Published in Blood on January 25, 2005
Forging a field: the golden age of iron biology. Blood (2008) 3.83
Hepcidin and iron regulation, 10 years later. Blood (2011) 3.80
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest (2007) 3.40
Suppression of hepcidin during anemia requires erythropoietic activity. Blood (2006) 3.32
Hepcidin and iron homeostasis. Biochim Biophys Acta (2012) 2.96
Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet (2014) 2.70
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest (2010) 2.18
Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med (2010) 2.04
Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol (2006) 1.99
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia. Blood (2012) 1.94
Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia. Blood (2015) 1.84
17β-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site. Endocrinology (2012) 1.79
Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis (2007) 1.76
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood (2006) 1.74
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood (2010) 1.63
Mechanisms of mammalian iron homeostasis. Biochemistry (2012) 1.51
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin. Haematologica (2009) 1.49
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood (2011) 1.49
Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood (2008) 1.43
Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology (2011) 1.38
Cardiac iron across different transfusion-dependent diseases. Blood Rev (2008) 1.37
Ferroportin1 is required for normal iron cycling in zebrafish. J Clin Invest (2005) 1.27
Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia. Blood (2012) 1.25
Molecular diagnostic and pathogenesis of hereditary hemochromatosis. Int J Mol Sci (2012) 1.22
Survival of the fittest: in vivo selection and stem cell gene therapy. Blood (2005) 1.19
Iron overload in sickle cell disease. Adv Hematol (2010) 1.15
Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia. Hematol Oncol Clin North Am (2010) 1.14
Wild-type and mutant ferroportins do not form oligomers in transfected cells. Biochem J (2006) 1.12
Iron overload cardiomyopathy: better understanding of an increasing disorder. J Am Coll Cardiol (2010) 1.11
The heart in transfusion dependent homozygous thalassaemia today--prediction, prevention and management. Eur J Haematol (2007) 1.10
Hepcidin modulation in human diseases: from research to clinic. World J Gastroenterol (2009) 1.09
Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major. J Magn Reson Imaging (2009) 1.09
Reduction of serum hepcidin by hemodialysis in pediatric and adult patients. Clin J Am Soc Nephrol (2010) 1.07
A novel immunological assay for hepcidin quantification in human serum. PLoS One (2009) 1.05
Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. Blood (2010) 1.03
Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis. J Biol Chem (2011) 1.03
Differences in the erythropoiesis-hepcidin-iron store axis between hemoglobin H disease and β-thalassemia intermedia. Haematologica (2015) 1.03
Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb Perspect Med (2012) 1.01
Pathophysiology of hereditary hemochromatosis. Semin Liver Dis (2005) 1.01
Ineffective erythropoiesis in β -thalassemia. ScientificWorldJournal (2013) 1.01
The small molecule, genistein, increases hepcidin expression in human hepatocytes. Hepatology (2013) 1.00
Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. Biochem J (2009) 1.00
Hepcidin regulation of iron transport. J Nutr (2008) 1.00
Molecular insights into the pathogenesis of hereditary haemochromatosis. Gut (2006) 0.98
beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload. Adv Hematol (2010) 0.98
Molecular and clinical aspects of iron homeostasis: From anemia to hemochromatosis. Wien Klin Wochenschr (2006) 0.97
Regulation of iron absorption in hemoglobinopathies. Curr Mol Med (2008) 0.97
Hepcidin--the iron regulatory hormone. Clin Biochem Rev (2005) 0.96
Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1. Haematologica (2013) 0.96
Iron metabolism in thalassemia and sickle cell disease. Mediterr J Hematol Infect Dis (2009) 0.95
Gender-related variations in iron metabolism and liver diseases. World J Hepatol (2010) 0.94
Hepcidin in the diagnosis of iron disorders. Blood (2016) 0.93
Clinical, pathological, and molecular correlates in ferroportin disease: a study of two novel mutations. J Hepatol (2008) 0.92
Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency. J Cell Mol Med (2009) 0.90
Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia. Am J Hematol (2015) 0.89
Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood (2005) 0.89
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. Acta Neuropathol Commun (2013) 0.88
Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait. Blood (2014) 0.87
Gastrins, iron homeostasis and colorectal cancer. Biochim Biophys Acta (2011) 0.86
DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood (2006) 0.85
Hereditary hemochromatosis and transferrin receptor 2. Biochim Biophys Acta (2011) 0.85
Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods. Cell Mol Life Sci (2012) 0.84
Relationship Between Serum Hepcidin and Ferritin Levels in Patients With Thalassemia Major and Intermedia in Southern Iran. Iran Red Crescent Med J (2015) 0.84
Liver-gut axis in the regulation of iron homeostasis. World J Gastroenterol (2007) 0.84
Serum Hepcidin as a Diagnostic Marker of Severe Iron Overload in Beta-thalassemia Major. Indian J Pediatr (2017) 0.83
Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. Haematologica (2008) 0.83
Serum hepcidin: a novel diagnostic tool in disorders of iron metabolism. Haematologica (2009) 0.81
HFE gene in primary and secondary hepatic iron overload. World J Gastroenterol (2007) 0.81
Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders. J Gastroenterol (2010) 0.81
Serum hepcidin levels and reticulocyte hemoglobin concentrations as indicators of the iron status of peritoneal dialysis patients. Int J Nephrol (2012) 0.81
Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica (2013) 0.81
Of mice and men: the iron age. J Clin Invest (2005) 0.81
A chemical screen identifies small molecules that regulate hepcidin expression. Blood Cells Mol Dis (2014) 0.80
Iron homeostasis: An anthropocentric perspective. J Biol Chem (2017) 0.80
Iron transport proteins: Gateways of cellular and systemic iron homeostasis. J Biol Chem (2017) 0.80
Heterozygous beta-globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C. Gut (2006) 0.79
BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin. PLoS One (2011) 0.79
Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver. Exp Hematol (2015) 0.78
Hepcidin-minireview. J Clin Diagn Res (2013) 0.78
Hydroxyurea could be a good clinically relevant iron chelator. PLoS One (2013) 0.77
Iron metabolism in children: confounding factors. Food Nutr Bull (2007) 0.77
Laboratory use of hepcidin in renal transplant recipients. Biochem Med (Zagreb) (2016) 0.76
Chamomile decoction extract inhibits human neutrophils ROS production and attenuates alcohol-induced haematological parameters changes and erythrocytes oxidative stress in rat. Lipids Health Dis (2016) 0.76
New strategies to target iron metabolism for the treatment of beta thalassemia. Ann N Y Acad Sci (2016) 0.75
Cardiac function and iron chelation in thalassemia major and intermedia: a review of the underlying pathophysiology and approach to chelation management. Mediterr J Hematol Infect Dis (2009) 0.75
Dietary supplementation with ipriflavone decreases hepatic iron stores in wild type mice. Blood Cells Mol Dis (2016) 0.75
Coinheritance of hereditary spherocytosis and reversibility of cirrhosis in a young female patient with hereditary hemochromatosis. Eur J Med Res (2009) 0.75
Liver Enzymes in Children with beta-Thalassemia Major: Correlation with Iron Overload and Viral Hepatitis. Open Access Maced J Med Sci (2015) 0.75
3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach. Pharmaceuticals (Basel) (2016) 0.75
Retracted Deficits of learning and memory in Hemojuvelin knockout mice. J Vet Med Sci (2015) 0.75
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest (2004) 11.05
Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem (2000) 8.39
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest (2002) 7.90
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood (2002) 7.58
Disorders of iron metabolism. N Engl J Med (1999) 7.49
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet (2003) 5.82
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A (2001) 5.77
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A (2002) 4.64
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet (2003) 4.49
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet (2002) 4.19
Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood (2002) 3.93
Regulators of iron balance in humans. Blood (1994) 3.67
Hepcidin is decreased in TFR2 hemochromatosis. Blood (2004) 3.46
Complications of beta-thalassemia major in North America. Blood (2004) 2.97
The ferroportin disease. Blood Cells Mol Dis (2004) 2.90
Decreased hepcidin mRNA expression in thalassemic mice. Br J Haematol (2004) 1.61
Hepcidin in iron metabolism. Curr Opin Hematol (2004) 1.54
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood (2004) 1.44
Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3). Br J Haematol (2002) 1.32
Ferroportin mutation in autosomal dominant hemochromatosis: loss of function, gain in understanding. J Clin Invest (2001) 0.90
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest (2004) 11.05
Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med (2002) 9.01
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood (2002) 7.58
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet (2003) 5.82
Immunoassay for human serum hepcidin. Blood (2008) 5.32
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med (2007) 5.18
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
Regulation of iron metabolism by hepcidin. Annu Rev Nutr (2006) 3.96
Hepcidin is decreased in TFR2 hemochromatosis. Blood (2004) 3.46
Defensins of vertebrate animals. Curr Opin Immunol (2002) 3.41
Suppression of hepcidin during anemia requires erythropoietic activity. Blood (2006) 3.32
Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol (2002) 3.13
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood (2005) 3.10
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
Hepcidin and iron homeostasis. Biochim Biophys Acta (2012) 2.96
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet (2002) 2.90
The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica (2006) 2.80
Systemic iron homeostasis. Physiol Rev (2013) 2.69
Hepcidin and disorders of iron metabolism. Annu Rev Med (2011) 2.67
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood (2005) 2.66
Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood (2009) 2.65
Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. Clin J Am Soc Nephrol (2009) 2.61
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A (2005) 2.60
Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica (2007) 2.52
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood (2007) 2.51
Retracted The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab (2008) 2.25
Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. Br J Haematol (2008) 2.25
Proinflammatory state, hepcidin, and anemia in older persons. Blood (2010) 2.19
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest (2010) 2.18
Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol (2002) 2.17
The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A (2005) 2.10
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood (2005) 2.08
In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood (2010) 2.03
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol (2007) 2.02
Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics (2005) 1.97
Detection, evaluation, and management of iron-restricted erythropoiesis. Blood (2010) 1.93
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem (2002) 1.89
The role of hepcidin in iron metabolism. Acta Haematol (2009) 1.88
Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol (2003) 1.88
Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol (2002) 1.86
Iron sequestration and anemia of inflammation. Semin Hematol (2009) 1.85
Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology (2011) 1.82
Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol (2003) 1.82
Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol (2006) 1.81
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood (2007) 1.78
Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis (2007) 1.76
Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest (2007) 1.72
Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta (2006) 1.72
Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates. Am J Hum Genet (2004) 1.70
Antimicrobial components of vaginal fluid. Am J Obstet Gynecol (2002) 1.67
Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. Blood (2004) 1.64
Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis (2004) 1.63
The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood (2005) 1.60
Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer (2007) 1.58
Cationic polypeptides are required for antibacterial activity of human airway fluid. J Immunol (2002) 1.58
Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology (2010) 1.58
Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res (2008) 1.57
Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol (2006) 1.55
By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol (2003) 1.54
The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood (2009) 1.51
Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica (2009) 1.51
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood (2012) 1.51
Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. J Clin Endocrinol Metab (2010) 1.50
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest (2011) 1.49
Hepcidin and iron-loading anemias. Haematologica (2006) 1.49
Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol (2009) 1.48
Novel urine hepcidin assay by mass spectrometry. Blood (2005) 1.46
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood (2004) 1.44
Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation. Inflamm Bowel Dis (2006) 1.43
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab (2012) 1.42
Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol (2005) 1.41