|
1
|
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse.
|
Neuropharmacology
|
2007
|
2.39
|
|
2
|
Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats.
|
Neuropharmacology
|
2005
|
1.34
|
|
3
|
Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model.
|
Behav Brain Res
|
2007
|
1.28
|
|
4
|
mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats.
|
Neuropharmacology
|
2006
|
1.15
|
|
5
|
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect.
|
Neuropharmacology
|
2005
|
1.15
|
|
6
|
The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat.
|
Neuropsychopharmacology
|
2005
|
1.12
|
|
7
|
Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease.
|
J Neurochem
|
2007
|
1.12
|
|
8
|
Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats.
|
Neuropharmacology
|
2002
|
1.06
|
|
9
|
A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.
|
Neurobiol Dis
|
2010
|
1.04
|
|
10
|
Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine.
|
Behav Pharmacol
|
2006
|
1.04
|
|
11
|
Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.
|
Neuropharmacology
|
2006
|
1.03
|
|
12
|
Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats.
|
Psychopharmacology (Berl)
|
2006
|
1.02
|
|
13
|
Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.
|
Eur J Pharmacol
|
2005
|
1.01
|
|
14
|
Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease.
|
Brain Res Bull
|
2006
|
1.00
|
|
15
|
Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane.
|
Pharmacol Biochem Behav
|
2006
|
1.00
|
|
16
|
Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition.
|
Behav Pharmacol
|
2009
|
1.00
|
|
17
|
Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo.
|
Eur J Pharmacol
|
2006
|
0.99
|
|
18
|
Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.
|
J Pharmacol Exp Ther
|
2009
|
0.98
|
|
19
|
Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice.
|
Eur Neuropsychopharmacol
|
2005
|
0.98
|
|
20
|
Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease.
|
Neurotox Res
|
2013
|
0.96
|
|
21
|
Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity.
|
Eur J Pharmacol
|
2009
|
0.96
|
|
22
|
The role of excitotoxicity in neurodegeneration.
|
Folia Neuropathol
|
2005
|
0.93
|
|
23
|
Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats.
|
Psychopharmacology (Berl)
|
2007
|
0.93
|
|
24
|
Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia.
|
Pharmacol Biochem Behav
|
2009
|
0.92
|
|
25
|
The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning.
|
Neuropharmacology
|
2009
|
0.92
|
|
26
|
Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction.
|
Neurotox Res
|
2008
|
0.92
|
|
27
|
Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists.
|
Eur J Pharmacol
|
2005
|
0.89
|
|
28
|
Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder.
|
Eur Neuropsychopharmacol
|
2008
|
0.88
|
|
29
|
Evaluation of brain pharmacokinetics of (+)MK-801 in relation to behaviour.
|
Neurosci Lett
|
2011
|
0.87
|
|
30
|
Behavioural and cellular effects of exogenous amyloid-β peptides in rodents.
|
Behav Brain Res
|
2011
|
0.87
|
|
31
|
Neuroprotective potential of group I metabotropic glutamate receptor antagonists in two ischemic models.
|
Neurochem Int
|
2006
|
0.86
|
|
32
|
N-methyl-D-aspartate and group I metabotropic glutamate receptors are involved in the expression of ethanol-induced sensitization in mice.
|
Behav Pharmacol
|
2006
|
0.86
|
|
33
|
A new automated method to assess the rat recognition memory: validation of the method.
|
Behav Brain Res
|
2011
|
0.85
|
|
34
|
Proteomic analysis of striatal proteins in the rat model of L-DOPA-induced dyskinesia.
|
J Neurochem
|
2007
|
0.83
|
|
35
|
Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function.
|
Behav Pharmacol
|
2012
|
0.83
|
|
36
|
Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain.
|
Neuropharmacology
|
2004
|
0.83
|
|
37
|
Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity.
|
Behav Pharmacol
|
2011
|
0.82
|
|
38
|
Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats.
|
Behav Pharmacol
|
2008
|
0.82
|
|
39
|
The role of group I mGlu receptors in the expression of ethanol-induced conditioned place preference and ethanol withdrawal seizures in rats.
|
Eur J Pharmacol
|
2011
|
0.81
|
|
40
|
A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine.
|
Psychopharmacology (Berl)
|
2008
|
0.81
|
|
41
|
Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition.
|
Behav Pharmacol
|
2007
|
0.80
|
|
42
|
Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats.
|
J Neural Transm (Vienna)
|
2008
|
0.80
|
|
43
|
Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication.
|
Eur J Pharmacol
|
2012
|
0.79
|
|
44
|
mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy.
|
Neuropharmacology
|
2006
|
0.79
|
|
45
|
Enhancement of antidepressant-like effects but not brain-derived neurotrophic factor mRNA expression by the novel N-methyl-D-aspartate receptor antagonist neramexane in mice.
|
J Pharmacol Exp Ther
|
2006
|
0.78
|
|
46
|
Effects of morphine on formalin-induced nociception in rats.
|
Eur J Pharmacol
|
2003
|
0.78
|
|
47
|
Oral creatine supplementation attenuates L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats.
|
Behav Brain Res
|
2008
|
0.78
|
|
48
|
Anti-allodynic interactions between NMDA receptor channel blockers and morphine or clonidine in neuropathic rats.
|
Eur J Pharmacol
|
2005
|
0.77
|
|
49
|
Neuroprotective effects of NS-7, voltage-gated Na+/Ca2+ channel blocker in a rodent model of transient focal ischaemia.
|
Neurotox Res
|
2003
|
0.77
|
|
50
|
Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats.
|
Toxicol Appl Pharmacol
|
2009
|
0.77
|
|
51
|
Effect of 5-HT5A antagonists in animal models of schizophrenia, anxiety and depression.
|
Behav Pharmacol
|
2012
|
0.76
|
|
52
|
Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia.
|
J Neural Transm (Vienna)
|
2010
|
0.76
|
|
53
|
Effect of neramexane on ethanol dependence and reinforcement.
|
Eur J Pharmacol
|
2004
|
0.76
|
|
54
|
Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats.
|
Eur J Pharmacol
|
2003
|
0.76
|
|
55
|
Neuroprotective activity of a nanoparticulate formulation of the glycineB site antagonist MRZ 2/576 in transient focal ischaemia in rats.
|
Arzneimittelforschung
|
2002
|
0.76
|
|
56
|
Effects of dopamine uptake inhibitor MRZ-9547 in animal models of Parkinson's disease.
|
J Neural Transm (Vienna)
|
2014
|
0.76
|
|
57
|
Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model.
|
Pharmacology
|
2008
|
0.75
|
|
58
|
Effects of mGluR5 positive and negative allosteric modulators on brain damage evoked by hypoxia-ischemia in neonatal rats.
|
Folia Neuropathol
|
2015
|
0.75
|