inflamm Bowel Dis (2007) 1.40
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A (2009) 1.40
De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. PLoS One (2009) 1.39
Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells. Proc Natl Acad Sci U S A (2008) 1.38
Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice. Carcinogenesis (2012) 1.31
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A (2010) 1.29
Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative. Anal Chem (2004) 1.28
Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease. Gastroenterology (2007) 1.24
Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J Biol Chem (2004) 1.24
Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of Clostridium difficile-associated diarrhea in hospitalized patients. Antimicrob Agents Chemother (2009) 1.22
Airway inflammation and IgE production induced by dust mite allergen-specific memory/effector Th2 cell line can be effectively attenuated by IL-35. J Immunol (2011) 1.16
Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1. EMBO J (2002) 1.16
SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther (2010) 1.14
Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity. Exp Cell Res (2007) 1.13
Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes. EMBO Rep (2004) 1.11
Establishment of normal gut microbiota is compromised under excessive hygiene conditions. PLoS One (2011) 1.07
PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. Inflamm Bowel Dis (2009) 1.06
Tetracycline resistome of the organic pig gut. Appl Environ Microbiol (2009) 1.06
Inflammatory bowel disease, gut bacteria and probiotic therapy. Int J Med Microbiol (2009) 1.03
WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. Exp Cell Res (2008) 0.99
Effects of personal exposure to particulate matter and ozone on arterial stiffness and heart rate variability in healthy adults. Am J Epidemiol (2010) 0.99
Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation. PLoS One (2009) 0.99
Restricting microbial exposure in early life negates the immune benefits associated with gut colonization in environments of high microbial diversity. PLoS One (2011) 0.98
ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways. Am J Physiol Gastrointest Liver Physiol (2013) 0.93
Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: an NMR study on Blomia tropicalis major allergen. Structure (2008) 0.91
Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's disease. Inflamm Bowel Dis (2007) 0.91
Abrogated lymphocyte infiltration and lowered CD14 in dextran sulfate induced colitis in mice treated with p65 antisense oligonucleotides. Int J Colorectal Dis (2002) 0.91
Gut microbial communities modulating brain development and function. Gut Microbes (2012) 0.90
Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker. BMC Med Genomics (2013) 0.90
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem Cell Reports (2015) 0.89
Efficient antigen presentation of soluble, but not particulate, antigen in the absence of Wiskott-Aldrich syndrome protein. Immunology (2003) 0.89
DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE. Nucleic Acids Res (2005) 0.89
Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. Inflamm Bowel Dis (2010) 0.89
Phosphoinositide 3-kinase regulates a subset of interferon-alpha-stimulated genes. Exp Cell Res (2006) 0.88
A novel carbazole derivative, BMVC: a potential antitumor agent and fluorescence marker of cancer cells. Chem Biodivers (2004) 0.88
The gut microbiome: scourge, sentinel or spectator? J Oral Microbiol (2012) 0.88
ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice. Carcinogenesis (2013) 0.86
Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition. PLoS One (2008) 0.85
The NF-κB binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells. Eur J Immunol (2013) 0.85
Novel immunostimulatory agent based on CpG oligodeoxynucleotide linked to the nontoxic B subunit of cholera toxin. J Immunol (2006) 0.84
Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets. Am J Physiol Gastrointest Liver Physiol (2013) 0.84
Direct experimental evidence that early-life farm environment influences regulation of immune responses. Pediatr Allergy Immunol (2012) 0.84
G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells. Mol Cancer Res (2008) 0.84
The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis. Int J Biol Sci (2010) 0.83
Recombinant adenovirus vector activates and protects human monocyte-derived dendritic cells from apoptosis. Hum Gene Ther (2002) 0.83
Investigating the association of cardiovascular effects with personal exposure to particle components and sources. Sci Total Environ (2012) 0.83
Venom immunotherapy reduces large local reactions to insect stings. J Allergy Clin Immunol (2009) 0.83
The Blomia tropicalis allergens. Protein Pept Lett (2007) 0.83
A constitutively active aryl hydrocarbon receptor causes loss of peritoneal B1 cells. Biochem Biophys Res Commun (2003) 0.81
Identification of a new WASP and FKBP-like (WAFL) protein in inflammatory bowel disease: a potential marker gene for ulcerative colitis. Int J Colorectal Dis (2008) 0.81
PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse. PLoS One (2012) 0.81
A CLA's act: feeding away inflammation. Gastroenterology (2004) 0.81
Profiles of Microbial Fatty Acids in the Human Metabolome are Disease-Specific. Front Microbiol (2011) 0.81
The Crohn's associated NOD2 3020InsC frameshift mutation does not confer susceptibility to ankylosing spondylitis. J Rheumatol (2002) 0.81
DNA vaccines for the prevention and treatment of allergy. Curr Opin Allergy Clin Immunol (2009) 0.80
The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis. Oncogene (2005) 0.80
Functional interaction of CARD15/NOD2 and Crohn's disease-associated TNFalpha polymorphisms. Int J Colorectal Dis (2005) 0.80
Posttranslational inhibition of proinflammatory chemokine secretion in intestinal epithelial cells: implications for specific IBD indications. J Clin Gastroenterol (2010) 0.80
Regulation of N-glycolylneuraminic acid biosynthesis in developing pig small intestine. Biochem J (2003) 0.80
Signaling through a mutant IFN-gamma receptor. J Immunol (2005) 0.79
Hyper-responsive T-cell cytokine profile in association with development of early childhood wheeze but not eczema at 2 years. Asian Pac J Allergy Immunol (2014) 0.78
Intramuscular immunization with DNA construct containing Der p 2 and signal peptide sequences primed strong IgE production. Vaccine (2006) 0.78
The long and winding road to gut homeostasis. Curr Opin Gastroenterol (2006) 0.78
Structural isomers and binding sites of guanine-rich quadruplexes investigated by induced circular dichroism of thionin: loops and tails. J Biomol Struct Dyn (2003) 0.77
Comparative analysis of cytokine profiles in autoinflammatory and autoimmune conditions. Cytokine (2010) 0.77