Published in Nature on October 20, 2005
Complete subunit architecture of the proteasome regulatory particle. Nature (2012) 4.41
Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding. Nat Struct Mol Biol (2008) 3.41
Running in reverse: the structural basis for translocation polarity in hexameric helicases. Cell (2009) 3.38
Intersubunit coordination in a homomeric ring ATPase. Nature (2009) 2.93
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell (2009) 2.87
ATP-dependent proteases of bacteria: recognition logic and operating principles. Trends Biochem Sci (2006) 2.86
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The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell (2012) 2.37
ClpX(P) generates mechanical force to unfold and translocate its protein substrates. Cell (2011) 2.31
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ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle. Cell (2011) 2.27
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An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol Cell (2009) 2.12
The ClpXP protease unfolds substrates using a constant rate of pulling but different gears. Cell (2013) 2.06
Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell (2012) 2.03
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Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol Cell (2007) 1.91
Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase. EMBO J (2006) 1.89
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Mechanism of one-way traffic of hexameric phi29 DNA packaging motor with four electropositive relaying layers facilitating antiparallel revolution. ACS Nano (2013) 1.77
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The molecular architecture of the metalloprotease FtsH. Proc Natl Acad Sci U S A (2006) 1.74
Proteasome activators. Mol Cell (2011) 1.62
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Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine. Cell (2013) 1.56
Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J Biol Chem (2008) 1.55
Unfoldase-mediated protein translocation through an α-hemolysin nanopore. Nat Biotechnol (2013) 1.49
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Multitasking in the mitochondrion by the ATP-dependent Lon protease. Biochim Biophys Acta (2011) 1.41
Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase. Nat Struct Mol Biol (2013) 1.40
Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome. Proc Natl Acad Sci U S A (2014) 1.37
High degree of coordination and division of labor among subunits in a homomeric ring ATPase. Cell (2012) 1.35
Motor mechanism for protein threading through Hsp104. Mol Cell (2009) 1.33
Polypeptide translocation by the AAA+ ClpXP protease machine. Chem Biol (2009) 1.32
Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine. Nat Struct Mol Biol (2012) 1.26
Slippery substrates impair function of a bacterial protease ATPase by unbalancing translocation versus exit. J Biol Chem (2013) 1.22
Fusing catalase to an alkane-producing enzyme maintains enzymatic activity by converting the inhibitory byproduct H2O2 to the cosubstrate O2. Proc Natl Acad Sci U S A (2013) 1.17
The minichromosome maintenance replicative helicase. Cold Spring Harb Perspect Biol (2013) 1.16
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding. J Mol Biol (2010) 1.16
Asymmetric nucleotide transactions of the HslUV protease. J Mol Biol (2008) 1.16
Stochastic but highly coordinated protein unfolding and translocation by the ClpXP proteolytic machine. Cell (2014) 1.15
A tightly regulated molecular toggle controls AAA+ disaggregase. Nat Struct Mol Biol (2012) 1.13
P. aeruginosa PilT structures with and without nucleotide reveal a dynamic type IV pilus retraction motor. J Mol Biol (2010) 1.12
Novel mechanism of hexamer ring assembly in protein/RNA interactions revealed by single molecule imaging. Nucleic Acids Res (2008) 1.12
Revolution rather than rotation of AAA+ hexameric phi29 nanomotor for viral dsDNA packaging without coiling. Virology (2013) 1.11
Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease. Proc Natl Acad Sci U S A (2009) 1.11
The tyrosine kinase McsB is a regulated adaptor protein for ClpCP. EMBO J (2007) 1.11
Altered specificity of a AAA+ protease. Mol Cell (2007) 1.10
Regulation of the co-evolved HrpR and HrpS AAA+ proteins required for Pseudomonas syringae pathogenicity. Nat Commun (2011) 1.09
Separating speed and ability to displace roadblocks during DNA translocation by FtsK. EMBO J (2010) 1.09
Allosteric mechanisms can be distinguished using structural mass spectrometry. Proc Natl Acad Sci U S A (2013) 1.08
Coupling ATP utilization to protein remodeling by ClpB, a hexameric AAA+ protein. Proc Natl Acad Sci U S A (2009) 1.08
Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen. Proc Natl Acad Sci U S A (2006) 1.08
Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases. Mol Microbiol (2008) 1.07
Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation. Front Mol Biosci (2015) 1.07
Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly. Mol Biol Cell (2010) 1.06
Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase. Proc Natl Acad Sci U S A (2009) 1.05
The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome. J Biol Chem (2013) 1.04
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate. Nat Commun (2016) 1.04
Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila. Proc Natl Acad Sci U S A (2010) 1.03
Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains. Protein Sci (2006) 1.03
The ATPase of the phi29 DNA packaging motor is a member of the hexameric AAA+ superfamily. Virology (2013) 1.02
Mechanochemical basis of protein degradation by a double-ring AAA+ machine. Nat Struct Mol Biol (2014) 1.02
Peptide- and proton-driven allosteric clamps catalyze anthrax toxin translocation across membranes. Proc Natl Acad Sci U S A (2016) 1.02
Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines. Nat Rev Microbiol (2015) 1.01
ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome. J Biol Chem (2012) 1.00
Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber. EMBO J (2010) 1.00
Altered intersubunit communication is the molecular basis for functional defects of pathogenic p97 mutants. J Biol Chem (2013) 0.99
Design principles of a universal protein degradation machine. J Mol Biol (2012) 0.98
Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity. J Am Chem Soc (2014) 0.98
Stable incorporation of ATPase subunits into 19 S regulatory particle of human proteasome requires nucleotide binding and C-terminal tails. J Biol Chem (2012) 0.97
Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism. J Biol Chem (2010) 0.97
Engineered interfaces of an AAA+ ATPase reveal a new nucleotide-dependent coordination mechanism. J Biol Chem (2010) 0.97
Regulatory circuits of the AAA+ disaggregase Hsp104. J Biol Chem (2011) 0.97
Characterization of Empty adenovirus particles assembled in the absence of a functional adenovirus IVa2 protein. J Virol (2011) 0.96
Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine. Nat Chem Biol (2015) 0.95
Membrane protein targeting to the MVB/lysosome. Chem Rev (2009) 0.95
Positive cooperativity of the p97 AAA ATPase is critical for essential functions. J Biol Chem (2011) 0.94
Functional characterization of ice plant SKD1, an AAA-type ATPase associated with the endoplasmic reticulum-Golgi network, and its role in adaptation to salt stress. Plant Physiol (2006) 0.94
Marching to the beat of the ring: polypeptide translocation by AAA+ proteases. Trends Biochem Sci (2013) 0.93
Oligomerization of EpsE coordinates residues from multiple subunits to facilitate ATPase activity. J Biol Chem (2011) 0.93
The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation. Proc Natl Acad Sci U S A (2009) 0.92
Paddling mechanism for the substrate translocation by AAA+ motor revealed by multiscale molecular simulations. Proc Natl Acad Sci U S A (2009) 0.92
Common mechanisms of DNA translocation motors in bacteria and viruses using one-way revolution mechanism without rotation. Biotechnol Adv (2014) 0.92
Engineering synthetic adaptors and substrates for controlled ClpXP degradation. J Biol Chem (2009) 0.92
Large nucleotide-dependent movement of the N-terminal domain of the ClpX chaperone. EMBO J (2006) 0.92
Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels. Biomaterials (2010) 0.90
Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX. Nat Struct Mol Biol (2015) 0.90
ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function. Nat Commun (2015) 0.90
Molecular determinants of MecA as a degradation tag for the ClpCP protease. J Biol Chem (2009) 0.89
The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits. J Mol Biol (2015) 0.89
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy. Proc Natl Acad Sci U S A (2015) 0.89
Dissection of Axial-Pore Loop Function during Unfolding and Translocation by a AAA+ Proteolytic Machine. Cell Rep (2015) 0.88
The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase. Nature (2014) 0.88
OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain. Cell (2003) 4.21
Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Mol Cell (2003) 3.95
Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell (2004) 3.83
AAA+ proteases: ATP-fueled machines of protein destruction. Annu Rev Biochem (2011) 3.60
Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding. Nat Struct Mol Biol (2008) 3.41
Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine. Cell (2003) 3.33
The tmRNA system for translational surveillance and ribosome rescue. Annu Rev Biochem (2007) 3.21
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell (2009) 2.87
ATP-dependent proteases of bacteria: recognition logic and operating principles. Trends Biochem Sci (2006) 2.86
Cleavage of the A site mRNA codon during ribosome pausing provides a mechanism for translational quality control. Mol Cell (2003) 2.67
Segregation of molecules at cell division reveals native protein localization. Nat Methods (2012) 2.44
Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell (2011) 2.40
Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine. Cell (2005) 2.33
Allosteric activation of DegS, a stress sensor PDZ protease. Cell (2007) 2.32
Engineering controllable protein degradation. Mol Cell (2006) 2.23
ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta (2011) 2.17
Proline residues at the C terminus of nascent chains induce SsrA tagging during translation termination. J Biol Chem (2002) 2.15
Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates. Genes Dev (2004) 2.11
Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation. Genes Dev (2004) 2.08
Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.02
Design principles of the proteolytic cascade governing the sigmaE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction. Genes Dev (2007) 1.99
Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates. Mol Cell (2008) 1.96
Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes. Nat Struct Mol Biol (2008) 1.95
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol Cell (2007) 1.91
Communication between ClpX and ClpP during substrate processing and degradation. Nat Struct Mol Biol (2004) 1.85
Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing. Proc Natl Acad Sci U S A (2005) 1.85
Specificity versus stability in computational protein design. Proc Natl Acad Sci U S A (2005) 1.80
Recognition of misfolded proteins by Lon, a AAA(+) protease. Genes Dev (2008) 1.77
Proteomic profiling of ClpXP substrates after DNA damage reveals extensive instability within SOS regulon. Mol Cell (2006) 1.74
Crystal structure of the nickel-responsive transcription factor NikR. Nat Struct Biol (2003) 1.74
Ribosome rescue: tmRNA tagging activity and capacity in Escherichia coli. Mol Microbiol (2005) 1.69
Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks. Mol Cell (2011) 1.64
Cytoplasmic degradation of ssrA-tagged proteins. Mol Microbiol (2005) 1.62
Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase. Mol Microbiol (2014) 1.62
Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease. Mol Cell (2003) 1.61
Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation. J Struct Biol (2004) 1.61
Characterization of a specificity factor for an AAA+ ATPase: assembly of SspB dimers with ssrA-tagged proteins and the ClpX hexamer. Chem Biol (2002) 1.60
Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag. Mol Cell (2003) 1.57
Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine. Cell (2013) 1.56
Design, construction and characterization of a set of insulated bacterial promoters. Nucleic Acids Res (2010) 1.55
Direct and adaptor-mediated substrate recognition by an essential AAA+ protease. Proc Natl Acad Sci U S A (2007) 1.51
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Mol Cell (2004) 1.48
NikR repressor: high-affinity nickel binding to the C-terminal domain regulates binding to operator DNA. Chem Biol (2002) 1.41
Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing. Protein Sci (2003) 1.39
The molecular basis of N-end rule recognition. Mol Cell (2008) 1.36
Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease. Proc Natl Acad Sci U S A (2003) 1.36
Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study. Mol Cell (2004) 1.35
Stepwise unfolding of a β barrel protein by the AAA+ ClpXP protease. J Mol Biol (2011) 1.33
Polypeptide translocation by the AAA+ ClpXP protease machine. Chem Biol (2009) 1.32
Inhibition of regulated proteolysis by RseB. Proc Natl Acad Sci U S A (2007) 1.32
Control of Pseudomonas aeruginosa AlgW protease cleavage of MucA by peptide signals and MucB. Mol Microbiol (2009) 1.31
Toxin-antitoxin pairs in bacteria: killers or stress regulators? Cell (2003) 1.28
Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine. Proc Natl Acad Sci U S A (2009) 1.27
ClpS modulates but is not essential for bacterial N-end rule degradation. Genes Dev (2007) 1.26
Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine. Nat Struct Mol Biol (2012) 1.26
Latent ClpX-recognition signals ensure LexA destruction after DNA damage. Genes Dev (2003) 1.24
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science (2012) 1.22
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease. Nat Struct Mol Biol (2005) 1.22
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB. Nat Struct Mol Biol (2005) 1.22
Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects. Nat Struct Biol (2002) 1.20
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding. J Mol Biol (2010) 1.16
Asymmetric nucleotide transactions of the HslUV protease. J Mol Biol (2008) 1.16
Remodeling protein complexes: insights from the AAA+ unfoldase ClpX and Mu transposase. Protein Sci (2005) 1.14
OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations. Mol Cell (2009) 1.14