PubRank

Robert J Lefkowitz

Author PubWeight™ 276.14‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Seven-transmembrane receptors. Nat Rev Mol Cell Biol 2002 11.50
2 Beta-arrestins and cell signaling. Annu Rev Physiol 2007 8.65
3 Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov 2010 5.76
4 An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 2005 5.60
5 Seven-transmembrane-spanning receptors and heart function. Nature 2002 5.38
6 The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 2002 5.04
7 beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem 2005 4.91
8 Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 2004 4.44
9 Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol Sci 2007 4.35
10 Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proc Natl Acad Sci U S A 2003 3.99
11 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A 2007 3.82
12 Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 2003 3.52
13 Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science 2002 3.46
14 GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 2006 3.34
15 Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science 2003 3.27
16 Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol 2011 3.15
17 Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest 2007 3.15
18 Beta-arrestin-mediated localization of smoothened to the primary cilium. Science 2008 3.10
19 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A 2007 3.08
20 Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. J Biol Chem 2004 3.07
21 β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci 2011 3.02
22 Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J Biol Chem 2006 3.00
23 Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends Mol Med 2010 2.82
24 Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proc Natl Acad Sci U S A 2009 2.76
25 Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol 2002 2.76
26 A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 2008 2.76
27 Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 2007 2.65
28 Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal 2011 2.56
29 Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol Pharmacol 2003 2.55
30 Trafficking of G protein-coupled receptors. Circ Res 2006 2.54
31 Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci U S A 2005 2.53
32 beta-arrestin-biased agonism at the beta2-adrenergic receptor. J Biol Chem 2007 2.51
33 Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci 2011 2.51
34 Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A 2005 2.48
35 The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem 2002 2.47
36 beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proc Natl Acad Sci U S A 2003 2.43
37 beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. J Biol Chem 2002 2.42
38 Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem J 2003 2.42
39 beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem 2007 2.42
40 Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proc Natl Acad Sci U S A 2003 2.40
41 Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science 2003 2.31
42 Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Proc Natl Acad Sci U S A 2002 2.26
43 Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science 2007 2.25
44 A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci Transl Med 2009 2.24
45 Multiple ligand-specific conformations of the β2-adrenergic receptor. Nat Chem Biol 2011 2.23
46 Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 2004 2.19
47 Seven-transmembrane receptor signaling through beta-arrestin. Sci STKE 2005 2.18
48 Overview of the Alliance for Cellular Signaling. Nature 2002 2.15
49 Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature 2013 2.14
50 Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol 2011 2.08
51 Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proc Natl Acad Sci U S A 2008 2.06
52 Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron 2003 2.03
53 Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Natl Acad Sci U S A 2006 2.01
54 Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. J Neurosci 2002 2.01
55 beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Proc Natl Acad Sci U S A 2004 1.91
56 Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. J Biol Chem 2003 1.90
57 Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. J Biol Chem 2004 1.86
58 Beta-arrestin-2 regulates the development of allergic asthma. J Clin Invest 2003 1.85
59 Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc Natl Acad Sci U S A 2009 1.84
60 Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell 2009 1.83
61 beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. J Clin Invest 2009 1.79
62 Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. J Biol Chem 2003 1.76
63 Activation-dependent conformational changes in {beta}-arrestin 2. J Biol Chem 2004 1.76
64 Regulation of G protein-coupled receptor signaling by scaffold proteins. Circ Res 2002 1.75
65 beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem 2004 1.75
66 G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. J Biol Chem 2006 1.73
67 beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. J Biol Chem 2001 1.70
68 Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. J Biol Chem 2003 1.66
69 Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Sci Signal 2009 1.66
70 Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A 2010 1.64
71 A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature 2011 1.64
72 S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. Mol Cell 2008 1.63
73 {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. J Biol Chem 2009 1.59
74 Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. J Biol Chem 2009 1.57
75 Arresting developments in heptahelical receptor signaling and regulation. Trends Cell Biol 2002 1.55
76 Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature 2016 1.55
77 Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 2004 1.52
78 Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. J Biol Chem 2003 1.50
79 Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. J Biol Chem 2002 1.50
80 Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. J Neurosci 2003 1.49
81 Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A 2009 1.49
82 Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem 2005 1.47
83 Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J Biol Chem 2003 1.45
84 Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. J Biol Chem 2004 1.41
85 The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. J Biol Chem 2007 1.41
86 beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. J Biol Chem 2004 1.39
87 Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol 2006 1.38
88 Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circ Res 2008 1.37
89 Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. J Biol Chem 2007 1.36
90 Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. J Biol Chem 2007 1.34
91 Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol Pharmacol 2005 1.33
92 {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem 2005 1.31
93 Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. J Neurosci 2004 1.26
94 Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. Biochemistry 2002 1.24
95 When 7 transmembrane receptors are not G protein-coupled receptors. J Clin Invest 2005 1.24
96 Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem 2002 1.24
97 G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. Br J Pharmacol 2003 1.23
98 The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. Proc Natl Acad Sci U S A 2004 1.23
99 N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. J Biol Chem 2003 1.23
100 G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. J Biol Chem 2003 1.20
101 GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. J Biol Chem 2003 1.20
102 G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron 2004 1.19
103 Beta-arrestin-mediated signaling regulates protein synthesis. J Biol Chem 2008 1.18
104 Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation 2005 1.14
105 PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. Cell Signal 2004 1.11
106 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. Biochem J 2005 1.10
107 Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. J Immunol 2003 1.10
108 β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Sci Transl Med 2011 1.06
109 Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. J Biol Chem 2004 1.05
110 Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. J Biol Chem 2002 1.04
111 Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. Acta Crystallogr D Biol Crystallogr 2003 1.04
112 Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J Biol Chem 2010 1.03
113 Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation. J Clin Invest 2004 1.01
114 G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J Biol Chem 2009 1.01
115 Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. Biochemistry 2002 1.01
116 Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. ACS Chem Biol 2013 1.01
117 G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. J Biol Chem 2006 1.00
118 Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. Mol Pharmacol 2013 0.98
119 A crystal clear view of the beta2-adrenergic receptor. Nat Biotechnol 2008 0.98
120 Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. Mol Syst Biol 2012 0.97
121 Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clin Immunol 2008 0.96
122 Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Sci STKE 2005 0.94
123 β-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proc Natl Acad Sci U S A 2012 0.93
124 Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. J Biol Chem 2008 0.92
125 Crystallizing thinking about the beta2-adrenergic receptor. Mol Pharmacol 2008 0.90
126 Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle 2012 0.89
127 Inspiring the next generation of physician-scientists. J Clin Invest 2015 0.88
128 Receptor regulation: beta-arrestin moves up a notch. Nat Cell Biol 2005 0.88
129 beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol 2004 0.86
130 G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. J Biol Chem 2001 0.85
131 β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. PLoS One 2013 0.84
132 Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling. Circ Res 2011 0.78
133 Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. J Mol Cell Cardiol 2002 0.78
134 A magnificent time with the "magnificent seven" transmembrane spanning receptors. Circ Res 2003 0.77
135 An interview with Robert J. Lefkowitz. Trends Pharmacol Sci 2012 0.76
136 Resonating to the music of ubiquitination. Nat Methods 2004 0.75
137 Focus on the research journey. An interview with Robert J. Lefkowitz, MD, scientist, mentor, and recipient of the 2007 National Medal of Science by Elaine Musgrave. Clin Transl Sci 2009 0.75
138 An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser. Assay Drug Dev Technol 2003 0.75