Published in Proc Natl Acad Sci U S A on January 25, 2005
A genetically encoded boronate-containing amino acid. Angew Chem Int Ed Engl (2008) 1.54
Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids. ACS Chem Biol (2011) 1.28
Structural plasticity of an aminoacyl-tRNA synthetase active site. Proc Natl Acad Sci U S A (2006) 1.13
Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms. Nucleic Acids Res (2007) 1.07
Transplantation of a tyrosine editing domain into a tyrosyl-tRNA synthetase variant enhances its specificity for a tyrosine analog. Proc Natl Acad Sci U S A (2008) 0.97
Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion. Nucleic Acids Res (2010) 0.92
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids. Nat Biotechnol (2015) 0.86
Non-natural nucleotides as probes for the mechanism and fidelity of DNA polymerases. Biochim Biophys Acta (2009) 0.82
Role of tRNA orthogonality in an expanded genetic code. ACS Chem Biol (2014) 0.76
Proofreading optimizes iodotyrosine insertion into the genetic code. Proc Natl Acad Sci U S A (2008) 0.75
Structural states of the flexible catalytic loop of M. tuberculosis tyrosyl-tRNA synthetase in different enzyme-substrate complexes. Eur Biophys J (2014) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Expanding the genetic code of Escherichia coli. Science (2001) 7.25
An expanded eukaryotic genetic code. Science (2003) 4.66
Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proc Natl Acad Sci U S A (2002) 3.77
Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate. J Mol Biol (1989) 3.16
PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules. J Comput Aided Mol Des (1996) 2.94
Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. J Am Chem Soc (2002) 2.88
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion. Nat Struct Biol (2003) 2.71
Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition. EMBO J (2002) 2.09
An expanded genetic code with a functional quadruplet codon. Proc Natl Acad Sci U S A (2004) 2.09
An efficient system for the evolution of aminoacyl-tRNA synthetase specificity. Nat Biotechnol (2002) 1.73
Site-specific incorporation of an unnatural amino acid into proteins in mammalian cells. Nucleic Acids Res (2002) 1.64
Retracted A new strategy for the synthesis of glycoproteins. Science (2004) 1.44
Crystal structure of a human aminoacyl-tRNA synthetase cytokine. Proc Natl Acad Sci U S A (2002) 1.40
An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system. Proc Natl Acad Sci U S A (2002) 1.35
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 1.35
Structural snapshots of the KMSKS loop rearrangement for amino acid activation by bacterial tyrosyl-tRNA synthetase. J Mol Biol (2004) 1.22
Adding L-3-(2-Naphthyl)alanine to the genetic code of E. coli. J Am Chem Soc (2002) 1.16
Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci (2001) 1.13
Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine. J Mol Biol (1987) 1.13
Biosynthesis of a protein containing a nonprotein amino acid by Escherichia coli: L-2-aminohexanoic acid at position 21 in human epidermal growth factor. Proc Natl Acad Sci U S A (1988) 0.93
Correlations between kinetic and X-ray analyses of engineered enzymes: crystal structures of mutants Cys----Gly-35 and Tyr----Phe-34 of tyrosyl-tRNA synthetase. Biochemistry (1991) 0.81
Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution. Nature (2002) 6.74
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell (2006) 6.09
Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell (2006) 5.70
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell (2002) 5.64
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell (2003) 5.06
Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell (2007) 4.73
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev (2007) 4.35
Protein production and purification. Nat Methods (2008) 3.97
Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription. Cell (2004) 3.39
ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding. EMBO J (2003) 3.14
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature (2013) 2.74
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion. Nat Struct Biol (2003) 2.71
Structural basis for substrate selection by t7 RNA polymerase. Cell (2004) 2.62
Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors. Mol Cell (2007) 2.62
Structural basis for transcription regulation by alarmone ppGpp. Cell (2004) 2.60
Structure of a T7 RNA polymerase elongation complex at 2.9 A resolution. Nature (2002) 2.57
An unnatural hydrophobic base pair system: site-specific incorporation of nucleotide analogs into DNA and RNA. Nat Methods (2006) 2.46
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol (2007) 2.38
Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases. Biochem Biophys Res Commun (2008) 2.29
Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif-like domain. Protein Sci (2006) 2.29
Alternative tertiary structure of tRNA for recognition by a posttranscriptional modification enzyme. Cell (2003) 2.29
Preparation of Escherichia coli cell extract for highly productive cell-free protein expression. J Struct Funct Genomics (2004) 2.14
Multistep engineering of pyrrolysyl-tRNA synthetase to genetically encode N(epsilon)-(o-azidobenzyloxycarbonyl) lysine for site-specific protein modification. Chem Biol (2008) 2.13
Reconstitution reveals the functional core of mammalian eIF3. EMBO J (2007) 2.06
A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction. J Virol (2009) 2.03
Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein. Nature (2010) 2.01
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain. EMBO Rep (2003) 2.01
A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling. Biochem J (2003) 2.00
Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form. Mol Cell (2002) 1.98
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome. Structure (2007) 1.97
Inference of S-system models of genetic networks using a cooperative coevolutionary algorithm. Bioinformatics (2004) 1.96
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly. Mol Cell (2005) 1.93
Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer. J Biol Chem (2004) 1.89
The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation. Nat Struct Mol Biol (2005) 1.87
Aminoacylation complex structures of leucyl-tRNA synthetase and tRNALeu reveal two modes of discriminator-base recognition. Nat Struct Mol Biol (2005) 1.82
Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression. J Natl Cancer Inst (2002) 1.78
Primary sequence of glutamic acid tRNA II from Escherichia coli. FEBS Lett (1972) 1.77
An enzyme with a deep trefoil knot for the active-site architecture. Acta Crystallogr D Biol Crystallogr (2002) 1.72
Codon reassignment in the Escherichia coli genetic code. Nucleic Acids Res (2010) 1.68
Protein photo-cross-linking in mammalian cells by site-specific incorporation of a photoreactive amino acid. Nat Methods (2005) 1.67
UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet (2012) 1.67
Crystal structure of elongation factor P from Thermus thermophilus HB8. Proc Natl Acad Sci U S A (2004) 1.65
Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors. Chem Biol (2011) 1.65
Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography. Structure (2009) 1.64
Site-specific incorporation of an unnatural amino acid into proteins in mammalian cells. Nucleic Acids Res (2002) 1.64
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood (2012) 1.63
Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G. EMBO J (2009) 1.63
Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. Mol Cell Biol (2010) 1.63
A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P. Nat Struct Mol Biol (2010) 1.62
Site-specific incorporation of a photo-crosslinking component into RNA by T7 transcription mediated by unnatural base pairs. Chem Biol (2004) 1.59
Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. Mol Cell (2004) 1.57
An unnatural base pair system for efficient PCR amplification and functionalization of DNA molecules. Nucleic Acids Res (2008) 1.56
The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem (2006) 1.56
Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase. Structure (2006) 1.56
Expression and purification of recombinant human histones. Methods (2004) 1.54
Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4. J Biol Chem (2006) 1.54
Structural basis of replication origin recognition by the DnaA protein. Nucleic Acids Res (2003) 1.54
Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme. Structure (2004) 1.53
Drosophila U6 promoter-driven short hairpin RNAs effectively induce RNA interference in Schneider 2 cells. Biochem Biophys Res Commun (2005) 1.53
Structural basis for functional mimicry of long-variable-arm tRNA by transfer-messenger RNA. Proc Natl Acad Sci U S A (2007) 1.52
Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression. RNA (2009) 1.50
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol (2006) 1.47
Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol (2003) 1.47
A common mechanism for the ATP-DnaA-dependent formation of open complexes at the replication origin. J Biol Chem (2008) 1.46
Solution structure of an Arabidopsis WRKY DNA binding domain. Plant Cell (2005) 1.45
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J (2006) 1.45
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. Nat Struct Mol Biol (2009) 1.45
KUJIRA, a package of integrated modules for systematic and interactive analysis of NMR data directed to high-throughput NMR structure studies. J Biomol NMR (2007) 1.44
Functional convergence of two lysyl-tRNA synthetases with unrelated topologies. Nat Struct Biol (2002) 1.43
Mutational separation of two pathways for editing by a class I tRNA synthetase. Mol Cell (2002) 1.42
Highly specific unnatural base pair systems as a third base pair for PCR amplification. Nucleic Acids Res (2011) 1.42
An efficient unnatural base pair for PCR amplification. J Am Chem Soc (2007) 1.41
RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes. Biol Reprod (2012) 1.40
Solution structure of the B3 DNA binding domain of the Arabidopsis cold-responsive transcription factor RAV1. Plant Cell (2004) 1.40
Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A. Genes Dev (2011) 1.40
Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases. Structure (2008) 1.38
The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP DnaA-specific initiation complexes. Genes Dev (2007) 1.37
Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1 . Biochemistry (2010) 1.36
Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation. J Mol Biol (2004) 1.35
A two-unnatural-base-pair system toward the expansion of the genetic code. J Am Chem Soc (2004) 1.35
An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system. Proc Natl Acad Sci U S A (2002) 1.35
An unnatural base pair for incorporating amino acid analogs into proteins. Nat Biotechnol (2002) 1.35
Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha. J Virol (2011) 1.34
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase. Nat Struct Mol Biol (2004) 1.34
Lessons from structural genomics. Annu Rev Biophys (2009) 1.33
Activation of the pyrrolysine suppressor tRNA requires formation of a ternary complex with class I and class II lysyl-tRNA synthetases. Mol Cell (2003) 1.33
13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit. Bioorg Med Chem (2005) 1.32
Structural basis for the recognition between the regulatory particles Nas6 and Rpt3 of the yeast 26S proteasome. Biochem Biophys Res Commun (2007) 1.32
A novel zinc-binding motif revealed by solution structures of DNA-binding domains of Arabidopsis SBP-family transcription factors. J Mol Biol (2004) 1.31
Structural insight into the zinc finger CW domain as a histone modification reader. Structure (2010) 1.30
Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family. J Biol Chem (2005) 1.30
Structure of dNTP-inducible dNTP triphosphohydrolase: insight into broad specificity for dNTPs and triphosphohydrolase-type hydrolysis. Acta Crystallogr D Biol Crystallogr (2007) 1.29