Published in Am J Respir Crit Care Med on May 15, 2015
Genotypes and Phenotypes in Pediatric SIRS and Sepsis (GAPPSS) | NCT02728401
Understanding the global epidemiology of pediatric critical illness: the power, pitfalls, and practicalities of point prevalence studies. Pediatr Crit Care Med (2014) 1.00
Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. Crit Care (2015) 0.87
Could Biomarkers Direct Therapy for the Septic Patient? J Pharmacol Exp Ther (2016) 0.84
Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review. Pediatr Crit Care Med (2017) 0.80
Decreased ADAMTS 13 Activity is Associated With Disease Severity and Outcome in Pediatric Severe Sepsis. Medicine (Baltimore) (2016) 0.80
Augmented Renal Clearance Implies a Need for Increased Amoxicillin-Clavulanic Acid Dosing in Critically Ill Children. Antimicrob Agents Chemother (2015) 0.78
Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs. Pediatr Crit Care Med (2016) 0.77
Understanding the global burden of pediatric sepsis. Am J Respir Crit Care Med (2015) 0.77
Association of Fluid Accumulation with Clinical Outcomes in Critically Ill Children with Severe Sepsis. PLoS One (2016) 0.76
Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill. Crit Care (2015) 0.76
Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia. Am J Physiol Endocrinol Metab (2016) 0.75
Multiple organ dysfunction syndrome in critically ill children: clinical value of two lists of diagnostic criteria. Ann Intensive Care (2016) 0.75
Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome. Front Pharmacol (2017) 0.75
Sepsis in Pediatric Cardiac Intensive Care. Pediatr Crit Care Med (2016) 0.75
2016 Update for the Rogers' Textbook of Pediatric Intensive Care: Recognition and Initial Management of Shock. Pediatr Crit Care Med (2016) 0.75
Use of biomarkers in pediatric sepsis: literature review. Rev Bras Ter Intensiva (2017) 0.75
It's About Time …. Pediatr Crit Care Med (2015) 0.75
Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability. Crit Care Med (2016) 0.75
Epidemiology and Outcomes of Pediatric Multiple Organ Dysfunction Syndrome. Pediatr Crit Care Med (2017) 0.75
Evaluation of mRNA Biomarkers to Identify Risk of Hospital Acquired Infections in Children Admitted to Paediatric Intensive Care Unit. PLoS One (2016) 0.75
Clinical Trials in Pediatric Sepsis: What's the (End) Point? Pediatr Crit Care Med (2017) 0.75
Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies. Pediatr Crit Care Med (2017) 0.75
Role of vasopressin and terlipressin in refractory shock compared to conventional therapy in the neonatal and pediatric population: a systematic review, meta-analysis, and trial sequential analysis. Crit Care (2017) 0.75
Protocolized Treatment Is Associated With Decreased Organ Dysfunction in Pediatric Severe Sepsis. Pediatr Crit Care Med (2016) 0.75
Pediatric sepsis. Curr Opin Pediatr (2016) 0.75
Fluid Resuscitation in Pediatric Sepsis: Lack of Data Versus Lack of Equipoise. Pediatr Crit Care Med (2015) 0.75
Cortisol Correlates with Severity of Illness and Poorly Reflects Adrenal Function in Pediatric Acute Respiratory Distress Syndrome. J Pediatr (2016) 0.75
Risk factors and outcome of Shigella encephalopathy in Bangladeshi children. PLoS Negl Trop Dis (2017) 0.75
Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis. Shock (2017) 0.75
Significance of hydrogen sulfide in sepsis-induced myocardial injury in rats. Exp Ther Med (2017) 0.75
Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign-Based Electronic Alert and Bedside Clinician Identification. Ann Emerg Med (2017) 0.75
Treatment with milk fat globule epidermal growth factor-factor 8 (MFG-E8) reduces inflammation and lung injury in neonatal sepsis. Surgery (2017) 0.75
Prediction of pediatric sepsis mortality within 1 h of intensive care admission. Intensive Care Med (2017) 0.75
Population Pharmacokinetics and Pharmacodynamic Target Attainment of Meropenem in Critically Ill Young Children. J Pediatr Pharmacol Ther (2017) 0.75
Clinical outcomes and mortality before and after implementation of a pediatric sepsis protocol in a limited resource setting: A retrospective cohort study in Bangladesh. PLoS One (2017) 0.75
Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform (2008) 71.12
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control (2008) 24.70
International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med (2005) 13.40
Simulation study of confounder-selection strategies. Am J Epidemiol (1993) 12.76
Sepsis in European intensive care units: results of the SOAP study. Crit Care Med (2006) 11.78
International study of the prevalence and outcomes of infection in intensive care units. JAMA (2009) 11.57
Mortality after fluid bolus in African children with severe infection. N Engl J Med (2011) 10.99
Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med (2009) 7.55
Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA (2014) 6.11
Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet (2003) 5.40
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet (2007) 5.23
Assessing the outcome of pediatric intensive care. J Pediatr (1992) 4.92
The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med (2002) 4.72
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Trends in the epidemiology of pediatric severe sepsis*. Pediatr Crit Care Med (2013) 2.67
Pediatric severe sepsis in U.S. children's hospitals. Pediatr Crit Care Med (2014) 2.43
Pediatric severe sepsis: current trends and outcomes from the Pediatric Health Information Systems database. Pediatr Crit Care Med (2014) 2.41
ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation. Intensive Care Med (2008) 2.40
Red blood cell transfusion thresholds in pediatric patients with sepsis. Pediatr Crit Care Med (2011) 2.35
Paediatric index of mortality 3: an updated model for predicting mortality in pediatric intensive care*. Pediatr Crit Care Med (2013) 2.08
The pediatric sepsis biomarker risk model. Crit Care (2012) 1.99
Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure. Crit Care Med (2008) 1.97
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med (2010) 1.95
A retrospective cohort study of prognostic factors associated with outcome in pediatric severe sepsis: what is the role of steroids? Pediatr Crit Care Med (2005) 1.87
Timing and predictors of death in pediatric patients with multiple organ system failure. Crit Care Med (1994) 1.84
Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med (2014) 1.81
Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. Pediatrics (2007) 1.78
Epidemiology of sepsis in pediatric intensive care units: first Colombian multicenter study. Pediatr Crit Care Med (2012) 1.76
Vasopressin in pediatric vasodilatory shock: a multicenter randomized controlled trial. Am J Respir Crit Care Med (2009) 1.71
Functional outcomes in pediatric severe sepsis: further analysis of the researching severe sepsis and organ dysfunction in children: a global perspective trial. Pediatr Crit Care Med (2013) 1.70
Defining pediatric sepsis by different criteria: discrepancies in populations and implications for clinical practice. Pediatr Crit Care Med (2012) 1.51
Comparison of trends in sepsis incidence and coding using administrative claims versus objective clinical data. Clin Infect Dis (2014) 1.51
Epidemiology of preterm birth and neonatal outcome. Semin Fetal Neonatal Med (2004) 1.49
Pediatric transplantation in the United States, 1997-2006. Am J Transplant (2008) 1.46
Readmission and late mortality after pediatric severe sepsis. Pediatrics (2009) 1.38
An emergency department septic shock protocol and care guideline for children initiated at triage. Pediatrics (2011) 1.37
Adherence to PALS Sepsis Guidelines and Hospital Length of Stay. Pediatrics (2012) 1.35
Implementation of goal-directed therapy for children with suspected sepsis in the emergency department. Pediatrics (2011) 1.34
The pediatric multiple organ dysfunction syndrome. Pediatr Crit Care Med (2009) 1.24
Emerging resistant Gram-negative aerobic bacilli in hospital-acquired infections. Chemotherapy (2010) 1.23
Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infection in neutropenic cancer patients. Clin Microbiol Infect (2012) 1.16
Alternative outcome measures for pediatric clinical sepsis trials. Pediatr Crit Care Med (2005) 1.16
Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis. PLoS One (2014) 1.13
Mortality rates in pediatric septic shock with and without multiple organ system failure. Pediatr Crit Care Med (2003) 1.11
Understanding the global epidemiology of pediatric critical illness: the power, pitfalls, and practicalities of point prevalence studies. Pediatr Crit Care Med (2014) 1.00
Incidence of and mortality due to sepsis, severe sepsis and septic shock in Italian Pediatric Intensive Care Units: a prospective national survey. Intensive Care Med (2008) 0.96
High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05
Survival from in-hospital cardiac arrest during nights and weekends. JAMA (2008) 6.03
Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med (2015) 4.90
A randomized trial of hyperglycemic control in pediatric intensive care. N Engl J Med (2014) 4.46
Duration of cardiopulmonary resuscitation and illness category impact survival and neurologic outcomes for in-hospital pediatric cardiac arrests. Circulation (2013) 4.46
Pediatric calfactant in acute respiratory distress syndrome trial. Pediatr Crit Care Med (2013) 3.73
Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics (2007) 3.37
Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial. JAMA (2005) 3.29
Part 14: pediatric advanced life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation (2010) 3.20
Rhythms and outcomes of adult in-hospital cardiac arrest. Crit Care Med (2010) 3.19
Characterizing degree of lung injury in pediatric acute respiratory distress syndrome. Crit Care Med (2015) 2.85
Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study. Ann Intern Med (2014) 2.73
Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med (2007) 2.58
Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med (2015) 2.44
Exception from informed consent for pediatric resuscitation research: community consultation for a trial of brain cooling after in-hospital cardiac arrest. Pediatrics (2004) 2.41
Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood (2013) 2.39
Part 1: Executive summary: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2010) 2.31
Early postresuscitation hypotension is associated with increased mortality following pediatric cardiac arrest. Crit Care Med (2014) 2.26
Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med (2009) 2.23
Value and the medical home: effects of transformed primary care. Am J Manag Care (2010) 2.22
Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Blood (2007) 2.21
Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med (2011) 2.20
Backboards are important when chest compressions are provided on a soft mattress. Resuscitation (2012) 2.19
Survival outcomes after extracorporeal cardiopulmonary resuscitation instituted during active chest compressions following refractory in-hospital pediatric cardiac arrest. Pediatr Crit Care Med (2004) 2.11
Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med (2015) 2.09
A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest. N Engl J Med (2004) 2.08
Jading in the pediatric intensive care unit: Implications for healthcare providers of medically complex children. Pediatr Crit Care Med (2004) 2.06
Pulse oximetry vs. PaO2 metrics in mechanically ventilated children: Berlin definition of ARDS and mortality risk. Intensive Care Med (2014) 2.06
Tumor lysis syndrome. Indian J Pediatr (2012) 2.01
Dexamethasone pretreatment for 24 h versus 6 h for prevention of postextubation airway obstruction in children: a randomized double-blind trial. Intensive Care Med (2014) 2.01
The pediatric sepsis biomarker risk model. Crit Care (2012) 1.99
Validating the genomic signature of pediatric septic shock. Physiol Genomics (2008) 1.96
Primary outcomes for resuscitation science studies: a consensus statement from the American Heart Association. Circulation (2011) 1.93
Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health. Am J Physiol Lung Cell Mol Physiol (2006) 1.83
Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med (2014) 1.81
Corticosteroid exposure in pediatric acute respiratory distress syndrome. Intensive Care Med (2015) 1.77
Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory inhospital pediatric cardiac arrest: a report from the National Registry of Cardiopulmonary Resuscitation. Pediatr Crit Care Med (2010) 1.76
Induction of CD8+ T cells to an HIV-1 antigen through a prime boost regimen with heterologous E1-deleted adenoviral vaccine carriers. J Immunol (2003) 1.75
Interdisciplinary ICU cardiac arrest debriefing improves survival outcomes*. Crit Care Med (2014) 1.73
Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged men. Crit Care Med (2010) 1.73
Post-ICU admission fluid balance and pediatric septic shock outcomes: a risk-stratified analysis. Crit Care Med (2014) 1.72
Comparison of SpO2 to PaO2 based markers of lung disease severity for children with acute lung injury. Crit Care Med (2012) 1.71
Part 16: education, implementation, and teams: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation (2010) 1.70
A National Emergency Airway Registry for children: landscape of tracheal intubation in 15 PICUs. Crit Care Med (2013) 1.68
Characterization of tracheal intubation process of care and safety outcomes in a tertiary pediatric intensive care unit. Pediatr Crit Care Med (2012) 1.68
Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing. Crit Care Med (2013) 1.65
Clinical and hemodynamic comparison of 15:2 and 30:2 compression-to-ventilation ratios for cardiopulmonary resuscitation. Crit Care Med (2006) 1.64
Hemodynamic directed cardiopulmonary resuscitation improves short-term survival from ventricular fibrillation cardiac arrest. Crit Care Med (2013) 1.62
The formula for survival in resuscitation. Resuscitation (2013) 1.61
Assessment of parental presence during bedside pediatric intensive care unit rounds: effect on duration, teaching, and privacy. Pediatr Crit Care Med (2007) 1.60
Demographics of abusive head trauma in the Commonwealth of Pennsylvania. J Neurosurg Pediatr (2008) 1.60
Mitochondrial dysfunction in peripheral blood mononuclear cells in pediatric septic shock. Pediatr Crit Care Med (2015) 1.59
Out-of-hospital cardiac arrest due to drowning among children and adults from the Utstein Osaka Project. Resuscitation (2013) 1.59
Non traumatic coma. Indian J Pediatr (2005) 1.58
The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med (2011) 1.57
Site-level variance for adverse tracheal intubation-associated events across 15 North American PICUs: a report from the national emergency airway registry for children*. Pediatr Crit Care Med (2014) 1.57
Resuscitation training in developing countries: a systematic review. Resuscitation (2010) 1.57
Decreasing unplanned extubations: utilization of the Penn State Children's Hospital Sedation Algorithm. Pediatr Crit Care Med (2004) 1.55
Survival trends in pediatric in-hospital cardiac arrests: an analysis from Get With the Guidelines-Resuscitation. Circ Cardiovasc Qual Outcomes (2012) 1.53
Clinical equipoise regarding glycemic control: a survey of pediatric intensivist perceptions. Pediatr Crit Care Med (2013) 1.52
Hypothermia for Traumatic Brain Injury in Children-A Phase II Randomized Controlled Trial. Crit Care Med (2015) 1.52
Comparison of a 10-breaths-per-minute versus a 2-breaths-per-minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrest. Respir Care (2008) 1.52
Incidence and associated factors of difficult tracheal intubations in pediatric ICUs: a report from National Emergency Airway Registry for Children: NEAR4KIDS. Intensive Care Med (2014) 1.51
Change in regional (somatic) near-infrared spectroscopy is not a useful indicator of clinically detectable low cardiac output in children after surgery for congenital heart defects. Pediatr Crit Care Med (2012) 1.50
Part 10: Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2010) 1.50
Examining pediatric resuscitation education using simulation and scripted debriefing: a multicenter randomized trial. JAMA Pediatr (2013) 1.49
Sternal wall pressure comparable to leaning during CPR impacts intrathoracic pressure and haemodynamics in anaesthetized children during cardiac catheterization. Resuscitation (2013) 1.49
Post hoc analysis of calfactant use in immunocompromised children with acute lung injury: Impact and feasibility of further clinical trials. Pediatr Crit Care Med (2008) 1.49
A Multibiomarker-Based Model for Estimating the Risk of Septic Acute Kidney Injury. Crit Care Med (2015) 1.49
Patient-centric blood pressure-targeted cardiopulmonary resuscitation improves survival from cardiac arrest. Am J Respir Crit Care Med (2014) 1.48
Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells. Proc Natl Acad Sci U S A (2006) 1.48
Improved oxygenation 24 hours after transition to airway pressure release ventilation or high-frequency oscillatory ventilation accurately discriminates survival in immunocompromised pediatric patients with acute respiratory distress syndrome*. Pediatr Crit Care Med (2014) 1.48
The impact of 24-hr, in-hospital pediatric critical care attending physician presence on process of care and patient outcomes*. Crit Care Med (2012) 1.48
Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. Pediatr Crit Care Med (2015) 1.44
National survey of pediatric critical care medicine fellowship clinical and research time allocation. Pediatr Crit Care Med (2009) 1.44
Outcomes of in-hospital ventricular fibrillation in children. N Engl J Med (2006) 1.44
Part 1: Executive summary: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Resuscitation (2010) 1.43
Higher survival rates among younger patients after pediatric intensive care unit cardiac arrests. Pediatrics (2006) 1.41
Increased Occurrence of Tracheal Intubation-Associated Events During Nights and Weekends in the PICU. Crit Care Med (2015) 1.41
Prospective assessment of guidelines for determining appropriate depth of endotracheal tube placement in children. Pediatr Crit Care Med (2005) 1.41
Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med (2016) 1.41
An under-recognized benefit of cardiopulmonary resuscitation: organ transplantation. Crit Care Med (2013) 1.41
Antecedent bradycardia and in-hospital cardiopulmonary arrest mortality in telemetry-monitored patients outside the ICU. Resuscitation (2012) 1.41
Early Head CT Findings Are Associated With Outcomes After Pediatric Out-of-Hospital Cardiac Arrest. Pediatr Crit Care Med (2015) 1.40
Implementation of a pediatric critical care focused bedside ultrasound training program in a large academic PICU. Pediatr Crit Care Med (2015) 1.40
Variability of characteristics and outcomes following cardiopulmonary resuscitation events in diverse ICU settings in a single, tertiary care children's hospital*. Pediatr Crit Care Med (2014) 1.39
Optimizing Virus Identification in Critically Ill Children Suspected of Having an Acute Severe Viral Infection. Pediatr Crit Care Med (2016) 1.39
Invasive Mechanical Ventilation and Mortality in Pediatric Hematopoietic Stem Cell Transplantation: A Multicenter Study. Pediatr Crit Care Med (2016) 1.39
Leaning during chest compressions impairs cardiac output and left ventricular myocardial blood flow in piglet cardiac arrest. Crit Care Med (2010) 1.38
Comparison of relative and actual chest compression depths during cardiac arrest in children, adolescents, and young adults. Resuscitation (2011) 1.37
Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care (2012) 1.31
Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med (2008) 1.25
Major changes in the 2005 AHA Guidelines for CPR and ECC: reaching the tipping point for change. Circulation (2005) 1.25