Published in Eur J Pharmacol on October 10, 2006
Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia (2009) 1.28
Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem (2009) 1.15
Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition. Proc Natl Acad Sci U S A (2009) 1.09
Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats. Alcohol (2008) 0.95
Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemia. ASN Neuro (2013) 0.87
Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental traumatic brain injury. Neurotherapeutics (2014) 0.87
Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis. Mol Brain (2013) 0.85
The effect of treadmill training pre-exercise on glutamate receptor expression in rats after cerebral ischemia. Int J Mol Sci (2010) 0.84
N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. PLoS One (2012) 0.83
PET brain kinetics studies of (11)C-ITMM and (11)C-ITDM,radioprobes for metabotropic glutamate receptor type 1, in a nonhuman primate. Am J Nucl Med Mol Imaging (2014) 0.82
Selective mGluR1 antagonist EMQMCM inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus. Neurotox Res (2011) 0.78
A glutamate receptor antagonist, S-4-carboxyphenylglycine (S-4-CPG), inhibits vasospasm after subarachnoid hemorrhage in haptoglobin 2-2 mice [corrected]. Neurosurgery (2013) 0.77
Noninvasive quantification of metabotropic glutamate receptor type 1 with [¹¹C]ITDM: a small-animal PET study. J Cereb Blood Flow Metab (2014) 0.77
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse. Neuropharmacology (2007) 2.39
The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia. J Mol Med (Berl) (2013) 1.64
Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas. PLoS One (2011) 1.50
The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence. Int J Geriatr Psychiatry (2003) 1.50
Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats. Neuropharmacology (2005) 1.34
Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model. Behav Brain Res (2007) 1.28
The invasion promoting effect of microglia on glioblastoma cells is inhibited by cyclosporin A. Brain (2006) 1.27
Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections. Br J Pharmacol (2012) 1.26
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression. Cancer Res (2011) 1.25
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol (2009) 1.19
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology (2005) 1.15
mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats. Neuropharmacology (2006) 1.15
Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells. Oncogene (2003) 1.15
The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology (2005) 1.12
Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease. J Neurochem (2007) 1.12
Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response. J Pathol (2013) 1.10
Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices. Neuropharmacology (2011) 1.10
Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-D-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors. Neuropharmacology (2009) 1.08
Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Cell Signal (2005) 1.07
Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats. Neuropharmacology (2002) 1.06
A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys. Neurobiol Dis (2010) 1.04
Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine. Behav Pharmacol (2006) 1.04
Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration. Neuropharmacology (2006) 1.03
Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats. Psychopharmacology (Berl) (2006) 1.02
Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats. Eur J Pharmacol (2005) 1.01
Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease. Brain Res Bull (2006) 1.00
Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition. Behav Pharmacol (2009) 1.00
Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane. Pharmacol Biochem Behav (2006) 1.00
A novel mechanism of FK506-mediated neuroprotection: downregulation of cytokine expression in glial cells. Glia (2005) 1.00
Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice. Eur Neuropsychopharmacol (2005) 0.98
Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling. J Pharmacol Exp Ther (2009) 0.98
Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression. Biochim Biophys Acta (2011) 0.97
Cross-talk between Smad and p38 MAPK signalling in transforming growth factor beta signal transduction in human glioblastoma cells. Biochem Biophys Res Commun (2007) 0.97
Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease. Neurotox Res (2013) 0.96
Improvement of ballistocardiogram processing by inclusion of respiration information. Physiol Meas (2008) 0.96
Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity. Eur J Pharmacol (2009) 0.96
Expression of polyglutamine-expanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors. J Biol Chem (2003) 0.95
Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells. Autophagy (2011) 0.95
Influence of chemical and ischemic preconditioning on cytokine expression after focal brain ischemia. J Neurosci Res (2004) 0.94
Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia. Glia (2013) 0.93
Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats. Psychopharmacology (Berl) (2007) 0.93
The role of excitotoxicity in neurodegeneration. Folia Neuropathol (2005) 0.93
Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia. Pharmacol Biochem Behav (2009) 0.92
Optical resonance transmission properties of nano-hole arrays in a gold film: effect of adhesion layer. Opt Express (2011) 0.92
The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning. Neuropharmacology (2009) 0.92
Prolonged activation of ERK triggers glutamate-induced apoptosis of astrocytes: neuroprotective effect of FK506. J Neurochem (2010) 0.92
Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction. Neurotox Res (2008) 0.92
Nanohole-array-based device for 2D snapshot multispectral imaging. Sci Rep (2013) 0.91
Non-apoptotic Fas signaling regulates invasiveness of glioma cells and modulates MMP-2 activity via NFkappaB-TIMP-2 pathway. Cell Signal (2009) 0.91
Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A. J Biol Chem (2002) 0.90
The antitumorigenic response of neural precursors depends on subventricular proliferation and age. Stem Cells (2008) 0.90
Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications. Am J Pathol (2010) 0.90
Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes. Mol Cell Neurosci (2003) 0.89
Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists. Eur J Pharmacol (2005) 0.89
Comparative analysis of three different modalities for characterization of the seismocardiogram. Conf Proc IEEE Eng Med Biol Soc (2009) 0.89
Early steps of microglial activation are directly affected by neuroprotectant FK506 in both in vitro inflammation and in rat model of stroke. J Mol Med (Berl) (2012) 0.88
The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism. Neuropharmacology (2006) 0.88
Dimer composition and promoter context contribute to functional cooperation between AP-1 and NFAT. J Mol Biol (2007) 0.88
Neuroprotectant FK506 inhibits glutamate-induced apoptosis of astrocytes in vitro and in vivo. J Neurochem (2006) 0.88
Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder. Eur Neuropsychopharmacol (2008) 0.88
Infrasonic cardiac signals: complementary windows to cardiovascular dynamics. Conf Proc IEEE Eng Med Biol Soc (2011) 0.88
Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFα- and NK cytotoxicity. Exp Cell Res (2012) 0.87
Evaluation of brain pharmacokinetics of (+)MK-801 in relation to behaviour. Neurosci Lett (2011) 0.87
Evaluation of a novel integrated sensor system for synchronous measurement of cardiac vibrations and cardiac potentials. J Med Syst (2009) 0.87
Experimental and numerical analysis on the optical resonance transmission properties of nano-hole arrays. Opt Express (2010) 0.87
Behavioural and cellular effects of exogenous amyloid-β peptides in rodents. Behav Brain Res (2011) 0.87
Neuroprotective potential of group I metabotropic glutamate receptor antagonists in two ischemic models. Neurochem Int (2006) 0.86
Cyclosporine A and its non-immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in in vitro and in vivo studies. Int J Cancer (2005) 0.86
Effect of surface plasmon cross-talk on optical properties of closely packed nano-hole arrays. Opt Express (2011) 0.86
N-methyl-D-aspartate and group I metabotropic glutamate receptors are involved in the expression of ethanol-induced sensitization in mice. Behav Pharmacol (2006) 0.86
N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery. Gastroenterology (2005) 0.85
Transillumination hyperspectral imaging for histopathological examination of excised tissue. J Biomed Opt (2011) 0.85
A new automated method to assess the rat recognition memory: validation of the method. Behav Brain Res (2011) 0.85
Identification of pathway deregulation--gene expression based analysis of consistent signal transduction. PLoS One (2012) 0.84
BSeg++: a modified blind segmentation method for Ballistocardiogram cycle extraction. Conf Proc IEEE Eng Med Biol Soc (2007) 0.84
Cyclosporine a induces growth arrest or programmed cell death of human glioma cells. Neurochem Int (2005) 0.84
Signal transducer and activator of transcription 1 (Stat1) maintains basal mRNA expression of pro-survival stat3-target genes in glioma C6 cells. J Cell Biochem (2011) 0.84
Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and pediatric brain tumors. Brain Res (2006) 0.84
Neuroprotective potential of ionotropic glutamate receptor antagonists. Neurotox Res (2002) 0.84
Proteomic analysis of striatal proteins in the rat model of L-DOPA-induced dyskinesia. J Neurochem (2007) 0.83
Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells. Cancer Biol Ther (2012) 0.83
Alternative pathway of transcriptional induction of p21WAF1/Cip1 by cyclosporine A in p53-deficient human glioblastoma cells. Cell Signal (2007) 0.83
Validation of respiratory signal derived from suprasternal notch acceleration for sleep apnea detection. Conf Proc IEEE Eng Med Biol Soc (2011) 0.83
STAT signaling in glioma cells. Adv Exp Med Biol (2013) 0.83
Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain. Neuropharmacology (2004) 0.83
Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function. Behav Pharmacol (2012) 0.83
Comparative analysis of cis-regulation following stroke and seizures in subspaces of conserved eigensystems. BMC Syst Biol (2010) 0.83
Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity. Behav Pharmacol (2011) 0.82
The diversity of p53 mutations among human brain tumors and their functional consequences. Neurochem Int (2002) 0.82
Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats. Behav Pharmacol (2008) 0.82
Nencki Genomics Database--Ensembl funcgen enhanced with intersections, user data and genome-wide TFBS motifs. Database (Oxford) (2013) 0.81
A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine. Psychopharmacology (Berl) (2008) 0.81
The role of group I mGlu receptors in the expression of ethanol-induced conditioned place preference and ethanol withdrawal seizures in rats. Eur J Pharmacol (2011) 0.81
Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol (2007) 0.80
Development of a novel contactless mechanocardiograph device. Int J Telemed Appl (2008) 0.80
Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. J Neural Transm (Vienna) (2008) 0.80
Off-target effects of plasmid-transcribed shRNAs on NFκB signaling pathway and cell survival of human melanoma cells. Mol Biol Rep (2013) 0.80