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1
|
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate.
|
Curr Pharm Des
|
2007
|
2.14
|
|
2
|
Heparanase: busy at the cell surface.
|
Trends Biochem Sci
|
2009
|
2.07
|
|
3
|
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.
|
Cancer Res
|
2006
|
2.02
|
|
4
|
Processing and activation of latent heparanase occurs in lysosomes.
|
J Cell Sci
|
2004
|
1.82
|
|
5
|
Heparanase induces endothelial cell migration via protein kinase B/Akt activation.
|
J Biol Chem
|
2004
|
1.78
|
|
6
|
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.
|
FEBS J
|
2010
|
1.78
|
|
7
|
Heparanase affects adhesive and tumorigenic potential of human glioma cells.
|
Cancer Res
|
2003
|
1.54
|
|
8
|
Significance of heparanase in cancer and inflammation.
|
Cancer Microenviron
|
2011
|
1.46
|
|
9
|
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans.
|
J Biol Chem
|
2004
|
1.43
|
|
10
|
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression.
|
Cancer Res
|
2008
|
1.35
|
|
11
|
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling.
|
Cancer Res
|
2009
|
1.34
|
|
12
|
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models.
|
FASEB J
|
2005
|
1.32
|
|
13
|
Heparanase induces VEGF C and facilitates tumor lymphangiogenesis.
|
Int J Cancer
|
2008
|
1.31
|
|
14
|
Heparanase: one molecule with multiple functions in cancer progression.
|
Connect Tissue Res
|
2008
|
1.29
|
|
15
|
The impact of heparanese and heparin on cancer metastasis and angiogenesis.
|
Pathophysiol Haemost Thromb
|
2006
|
1.29
|
|
16
|
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.
|
Neoplasia
|
2006
|
1.28
|
|
17
|
The heparanase system and tumor metastasis: is heparanase the seed and soil?
|
Cancer Metastasis Rev
|
2011
|
1.28
|
|
18
|
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.
|
J Biol Chem
|
2005
|
1.27
|
|
19
|
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.
|
J Biol Chem
|
2010
|
1.19
|
|
20
|
Heterodimer formation is essential for heparanase enzymatic activity.
|
Biochem Biophys Res Commun
|
2003
|
1.17
|
|
21
|
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts.
|
J Immunol
|
2004
|
1.16
|
|
22
|
Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans.
|
PLoS One
|
2008
|
1.14
|
|
23
|
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.
|
FASEB J
|
2009
|
1.13
|
|
24
|
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts.
|
J Cell Sci
|
2002
|
1.12
|
|
25
|
Tumorigenic and adhesive properties of heparanase.
|
Semin Cancer Biol
|
2010
|
1.10
|
|
26
|
Heparanase upregulation by colonic epithelium in inflammatory bowel disease.
|
Mod Pathol
|
2006
|
1.09
|
|
27
|
Characterization of mechanisms involved in secretion of active heparanase.
|
J Biol Chem
|
2006
|
1.08
|
|
28
|
Human heparanase is localized within lysosomes in a stable form.
|
Exp Cell Res
|
2002
|
1.07
|
|
29
|
Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatment.
|
Neoplasia
|
2007
|
1.04
|
|
30
|
Heparanase induces Akt phosphorylation via a lipid raft receptor.
|
Biochem Biophys Res Commun
|
2007
|
1.04
|
|
31
|
An ELISA method for the detection and quantification of human heparanase.
|
Biochem Biophys Res Commun
|
2006
|
1.03
|
|
32
|
Pre-clinical and clinical significance of heparanase in Ewing's sarcoma.
|
J Cell Mol Med
|
2011
|
1.02
|
|
33
|
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis.
|
Proc Natl Acad Sci U S A
|
2009
|
1.02
|
|
34
|
Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.
|
Mod Pathol
|
2006
|
1.02
|
|
35
|
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.
|
PLoS One
|
2011
|
1.01
|
|
36
|
Clinical significance of urine heparanase in bladder cancer progression.
|
Neoplasia
|
2008
|
1.01
|
|
37
|
Human heparanase nuclear localization and enzymatic activity.
|
Lab Invest
|
2004
|
1.00
|
|
38
|
Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival.
|
Neoplasia
|
2006
|
0.98
|
|
39
|
Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression.
|
Arterioscler Thromb Vasc Biol
|
2012
|
0.98
|
|
40
|
Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer.
|
J Biol Chem
|
2011
|
0.98
|
|
41
|
Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells.
|
Thromb Haemost
|
2008
|
0.95
|
|
42
|
Heparanase, heparin and the coagulation system in cancer progression.
|
Thromb Res
|
2007
|
0.95
|
|
43
|
The molecular and cellular basis of exostosis formation in hereditary multiple exostoses.
|
Int J Exp Pathol
|
2008
|
0.93
|
|
44
|
Involvement of heparanase in atherosclerosis and other vessel wall pathologies.
|
Matrix Biol
|
2013
|
0.93
|
|
45
|
Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element.
|
FASEB J
|
2010
|
0.92
|
|
46
|
Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications.
|
Rambam Maimonides Med J
|
2011
|
0.92
|
|
47
|
Heparanase processing by lysosomal/endosomal protein preparation.
|
FEBS Lett
|
2005
|
0.92
|
|
48
|
Heparanase is overexpressed in lung cancer and correlates inversely with patient survival.
|
Cancer
|
2008
|
0.92
|
|
49
|
Low and high affinity receptors mediate cellular uptake of heparanase.
|
Int J Biochem Cell Biol
|
2007
|
0.91
|
|
50
|
Heparanase expression during normal liver development and following partial hepatectomy.
|
J Pathol
|
2004
|
0.91
|
|
51
|
Heparanase up-regulation in tongue cancer: tissue and saliva analysis.
|
Cancer
|
2007
|
0.91
|
|
52
|
Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.
|
Proc Natl Acad Sci U S A
|
2005
|
0.89
|
|
53
|
Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.
|
Blood
|
2008
|
0.89
|
|
54
|
Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients?
|
Am J Physiol Heart Circ Physiol
|
2007
|
0.88
|
|
55
|
Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin.
|
Cell Mol Life Sci
|
2014
|
0.87
|
|
56
|
Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.
|
PLoS One
|
2012
|
0.86
|
|
57
|
Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence.
|
J Biol Chem
|
2013
|
0.86
|
|
58
|
Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.
|
J Leukoc Biol
|
2009
|
0.84
|
|
59
|
Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression.
|
Mod Pathol
|
2009
|
0.83
|
|
60
|
Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
|
Gynecol Oncol
|
2006
|
0.83
|
|
61
|
Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing.
|
FASEB J
|
2007
|
0.83
|
|
62
|
Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma.
|
Clin Exp Metastasis
|
2004
|
0.81
|
|
63
|
Heparanase pretreatment attenuates endotoxin-induced acute lung injury in rats.
|
Shock
|
2007
|
0.81
|
|
64
|
Prognostic value of heparanase expression and cellular localization in oral cancer.
|
Head Neck
|
2010
|
0.81
|
|
65
|
Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody.
|
PLoS One
|
2012
|
0.79
|
|
66
|
Expression of heparanase in soft tissue sarcomas of adults.
|
J Exp Clin Cancer Res
|
2014
|
0.79
|
|
67
|
Plasma heparanase as a significant marker of treatment response in children with Hodgkin lymphoma: pilot study.
|
Pediatr Hematol Oncol
|
2009
|
0.79
|
|
68
|
Heparanase enhances early hepatocyte inclusion in the recipient liver after transplantation in partially hepatectomized rats.
|
Tissue Eng Part A
|
2008
|
0.77
|
|
69
|
Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms.
|
Thromb Haemost
|
2007
|
0.77
|
|
70
|
Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP.
|
J Leukoc Biol
|
2013
|
0.77
|
|
71
|
Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells.
|
Endocrinology
|
2011
|
0.76
|
|
72
|
Focus on molecules: heparanase.
|
Exp Eye Res
|
2010
|
0.75
|
|
73
|
Heparanase expression increases throughout the endometrial hyperplasia-cancer sequence.
|
Int J Gynaecol Obstet
|
2008
|
0.75
|
|
74
|
Heparanase expression in Langerhans cell histiocytosis.
|
Pediatr Blood Cancer
|
2014
|
0.75
|