Published in N Engl J Med on April 25, 2015
Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med (2017) 3.89
Variability in Postarrest Targeted Temperature Management Practice: Implications of the 2015 Guidelines. Ther Hypothermia Temp Manag (2015) 1.41
Therapeutic Hypothermia in Children. N Engl J Med (2015) 0.96
Therapeutic Hypothermia in Children. N Engl J Med (2015) 0.95
Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons. Neuroscience (2015) 0.87
Targeted Temperature Management After Pediatric Cardiac Arrest Due To Drowning: Outcomes and Complications. Pediatr Crit Care Med (2016) 0.84
Sudden Cardiac Death in the Young. Circulation (2016) 0.83
Neurobehavioral Outcomes in Children After Out-of-Hospital Cardiac Arrest. Pediatrics (2016) 0.83
Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations. Ther Hypothermia Temp Manag (2016) 0.80
Difficulty interpreting the results of some trials: the case of therapeutic hypothermia after pediatric cardiac arrest. Crit Care (2015) 0.80
Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review. Pediatr Crit Care Med (2017) 0.80
Optimizing Mouse Surgery with Online Rectal Temperature Monitoring and Preoperative Heat Supply. Effects on Post-Ischemic Acute Kidney Injury. PLoS One (2016) 0.79
Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome. Pediatr Crit Care Med (2016) 0.79
Functional Outcome Trajectories After Out-of-Hospital Pediatric Cardiac Arrest. Crit Care Med (2016) 0.78
The Brain and Hypothermia-From Aristotle to Targeted Temperature Management. Crit Care Med (2017) 0.78
Therapeutic Hypothermia and the Risk of Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore) (2015) 0.77
Family Burden After Out-of-Hospital Cardiac Arrest in Children. Pediatr Crit Care Med (2016) 0.77
Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials. Ann Card Anaesth (2016) 0.76
Early Electroencephalographic Background Features Predict Outcomes in Children Resuscitated From Cardiac Arrest. Pediatr Crit Care Med (2016) 0.76
Neuroprotective effects of deep hypothermia in refractory status epilepticus. Ann Clin Transl Neurol (2015) 0.76
Management of the Pediatric Neurocritical Care Patient. Semin Neurol (2016) 0.75
Neonatal Seizures: Impact on Neurodevelopmental Outcomes. Front Pediatr (2015) 0.75
Emergency cooling doesn't improve outcomes in children with cardiac arrest, study shows. BMJ (2015) 0.75
Cardiac resuscitation: No benefit of therapeutic hypothermia after cardiac arrest in children. Nat Rev Cardiol (2015) 0.75
Brain hypothermia therapy for childhood acute encephalopathy based on clinical evidence. Exp Ther Med (2015) 0.75
Targeted temperature management in emergency medicine: current perspectives. Open Access Emerg Med (2015) 0.75
Therapeutic hypothermia protects against ischemia-induced impairment of synaptic plasticity following juvenile cardiac arrest in sex-dependent manner. Neuroscience (2016) 0.75
Therapeutic hypothermia increases the risk of cardiac arrhythmia for perinatal hypoxic ischaemic encephalopathy: A meta-analysis. PLoS One (2017) 0.75
Challenging orthodoxy in critical care trial design: physiological responsiveness. Ann Transl Med (2016) 0.75
Strategic Planning for Research in Pediatric Critical Care. Pediatr Crit Care Med (2016) 0.75
A "Metamorphosis" in Our Approach to Treatment Is Not Likely to Result From a Meta-Analysis of the Use of Therapeutic Hypothermia in Severe Traumatic Brain Injury. Crit Care Med (2017) 0.75
Part 6. Pediatric advanced life support: 2015 Korean Guidelines for Cardiopulmonary Resuscitation. Clin Exp Emerg Med (2016) 0.75
Pediatric cardiac arrest due to drowning and other respiratory etiologies: Neurobehavioral outcomes in initially comatose children. Resuscitation (2017) 0.75
The benefits of youth are lost on the young cardiac arrest patient. F1000Res (2017) 0.75
Targeted temperature management in the ICU: guidelines from a French expert panel. Ann Intensive Care (2017) 0.75
Extracorporeal cardiopulmonary resuscitation. Ann Transl Med (2017) 0.75
International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study. Pediatr Crit Care Med (2017) 0.75
Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest. Evid Based Preclin Med (2016) 0.75
Targeted Temperature Management After Cardiac Arrest Due to Drowning: "Frequentist" and "Bayesian" Decision Making. Pediatr Crit Care Med (2016) 0.75
Exploring the safety and efficacy of targeted temperature management amongst infants with out-of-hospital cardiac arrest due to apparent life threatening events. Resuscitation (2016) 0.75
Relevant Outcomes in Pediatric Acute Respiratory Distress Syndrome Studies. Front Pediatr (2016) 0.75
Early Electroencephalographic Findings Correlate With Neurologic Outcome in Children Following Cardiac Arrest. Pediatr Crit Care Med (2016) 0.75
Therapeutic Hypothermia in Children. N Engl J Med (2015) 0.75
Pediatric Out-of-Hospital Cardiac Arrest Outcomes: A Case of Male/Female Inequality? Pediatr Crit Care Med (2015) 0.75
Should we treat pyrexia? And how do we do it? Crit Care (2016) 0.75
The Anesthesiologist's Role in Treating Abusive Head Trauma. Anesth Analg (2016) 0.75
Targeted temperature management in neurological intensive care unit. World J Methodol (2017) 0.75
Emergency Neurological Life Support: Resuscitation Following Cardiac Arrest. Neurocrit Care (2017) 0.75
A multiple testing procedure for clinical trials. Biometrics (1979) 26.80
Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med (2002) 22.37
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med (2002) 21.40
Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med (2013) 20.70
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med (2005) 13.96
Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med (2009) 7.94
Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 6.10
Part 9: post-cardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation (2010) 6.01
Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med (2001) 5.48
Assessing the outcome of pediatric intensive care. J Pediatr (1992) 4.92
Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial. Lancet Neurol (2013) 4.20
Out-of-hospital pediatric cardiac arrest: an epidemiologic review and assessment of current knowledge. Ann Emerg Med (2005) 3.79
Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med (2011) 3.05
Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med (2011) 2.80
In-hospital versus out-of-hospital pediatric cardiac arrest: a multicenter cohort study. Crit Care Med (2009) 2.70
Intercenter variance in clinical trials of head trauma--experience of the National Acute Brain Injury Study: Hypothermia. J Neurosurg (2001) 2.39
A prospective, population-based study of the epidemiology and outcome of out-of-hospital pediatric cardiopulmonary arrest. Pediatrics (2004) 2.11
A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest. Pediatr Crit Care Med (2010) 1.90
Efficacy outcome selection in the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med (2015) 1.82
Hypothermia and hyperthermia in children after resuscitation from cardiac arrest. Pediatrics (2000) 1.80
Influence of hypothermia, barbiturate therapy, and intracranial pressure monitoring on morbidity and mortality after near-drowning. Crit Care Med (1986) 1.66
Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome. Arch Intern Med (2001) 1.50
Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. Pediatrics (2008) 1.39
Rationale, timeline, study design, and protocol overview of the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med (2013) 1.35
Hypothermia and neonatal encephalopathy. Pediatrics (2014) 1.34
Hypothermia therapy after pediatric cardiac arrest. Circulation (2009) 1.19
Therapeutic hypothermia after pediatric cardiac arrest trials: the vanguard phase experience and implications for other trials. Pediatr Crit Care Med (2013) 1.15
Intercenter variance. J Neurosurg (2001) 1.01
Hypothermia pediatric head injury trial: the value of a pretrial clinical evaluation phase. Dev Neurosci (2006) 1.00
Therapeutic hypothermia: applications in pediatric cardiac arrest. J Neurotrauma (2009) 0.98
Neonatal ECMO study of temperature (NEST): a randomized controlled trial. Pediatrics (2013) 0.97
Hypothermia for neuroprotection in children after cardiopulmonary arrest. Cochrane Database Syst Rev (2013) 0.92
Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol (2002) 10.93
Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics (2002) 9.87
Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics (2010) 9.15
High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05
Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet (2009) 7.23
Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol (2007) 6.68
A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis. N Engl J Med (2007) 6.50
Survival from in-hospital cardiac arrest during nights and weekends. JAMA (2008) 6.03
Atenolol versus losartan in children and young adults with Marfan's syndrome. N Engl J Med (2014) 5.11
Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N Engl J Med (2002) 4.62
Duration of cardiopulmonary resuscitation and illness category impact survival and neurologic outcomes for in-hospital pediatric cardiac arrests. Circulation (2013) 4.46
Carvedilol for children and adolescents with heart failure: a randomized controlled trial. JAMA (2007) 4.27
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int (2008) 4.16
Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med (2017) 3.89
Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics (2011) 3.84
Children with complex chronic conditions in inpatient hospital settings in the United States. Pediatrics (2010) 3.84
Pediatric calfactant in acute respiratory distress syndrome trial. Pediatr Crit Care Med (2013) 3.73
Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics (2007) 3.37
Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial. JAMA (2005) 3.29
Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents. Pediatrics (2005) 3.29
Dilated cardiomyopathy following right ventricular pacing for AV block in young patients: resolution after upgrading to biventricular pacing systems. J Cardiovasc Electrophysiol (2006) 3.28
Part 14: pediatric advanced life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation (2010) 3.20
Rhythms and outcomes of adult in-hospital cardiac arrest. Crit Care Med (2010) 3.19
The maternal lifestyle study: effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infants. Pediatrics (2002) 3.07
Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med (2011) 3.05
A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere (2006) 3.03
The circulatory-respiratory determination of death in organ donation. Crit Care Med (2010) 3.02
Parents' perspectives on physician-parent communication near the time of a child's death in the pediatric intensive care unit. Pediatr Crit Care Med (2008) 3.00
Results of small incision lenticule extraction: All-in-one femtosecond laser refractive surgery. J Cataract Refract Surg (2011) 2.95
Characterizing degree of lung injury in pediatric acute respiratory distress syndrome. Crit Care Med (2015) 2.85
Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med (2005) 2.81
Effectiveness of fundoplication at the time of gastrostomy in infants with neurological impairment. JAMA Pediatr (2013) 2.81
Multicenter cohort study of in-hospital pediatric cardiac arrest. Pediatr Crit Care Med (2009) 2.81
Higher Dead Space Is Associated With Increased Mortality in Critically Ill Children. Crit Care Med (2015) 2.73
Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA (2002) 2.71
In-hospital versus out-of-hospital pediatric cardiac arrest: a multicenter cohort study. Crit Care Med (2009) 2.70
Identification, evaluation, and management of obesity in an academic primary care center. Pediatrics (2004) 2.66
Baseline serum concentrations of zinc, selenium, and prolactin in critically ill children. Pediatr Crit Care Med (2013) 2.66
Diagnostic Errors in a PICU: Insights From the Morbidity and Mortality Conference. Pediatr Crit Care Med (2015) 2.65
Between-hospital variation in treatment and outcomes in extremely preterm infants. N Engl J Med (2015) 2.59
Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med (2007) 2.58
Antivenom for critically ill children with neurotoxicity from scorpion stings. N Engl J Med (2009) 2.53
Risk factors for pediatric arachnoid cyst rupture/hemorrhage: a case-control study. Neurosurgery (2013) 2.51
The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med (2003) 2.48
Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med (2010) 2.44
Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med (2015) 2.44
Functional Status Scale: new pediatric outcome measure. Pediatrics (2009) 2.42
Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement. Crit Care Med (2015) 2.42
Exception from informed consent for pediatric resuscitation research: community consultation for a trial of brain cooling after in-hospital cardiac arrest. Pediatrics (2004) 2.41
Medication errors and adverse drug events in an intensive care unit: direct observation approach for detection. Crit Care Med (2006) 2.34
Enrollment of extremely low birth weight infants in a clinical research study may not be representative. Pediatrics (2012) 2.32
Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants. Am J Respir Crit Care Med (2011) 2.31
Part 1: Executive summary: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2010) 2.31
Acute lung injury in children: therapeutic practice and feasibility of international clinical trials. Pediatr Crit Care Med (2010) 2.30
Endoscopic third ventriculostomy and choroid plexus cauterization in infants with hydrocephalus: a retrospective Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr (2014) 2.27
Early postresuscitation hypotension is associated with increased mortality following pediatric cardiac arrest. Crit Care Med (2014) 2.26
Simultaneous Prediction of New Morbidity, Mortality, and Survival Without New Morbidity From Pediatric Intensive Care: A New Paradigm for Outcomes Assessment. Crit Care Med (2015) 2.24
Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med (2009) 2.23
Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr (2011) 2.22
Guidelines for the determination of brain death in infants and children: an update of the 1987 task force recommendations-executive summary. Ann Neurol (2012) 2.20
Off-label drug use in hospitalized children. Arch Pediatr Adolesc Med (2007) 2.20
Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med (2011) 2.20
A neural switch for active and passive fear. Neuron (2010) 2.19
Identifying children at very low risk of clinically important blunt abdominal injuries. Ann Emerg Med (2013) 2.19
Backboards are important when chest compressions are provided on a soft mattress. Resuscitation (2012) 2.19
Parents' perspectives regarding a physician-parent conference after their child's death in the pediatric intensive care unit. J Pediatr (2007) 2.18
Interdisciplinary behavioral rehabilitation of pediatric pain-associated disability: retrospective review of an inpatient treatment protocol. J Pediatr Psychol (2009) 2.18