| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.
|
Nat Genet
|
2003
|
5.82
|
|
2
|
Immunoassay for human serum hepcidin.
|
Blood
|
2008
|
5.32
|
|
3
|
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS.
|
Blood
|
2005
|
3.10
|
|
4
|
The molecular mechanism of hepcidin-mediated ferroportin down-regulation.
|
Mol Biol Cell
|
2007
|
2.99
|
|
5
|
Hepcidin and iron homeostasis.
|
Biochim Biophys Acta
|
2012
|
2.96
|
|
6
|
Hepcidin in iron overload disorders.
|
Blood
|
2005
|
2.88
|
|
7
|
Hepcidin and disorders of iron metabolism.
|
Annu Rev Med
|
2011
|
2.67
|
|
8
|
Hepcidin--a potential novel biomarker for iron status in chronic kidney disease.
|
Clin J Am Soc Nephrol
|
2009
|
2.61
|
|
9
|
Liver iron concentrations and urinary hepcidin in beta-thalassemia.
|
Haematologica
|
2007
|
2.52
|
|
10
|
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
|
Blood
|
2007
|
2.51
|
|
11
|
Retracted
The hepcidin-binding site on ferroportin is evolutionarily conserved.
|
Cell Metab
|
2008
|
2.25
|
|
12
|
Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis.
|
Br J Haematol
|
2008
|
2.25
|
|
13
|
Proinflammatory state, hepcidin, and anemia in older persons.
|
Blood
|
2010
|
2.19
|
|
14
|
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.
|
J Clin Invest
|
2010
|
2.18
|
|
15
|
The molecular basis of ferroportin-linked hemochromatosis.
|
Proc Natl Acad Sci U S A
|
2005
|
2.10
|
|
16
|
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.
|
Blood
|
2005
|
2.08
|
|
17
|
In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2.
|
Blood
|
2010
|
2.03
|
|
18
|
Detection, evaluation, and management of iron-restricted erythropoiesis.
|
Blood
|
2010
|
1.93
|
|
19
|
Iron sequestration and anemia of inflammation.
|
Semin Hematol
|
2009
|
1.85
|
|
20
|
Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice.
|
Hepatology
|
2011
|
1.82
|
|
21
|
Iron imports. IV. Hepcidin and regulation of body iron metabolism.
|
Am J Physiol Gastrointest Liver Physiol
|
2006
|
1.81
|
|
22
|
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis.
|
Blood
|
2007
|
1.78
|
|
23
|
Regulation of iron acquisition and iron distribution in mammals.
|
Biochim Biophys Acta
|
2006
|
1.72
|
|
24
|
Urinary hepcidin in congenital chronic anemias.
|
Pediatr Blood Cancer
|
2007
|
1.58
|
|
25
|
Involvement of hepcidin in the anemia of multiple myeloma.
|
Clin Cancer Res
|
2008
|
1.57
|
|
26
|
The molecular basis of hepcidin-resistant hereditary hemochromatosis.
|
Blood
|
2009
|
1.51
|
|
27
|
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis.
|
Blood
|
2012
|
1.51
|
|
28
|
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload.
|
J Clin Invest
|
2011
|
1.49
|
|
29
|
Hepcidin and iron-loading anemias.
|
Haematologica
|
2006
|
1.49
|
|
30
|
Reduced serum hepcidin levels in patients with chronic hepatitis C.
|
J Hepatol
|
2009
|
1.48
|
|
31
|
Novel urine hepcidin assay by mass spectrometry.
|
Blood
|
2005
|
1.46
|
|
32
|
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia.
|
Blood
|
2004
|
1.44
|
|
33
|
Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation.
|
Inflamm Bowel Dis
|
2006
|
1.43
|
|
34
|
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.
|
Cell Metab
|
2012
|
1.42
|
|
35
|
Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site.
|
Blood Cells Mol Dis
|
2007
|
1.40
|
|
36
|
Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function.
|
Blood
|
2005
|
1.38
|
|
37
|
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin.
|
Blood
|
2013
|
1.34
|
|
38
|
Manipulation of the hepcidin pathway for therapeutic purposes.
|
Haematologica
|
2013
|
1.32
|
|
39
|
Elevated systemic hepcidin and iron depletion in obese premenopausal females.
|
Obesity (Silver Spring)
|
2009
|
1.28
|
|
40
|
Molecular and clinical correlates in iron overload associated with mutations in ferroportin.
|
Haematologica
|
2006
|
1.23
|
|
41
|
Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors.
|
Haematologica
|
2011
|
1.21
|
|
42
|
Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis.
|
Blood Cells Mol Dis
|
2007
|
1.20
|
|
43
|
Inhibition of hepcidin transcription by growth factors.
|
Hepatology
|
2012
|
1.17
|
|
44
|
Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin.
|
J Acad Nutr Diet
|
2012
|
1.10
|
|
45
|
Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells.
|
Aging Cell
|
2013
|
1.07
|
|
46
|
Excess adiposity, inflammation, and iron-deficiency in female adolescents.
|
J Am Diet Assoc
|
2009
|
1.07
|
|
47
|
Reduction of serum hepcidin by hemodialysis in pediatric and adult patients.
|
Clin J Am Soc Nephrol
|
2010
|
1.07
|
|
48
|
A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis.
|
Haematologica
|
2010
|
1.07
|
|
49
|
Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation.
|
Blood
|
2009
|
1.04
|
|
50
|
Iron metabolism: interactions with normal and disordered erythropoiesis.
|
Cold Spring Harb Perspect Med
|
2012
|
1.01
|
|
51
|
Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia.
|
Haematologica
|
2007
|
1.01
|
|
52
|
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
|
Cell Metab
|
2012
|
1.00
|
|
53
|
Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6.
|
Infect Immun
|
2013
|
0.99
|
|
54
|
The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders.
|
Hematology Am Soc Hematol Educ Program
|
2011
|
0.99
|
|
55
|
New insights into iron regulation and erythropoiesis.
|
Curr Opin Hematol
|
2015
|
0.98
|
|
56
|
Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload.
|
J Hepatol
|
2008
|
0.97
|
|
57
|
Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery.
|
Obesity (Silver Spring)
|
2010
|
0.95
|
|
58
|
Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease.
|
Hepatology
|
2005
|
0.95
|
|
59
|
Hepcidin is a key mediator of anemia of inflammation in Crohn's disease.
|
J Crohns Colitis
|
2012
|
0.94
|
|
60
|
Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin.
|
J Hepatol
|
2009
|
0.92
|
|
61
|
High-throughput screening of small molecules identifies hepcidin antagonists.
|
Mol Pharmacol
|
2013
|
0.91
|
|
62
|
Cellular catabolism of the iron-regulatory peptide hormone hepcidin.
|
PLoS One
|
2013
|
0.87
|
|
63
|
Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc.
|
Am J Physiol Cell Physiol
|
2013
|
0.86
|
|
64
|
Understanding the structure/activity relationships of the iron regulatory peptide hepcidin.
|
Chem Biol
|
2011
|
0.85
|
|
65
|
DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis.
|
Blood
|
2006
|
0.85
|
|
66
|
Subcutaneous adipose tissue from obese and lean adults does not release hepcidin in vivo.
|
ScientificWorldJournal
|
2011
|
0.84
|
|
67
|
Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium.
|
Am J Clin Nutr
|
2010
|
0.84
|
|
68
|
Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy.
|
Haematologica
|
2013
|
0.81
|
|
69
|
Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism.
|
Eur J Appl Physiol
|
2009
|
0.81
|
|
70
|
Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome.
|
Liver Int
|
2011
|
0.81
|
|
71
|
Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin.
|
Biopolymers
|
2013
|
0.80
|
|
72
|
Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl.
|
Angew Chem Int Ed Engl
|
2014
|
0.77
|
|
73
|
Intestinal ferroportin expression in pediatric Crohn's disease.
|
Inflamm Bowel Dis
|
2011
|
0.77
|
|
74
|
Crosstalk between Erythropoiesis and Iron Metabolism.
|
Adv Hematol
|
2010
|
0.76
|
|
75
|
Novel tools for the evaluation of iron metabolism.
|
Haematologica
|
2010
|
0.75
|
|
76
|
IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011).
|
J Zoo Wildl Med
|
2012
|
0.75
|
|
77
|
Iron Metabolism in African American Women in the Second and Third Trimesters of High-Risk Pregnancies.
|
J Obstet Gynecol Neonatal Nurs
|
2016
|
0.75
|
|
78
|
In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively Than Iron and Erythropoietin Treatment.
|
Shock
|
2017
|
0.75
|
|
79
|
Iron homeostasis and its disorders in mice and men: potential lessons for rhinos.
|
J Zoo Wildl Med
|
2012
|
0.75
|