Published in JAMA on January 26, 2005
Infants With Severe Acute Respiratory Distress Syndrome: The Prone Trial | NCT05002478
Nonventilatory treatments for acute lung injury and ARDS. Chest (2007) 3.02
Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med (2006) 2.47
Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28
Weaning and extubation readiness in pediatric patients. Pediatr Crit Care Med (2009) 2.00
Defining acute lung disease in children with the oxygenation saturation index. Pediatr Crit Care Med (2010) 1.92
Mortality-adjusted duration of mechanical ventilation in critically ill children with symptomatic central venous line-related deep venous thrombosis. Crit Care Med (2011) 1.61
Improved oxygenation 24 hours after transition to airway pressure release ventilation or high-frequency oscillatory ventilation accurately discriminates survival in immunocompromised pediatric patients with acute respiratory distress syndrome*. Pediatr Crit Care Med (2014) 1.48
An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Care Med (2011) 1.40
Lung contusion: inflammatory mechanisms and interaction with other injuries. Shock (2009) 1.32
Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med (2009) 1.14
Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem (2008) 1.13
Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Crit Care (2006) 1.13
Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis. Crit Care (2007) 1.11
Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration. Respir Res (2007) 1.09
Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model. Shock (2008) 1.07
Characteristics of children intubated and mechanically ventilated in 16 PICUs. Chest (2009) 1.06
Clinical review: Respiratory monitoring in the ICU - a consensus of 16. Crit Care (2012) 1.05
Ventilator-induced lung injury: historical perspectives and clinical implications. Ann Intensive Care (2011) 1.05
Surfactant therapy for acute lung injury and acute respiratory distress syndrome. Crit Care Clin (2011) 1.04
Overcoming rapid inactivation of lung surfactant: analogies between competitive adsorption and colloid stability. Biochim Biophys Acta (2009) 1.02
Computed tomography assessment of exogenous surfactant-induced lung reaeration in patients with acute lung injury. Crit Care (2010) 1.01
The design of future pediatric mechanical ventilation trials for acute lung injury. Am J Respir Crit Care Med (2010) 0.99
An overview of pulmonary surfactant in the neonate: genetics, metabolism, and the role of surfactant in health and disease. Mol Genet Metab (2009) 0.95
Biomarkers in acute lung injury--marking forward progress. Crit Care Clin (2011) 0.95
Anti-inflammatory effects of triptolide in LPS-induced acute lung injury in mice. Inflammation (2014) 0.95
Surfactant for pediatric acute lung injury. Pediatr Clin North Am (2008) 0.94
Transcriptional responses of Mycobacterium tuberculosis to lung surfactant. Microb Pathog (2009) 0.92
Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype. Thorax (2005) 0.90
Activity and inhibition resistance of a phospholipase-resistant synthetic surfactant in rat lungs. Am J Respir Cell Mol Biol (2007) 0.90
What's new in surfactant? A clinical view on recent developments in neonatology and paediatrics. Eur J Pediatr (2007) 0.90
Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant. PLoS One (2007) 0.89
Variability in usual care mechanical ventilation for pediatric acute lung injury: the potential benefit of a lung protective computer protocol. Intensive Care Med (2011) 0.88
Synthetic surfactant containing SP-B and SP-C mimics is superior to single-peptide formulations in rabbits with chemical acute lung injury. PeerJ (2014) 0.86
Surfactant administration prior to one lung ventilation: physiological and inflammatory correlates in a piglet model. Pediatr Pulmonol (2011) 0.85
Competitive adsorption: a physical model for lung surfactant inactivation. Langmuir (2009) 0.85
Mechanisms of polyelectrolyte enhanced surfactant adsorption at the air-water interface. Biochim Biophys Acta (2009) 0.84
The pharmacology of acute lung injury in sepsis. Adv Pharmacol Sci (2011) 0.82
Rediscovering the Schulze-Hardy rule in competitive adsorption to an air-water interface. Langmuir (2009) 0.82
Preventing ARDS: progress, promise, and pitfalls. Chest (2014) 0.82
Efficacy and safety of lung recruitment in pediatric patients with acute lung injury. Pediatr Crit Care Med (2011) 0.82
Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration. J Trauma (2009) 0.81
High frequency oscillation and airway pressure release ventilation in pediatric respiratory failure. Pediatr Pulmonol (2013) 0.80
Pulmonary surfactant proteins and polymer combinations reduce surfactant inhibition by serum. Biochim Biophys Acta (2011) 0.79
Synthesis and activity of a novel diether phosphonoglycerol in phospholipase-resistant synthetic lipid:peptide lung surfactants(). Medchemcomm (2011) 0.79
Delivery and performance of surfactant replacement therapies to treat pulmonary disorders. Ther Deliv (2013) 0.78
Surfactant replacement and open lung concept--comparison of two treatment strategies in an experimental model of neonatal ARDS. BMC Pulm Med (2008) 0.78
Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. Front Pediatr (2016) 0.77
A critical appraisal of a randomized controlled trial: Willson et al: Effect of exogenous surfactant (calfactant) in pediatric acute lung injury (JAMA 2005, 293: 470-476). Pediatr Crit Care Med (2007) 0.77
Postperfusion lung syndrome: physiopathology and therapeutic options. Rev Bras Cir Cardiovasc (2014) 0.77
Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine. J Cell Mol Med (2012) 0.76
Relevant Outcomes in Pediatric Acute Respiratory Distress Syndrome Studies. Front Pediatr (2016) 0.75
Surfactant and pediatric acute lung injury. JAMA (2005) 0.75
Did Reduced Alveolar Delivery of Surfactant Contribute to Negative Results in Adults with Acute Respiratory Distress Syndrome? Am J Respir Crit Care Med (2017) 0.75
A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials. BMC Pediatr (2009) 0.75
Fundamentals of aerosol therapy in critical care. Crit Care (2016) 0.75
Surfactant Administration During Pediatric Extracorporeal Membrane Oxygenation. ASAIO J (2015) 0.75
Surfactant for acute respiratory failure in children: where should it fit in our treatment algorithm? Crit Care (2007) 0.75
Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants. Biomed Hub (2016) 0.75
Argument against the Routine Use of Steroids for Pediatric Acute Respiratory Distress Syndrome. Front Pediatr (2016) 0.75
Pediatric Acute Respiratory Distress Syndrome: Fibrosis versus Repair. Front Pediatr (2016) 0.75
Efficacy study of pulmonary surfactant combined with assisted ventilation for acute respiratory distress syndrome management of term neonates. Exp Ther Med (2017) 0.75
Surfactants in Acute Respiratory Distress Syndrome in Infants and Children: Past, Present and Future. Clin Drug Investig (2017) 0.75
High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05
Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med (2015) 4.90
Pediatric calfactant in acute respiratory distress syndrome trial. Pediatr Crit Care Med (2013) 3.73
Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics (2007) 3.37
Survey of in-house coverage by pediatric intensivists: characterization of 24/7 in-hospital pediatric critical care faculty coverage*. Pediatr Crit Care Med (2014) 3.09
Characterizing degree of lung injury in pediatric acute respiratory distress syndrome. Crit Care Med (2015) 2.85
Translating lifestyle intervention to practice in obese patients with type 2 diabetes: Improving Control with Activity and Nutrition (ICAN) study. Diabetes Care (2004) 2.84
Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med (2007) 2.58
Fluid overload is associated with impaired oxygenation and morbidity in critically ill children. Pediatr Crit Care Med (2012) 2.54
Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med (2009) 2.23
Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med (2011) 2.20
Efficacy and complications of covered Wallstents in malignant distal biliary obstruction. Gastrointest Endosc (2005) 2.18
Continual reassessment method for partial ordering. Biometrics (2011) 2.11
Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med (2015) 2.09
Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med (2015) 2.09
Jading in the pediatric intensive care unit: Implications for healthcare providers of medically complex children. Pediatr Crit Care Med (2004) 2.06
RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res (2002) 2.01
Profiling the evolution of human metastatic bladder cancer. Cancer Res (2004) 2.00
The pediatric sepsis biomarker risk model. Crit Care (2012) 1.99
Chronic conditions among children admitted to U.S. pediatric intensive care units: their prevalence and impact on risk for mortality and prolonged length of stay*. Crit Care Med (2012) 1.97
Validating the genomic signature of pediatric septic shock. Physiol Genomics (2008) 1.96
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood (2012) 1.95
Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health. Am J Physiol Lung Cell Mol Physiol (2006) 1.83
Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med (2014) 1.81
Extracellular hsp70 levels in children with septic shock. Pediatr Crit Care Med (2005) 1.79
Corticosteroid exposure in pediatric acute respiratory distress syndrome. Intensive Care Med (2015) 1.77
Post-ICU admission fluid balance and pediatric septic shock outcomes: a risk-stratified analysis. Crit Care Med (2014) 1.72
Comparison of SpO2 to PaO2 based markers of lung disease severity for children with acute lung injury. Crit Care Med (2012) 1.71
Dose-finding design for multi-drug combinations. Clin Trials (2011) 1.63
Effects of lifestyle intervention on health care costs: Improving Control with Activity and Nutrition (ICAN). J Am Diet Assoc (2007) 1.62
Assessment of parental presence during bedside pediatric intensive care unit rounds: effect on duration, teaching, and privacy. Pediatr Crit Care Med (2007) 1.60
Demographics of abusive head trauma in the Commonwealth of Pennsylvania. J Neurosurg Pediatr (2008) 1.60
The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med (2011) 1.57
Decreasing unplanned extubations: utilization of the Penn State Children's Hospital Sedation Algorithm. Pediatr Crit Care Med (2004) 1.55
Multifactor clinical score and outcome of mechanical ventilation weaning trials: Burns Wean Assessment Program. Am J Crit Care (2010) 1.50
Post hoc analysis of calfactant use in immunocompromised children with acute lung injury: Impact and feasibility of further clinical trials. Pediatr Crit Care Med (2008) 1.49
A Multibiomarker-Based Model for Estimating the Risk of Septic Acute Kidney Injury. Crit Care Med (2015) 1.49
Improved oxygenation 24 hours after transition to airway pressure release ventilation or high-frequency oscillatory ventilation accurately discriminates survival in immunocompromised pediatric patients with acute respiratory distress syndrome*. Pediatr Crit Care Med (2014) 1.48
Helium/oxygen-driven albuterol nebulization in the management of children with status asthmaticus: a randomized, placebo-controlled trial. Pediatr Crit Care Med (2010) 1.48
Effect of race on the timing of the Glenn and Fontan procedures for single-ventricle congenital heart disease. Pediatr Crit Care Med (2012) 1.48
Recombinant urokinase is safe and effective in restoring patency to occluded central venous access devices: a multiple-center, international trial. Crit Care Med (2004) 1.47
Inpatient verbal orders and the impact of computerized provider order entry. J Pediatr (2006) 1.46
Extended-release glipizide overdose presenting with delayed hypoglycemia and treated with subcutaneous octreotide. J Pediatr Endocrinol Metab (2009) 1.43
Is shock index associated with outcome in children with sepsis/septic shock?*. Pediatr Crit Care Med (2013) 1.41
Prospective assessment of guidelines for determining appropriate depth of endotracheal tube placement in children. Pediatr Crit Care Med (2005) 1.41
Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med (2016) 1.41
Psychometric evaluation of a modified version of the family satisfaction in the ICU survey in parents/caregivers of critically ill children*. Pediatr Crit Care Med (2013) 1.40
Institutional policies on determination of medically inappropriate interventions: use in five pediatric patients. Pediatr Crit Care Med (2007) 1.38
Hypoglycemia adverse events in PICUs and cardiac ICUs: differentiating preventable and nonpreventable events*. Pediatr Crit Care Med (2013) 1.38
Ninety-day outcome rates of a prospective cohort of consecutive patients with mild ischemic stroke. Stroke (2011) 1.32
Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care (2012) 1.31
Specifications of a continual reassessment method design for phase I trials of combined drugs. Pharm Stat (2013) 1.26
Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med (2008) 1.25
Glucose Regulation in Acute Stroke Patients (GRASP) trial: a randomized pilot trial. Stroke (2009) 1.24
Day 1 multiple organ dysfunction syndrome is associated with poor functional outcome and mortality in the pediatric intensive care unit. Pediatr Crit Care Med (2009) 1.22
Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock. Am J Respir Crit Care Med (2014) 1.20
The relationship of fluid administration to outcome in the pediatric calfactant in acute respiratory distress syndrome trial. Pediatr Crit Care Med (2013) 1.19
Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray. Crit Care (2011) 1.16
Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants. Infect Immun (2007) 1.13
Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactions. Mol Endocrinol (2003) 1.11
Adaptive hypersensitivity following long-term estrogen deprivation: involvement of multiple signal pathways. J Steroid Biochem Mol Biol (2003) 1.11
F2-isoprostane and neuron-specific enolase in cerebrospinal fluid after severe traumatic brain injury in infants and children. J Neurotrauma (2003) 1.11
Mortality rates in pediatric septic shock with and without multiple organ system failure. Pediatr Crit Care Med (2003) 1.11
Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids. Crit Care Med (2016) 1.08
Less is more, or almost as much: a 15-item quality-of-life instrument for myasthenia gravis. Muscle Nerve (2008) 1.08
Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers. J Neurotrauma (2004) 1.07
Comments on 'A dose-finding approach based on shrunken predictive probability for combinations of two agents in phase I trials' by Akihiro Hirakawa, Chikuma Hamada, and Shigeyuki Matsui. Stat Med (2014) 1.06
Characteristics of children intubated and mechanically ventilated in 16 PICUs. Chest (2009) 1.06
Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res (2010) 1.05
Computerized reminders reduce the use of medications during shortages. J Am Med Inform Assoc (2004) 1.04
Mechanisms, clinical presentations, injuries, and outcomes from inflicted versus noninflicted head trauma during infancy: results of a prospective, multicentered, comparative study. Pediatrics (2007) 1.03
Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products. J Biol Chem (2010) 1.03
Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924. Mol Cancer Ther (2013) 1.03
Prediction of muscle-invasive bladder cancer using urinary proteomics. Clin Cancer Res (2009) 1.02
Outcome of pediatric acute myeloid leukemia patients receiving intensive care in the United States. Pediatr Crit Care Med (2014) 1.02
Percutaneous injuries before and after the Needlestick Safety and Prevention Act. N Engl J Med (2012) 1.00
Organ dysfunction is associated with hyperglycemia in critically ill children. Intensive Care Med (2009) 0.99
Predicting rural practice using different definitions to classify medical school applicants as having a rural upbringing. J Rural Health (2007) 0.98
Construction of an efficient evaluative instrument for myasthenia gravis: the MG composite. Muscle Nerve (2008) 0.97
Performance of two-stage continual reassessment method relative to an optimal benchmark. Clin Trials (2013) 0.97
Dobutamine response and myocardial infarct transmurality: functional improvement after coronary artery bypass grafting--initial experience. Radiology (2006) 0.96
Using the time-to-event continual reassessment method in the presence of partial orders. Stat Med (2012) 0.95
Influence of hemoglobin levels on inpatient rehabilitation outcomes after total knee arthroplasty. J Arthroplasty (2006) 0.95
Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype. Crit Care Med (2016) 0.93
Phase I/II adaptive design for drug combination oncology trials. Stat Med (2014) 0.92
Statin therapy improves outcomes after valvular heart surgery. Ann Thorac Surg (2008) 0.92
Duration of cardiopulmonary resuscitation before extracorporeal rescue: how long is not long enough? ASAIO J (2005) 0.92
Efficacy of bystander cardiopulmonary resuscitation and out-of-hospital automated external defibrillation as life-saving therapy in commotio cordis. J Pediatr (2005) 0.92
Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury. J Neurotrauma (2007) 0.92
Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptor. Mol Endocrinol (2007) 0.91
Clinical and consumer trial performance of a sensitive immunodiagnostic home test that qualitatively detects low concentrations of sperm following vasectomy. J Urol (2008) 0.91
The 2003 national pediatric pressure ulcer and skin breakdown prevalence survey: a multisite study. J Wound Ostomy Continence Nurs (2005) 0.90
Methodology of the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med (2015) 0.90
Mycophenolate mofetil in AChR-antibody-positive myasthenia gravis: outcomes in 102 patients. Muscle Nerve (2010) 0.89
IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res (2012) 0.89