Published in Assay Drug Dev Technol on October 01, 2004
The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discov Today (2010) 1.43
A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Anal Biochem (2009) 1.11
Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation. J Physiol (2010) 1.03
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol (2011) 1.00
hERG subunit composition determines differential drug sensitivity. Br J Pharmacol (2011) 0.90
A novel method for patch-clamp automation. Pflugers Arch (2006) 0.85
Automated electrophysiology makes the pace for cardiac ion channel safety screening. Front Pharmacol (2011) 0.83
Toxicological evaluation of a novel umami flavour compound: 2-(((3-(2,3-Dimethoxyphenyl)-1H-1,2,4-triazol-5-yl)thio)methyl)pyridine. Toxicol Rep (2016) 0.75
Toxicological evaluation of a novel cooling compound: 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acetamide. Toxicol Rep (2015) 0.75
Toxicological evaluation of the flavour ingredient N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218). Toxicol Rep (2017) 0.75
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science (2008) 8.62
Data sharing by scientists: practices and perceptions. PLoS One (2011) 6.48
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39
Target RNA-directed trimming and tailing of small silencing RNAs. Science (2010) 3.98
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet (2003) 3.70
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA (2009) 3.19
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell (2009) 3.13
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). Br J Haematol (2013) 2.33
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell (2013) 2.23
Changes in smoking behavior and subsequent mortality risk during a 35-year follow-up of a cohort in Xi'an, China. Am J Epidemiol (2014) 2.16
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell (2011) 1.79
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res (2008) 1.77
Adaptation to P element transposon invasion in Drosophila melanogaster. Cell (2011) 1.76
Antimicrobial susceptibility and molecular determinants of quinolone resistance in Neisseria gonorrhoeae isolates from Shanghai. J Antimicrob Chemother (2006) 1.69
Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients. J Exp Clin Cancer Res (2008) 1.58
Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell (2012) 1.57
3D in vivo optical coherence tomography based on a low-voltage, large-scan-range 2D MEMS mirror. Opt Express (2010) 1.55
UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell (2012) 1.53
Race Disparities and Decreasing Birth Weight: Are All Babies Getting Smaller? Am J Epidemiol (2015) 1.53
Visual outcome after extended endoscopic endonasal transsphenoidal surgery for tuberculum sellae meningiomas. World Neurosurg (2010) 1.52
Intake of high sucrose during pregnancy altered large-conductance Ca2+-activated K+ channels and vessel tone in offspring's mesenteric arteries. Hypertens Res (2012) 1.48
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PLoS One (2012) 1.46
Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells. PLoS One (2010) 1.36
Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell (2011) 1.31
Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells. Toxicology (2007) 1.31
Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity. Proc Natl Acad Sci U S A (2011) 1.31
Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immunol (2011) 1.25
Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection. PLoS Genet (2010) 1.19
Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA (2010) 1.19
Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis. J Cell Biochem (2009) 1.18
Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis? Diabetes Care (2008) 1.17
Prediction of radiation pneumonitis in lung cancer patients: a systematic review. J Cancer Res Clin Oncol (2012) 1.16
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem (2011) 1.16
Valve replacement surgery in end-stage renal failure: mechanical prostheses versus bioprostheses. Ann Thorac Surg (2006) 1.15
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Mol Cell Biol (2002) 1.13
Ion-channel assay technologies: quo vadis? Drug Discov Today (2001) 1.12
Suppression of the vacuolar invertase gene prevents cold-induced sweetening in potato. Plant Physiol (2010) 1.11
Aurora kinase inhibition downregulates NF-kappaB and sensitises tumour cells to chemotherapeutic agents. Biochem Biophys Res Commun (2006) 1.11
Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. Cancer Res (2007) 1.11
Imaging measures predict progression in progressive supranuclear palsy. Mov Disord (2012) 1.08
Senescence-inducible expression of isopentenyl transferase extends leaf life, increases drought stress resistance and alters cytokinin metabolism in cassava. J Integr Plant Biol (2010) 1.08
Rates of brain atrophy and clinical decline over 6 and 12-month intervals in PSP: determining sample size for treatment trials. Parkinsonism Relat Disord (2011) 1.08
Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress. Lab Chip (2009) 1.07
Drug-eluting balloon for instent restenosis. Heart (2013) 1.07
Effect of prosthesis-patient mismatch on long-term survival with aortic valve replacement: assessment to 15 years. Ann Thorac Surg (2010) 1.07
Increasing Prevalence of Metabolic Syndrome in a Chinese Elderly Population: 2001-2010. PLoS One (2013) 1.04
Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp. J Biomol Screen (2005) 1.04
An albumin-conjugated peptide exhibits potent anti-HIV activity and long in vivo half-life. Antimicrob Agents Chemother (2009) 1.04
Photoacoustic imaging based on MEMS mirror scanning. Biomed Opt Express (2010) 1.03
The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-alpha production with antitumor activity. Cancer Res (2006) 1.03
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel. Circ Res (2002) 1.02
G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract. Development (2010) 1.01
Genetic variants in TGF-β pathway are associated with ovarian cancer risk. PLoS One (2011) 1.01
Down-regulation of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human gastric cancer cells. PLoS One (2012) 1.00
Does aromatherapy massage benefit patients with cancer attending a specialist palliative care day centre? Palliat Med (2004) 1.00
Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells. PLoS One (2011) 1.00
Macrophages participate in IL-17-mediated inflammation. Eur J Immunol (2012) 1.00
The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. Cell Cycle (2007) 0.99
Highly sensitive and fast responsive fluorescence turn-on chemodosimeter for Cu2+ and its application in live cell imaging. Chemistry (2008) 0.99
Phylogenetic analysis of infectious bronchitis coronaviruses newly isolated in China, and pathogenicity and evaluation of protection induced by Massachusetts serotype H120 vaccine against QX-like strains. Avian Pathol (2011) 0.99
Secondhand smoke exposure predicted COPD and other tobacco-related mortality in a 17-year cohort study in China. Chest (2012) 0.99
The role of aquaporin-4 antibodies in Chinese patients with neuromyelitis optica. J Clin Neurosci (2012) 0.98
Agrobacterium-mediated transient gene expression and silencing: a rapid tool for functional gene assay in potato. PLoS One (2009) 0.97
Antioxidant properties and neuroprotective effects of isocampneoside II on hydrogen peroxide-induced oxidative injury in PC12 cells. Food Chem Toxicol (2013) 0.97
THY1 expression is associated with tumor suppression of human ovarian cancer. Cancer Genet Cytogenet (2003) 0.97
Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging. Opt Express (2012) 0.95
Clusters of circulating Neisseria gonorrhoeae strains and association with antimicrobial resistance in Shanghai. J Antimicrob Chemother (2008) 0.95
Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation. Cancer Res (2009) 0.94
Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers. BMC Cancer (2010) 0.93
Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats. Exp Neurol (2010) 0.93
Isolation and RNA1 nucleotide sequence determination of a new insect nodavirus from Pieris rapae larvae in Wuhan city, China. Virus Res (2006) 0.93
Metabolic syndrome vs. its components for prediction of cardiovascular mortality: A cohort study in Chinese elderly adults. J Geriatr Cardiol (2012) 0.92
Phylogenetic analysis reveals that a dwarfing disease on different cereal crops in China is due to rice black streaked dwarf virus (RBSDV). Virus Genes (2002) 0.92
Comparing the performance characteristics of CSF-TRUST and CSF-VDRL for syphilis: a cross-sectional study. BMJ Open (2013) 0.91
Carpentier-Edwards supra-annular aortic porcine bioprosthesis: clinical performance over 20 years. J Thorac Cardiovasc Surg (2005) 0.90
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells. Breast Cancer Res (2012) 0.90
The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice. Dig Dis Sci (2011) 0.90
Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture. J Mol Cell Cardiol (2010) 0.90
Promoter methylation of p16, Runx3, DAPK and CHFR genes is frequent in gastric carcinoma. Tumori (2011) 0.89
Effect of prosthesis-patient mismatch on long-term survival with mitral valve replacement: assessment to 15 years. Ann Thorac Surg (2009) 0.89
A study of the relationship between trace element Mo and gastric cancer. World J Gastroenterol (1998) 0.89
Angiotensin II-mediated vascular changes in aged offspring rats exposed to perinatal nicotine. Peptides (2013) 0.89
The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model. Molecules (2011) 0.89
The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis. Fitoterapia (2013) 0.89
The spatiospectral characterization of brain networks: fusing concurrent EEG spectra and fMRI maps. Neuroimage (2012) 0.88
Fatal eosinophilic myocarditis develops in the absence of IFN-γ and IL-17A. J Immunol (2013) 0.88
A benchmark study with sealchip planar patch-clamp technology. Assay Drug Dev Technol (2003) 0.88
E2F2 expression induces proliferation of terminally differentiated cardiomyocytes in vivo. Cardiovasc Res (2008) 0.88
Prognostic value of mutational characteristics in gastrointestinal stromal tumors: a single-center experience in 275 cases. Med Oncol (2013) 0.87
Refractive index measurement of acute rat brain tissue slices using optical coherence tomography. Opt Express (2012) 0.87
Salicylic acid-altering arabidopsis mutants response to NO(2) exposure. Bull Environ Contam Toxicol (2009) 0.87
New fusion transcripts identified in normal karyotype acute myeloid leukemia. PLoS One (2012) 0.87
High average power picosecond pulse and supercontinuum generation from a thulium-doped, all-fiber amplifier. Opt Lett (2013) 0.87
Probucol for the prevention of cystatin C-based contrast-induced acute kidney injury following primary or urgent angioplasty: a randomized, controlled trial. Int J Cardiol (2012) 0.87
Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats. J Ethnopharmacol (2011) 0.87
Role of probucol in preventing contrast-induced acute kidney injury after coronary interventional procedure. Am J Cardiol (2008) 0.87
Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT. J Interferon Cytokine Res (2005) 0.86
Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia-reperfusion injury: role of AMP-activated protein kinase pathway. Exp Biol Med (Maywood) (2011) 0.86