Published in Proc Natl Acad Sci U S A on January 25, 2005
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ClpX(P) generates mechanical force to unfold and translocate its protein substrates. Cell (2011) 2.31
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Altered specificity of a AAA+ protease. Mol Cell (2007) 1.10
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Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines. Nat Rev Microbiol (2015) 1.01
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Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine. Nat Chem Biol (2015) 0.95
The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell (2011) 0.94
Forced extraction of targeted components from complex macromolecular assemblies. Proc Natl Acad Sci U S A (2008) 0.94
Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX. Nat Struct Mol Biol (2015) 0.90
Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus. Proc Natl Acad Sci U S A (2013) 0.89
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Small-molecule control of protein degradation using split adaptors. ACS Chem Biol (2011) 0.86
Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase. ACS Chem Biol (2013) 0.86
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Engineering fluorescent protein substrates for the AAA+ Lon protease. Protein Eng Des Sel (2013) 0.85
The I domain of the AAA+ HslUV protease coordinates substrate binding, ATP hydrolysis, and protein degradation. Protein Sci (2012) 0.84
Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function. J Mol Biol (2013) 0.84
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Conformation of a plasmid replication initiator protein affects its proteolysis by ClpXP system. Protein Sci (2009) 0.80
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Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines. Proc Natl Acad Sci U S A (2017) 0.75
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Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Mol Cell (2003) 3.95
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Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease. Mol Cell (2003) 1.61
Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation. J Struct Biol (2004) 1.61
ClpA mediates directional translocation of substrate proteins into the ClpP protease. Proc Natl Acad Sci U S A (2001) 1.51
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Mol Cell (2004) 1.48
Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing. Protein Sci (2003) 1.39
ClpAP and ClpXP degrade proteins with tags located in the interior of the primary sequence. Proc Natl Acad Sci U S A (2002) 1.30
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OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain. Cell (2003) 4.21
Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines. Nature (2005) 4.05
Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Mol Cell (2003) 3.95
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Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding. Nat Struct Mol Biol (2008) 3.41
Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine. Cell (2003) 3.33
The tmRNA system for translational surveillance and ribosome rescue. Annu Rev Biochem (2007) 3.21
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell (2009) 2.87
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Cleavage of the A site mRNA codon during ribosome pausing provides a mechanism for translational quality control. Mol Cell (2003) 2.67
Segregation of molecules at cell division reveals native protein localization. Nat Methods (2012) 2.44
Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell (2011) 2.40
Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine. Cell (2005) 2.33
Allosteric activation of DegS, a stress sensor PDZ protease. Cell (2007) 2.32
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ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta (2011) 2.17
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Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation. Genes Dev (2004) 2.08
Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.02
Design principles of the proteolytic cascade governing the sigmaE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction. Genes Dev (2007) 1.99
Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates. Mol Cell (2008) 1.96
Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes. Nat Struct Mol Biol (2008) 1.95
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol Cell (2007) 1.91
Communication between ClpX and ClpP during substrate processing and degradation. Nat Struct Mol Biol (2004) 1.85
Specificity versus stability in computational protein design. Proc Natl Acad Sci U S A (2005) 1.80
Recognition of misfolded proteins by Lon, a AAA(+) protease. Genes Dev (2008) 1.77
Proteomic profiling of ClpXP substrates after DNA damage reveals extensive instability within SOS regulon. Mol Cell (2006) 1.74
Crystal structure of the nickel-responsive transcription factor NikR. Nat Struct Biol (2003) 1.74
Ribosome rescue: tmRNA tagging activity and capacity in Escherichia coli. Mol Microbiol (2005) 1.69
Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks. Mol Cell (2011) 1.64
Cytoplasmic degradation of ssrA-tagged proteins. Mol Microbiol (2005) 1.62
Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase. Mol Microbiol (2014) 1.62
Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease. Mol Cell (2003) 1.61
Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation. J Struct Biol (2004) 1.61
Characterization of a specificity factor for an AAA+ ATPase: assembly of SspB dimers with ssrA-tagged proteins and the ClpX hexamer. Chem Biol (2002) 1.60
Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag. Mol Cell (2003) 1.57
Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine. Cell (2013) 1.56
Design, construction and characterization of a set of insulated bacterial promoters. Nucleic Acids Res (2010) 1.55
Direct and adaptor-mediated substrate recognition by an essential AAA+ protease. Proc Natl Acad Sci U S A (2007) 1.51
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Mol Cell (2004) 1.48
NikR repressor: high-affinity nickel binding to the C-terminal domain regulates binding to operator DNA. Chem Biol (2002) 1.41
Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing. Protein Sci (2003) 1.39
The molecular basis of N-end rule recognition. Mol Cell (2008) 1.36
Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease. Proc Natl Acad Sci U S A (2003) 1.36
Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study. Mol Cell (2004) 1.35
Stepwise unfolding of a β barrel protein by the AAA+ ClpXP protease. J Mol Biol (2011) 1.33
Polypeptide translocation by the AAA+ ClpXP protease machine. Chem Biol (2009) 1.32
Inhibition of regulated proteolysis by RseB. Proc Natl Acad Sci U S A (2007) 1.32
Control of Pseudomonas aeruginosa AlgW protease cleavage of MucA by peptide signals and MucB. Mol Microbiol (2009) 1.31
Toxin-antitoxin pairs in bacteria: killers or stress regulators? Cell (2003) 1.28
Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine. Proc Natl Acad Sci U S A (2009) 1.27
Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine. Nat Struct Mol Biol (2012) 1.26
ClpS modulates but is not essential for bacterial N-end rule degradation. Genes Dev (2007) 1.26
Latent ClpX-recognition signals ensure LexA destruction after DNA damage. Genes Dev (2003) 1.24
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science (2012) 1.22
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease. Nat Struct Mol Biol (2005) 1.22
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB. Nat Struct Mol Biol (2005) 1.22
Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects. Nat Struct Biol (2002) 1.20
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding. J Mol Biol (2010) 1.16
Asymmetric nucleotide transactions of the HslUV protease. J Mol Biol (2008) 1.16
Remodeling protein complexes: insights from the AAA+ unfoldase ClpX and Mu transposase. Protein Sci (2005) 1.14
OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations. Mol Cell (2009) 1.14