Published in Clin Exp Metastasis on January 01, 2004
Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1). J Toxicol Environ Health A (2010) 1.02
Diagnostic accuracy of vascular endothelial growth factor for malignant pleural effusion: A meta-analysis. Exp Ther Med (2012) 0.95
Expression of HLA-G in malignant mesothelioma and clinically aggressive breast carcinoma. Virchows Arch (2006) 0.92
Expression of cancer-associated molecules in malignant mesothelioma. Biomark Insights (2007) 0.77
Differential Susceptibility of Human Pleural and Peritoneal Mesothelial Cells to Asbestos Exposure. J Cell Biochem (2015) 0.77
Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230. Oncotarget (2016) 0.75
Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem (1999) 11.87
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med (1999) 4.22
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. Nat Med (1999) 3.06
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest (2001) 2.98
Heparanase: a key enzyme involved in cell invasion. Biochim Biophys Acta (2001) 2.74
Heparanase as mediator of angiogenesis: mode of action. FASEB J (2001) 2.04
Processing and activation of latent heparanase occurs in lysosomes. J Cell Sci (2004) 1.82
The epidemiology of mesothelioma. Semin Oncol (2002) 1.72
Human heparanase. Purification, characterization, cloning, and expression. J Biol Chem (1999) 1.69
Heparanase expression in primary and metastatic pancreatic cancer. Cancer Res (2001) 1.67
Heparanases and tumor metastasis. J Cell Biochem (1988) 1.64
Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines. Science (1983) 1.63
Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo. FASEB J (2002) 1.61
Cloning and functional expression of a human heparanase gene. Biochem Biophys Res Commun (1999) 1.56
Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors. Proc Natl Acad Sci U S A (2001) 1.53
Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis. Am J Pathol (2000) 1.52
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A (2002) 1.45
The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma. Clin Cancer Res (2001) 1.44
Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma. J Pathol (2001) 1.41
Heparanase expression correlates with invasion and poor prognosis in gastric cancers. Lab Invest (2003) 1.25
Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase. Cancer Res (2000) 1.21
Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells. Biochem J (2003) 1.19
Interleukin 8: an autocrine growth factor for malignant mesothelioma. Cancer Res (1999) 1.18
Expression of three extracellular matrix degradative enzymes in bladder cancer. Int J Cancer (2001) 1.17
Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer. J Biol Chem (1999) 1.16
Heparanase protein and gene expression in bladder cancer. J Urol (2001) 1.13
Heparanase-1 expression is associated with the metastatic potential of breast cancer. Surgery (2002) 1.10
Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas. Jpn J Cancer Res (2001) 1.10
Angiogenic cytokines in mesothelioma: a study of VEGF, FGF-1 and -2, and TGF beta expression. J Pathol (1999) 1.09
Heparanase: a key enzyme in invasion and metastasis of gastric carcinoma. Mod Pathol (2002) 1.08
Human heparanase: a molecular determinant of brain metastasis. Adv Enzyme Regul (2001) 1.06
Expression and activation of the nerve growth factor receptor TrkA in serous ovarian carcinoma. Clin Cancer Res (2003) 1.05
Diagnostic problems in serous effusions. Diagn Cytopathol (1998) 1.02
The role of desmin and N-cadherin in effusion cytology: a comparative study using established markers of mesothelial and epithelial cells. Am J Surg Pathol (2001) 1.01
Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma. Breast Cancer Res Treat (2004) 1.01
Survival patterns for malignant mesothelioma: the SEER experience. Int J Cancer (1988) 1.00
Surgical treatment of malignant pleural mesothelioma: a review. Chest (2003) 0.99
Human heparanase-1 gene expression in pancreatic adenocarcinoma. J Gastrointest Surg (2002) 0.95
Expression of heparanase in oral cancer cell lines and oral cancer tissues. Oral Oncol (2001) 0.93
Heparanase gene expression and its correlation with spontaneous apoptosis in hepatocytes of cirrhotic liver and carcinoma. Eur J Cancer (2003) 0.86
Expression of heparanase, Mdm2, and erbB2 in ovarian cancer. Int J Oncol (2001) 0.85
Basic fibroblast growth factor in mesothelioma pleural effusions: correlation with patient survival and angiogenesis. Int J Oncol (2001) 0.84
Correlation of overexpression of the low-affinity p75 neurotrophin receptor with augmented invasion and heparanase production in human malignant melanoma cells. Int J Cancer (1999) 0.84
Quantitative analysis of heparanase messenger RNA expression in hepatocellular carcinoma. J Surg Oncol (2002) 0.84
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Mesothelioma. Cancer Genet Cytogenet (2001) 0.83
Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen. Oncogene (2002) 0.82
Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions. Clin Exp Metastasis (2002) 0.82
Effusion cytology in ovarian cancer: new molecular methods as aids to diagnosis and prognosis. Clin Lab Med (2003) 0.81
Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients. Clin Cancer Res (2001) 0.81
Expression of the nerve growth factor receptors TrkA and p75 in malignant mesothelioma. Lung Cancer (2004) 0.81
Heparanase expression in clinical digestive malignancies. Oncol Rep (2001) 0.75
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet (2002) 3.90
Aquaporin water channels--from atomic structure to clinical medicine. J Physiol (2002) 3.70
Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies. Arch Gen Psychiatry (2011) 3.57
Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer (2005) 3.26
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol (2006) 3.24
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol (1985) (2010) 2.74
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst (2004) 2.52
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis. J Biol Chem (2007) 2.25
Lithium treatment induces a marked proliferation of primarily principal cells in rat kidney inner medullary collecting duct. Am J Physiol Renal Physiol (2006) 2.17
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate. Curr Pharm Des (2007) 2.14
The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors. Mod Pathol (2011) 2.08
Heparanase: busy at the cell surface. Trends Biochem Sci (2009) 2.07
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res (2006) 2.02
Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits. Circulation (2002) 2.01
Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Proc Natl Acad Sci U S A (2002) 1.97
Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene (2002) 1.96
Processing and activation of latent heparanase occurs in lysosomes. J Cell Sci (2004) 1.82
Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem (2004) 1.78
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J (2010) 1.78
Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci U S A (2007) 1.76
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest (2009) 1.73
Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin. Proc Natl Acad Sci U S A (2008) 1.66
A current view of the mammalian aquaglyceroporins. Annu Rev Physiol (2008) 1.64
Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Circ Res (2008) 1.64
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J (2004) 1.64
A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic (2006) 1.62
Efficacy of ultrasound-guided percutaneous ethanol injection treatment in patients with a limited number of metastatic cervical lymph nodes from papillary thyroid carcinoma. J Clin Endocrinol Metab (2011) 1.61
Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney. Am J Physiol Renal Physiol (2002) 1.59
Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development. Semin Cancer Biol (2002) 1.57
Muscle strength in type 2 diabetes. Diabetes (2004) 1.56
Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res (2003) 1.54
VLDL-TG kinetics: a dual isotope study for quantifying VLDL-TG pool size, production rates, and fractional oxidation in humans. Am J Physiol Endocrinol Metab (2009) 1.54
Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues. Am J Physiol Regul Integr Comp Physiol (2007) 1.53
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood (2010) 1.53
RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy. Proc Natl Acad Sci U S A (2004) 1.52
Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A (2006) 1.52
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting. J Biol Chem (2005) 1.52
CD147 immunohistochemistry discriminates between reactive mesothelial cells and malignant mesothelioma. Diagn Cytopathol (2012) 1.51
Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia. Diabetes (2009) 1.51
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood (2007) 1.49
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J Biol Chem (2013) 1.49
Expression of E-cadherin transcriptional regulators in ovarian carcinoma. Virchows Arch (2006) 1.49
Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. J Virol (2008) 1.48
ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile. Gastroenterology (2008) 1.48
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One (2009) 1.46
Significance of heparanase in cancer and inflammation. Cancer Microenviron (2011) 1.46
Acute changes in lipoprotein subclasses during exercise. Metabolism (2013) 1.45
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A (2002) 1.45
Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression. Clin Cancer Res (2004) 1.44
Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46. J Immunol (2004) 1.43
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem (2004) 1.43
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. J Biol Chem (2008) 1.43
Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer (2006) 1.42
Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc Natl Acad Sci U S A (2002) 1.41
Non-anticoagulant heparins and inhibition of cancer. Pathophysiol Haemost Thromb (2009) 1.41
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice. Neurosci Lett (2011) 1.41
Heparanase mediates cell adhesion independent of its enzymatic activity. FASEB J (2003) 1.41
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis. Clin Cancer Res (2011) 1.40
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development (2007) 1.40
Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation. Am J Physiol Cell Physiol (2010) 1.37
Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens: a population-based study. BJU Int (2008) 1.37
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis. Proc Natl Acad Sci U S A (2005) 1.37
Distribution of sodium transporters and aquaporin-1 in the human choroid plexus. Am J Physiol Cell Physiol (2006) 1.36
Bidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation. Am J Physiol Renal Physiol (2004) 1.35
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res (2008) 1.35
Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer. Cancer (2010) 1.35
Role of endothelial heparanase in delayed-type hypersensitivity. Blood (2005) 1.35
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res (2009) 1.34
Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem (2003) 1.34
Increased AQP2 targeting in primary cultured IMCD cells in response to angiotensin II through AT1 receptor. Am J Physiol Renal Physiol (2006) 1.33
A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid. Biochem J (2002) 1.33
Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation. Proc Natl Acad Sci U S A (2008) 1.33
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J (2005) 1.32
Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem (2005) 1.32
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J Clin Invest (2011) 1.32
Heparanase induces VEGF C and facilitates tumor lymphangiogenesis. Int J Cancer (2008) 1.31
Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc (2010) 1.30
Heparanase: one molecule with multiple functions in cancer progression. Connect Tissue Res (2008) 1.29