Published in Cell on December 23, 2011
Multiple roles for Piwi in silencing Drosophila transposons. Genes Dev (2013) 1.96
piRNA-mediated transgenerational inheritance of an acquired trait. Genome Res (2012) 1.95
Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell (2013) 1.94
Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila. Cold Spring Harb Perspect Biol (2013) 1.76
Genome-defence small RNAs exapted for epigenetic mating-type inheritance. Nature (2014) 1.72
Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm. Nature (2016) 1.46
The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Cell (2014) 1.45
Hybrid Dysgenesis in Drosophila simulans Associated with a Rapid Invasion of the P-Element. PLoS Genet (2016) 1.38
Transposition-driven genomic heterogeneity in the Drosophila brain. Science (2013) 1.35
The selfish Segregation Distorter gene complex of Drosophila melanogaster. Genetics (2012) 1.25
The piRNA pathway in flies: highlights and future directions. Curr Opin Genet Dev (2013) 1.23
TEMP: a computational method for analyzing transposable element polymorphism in populations. Nucleic Acids Res (2014) 1.13
One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing. Trends Biochem Sci (2016) 1.08
Drosophila interspecific hybrids phenocopy piRNA-pathway mutants. PLoS Biol (2012) 1.04
Convergent evolution of argonaute-2 slicer antagonism in two distinct insect RNA viruses. PLoS Pathog (2012) 1.04
Ectopic assembly of heterochromatin in Drosophila melanogaster triggered by transposable elements. Proc Natl Acad Sci U S A (2012) 0.99
Untangling the web: the diverse functions of the PIWI/piRNA pathway. Mol Reprod Dev (2013) 0.98
Small but sturdy: small RNAs in cellular memory and epigenetics. Genes Dev (2014) 0.96
Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs. Mol Cell (2014) 0.96
Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate. RNA (2014) 0.96
piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing. Bioinformatics (2014) 0.95
Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells. EMBO Rep (2013) 0.93
Unique transposon landscapes are pervasive across Drosophila melanogaster genomes. Nucleic Acids Res (2015) 0.92
Analysis of piRNA-mediated silencing of active TEs in Drosophila melanogaster suggests limits on the evolution of host genome defense. Mol Biol Evol (2013) 0.91
The capacity of target silencing by Drosophila PIWI and piRNAs. RNA (2014) 0.91
Transposable element dynamics and PIWI regulation impacts lncRNA and gene expression diversity in Drosophila ovarian cell cultures. Genome Res (2014) 0.89
De novo piRNA cluster formation in the Drosophila germ line triggered by transgenes containing a transcribed transposon fragment. Nucleic Acids Res (2013) 0.88
Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus. Genome Res (2012) 0.88
piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals. RNA (2015) 0.88
The recent invasion of natural Drosophila simulans populations by the P-element. Proc Natl Acad Sci U S A (2015) 0.87
McClintock's challenge in the 21st century. Proc Natl Acad Sci U S A (2012) 0.86
Small RNAs, big impact: small RNA pathways in transposon control and their effect on the host stress response. Chromosome Res (2013) 0.86
Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors. Mol Cell (2016) 0.86
Variation in piRNA and transposable element content in strains of Drosophila melanogaster. Genome Biol Evol (2014) 0.85
Recurrent and recent selective sweeps in the piRNA pathway. Evolution (2013) 0.84
Tempo and Mode of Transposable Element Activity in Drosophila. PLoS Genet (2015) 0.83
Genomics of homoploid hybrid speciation: diversity and transcriptional activity of long terminal repeat retrotransposons in hybrid sunflowers. Philos Trans R Soc Lond B Biol Sci (2014) 0.83
Evolution of animal Piwi-interacting RNAs and prokaryotic CRISPRs. Brief Funct Genomics (2012) 0.82
Elusive inheritance: Transgenerational effects and epigenetic inheritance in human environmental disease. Prog Biophys Mol Biol (2015) 0.82
Recognizing the enemy within: licensing RNA-guided genome defense. Trends Biochem Sci (2013) 0.81
Distinct features of the piRNA pathway in somatic and germ cells: from piRNA cluster transcription to piRNA processing and amplification. Mob DNA (2014) 0.80
piRNAs Are Associated with Diverse Transgenerational Effects on Gene and Transposon Expression in a Hybrid Dysgenic Syndrome of D. virilis. PLoS Genet (2015) 0.79
Specific activation of an I-like element in Drosophila interspecific hybrids. Genome Biol Evol (2014) 0.79
Meiotic recombination initiation in and around retrotransposable elements in Saccharomyces cerevisiae. PLoS Genet (2013) 0.79
Genetic interactions between P elements involved in piRNA-mediated repression of hybrid dysgenesis in Drosophila melanogaster. G3 (Bethesda) (2014) 0.79
PIWIs Go Viral: Arbovirus-Derived piRNAs in Vector Mosquitoes. PLoS Pathog (2016) 0.78
What happens when Penelope comes?: An unusual retroelement invades a host species genome exploring different strategies. Mob Genet Elements (2013) 0.78
Host control of insect endogenous retroviruses: small RNA silencing and immune response. Viruses (2014) 0.78
piRNA dynamics in divergent zebrafish strains reveal long-lasting maternal influence on zygotic piRNA profiles. RNA (2013) 0.78
Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila. Mob Genet Elements (2014) 0.77
A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements. Stem Cells Int (2015) 0.77
P elements and the determinants of hybrid dysgenesis have different dynamics of propagation in Drosophila melanogaster populations. Genetica (2015) 0.76
Piwi Proteins and piRNAs step onto the systems biology stage. Adv Exp Med Biol (2014) 0.76
Targeting of P-Element Reporters to Heterochromatic Domains by Transposable Element 1360 in Drosophila melanogaster. Genetics (2015) 0.76
Learning to protect your genome on the fly. Cell (2011) 0.76
Reexamining the P-Element Invasion of Drosophila melanogaster Through the Lens of piRNA Silencing. Genetics (2016) 0.75
Comparison of methods for the determination of the transposition rate of mobile elements. Mob Genet Elements (2015) 0.75
Domestic chickens activate a piRNA defense against avian leukosis virus. Elife (2017) 0.75
P transposable elements in Drosophila and other eukaryotic organisms. Microbiol Spectr (2015) 0.75
Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis. Proc Natl Acad Sci U S A (2016) 0.75
Proteomics technique opens new frontiers in mobilome research. Mob Genet Elements (2017) 0.75
Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94
miRBase: tools for microRNA genomics. Nucleic Acids Res (2007) 38.61
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
FlyBase: enhancing Drosophila Gene Ontology annotations. Nucleic Acids Res (2008) 12.15
The small RNA profile during Drosophila melanogaster development. Dev Cell (2003) 11.46
The significance of responses of the genome to challenge. Science (1984) 11.29
Hybrid Dysgenesis in DROSOPHILA MELANOGASTER: A Syndrome of Aberrant Traits Including Mutation, Sterility and Male Recombination. Genetics (1977) 11.01
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
The molecular basis of P-M hybrid dysgenesis: the nature of induced mutations. Cell (1982) 7.07
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature (2001) 6.73
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39
Biogenesis and germline functions of piRNAs. Development (2007) 4.37
Spontaneous recombination in Drosophila melanogaster males. Proc Natl Acad Sci U S A (1971) 4.16
Mobile elements and mammalian genome evolution. Curr Opin Genet Dev (2003) 3.68
[A sterility phenomenon of nonmendelian determinism in Drosophila melanogaster]. C R Acad Sci Hebd Seances Acad Sci D (1972) 3.59
[Study of non Mendelian female sterility in Drosophila melanogaster. Hereditary transmission of the degree of efficacy of the reactor factor]. C R Acad Sci Hebd Seances Acad Sci D (1973) 3.41
Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 3.31
zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev Cell (2007) 3.29
Transposable element contributions to plant gene and genome evolution. Plant Mol Biol (2000) 3.24
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell (2009) 3.13
Germ plasm and the differentiation of the germ cell line. Int Rev Cytol (1975) 3.10
Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev Cell (2007) 2.86
Activation of a meiotic checkpoint regulates translation of Gurken during Drosophila oogenesis. Nat Cell Biol (1999) 2.76
Evidence for horizontal transmission of the P transposable element between Drosophila species. Genetics (1990) 2.67
Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities. Development (1994) 2.66
Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad. RNA (2007) 2.55
P element transposition in vitro proceeds by a cut-and-paste mechanism and uses GTP as a cofactor. Cell (1992) 2.33
P-M hybrid dysgenesis does not mobilize other transposable element families in D. melanogaster. Nature (1988) 2.27
DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis. Nucleic Acids Res (2002) 2.05
I transposable elements and I-R hybrid dysgenesis in Drosophila. Trends Genet (1990) 1.99
The take and give between retrotransposable elements and their hosts. Annu Rev Genet (2008) 1.86
Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila. Curr Biol (2007) 1.84
Non-mendelian female sterility in Drosophila melanogaster: quantitative variations in the efficiency of inducer and reactive strains. Heredity (Edinb) (1976) 1.73
Evidence for maternally transmitted small interfering RNA in the repression of transposition in Drosophila virilis. Proc Natl Acad Sci U S A (2005) 1.72
Retrotransposable elements and human disease. Genome Dyn (2006) 1.72
Diverse transposable elements are mobilized in hybrid dysgenesis in Drosophila virilis. Proc Natl Acad Sci U S A (1995) 1.66
Regulation of Drosophila P element transposition. Trends Genet (1991) 1.62
Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells. Cancer Cell Int (2006) 1.59
piRNAs, transposon silencing, and Drosophila germline development. J Cell Biol (2010) 1.55
Hybrid dysgenesis in Drosophila melanogaster: nature and inheritance of P element regulation. Genetics (1985) 1.54
Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk. Curr Biol (2002) 1.51
DNA damage activates transcription and transposition of yeast Ty retrotransposons. Mol Gen Genet (1989) 1.46
Meiotic recombination and chromosome segregation in Drosophila females. Annu Rev Genet (2002) 1.42
Fine structural observations on the form and distribution of nuage in germ cells of the rat. Anat Rec (1974) 1.42
Transposable element insertions have strongly affected human evolution. Proc Natl Acad Sci U S A (2010) 1.40
gurken and the I factor retrotransposon RNAs share common localization signals and machinery. Dev Cell (2005) 1.39
mei-P22 encodes a chromosome-associated protein required for the initiation of meiotic recombination in Drosophila melanogaster. Genetics (2002) 1.35
Non-Mendelian female sterility in Drosophila melanogaster: influence of aging and thermic treatments. III. Cumulative effects induced by these factors. Genetics (1979) 1.20
Checkpoint mechanisms at the intersection between DNA damage and repair. DNA Repair (Amst) (2009) 1.18
DNA damage checkpoint inactivation: adaptation and recovery. DNA Repair (Amst) (2009) 1.16
Small RNA-based silencing strategies for transposons in the process of invading Drosophila species. RNA (2010) 1.13
Horizontal transfer. Curr Opin Genet Dev (1992) 1.08
Activation of Ty transposition by mutagens. Mutat Res (2001) 1.05
Horizontal transmission versus ancient origin: mariner in the witness box. Genetica (1994) 1.01
Restless genomes humans as a model organism for understanding host-retrotransposable element dynamics. Adv Genet (2011) 0.84
[A partially inheritable aging influence on a non-Mendelian female sterility in Drosophila melanogaster]. C R Acad Sci Hebd Seances Acad Sci D (1975) 0.83
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol (2011) 18.34
High-resolution mapping and characterization of open chromatin across the genome. Cell (2008) 15.93
Assessing computational tools for the discovery of transcription factor binding sites. Nat Biotechnol (2005) 14.29
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
A distinct small RNA pathway silences selfish genetic elements in the germline. Science (2006) 11.63
A biochemical framework for RNA silencing in plants. Genes Dev (2003) 9.95
Perspective: machines for RNAi. Genes Dev (2005) 9.37
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell (2005) 9.35
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science (2008) 8.62
microPrimer: the biogenesis and function of microRNA. Development (2005) 8.19
Sequence-specific inhibition of small RNA function. PLoS Biol (2004) 7.98
A protein sensor for siRNA asymmetry. Science (2004) 7.77
ZDOCK: an initial-stage protein-docking algorithm. Proteins (2003) 7.52
RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med (2003) 7.37
Kinetic analysis of the RNAi enzyme complex. Nat Struct Mol Biol (2004) 7.26
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol (2005) 7.23
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell (2002) 6.43
Detection of functional DNA motifs via statistical over-representation. Nucleic Acids Res (2004) 6.31
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J (2004) 6.27
Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. PLoS Genet (2007) 5.93
RNAi: nature abhors a double-strand. Curr Opin Genet Dev (2002) 5.74
The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res (2007) 5.67
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol (2007) 5.35
Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell (2010) 5.22
Nucleosome positioning signals in genomic DNA. Genome Res (2007) 4.99
The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome. PLoS Genet (2008) 4.91
Unsupervised pattern discovery in human chromatin structure through genomic segmentation. Nat Methods (2012) 4.89
RISC assembly defects in the Drosophila RNAi mutant armitage. Cell (2004) 4.88
Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Res (2012) 4.80
Sorting of Drosophila small silencing RNAs. Cell (2007) 4.67
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39
Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial. Lancet Oncol (2013) 4.20
Modular recognition of RNA by a human pumilio-homology domain. Cell (2002) 4.17
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol (2008) 4.07
Cluster-Buster: Finding dense clusters of motifs in DNA sequences. Nucleic Acids Res (2003) 3.99
Target RNA-directed trimming and tailing of small silencing RNAs. Science (2010) 3.98
Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80
The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Curr Biol (2004) 3.68
Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV non-small-cell lung cancer. J Clin Oncol (2009) 3.58
Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35
Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol (2010) 3.30
Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet (2006) 3.23
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA (2009) 3.19
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell (2011) 3.19
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell (2009) 3.13
Protein-Protein Docking Benchmark 2.0: an update. Proteins (2005) 3.13
Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial. Lancet Oncol (2012) 2.98
Docking unbound proteins using shape complementarity, desolvation, and electrostatics. Proteins (2002) 2.95
Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial. Lancet Oncol (2013) 2.94
A protein-protein docking benchmark. Proteins (2003) 2.90
Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev Cell (2007) 2.86
MicroRNA biogenesis: drosha can't cut it without a partner. Curr Biol (2005) 2.85
ZRANK: reranking protein docking predictions with an optimized energy function. Proteins (2007) 2.79
Protein-protein docking benchmark version 4.0. Proteins (2010) 2.78
Modeling gene expression using chromatin features in various cellular contexts. Genome Biol (2012) 2.76
Structure, function, and evolution of transient and obligate protein-protein interactions. Proc Natl Acad Sci U S A (2005) 2.69
Understanding transcriptional regulation by integrative analysis of transcription factor binding data. Genome Res (2012) 2.66
The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell (2004) 2.59
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science. Hypertens Res (2013) 2.55
Protein-protein docking benchmark version 3.0. Proteins (2008) 2.54
Integrating statistical pair potentials into protein complex prediction. Proteins (2007) 2.53
Why do miRNAs live in the miRNP? Genes Dev (2002) 2.41
Transcription factor binding and modified histones in human bidirectional promoters. Genome Res (2007) 2.40
Finding functional sequence elements by multiple local alignment. Nucleic Acids Res (2004) 2.37