Published in Biochem J on April 01, 1992
Prostaglandin cyclooxygenase products but not thromboxane A(2) are involved in the pathogenesis of ewthromelalgia in thrombocythaemia. Mediators Inflamm (1993) 0.82
Phosphorylation of human pleckstrin on Ser-113 and Ser-117 by protein kinase C. Biochem J (1996) 0.80
Regulation of Transgene Expression in Tumor Cells by Exploiting Endogenous Intracellular Signals. Nanoscale Res Lett (2008) 0.78
Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets. Biochem J (1994) 0.78
The role of protein kinase C in carbachol-induced and of cAMP-dependent protein kinase in isoproterenol-induced secretion in primary cultured guinea pig parotid acinar cells. Biochem J (1996) 0.78
Carbachol-induced [Ca2+]i increase, but not activation of protein kinase C, stimulates exocytosis in rat parotid acini. J Physiol (2000) 0.76
Protein tyrosine kinase but not protein kinase C inhibition blocks receptor induced alveolar macrophage activation. Mediators Inflamm (1993) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (1984) 25.71
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
Some statistical methods useful in circulation research. Circ Res (1980) 11.88
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry (1984) 10.83
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase. Biochem Biophys Res Commun (1986) 7.96
'Quantal' Ca2+ release and the control of Ca2+ entry by inositol phosphates--a possible mechanism. FEBS Lett (1990) 5.35
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Trends Pharmacol Sci (1989) 4.41
Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets. Nature (1983) 4.34
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun (1989) 4.24
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem (1983) 3.69
Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci U S A (1979) 3.48
Potent selective inhibitors of protein kinase C. FEBS Lett (1989) 3.24
Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets. J Biol Chem (1983) 2.90
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets. Biochem Biophys Res Commun (1984) 2.59
Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen. Biochem J (1986) 2.50
Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity. Cell (1986) 2.15
Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase. J Biol Chem (1980) 2.15
Molecular cloning and expression of the major protein kinase C substrate of platelets. Nature (1988) 2.00
The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin. Biochem J (1988) 1.95
A role for inositol triphosphate in intracellular Ca2+ mobilization and granule secretion in platelets. J Biol Chem (1985) 1.76
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets. J Biol Chem (1985) 1.76
1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis. Proc Natl Acad Sci U S A (1985) 1.73
Inhibition of protein kinase C by tamoxifen. Cancer Res (1985) 1.56
Polymyxin B is a more selective inhibitor for phospholipid-sensitive Ca2+-dependent protein kinase than for calmodulin-sensitive Ca2+-dependent protein kinase. Biochem Biophys Res Commun (1982) 1.37
Phorbol esters and oleoyl acetoyl glycerol enhance release of arachidonic acid in platelets stimulated by Ca2+ ionophore A23187. J Biol Chem (1985) 1.26
The tumor-promoter phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate), a potent aggregating agent for blood platelets. J Cell Biol (1974) 1.21
Stimulation of Ca2+ efflux from fura-2-loaded platelets activated by thrombin or phorbol myristate acetate. FEBS Lett (1987) 1.20
Prostacyclin prolongs viability of washed human platelets. Biochim Biophys Acta (1982) 1.11
Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets. Biochem J (1983) 1.10
How do inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate regulate intracellular Ca2+? Biochem Soc Trans (1989) 1.10
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. Biochem Biophys Res Commun (1988) 1.06
Phosphorylation-dependent and -independent pathways of platelet aggregation. Biochem J (1989) 1.02
Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets. Biochem Biophys Res Commun (1985) 1.00
Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes. J Biol Chem (1989) 0.99
K252a, a new inhibitor of protein kinase C, concomitantly inhibits 40K protein phosphorylation and serotonin secretion in a phorbol ester-stimulated platelets. Biochem Biophys Res Commun (1987) 0.99
Diacylglycerol lipase pathway is a minor source of released arachidonic acid in thrombin-stimulated human platelets. Biochem Biophys Res Commun (1986) 0.98
Measurement of secretion of serotonin. Methods Enzymol (1989) 0.95
Differences in the effects of phorbol esters and diacylglycerols on protein kinase C. Biochemistry (1989) 0.92
Aminoacridines, potent inhibitors of protein kinase C. J Biol Chem (1988) 0.90
Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. Biochem J (1987) 0.86
Arachidonate metabolism in blood cells and the vessel wall. Clin Haematol (1986) 0.86
Phorbol esters modulate thrombin-operated calcium mobilisation and dense granule release in human platelets. Biochim Biophys Acta (1986) 0.84
Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets. Arch Biochem Biophys (1989) 0.82
Acridine orange, an inhibitor of protein kinase C, abolishes insulin and growth hormone stimulation of lipogenesis in rat adipocytes. FEBS Lett (1989) 0.81
Modes of inhibition of protein kinase C by triphenylacrylonitrile antiestrogens. Biochem Biophys Res Commun (1989) 0.79
Prostacyclin and thromboxane in non-insulin dependent diabetes: the chlorpropamide alcohol flush reaction revisited. Clin Sci (Lond) (1984) 0.78
Selectivity of protein kinase inhibitors in human intact platelets. Cell Signal (1990) 0.78
Role of protein kinase C in the regulation of phospholipase A2 activity in human platelets. Biochem Soc Trans (1990) 0.77
Direct evidence for the modulation of human platelet cytosolic free Ca2+ by intracellular cyclic AMP produced with a photoactivatable derivative. Biochem Biophys Res Commun (1987) 0.77
Protein kinase C and granule release in human platelets. Adv Exp Med Biol (1985) 0.76
Inhibition of protein kinase C by retro-inverso pseudosubstrate analogues. Biochem Biophys Res Commun (1989) 0.76
Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J Clin Invest (1990) 5.21
IL-4 inhibits the expression of IL-8 from stimulated human monocytes. J Immunol (1990) 2.41
Chemokines and T lymphocytes: more than an attraction. Immunity (1998) 2.29
Novel neutrophil-stimulating peptides. Immunol Today (1989) 2.16
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J Immunol (1999) 1.81
Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. J Clin Invest (1999) 1.46
The role of prostaglandins in rabbit monoarticular arthritis. Br J Pharmacol (1974) 1.40
Chemokine gene expression and secretion by cytokine-activated human microvascular endothelial cells. Differential regulation of monocyte chemoattractant protein-1 and interleukin-8 in response to interferon-gamma. Am J Pathol (1994) 1.39
Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma. J Immunol (2001) 1.35
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. J Biol Chem (1998) 1.34
Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol (1994) 1.31
Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists. Biochem Biophys Res Commun (1989) 1.30
Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation. Eur J Immunol (1993) 1.30
RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase. J Immunol (1995) 1.30
Elevation of PMN cytosolic free calcium and locomotion stimulated by novel peptides from IL-1-treated human synovial cell cultures. Biochem Biophys Res Commun (1988) 1.27
Human cytomegalovirus infection up-regulates interleukin-8 gene expression and stimulates neutrophil transendothelial migration. Immunology (1997) 1.25
Cytokines contribute to airway dysfunction in antigen-challenged guinea pigs: inhibition of airway hyperreactivity, pulmonary eosinophil accumulation, and tumor necrosis factor generation by pretreatment with an interleukin-1 receptor antagonist. Am J Respir Cell Mol Biol (1993) 1.23
Chemokines: understanding their role in T-lymphocyte biology. Biochem J (1998) 1.22
Human peritoneal mesothelial cells synthesize interleukin-8. Synergistic induction by interleukin-1 beta and tumor necrosis factor-alpha. Am J Pathol (1993) 1.21
Proceedings: The effect of sulphinpyrazone, sodium aspirin and oxprenolol on the formation of arterial platelet thrombi. Br J Pharmacol (1975) 1.20
beta-thromboglobulin and platelet factor 4 levels in retinal vein occlusion. Br J Ophthalmol (1983) 1.16
Low-molecular-weight heparin and prevention of postoperative deep vein thrombosis. Br Med J (Clin Res Ed) (1982) 1.16
Expression of inducible nitric oxide synthase activity in human colon epithelial cells: modulation by T lymphocyte derived cytokines. Gut (1998) 1.15
Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism. J Biol Chem (1999) 1.11
Production of interleukin-8, RANTES and MCP-1 in intrinsic and extrinsic asthmatics. Eur Respir J (1997) 1.11
Human vascular smooth muscle cells express receptors for CC chemokines. Arterioscler Thromb Vasc Biol (1998) 1.09
Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. Am J Pathol (1992) 1.08
Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29. Br J Pharmacol (1995) 1.08
Proceedings: Measurement of changes in the microvasculature. Br J Pharmacol (1976) 1.07
ADP metabolism in vascular tissue, a possible thrombo-regulatory mechanism. Thromb Res (1979) 1.07
Cytokine-activated human mesangial cells generate the neutrophil chemoattractant, interleukin 8. Kidney Int (1991) 1.05
Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29. J Biol Chem (1997) 1.03
Microvascular responses produced by the prostaglandin endoperoxide PGG2 in vivo [proceedings]. Br J Pharmacol (1977) 1.02
Regulation and expression of chemokines: potential role in glomerulonephritis. J Leukoc Biol (1996) 1.02
Chemokine production by human vascular smooth muscle cells: modulation by IL-13. Br J Pharmacol (1997) 0.99
Chemokines: new ligands, receptors and activities. Immunol Today (1995) 0.99
Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils. Biochem Biophys Res Commun (1989) 0.98
Neutrophil stimulation by recombinant cytokines and a factor produced by IL-1-treated human synovial cell cultures. Immunology (1988) 0.96
Interleukin 8 and monocyte chemoattractant protein 1 production by cultured human airway smooth muscle cells. Cytokine (1998) 0.95
Cytokine production and hemofiltration in children undergoing cardiopulmonary bypass. Ann Thorac Surg (1993) 0.94
Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways. Biochem Pharmacol (1984) 0.94
Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin. Eur J Immunol (1995) 0.93
Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Am J Physiol (1993) 0.92
C-X-C and C-C chemokine expression and secretion by the human colonic epithelial cell line, HT-29: differential effect of T lymphocyte-derived cytokines. Eur J Immunol (1999) 0.92
An X-ray analysis of adjuvant arthritis in the rat. The effect of prednisolone and indomethacin. Agents Actions (1977) 0.91
Selective antagonism of prostaglandin (PG) E1, PGD2 and prostacyclin (PGI2) on human and rabbit platelets by di-4-phloretin phosphate (DPP). Thromb Res (1978) 0.90
Nicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels. Neurosci Lett (1995) 0.88
Anti-inflammatory actions of interleukin-13: suppression of tumor necrosis factor-alpha and antigen-induced leukocyte accumulation in the guinea pig lung. Am J Respir Cell Mol Biol (1999) 0.88
IL-1 receptor antagonist inhibits monocyte chemotactic peptide 1 generation by human mesangial cells. Kidney Int (1992) 0.88
Enhanced in-vivo platelet release reaction, increased thromboxane synthesis, and decreased prostacyclin release after tourniquet ischaemia. Lancet (1980) 0.88
Activation of protein kinase C inhibits sodium fluoride-induced elevation of human platelet cytosolic free calcium and thromboxane B2 generation. Biochem Biophys Res Commun (1986) 0.87
Antisense RNA to the c-fos gene: restoration of density-dependent growth arrest in a transformed cell line. Biochem Biophys Res Commun (1987) 0.86
Regional heterogeneity of endothelium-dependent vasodilatation in the rabbit kidney. J Physiol (1991) 0.86
Effects of prostaglandins E2 and I2 on human lymphocyte transformation in the presence and absence of inhibitors of prostaglandin biosynthesis. Br J Pharmacol (1979) 0.86
The effect of pulmonary metabolites of prostaglandins E1, E2 and F2alpha on ADP-induced aggregation of human and rabbit platelets [proceedings]. Br J Pharmacol (1976) 0.86
Characterization of platelet-activating factor-induced elevation of cytosolic free calcium concentration in eosinophils. FEBS Lett (1989) 0.85
Comparison of the effects of prostaglandin analogues on rabbit platelets, rabbit isolated vascular tissues and rabbit skin microvasculature [proceedings]. Br J Pharmacol (1978) 0.85
Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells. Br J Pharmacol (1988) 0.85
Endothelin and cyclosporin nephrotoxicity. Lancet (1989) 0.84
Phorbol esters modulate thrombin-operated calcium mobilisation and dense granule release in human platelets. Biochim Biophys Acta (1986) 0.84
Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro. Thromb Res (1986) 0.84
Platelet activation during steady state sickle cell disease. J Med (1983) 0.83
Recombinant guinea pig and human RANTES activate macrophages but not eosinophils in the guinea pig. J Immunol (1997) 0.83
Airway inflammation induced by recombinant guinea pig tumor necrosis factor-alpha. Am J Physiol (1997) 0.83
Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man--effect of low-dose aspirin. Thromb Haemost (1987) 0.83
Do prostacyclin and thromboxane play a role in endotoxic shock? Br J Surg (1981) 0.82
Analysis of a transformed cell line using antisense c-fos RNA. Gene (1988) 0.82
Structural analogues of D-myo-inositol-1,4,5-trisphosphate and adenophostin A: recognition by cerebellar and platelet inositol-1,4,5-trisphosphate receptors. Mol Pharmacol (1997) 0.82
myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3, 6-trisphosphorothioate: partial agonists with very low intrinsic activity at the platelet myo-inositol 1,4,5-trisphosphate receptor. Mol Pharmacol (2000) 0.82
Modulation of thrombus formation in vivo by prostaglandins [proceedings]. Br J Pharmacol (1977) 0.82
Endothelin induces an increase in renal vascular resistance and a fall in glomerular filtration rate in the rabbit isolated perfused kidney. Br J Pharmacol (1989) 0.81
The effect of daphnane esters on platelet aggregation and erythema of the mouse ear. J Pharm Pharmacol (1980) 0.81
Endothelin-1 in the rabbit: interactions with cyclo-oxygenase and NO-synthase products. Br J Pharmacol (1993) 0.81
Differential effects of protein kinase C inhibitors on chemokine production in human synovial fibroblasts. Br J Pharmacol (1996) 0.81
Antibody ligation of CD7 leads to association with phosphoinositide 3-kinase and phosphatidylinositol 3,4,5-trisphosphate formation in T lymphocytes. Eur J Immunol (1995) 0.81
Increased vascular permeability and polymorphonuclear leucocyte accumulation in vivo in response to recombinant cytokines and supernatant from cultures of human synovial cells treated with interleukin 1. Br J Exp Pathol (1989) 0.81
Intraperitoneal injection of human recombinant neutrophil-activating factor/interleukin 8 (hrNAF/IL-8) produces a T cell and eosinophil infiltrate in the guinea pig lung. Effect of PAF antagonist WEB2086. Ann N Y Acad Sci (1991) 0.80
Mechanisms of calcium homeostasis in the polymorphonuclear leucocyte. Agents Actions (1986) 0.80
A role for protein phosphorylation in modulating Ca2+ elevation in rabbit platelets treated with thapsigargin. Biochem J (1996) 0.80
Inhibition by staurosporine of mitogen-induced calcium mobilisation in human T lymphoblasts. FEBS Lett (1988) 0.80
Enantiomers of myo-inositol-1,3,4-trisphosphate and myo-inositol-1,4,6 -trisphosphate: stereospecific recognition by cerebellar and platelet myo-inositol-1,4,5-trisphosphate receptors. Mol Pharmacol (1996) 0.80
Interleukin-8 production by the human colon epithelial cell line HT-29: modulation by interleukin-13. Br J Pharmacol (1996) 0.79
Synthesis of 1L-chiro-inositol 2,3,5-trisphosphorothioate, the first partial agonist at the platelet myo-inositol 1,4,5-trisphosphate receptor. Bioorg Med Chem (1994) 0.79
Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation. Am J Respir Cell Mol Biol (1994) 0.79
Rabbit monoarticular arthritis and synovial prostaglandins. Br J Pharmacol (1973) 0.79
D-myo-inositol 1,4,5-trisphosphate analogues modified at the 3-position inhibit phosphatidylinositol 3-kinase. J Biol Chem (1995) 0.79
Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice. Br J Surg (1982) 0.79
Prostaglandins and model aspects of thrombosis. Postgrad Med J (1977) 0.79
Interleukin-13 inhibits nitric oxide production in human colonic mucosa. Hepatogastroenterology (2000) 0.79
Interleukin-8--a mediator of inflammatory lung disease? Adv Exp Med Biol (1991) 0.79
Phorbol esters regulate CD2- and CD3-mediated calcium responses in peripheral blood-derived human T cells. J Immunol (1989) 0.79
Evidence for the presence and location of annexins in human platelets. Biochem Biophys Res Commun (1992) 0.79
Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. Br J Clin Pharmacol (1983) 0.78
Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid. Biochim Biophys Acta (1991) 0.78
hrIL-8-induced hyperresponsiveness in guinea pig perfused lungs. Ann N Y Acad Sci (1991) 0.78
A role for RANTES in T lymphocyte proliferation. Biochem Soc Trans (1996) 0.78
Disparate effects of phorbol esters, CD3 and the costimulatory receptors CD2 and CD28 on RANTES secretion by human T lymphocytes. Immunology (2000) 0.78
Nicotinic acetylcholine receptors in primary cultures of hippocampal neurons: pharmacology and Ca++ permeability. Biochem Soc Trans (1994) 0.78
Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets. Biochem J (1994) 0.78