Published in Science on February 01, 2008
Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev (2009) 9.60
The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31
Answering the ultimate question "what is the proximal cause of aging?". Aging (Albany NY) (2012) 2.04
WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol (2011) 2.00
Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation. Hum Reprod Update (2010) 1.89
MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol (2010) 1.68
Activation of dormant ovarian follicles to generate mature eggs. Proc Natl Acad Sci U S A (2010) 1.66
The ovary: basic biology and clinical implications. J Clin Invest (2010) 1.65
Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells. Mol Endocrinol (2008) 1.63
Mouse oocyte control of granulosa cell development and function: paracrine regulation of cumulus cell metabolism. Semin Reprod Med (2009) 1.61
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertil Steril (2008) 1.60
Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth. Dev Biol (2008) 1.59
Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet (2009) 1.58
Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function. Mol Endocrinol (2010) 1.57
PTEN, stem cells, and cancer stem cells. J Biol Chem (2008) 1.52
Geography of Follicle Formation in the Embryonic Mouse Ovary Impacts Activation Pattern During the First Wave of Folliculogenesis. Biol Reprod (2015) 1.49
Defining ovarian reserve to better understand ovarian aging. Reprod Biol Endocrinol (2011) 1.47
The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation. J Biol Chem (2012) 1.44
The current status of evidence for and against postnatal oogenesis in mammals: a case of ovarian optimism versus pessimism? Biol Reprod (2008) 1.41
The primordial pool of follicles and nest breakdown in mammalian ovaries. Mol Hum Reprod (2009) 1.41
Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc Natl Acad Sci U S A (2013) 1.38
Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development (2010) 1.37
FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Mol Endocrinol (2009) 1.27
PTEN at a glance. J Cell Sci (2012) 1.26
Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure. Endocrinology (2014) 1.22
The regulatory role of Dicer in folliculogenesis in mice. Mol Cell Endocrinol (2009) 1.20
FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment. Mol Endocrinol (2008) 1.17
Oocyte-specific deletion of Pten in mice reveals a stage-specific function of PTEN/PI3K signaling in oocytes in controlling follicular activation. PLoS One (2009) 1.13
Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence. Can J Physiol Pharmacol (2010) 1.10
Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions. Hum Mol Genet (2013) 1.09
Ovarian follicle culture: advances and challenges for human and nonhuman primates. Fertil Steril (2013) 1.09
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives. Aging (Albany NY) (2010) 1.07
Prepubertal primordial follicle loss in mice is not due to classical apoptotic pathways. Biol Reprod (2009) 1.06
The ageing ovary and uterus: new biological insights. Hum Reprod Update (2012) 1.04
C. elegans AMPKs promote survival and arrest germline development during nutrient stress. Biol Open (2012) 1.02
Androgen receptor (AR) physiological roles in male and female reproductive systems: lessons learned from AR-knockout mice lacking AR in selective cells. Biol Reprod (2013) 1.02
Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries. Toxicol Appl Pharmacol (2009) 1.02
Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats. Biol Reprod (2008) 0.99
Intraovarian control of early folliculogenesis. Endocr Rev (2014) 0.99
Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro. Hum Reprod (2012) 0.98
Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice. Proc Natl Acad Sci U S A (2014) 0.97
Germline energetics, aging, and female infertility. Cell Metab (2013) 0.97
Biological versus chronological ovarian age: implications for assisted reproductive technology. Reprod Biol Endocrinol (2009) 0.97
Portrait of an oocyte: our obscure origin. J Clin Invest (2010) 0.97
Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility. Endocrinology (2011) 0.95
Genomic markers of ovarian reserve. Semin Reprod Med (2013) 0.94
Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles. Mol Hum Reprod (2014) 0.93
Induction of ovarian primordial follicle assembly by connective tissue growth factor CTGF. PLoS One (2010) 0.93
Pharmacological inhibition of mTORC1 prevents over-activation of the primordial follicle pool in response to elevated PI3K signaling. PLoS One (2013) 0.92
Ontogeny of the ovary in polycystic ovary syndrome. Fertil Steril (2013) 0.92
Oogenesis and cell death in human prenatal ovaries: what are the criteria for oocyte selection? Mol Hum Reprod (2009) 0.92
The safe use of a PTEN inhibitor for the activation of dormant mouse primordial follicles and generation of fertilizable eggs. PLoS One (2012) 0.91
Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes. Cell Mol Life Sci (2014) 0.91
Inhibition of vascular endothelial growth factor receptor signal transduction blocks follicle progression but does not necessarily disrupt vascular development in perinatal rat ovaries. Biol Reprod (2009) 0.91
Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. Microbes Infect (2013) 0.91
Intraovarian transplantation of primordial follicles fails to rescue chemotherapy injured ovaries. Sci Rep (2013) 0.90
Genetics of primary ovarian insufficiency: new developments and opportunities. Hum Reprod Update (2015) 0.89
Manipulating insulin signaling to enhance mosquito reproduction. BMC Physiol (2009) 0.88
Inhibition of PIK3 signaling pathway members by the ovotoxicant 4-vinylcyclohexene diepoxide in rats. Biol Reprod (2010) 0.87
FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH. Mol Endocrinol (2013) 0.86
Polycystic ovary syndrome: current status and future perspective. Front Biosci (Elite Ed) (2014) 0.86
Involvement of androgens in ovarian health and disease. Mol Hum Reprod (2013) 0.86
PtdIns(3,4,5)P3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes. J Cell Sci (2012) 0.86
Glutamate Cysteine Ligase Modifier Subunit (Gclm) Null Mice Have Increased Ovarian Oxidative Stress and Accelerated Age-Related Ovarian Failure. Endocrinology (2015) 0.86
FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol (2015) 0.86
Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation. Dev Biol (2009) 0.86
Notch signaling regulates ovarian follicle formation and coordinates follicular growth. Mol Endocrinol (2014) 0.85
Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy. Open Med Chem J (2013) 0.85
Honey bee PTEN--description, developmental knockdown, and tissue-specific expression of splice-variants correlated with alternative social phenotypes. PLoS One (2011) 0.85
Incorporation of phosphatase inhibitor in culture prompts growth initiation of isolated non-growing oocytes. PLoS One (2013) 0.85
Mono(2-ethylhexyl) phthalate accelerates early folliculogenesis and inhibits steroidogenesis in cultured mouse whole ovaries and antral follicles. Biol Reprod (2015) 0.85
Biology and biotechnology of follicle development. ScientificWorldJournal (2012) 0.85
Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling. Toxicol Appl Pharmacol (2011) 0.84
Developmental competence of oocytes grown in vitro: Has it peaked already? J Reprod Dev (2015) 0.84
Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice. Mol Hum Reprod (2013) 0.84
Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans. Endocrinology (2011) 0.84
Regulation of the ovarian reserve by members of the transforming growth factor beta family. Mol Reprod Dev (2012) 0.84
Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells. Mol Cell Endocrinol (2011) 0.84
Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One (2015) 0.83
The Src homology 2 domain-containing adapter protein B (SHB) regulates mouse oocyte maturation. PLoS One (2010) 0.83
Transforming growth factor-β signaling participates in the maintenance of the primordial follicle pool in the mouse ovary. J Biol Chem (2014) 0.83
Murine folliculogenesis in vitro is stage-specifically regulated by insulin via the Akt signaling pathway. Histochem Cell Biol (2010) 0.83
The small GTPase Rheb is required for spermatogenesis but not oogenesis. Reproduction (2014) 0.83
High fat diet induced obesity alters ovarian phosphatidylinositol-3 kinase signaling gene expression. Reprod Toxicol (2013) 0.82
Impact of obesity on ovotoxicity induced by 7,12-dimethylbenz[a]anthracene in mice. Biol Reprod (2014) 0.82
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells. PLoS Genet (2015) 0.82
New insights into ovarian function. Handb Exp Pharmacol (2010) 0.81
Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators. PLoS One (2015) 0.81
Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure. J Biol Chem (2015) 0.81
Control of ovarian primordial follicle activation. Clin Exp Reprod Med (2012) 0.81
Primordial follicle activation in the ovary of Ames dwarf mice. J Ovarian Res (2014) 0.81
Lhx8 regulates primordial follicle activation and postnatal folliculogenesis. BMC Biol (2015) 0.81
Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis. Mol Ther (2014) 0.80
Interaction between the inducible 70-kDa heat shock protein and autophagy: effects on fertility and pregnancy. Cell Stress Chaperones (2015) 0.80
Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Endocrinology (2015) 0.80
Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice. Cell Death Dis (2015) 0.80
Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea. PLoS One (2013) 0.80
Activin A inhibits activation of human primordial follicles in vitro. J Assist Reprod Genet (2010) 0.80
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol (2001) 6.30
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature (2003) 5.04
Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res (2002) 4.92
VFDB: a reference database for bacterial virulence factors. Nucleic Acids Res (2005) 4.77
Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein. Proc Natl Acad Sci U S A (2009) 4.61
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30
Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity (2004) 3.98
Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228). Mol Microbiol (2003) 3.86
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res (2005) 3.56
Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell (2009) 3.53
Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy. J Genet Genomics (2012) 2.98
Association between genetic variation of CACNA1H and childhood absence epilepsy. Ann Neurol (2003) 2.79
GenomeComp: a visualization tool for microbial genome comparison. J Microbiol Methods (2003) 2.62
Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior. Nat Neurosci (2007) 2.55
Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis. Nat Med (2005) 2.43
Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol Cell Biol (2005) 2.32
Gamma-secretase gene mutations in familial acne inversa. Science (2010) 2.30
Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice. Biol Reprod (2004) 2.29
Association of estrogen receptor alpha polymorphisms with susceptibility to chronic hepatitis B virus infection. Hepatology (2004) 2.12
Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation. Mol Cell Biol (2005) 2.07
Failed efficacy of soluble human CD83-Ig in allogeneic mixed lymphocyte reactions and experimental autoimmune encephalomyelitis: implications for a lack of therapeutic potential. Immunol Lett (2007) 2.05
A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet (2011) 2.05
Abatacept in relapsing polychondritis. Ann Rheum Dis (2013) 2.01
Health Outcomes and Socio-Economic Status Among the Elderly in Gansu and Zhejiang Provinces, China: Evidence from the CHARLS Pilot. J Popul Ageing (2011) 1.87
Male hormonal contraception: a double-blind, placebo-controlled study. J Clin Endocrinol Metab (2008) 1.79
Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries. Proc Natl Acad Sci U S A (2012) 1.77
Fecal MicroRNAs as novel biomarkers for colon cancer screening. Cancer Epidemiol Biomarkers Prev (2010) 1.74
Type I IFN protects against murine lupus. J Immunol (2004) 1.71
Diagnosis and treatment of solid-pseudopapillary tumor of the pancreas. Hepatobiliary Pancreat Dis Int (2006) 1.71
Increased carotid atherosclerosis in andropausal middle-aged men. J Am Coll Cardiol (2005) 1.70
The draft genome of the fast-growing non-timber forest species moso bamboo (Phyllostachys heterocycla). Nat Genet (2013) 1.68
Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology (2005) 1.67
Molecular mechanisms underlying the activation of mammalian primordial follicles. Endocr Rev (2009) 1.64
Randomized phase II study of erlotinib in combination with placebo or R1507, a monoclonal antibody to insulin-like growth factor-1 receptor, for advanced-stage non-small-cell lung cancer. J Clin Oncol (2011) 1.63
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep (2012) 1.60
Characterization of ST-4821 complex, a unique Neisseria meningitidis clone. Genomics (2007) 1.59
Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet (2009) 1.58
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. Nat Struct Mol Biol (2011) 1.58
Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum (2006) 1.56
Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a. BMC Genomics (2006) 1.54
SH2D1A regulates T-dependent humoral autoimmunity. J Exp Med (2004) 1.51
The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression. Int J Rheumatol (2013) 1.51
Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation. Proc Natl Acad Sci U S A (2010) 1.50
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol (2009) 1.49
Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor. Fertil Steril (2002) 1.48
Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1. Science (2004) 1.46
Generation of viable male and female mice from two fathers. Biol Reprod (2010) 1.46
Retracted Differential recruitment of methylated CpG binding domains by the orphan receptor GCNF initiates the repression and silencing of Oct4 expression. Mol Cell Biol (2006) 1.45
LDA--a java-based linkage disequilibrium analyzer. Bioinformatics (2003) 1.44
Canonical Wnt/β-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression. Stem Cells (2010) 1.43
Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation. Biol Reprod (2011) 1.42
Preemptive scalp infiltration with 0.5% ropivacaine and 1% lidocaine reduces postoperative pain after craniotomy. Acta Neurochir (Wien) (2015) 1.41
Premature ovarian aging in mice deficient for Gpr3. Proc Natl Acad Sci U S A (2005) 1.41
Polymorphisms in androgen and estrogen receptor genes: effects on male aging. Exp Gerontol (2004) 1.39
Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome. Genome Res (2004) 1.38
Mechanisms maintaining the dormancy and survival of mammalian primordial follicles. Trends Endocrinol Metab (2009) 1.37
Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles. Mol Hum Reprod (2009) 1.36
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell (2013) 1.35
A synthetic prostone activates apical chloride channels in A6 epithelial cells. Am J Physiol Gastrointest Liver Physiol (2008) 1.35
Control of mammalian oocyte growth and early follicular development by the oocyte PI3 kinase pathway: new roles for an old timer. Dev Biol (2006) 1.35
Metabolomics coupled with proteomics advancing drug discovery toward more agile development of targeted combination therapies. Mol Cell Proteomics (2013) 1.34
Evolution and migration history of the Chinese population inferred from Chinese Y-chromosome evidence. J Hum Genet (2004) 1.33
Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han population. Arterioscler Thromb Vasc Biol (2003) 1.31
TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A (2004) 1.30
Prevention of hepatitis B recurrence after liver transplantation using lamivudine or lamivudine combined with hepatitis B Immunoglobulin prophylaxis. Liver Transpl (2006) 1.29
CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88. Eur J Immunol (2004) 1.29
Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium. FASEB J (2006) 1.29
Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model. Diabetes (2010) 1.29
PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles. Hum Mol Genet (2009) 1.28
Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a. Development (2007) 1.28
T cells require Foxo1 to populate the peripheral lymphoid organs. Eur J Immunol (2009) 1.27
Colorectal cancers with microsatellite instability display unique miRNA profiles. Clin Cancer Res (2011) 1.27
Prospects for minocycline neuroprotection. Arch Neurol (2010) 1.27
Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J Immunol (2005) 1.27
Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol (2010) 1.26
Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol (2005) 1.26
T-bet regulates T-independent IgG2a class switching. Int Immunol (2003) 1.25
Phosphatidylinositol 3,4,5-trisphosphate mediates aldosterone stimulation of epithelial sodium channel (ENaC) and interacts with gamma-ENaC. J Biol Chem (2005) 1.25
Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via phosphatidylinositol 3 kinase and ligand-independent activation of epidermal growth factor receptor in ovarian cancer cells. Mol Endocrinol (2005) 1.25