PubRank

Ilpo Huhtaniemi

Author PubWeight™ 104.44‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science 2008 3.80
2 Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior. Nat Neurosci 2007 2.55
3 Male hormonal contraception: a double-blind, placebo-controlled study. J Clin Endocrinol Metab 2008 1.79
4 Increased carotid atherosclerosis in andropausal middle-aged men. J Am Coll Cardiol 2005 1.70
5 Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet 2009 1.58
6 Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation. Proc Natl Acad Sci U S A 2010 1.50
7 Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor. Fertil Steril 2002 1.48
8 Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation. Biol Reprod 2011 1.42
9 Polymorphisms in androgen and estrogen receptor genes: effects on male aging. Exp Gerontol 2004 1.39
10 Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium. FASEB J 2006 1.29
11 PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles. Hum Mol Genet 2009 1.28
12 Assisted large fragment insertion by Red/ET-recombination (ALFIRE)--an alternative and enhanced method for large fragment recombineering. Nucleic Acids Res 2007 1.17
13 Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice. Endocrinology 2003 1.12
14 Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. Mol Endocrinol 2003 1.10
15 Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology 2010 1.09
16 Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. Endocrinology 2002 1.09
17 Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone. Mol Endocrinol 2006 1.08
18 Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin. Endocrinology 2003 1.05
19 A Novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure. J Clin Endocrinol Metab 2002 1.05
20 Novel concepts of human chorionic gonadotropin: reproductive system interactions and potential in the management of infertility. Fertil Steril 2005 1.04
21 The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Proc Natl Acad Sci U S A 2003 1.01
22 Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat. J Lipid Res 2012 1.00
23 Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice. Endocrinology 2004 1.00
24 Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling. PLoS One 2012 0.99
25 GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors. Endocrinology 2008 0.98
26 Mouse models of infertility due to swollen spermatozoa. Mol Cell Endocrinol 2004 0.98
27 Epididymal dysfunction initiated by the expression of simian virus 40 T-antigen leads to angulated sperm flagella and infertility in transgenic mice. Mol Endocrinol 2002 0.98
28 Sperm volume regulation: maturational changes in fertile and infertile transgenic mice and association with kinematics and tail angulation. Biol Reprod 2002 0.97
29 Aging of the human ovary and testis. Mol Cell Endocrinol 2008 0.96
30 Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles. Mol Endocrinol 2005 0.96
31 Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. J Biol Chem 2013 0.95
32 Is the adrenal cortex a target for gonadotropins? Trends Endocrinol Metab 2008 0.93
33 Human FSH beta subunit gene is highly conserved. Mol Hum Reprod 2005 0.93
34 Both testosterone and follicle-stimulating hormone independently inhibit spermatogonial differentiation in irradiated rats. Endocrinology 2005 0.92
35 What have gonadotrophin overexpressing transgenic mice taught us about gonadal function? Reproduction 2005 0.92
36 Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF-β receptor activation. FASEB J 2012 0.92
37 Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation. Endocrinology 2007 0.92
38 Functional characterization of the human FSH receptor with an inactivating Ala189Val mutation. Mol Hum Reprod 2002 0.92
39 Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner. Biol Reprod 2005 0.91
40 Inhibition of small ubiquitin-related modifier-1 expression by luteinizing hormone receptor stimulation is linked to induction of progesterone receptor during ovulation in mouse granulosa cells. Endocrinology 2003 0.91
41 Spatiotemporal expression of androgen receptors in the female rat brain during the oestrous cycle and the impact of exogenous androgen administration: a comparison with gonadally intact males. Mol Cell Endocrinol 2010 0.90
42 Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis. Endocrinology 2005 0.90
43 Epididymal protein Rnase10 is required for post-testicular sperm maturation and male fertility. FASEB J 2012 0.90
44 Endogenous testosterone and serum lipids in middle-aged men. Atherosclerosis 2007 0.89
45 Discovery and characterization of new epididymis-specific beta-defensins in mice. Biochim Biophys Acta 2005 0.88
46 Estrogen enhances recovery from radiation-induced spermatogonial arrest in rat testes. J Androl 2009 0.88
47 The polymorphic androgen receptor gene CAG repeat, pituitary-testicular function and andropausal symptoms in ageing men. Int J Androl 2003 0.88
48 Sexual dimorphism in superantigen shock involves elevated TNF-alpha and TNF-alpha induced hepatic apoptosis. Am J Respir Crit Care Med 2007 0.88
49 Murine relaxin-like factor promoter: functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1. Endocrinology 2002 0.87
50 Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse. Biol Reprod 2003 0.87
51 Complete Sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: evidence from genetic models of isolated FSH action. Endocrinology 2004 0.87
52 Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization. Endocrinology 2007 0.87
53 A new FSHbeta mutation in a 29-year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH. Eur J Endocrinol 2009 0.86
54 The adrenal gland may be a target of LH action in postmenopausal women. Eur J Endocrinol 2006 0.86
55 A novel approach of targeted ablation of mammary carcinoma cells through luteinizing hormone receptors using Hecate-CGbeta conjugate. Breast Cancer Res Treat 2003 0.86
56 Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4. Mol Endocrinol 2004 0.85
57 A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal contraception. J Clin Endocrinol Metab 2005 0.85
58 Inhibition of recovery of spermatogenesis in irradiated rats by different androgens. Endocrinology 2002 0.84
59 Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor. Am J Pathol 2004 0.84
60 Serum testosterone but not leptin predicts mortality in elderly men. Age Ageing 2008 0.84
61 Phenotypic characterisation of mice with exaggerated and missing LH/hCG action. Mol Cell Endocrinol 2006 0.84
62 Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Am J Pathol 2011 0.84
63 Sequestration of connexin43 in the early endosomes: an early event of Leydig cell tumor progression. Mol Carcinog 2003 0.83
64 Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice. Endocrinology 2002 0.83
65 Effects of medroxyprogesterone and estradiol on the recovery of spermatogenesis in irradiated rats. Endocrinology 2004 0.83
66 Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal luteinizing hormone action. J Clin Invest 2005 0.83
67 Novel epididymal protease inhibitors with Kazal or WAP family domain. Biochem Biophys Res Commun 2006 0.82
68 Loss of cysteine-rich secretory protein 4 (Crisp4) leads to deficiency in sperm-zona pellucida interaction in mice. Biol Reprod 2012 0.82
69 Di/oligomerization of GPCRs-mechanisms and functional significance. Prog Mol Biol Transl Sci 2013 0.82
70 High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene. Oncogene 2003 0.82
71 Targeted expression of human FSH receptor Asp567Gly mutant mRNA in testis of transgenic mice: role of human FSH receptor promoter. Asian J Androl 2003 0.82
72 Interactions of the GnRH receptor with heterotrimeric G proteins. Front Neuroendocrinol 2012 0.82
73 A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. Neoplasia 2005 0.82
74 Extragonadal LH/hCG action--not yet time to rewrite textbooks. Mol Cell Endocrinol 2007 0.82
75 Restoration of spermatogenesis in dibromochloropropane (DBCP)-treated rats by hormone suppression. Toxicol Sci 2003 0.81
76 Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary. Reproduction 2004 0.81
77 Endogenous testosterone and brachial artery endothelial function in middle-aged men with symptoms of late-onset hypogonadism. Aging Male 2011 0.81
78 Functional study of a recombinant form of human LHbeta-subunit variant carrying the Gly(102)Ser mutation found in Asian populations. Mol Hum Reprod 2002 0.80
79 Adrenal hyperplasia and tumours in mice in connection with aberrant pituitary-gonadal function. Mol Cell Endocrinol 2008 0.80
80 Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse. Biol Reprod 2007 0.80
81 Adenosine triphosphate induces Ca2+ signal in epithelial cells of the mouse caput epididymis through activation of P2X and P2Y purinergic receptors. Biol Reprod 2002 0.80
82 The gonadotropin receptors FSH-R and LH-R of Atlantic halibut (Hippoglossus hippoglossus)--2. Differential follicle expression and asynchronous oogenesis. Gen Comp Endocrinol 2008 0.80
83 TGF-beta1 system in Leydig cells. Part I: effect of hCG and progesterone. J Reprod Dev 2010 0.79
84 Targeted ablation of prostate carcinoma cells through LH receptor using Hecate-CGbeta conjugate: functional characteristic and molecular mechanism of cell death pathway. Exp Biol Med (Maywood) 2005 0.79
85 A novel Ala(-3)Thr mutation in the signal peptide of human luteinizing hormone beta-subunit: potentiation of the inositol phosphate signalling pathway and attenuation of the adenylate cyclase pathway by recombinant variant hormone. Mol Hum Reprod 2002 0.79
86 Androgen replacement therapy in late-onset hypogonadism: current concepts and controversies - a mini-review. Gerontology 2010 0.79
87 Structure-function relationships of glycoprotein hormones; lessons from mutations and polymorphisms of the thyrotrophin and gonadotrophin subunit genes. Hormones (Athens) 2006 0.78
88 Identification of novel epididymal genes by expression profiling and in silico gene discovery. Mol Cell Endocrinol 2006 0.78
89 Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations. Mol Hum Reprod 2004 0.78
90 Regional expression of androgen receptor coregulators and androgen action in the mouse epididymis. J Androl 2011 0.78
91 Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization. PLoS One 2012 0.78
92 Enhanced LH action in transgenic female mice expressing hCGbeta-subunit induces pituitary prolactinomas; the role of high progesterone levels. Endocr Relat Cancer 2010 0.78
93 Trafficking of the follitropin receptor. Methods Enzymol 2013 0.78
94 Sexual symptoms in aging men indicate poor life satisfaction and increased health service consumption. Urology 2007 0.77
95 Transgenic GATA-4 expression induces adrenocortical tumorigenesis in C57Bl/6 mice. J Cell Sci 2013 0.77
96 A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3. FASEB J 2011 0.77
97 Does variant luteinizing hormone (V-LH) predispose to improper testicular position in late pregnancy? Pediatr Res 2005 0.77
98 Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors. Reprod Biol Endocrinol 2011 0.77
99 Indirect Sertoli cell-mediated ablation of germ cells in mice expressing the inhibin-alpha promoter/herpes simplex virus thymidine kinase transgene. Biol Reprod 2004 0.77
100 Synergistic activation of innate and adaptive immune mechanisms in the treatment of gonadotropin-sensitive tumors. PLoS One 2013 0.77
101 Loss of Bmyc results in increased apoptosis associated with upregulation of Myc expression in juvenile murine testis. Reproduction 2012 0.77
102 The effects of chemicals on mammalian fertility. The report and recommendations of ECVAM Workshop 53--the first strategic workshop of the EU ReProTect Project. Altern Lab Anim 2005 0.77
103 Transgenic mice harboring murine luteinizing hormone receptor promoter/beta-galactosidase fusion genes: different structural and hormonal requirements of expression in the testis, ovary, and adrenal gland. Endocrinology 2002 0.76
104 Hecate-CGbeta conjugate and gonadotropin suppression shows two distinct mechanisms of action in the treatment of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen under inhibin-alpha promoter. Endocr Relat Cancer 2009 0.76
105 The permissive role of prolactin as a regulator of luteinizing hormone action in the female mouse ovary and extragonadal tumorigenesis. Am J Physiol Endocrinol Metab 2013 0.76
106 Immortalization by large T-antigen of the adult epididymal duct epithelium. Mol Cell Endocrinol 2004 0.76
107 Targeted therapy for adrenocortical tumors in transgenic mice through their LH receptor by Hecate-human chorionic gonadotropin beta conjugate. Endocr Relat Cancer 2008 0.76
108 Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta. Am J Pathol 2007 0.76
109 Focus on gonadotrophin signalling. Reproduction 2005 0.75
110 Smoking and low serum testosterone associates with high concentration of oxidized LDL. Ann Med 2008 0.75
111 Male contraception--quo vadis? Acta Obstet Gynecol Scand 2004 0.75
112 15th European Workshop on Molecular and Cellular Endocrinology of the Testis. Introduction. Mol Cell Endocrinol 2009 0.75
113 Epididymis-specific promoter-driven gene targeting: a new approach to control epididymal function? Mol Cell Endocrinol 2004 0.75
114 Does the andropause exist? Nat Clin Pract Endocrinol Metab 2007 0.75
115 Editorial. Hormones (Athens) 2016 0.75