Published in J Biol Chem on September 25, 1980
In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol (1989) 3.87
Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine. Proc Natl Acad Sci U S A (1980) 3.08
Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells. Proc Natl Acad Sci U S A (1983) 2.84
A molecular description of nerve terminal function. Annu Rev Biochem (1983) 1.82
Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes. Biophys J (1991) 1.60
Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6. Proc Natl Acad Sci U S A (1983) 1.59
Characterization of the activation of Na+/H+ exchange in lymphocytes by phorbol esters: change in cytoplasmic pH dependence of the antiport. Proc Natl Acad Sci U S A (1985) 1.50
A dominant trifluoperazine resistance gene from Saccharomyces cerevisiae has homology with F0F1 ATP synthase and confers calcium-sensitive growth. Mol Cell Biol (1988) 1.43
Vertebrate and yeast calmodulin, despite significant sequence divergence, are functionally interchangeable. Proc Natl Acad Sci U S A (1989) 1.29
Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine. Proc Natl Acad Sci U S A (1981) 1.28
Phorbol esters induce multidrug resistance in human breast cancer cells. Proc Natl Acad Sci U S A (1988) 1.24
Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases. J Cell Biol (1986) 1.23
Role of lysosomal and cytosolic pH in the regulation of macrophage lysosomal enzyme secretion. Biochem J (1990) 1.15
Increased expression of complement decay-accelerating factor during activation of human neutrophils. J Clin Invest (1987) 1.13
Endogenous substrate proteins for Ca2+-calmodulin-dependent, Ca2+-phospholipid-dependent and cyclic AMP-dependent protein kinases in mouse pancreatic islets. Biochem J (1984) 1.13
Polyamines inhibit phospholipid-sensitive and calmodulin-sensitive Ca2+-dependent protein kinases. Biochem J (1983) 1.08
Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells. Proc Natl Acad Sci U S A (1989) 1.05
Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents. Br J Cancer (1992) 1.02
Ionic requirements for entry of Shiga toxin from Shigella dysenteriae 1 into cells. Infect Immun (1987) 1.01
Mild proteolytic digestion restores exocytotic activity to N-ethylmaleimide-inactivated cell surface complex from sea urchin eggs. J Cell Biol (1985) 1.00
Inhibition by adriamycin of calmodulin-sensitive and phospholipid-sensitive calcium-dependent phosphorylation of endogenous proteins from heart. Biochem J (1981) 0.98
Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins. J Cell Biol (1985) 0.98
The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance. Br J Cancer (1990) 0.97
Inhibition of Escherichia coli DNA topoisomerase I activity by phospholipids. Biochem J (1992) 0.96
Ethanol-induced phospholipase C activation is inhibited by phorbol esters in isolated hepatocytes. Biochem J (1988) 0.95
Inhibition by melittin of phospholipid-sensitive and calmodulin-sensitive Ca2+-dependent protein kinases. Biochem J (1982) 0.95
Selective inhibition of protein kinase C. Effect on platelet-activating-factor-induced platelet functional responses. Biochem J (1992) 0.94
Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines. Br J Cancer (1992) 0.91
Effect of chlorpromazine on the development of experimental glomerulonephritis and Arthus reaction. Am J Pathol (1988) 0.89
Activation of protein kinase in the bovine corpus luteum by phospholipid and Ca2+. Biochem J (1983) 0.87
Effects of local anaesthetics on short-term desensitization of guinea-pig taenia caecum to histamine. Br J Pharmacol (1987) 0.87
Happy birthday protein kinase C: past, present and future of a superfamily. Pharmacol Res (2007) 0.83
Respiratory burst oxidase of fertilization. Proc Natl Acad Sci U S A (1989) 0.83
Intracellular cascades in the parathyroid-hormone-dependent regulation of Na+/phosphate cotransport in OK cells. Biochem J (1988) 0.83
The effect of K-252a, a potent microbial inhibitor of protein kinase, on activated cyclic nucleotide phosphodiesterase. Biochem J (1988) 0.82
Immunomodulatory effects of therapeutic gold compounds. Gold sodium thiomalate inhibits the activity of T cell protein kinase C. J Clin Invest (1992) 0.81
Transmodulation of the epidermal-growth-factor receptor in permeabilized 3T3 cells. Biochem J (1988) 0.81
Differential effects of chlorpromazine on secretion, protein phosphorylation and phosphoinositide metabolism in stimulated platelets. Biochem J (1986) 0.81
Daphnoretin, a new protein kinase C activator isolated from Wikstroemia indica C.A. Mey. Biochem J (1993) 0.81
Paramecium secretory granule content: quantitative studies on in vitro expansion and its regulation by calcium and pH. J Cell Biol (1984) 0.79
Ca2+- and calmodulin-dependent protein phosphorylation in rat lacrimal gland. Biochem J (1982) 0.78
Kinetic mechanism of activation by cardiolipin (diphosphatidylglycerol) of the rat liver multicatalytic proteinase. Biochem J (1993) 0.78
Inhibition of protein kinase C in multidrug-resistant cells by modulators of multidrug resistance. J Cancer Res Clin Oncol (1997) 0.77
Phorbol 12,13-dibutyrate binding to intact human platelets. The role of cytosolic free Ca2+. Biochem J (1991) 0.76
Effects of trifluoperazine and chlorpromazine on calcium-repleted injury in isolated ventricle strips. Basic Res Cardiol (1986) 0.75
Pig-skin epidermal calmodulin: effects of antagonists of calmodulin on DNA synthesis of pig-skin epidermis. Arch Dermatol Res (1985) 0.75
Chlorpromazine reduces UV-induced squamous cell carcinogenesis in hairless mice and enhances UV-induced DNA damage in cultured cells. Br J Cancer (1989) 0.75
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
Studies and perspectives of protein kinase C. Science (1986) 14.73
Turnover of inositol phospholipids and signal transduction. Science (1984) 5.76
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa. EMBO J (1993) 5.35
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem (1980) 5.08
Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci (2001) 4.99
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature (1998) 4.95
Comparison of guanosine triphosphate split and polypeptide synthesis with a purified E. coli system. Proc Natl Acad Sci U S A (1966) 4.72
Advanced glycation end-products: a review. Diabetologia (2001) 4.59
Comparison of MB-Check, BACTEC, and egg-based media for recovery of mycobacteria. J Clin Microbiol (1992) 4.55
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27
The structure, expression, and properties of additional members of the protein kinase C family. J Biol Chem (1988) 4.15
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc Natl Acad Sci U S A (1992) 4.13
Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem (1979) 4.12
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06
Binding of neuroligins to PSD-95. Science (1997) 3.88
Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI). J Cell Biol (1993) 3.87
Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. J Biol Chem (1968) 3.81
Aspergillosis complicating neoplastic disease. Am J Med (1973) 3.80
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem (1983) 3.69
Adaptive wavelet thresholding for image denoising and compression. IEEE Trans Image Process (2000) 3.67
Plasma (1-->3)-beta-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes. Lancet (1995) 3.64
Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties. J Biol Chem (1982) 3.64
Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J Biol Chem (1983) 3.60
Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. J Cell Biol (1999) 3.47
Rho1p, a yeast protein at the interface between cell polarization and morphogenesis. Science (1996) 3.42
Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med (1997) 3.35
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nat Genet (1997) 3.34
Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology (1996) 3.30
Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Proc Natl Acad Sci U S A (1989) 3.21
Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem (1997) 3.08
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J Biol Chem (1977) 3.02
Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development. Antimicrob Agents Chemother (1997) 2.98
Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem Biophys Res Commun (1979) 2.96
Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem (1992) 2.90
Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry (1995) 2.90
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene (1990) 2.89
Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.87
cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol (2000) 2.83
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol (1997) 2.82
Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. EMBO J (1997) 2.80
International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections. Clin Infect Dis (1997) 2.78
Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein. J Biol Chem (1990) 2.77
Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.76
Gender difference in delays to diagnosis and health care seeking behaviour in a rural area of Nepal. Int J Tuberc Lung Dis (2001) 2.75
Circadian clock-protein expression in cyanobacteria: rhythms and phase setting. EMBO J (2000) 2.75
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol (1994) 2.74
Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence. Proc Natl Acad Sci U S A (1989) 2.72
Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol Cell Biol (1993) 2.71
The protein kinase C family: heterogeneity and its implications. Annu Rev Biochem (1989) 2.70
Gallbladder torsion: case report and review of 245 cases reported in the Japanese literature. J Hepatobiliary Pancreat Surg (1999) 2.68
The interrelationship between guanosine triphosphatase and amino acid polymerization. Arch Biochem Biophys (1966) 2.64
Irradiation synchronized with respiration gate. Int J Radiat Oncol Biol Phys (1989) 2.63
A human gene responsible for Zellweger syndrome that affects peroxisome assembly. Science (1992) 2.63
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins. J Biol Chem (1993) 2.62
A comparison of knee joint motion patterns between men and women in selected athletic tasks. Clin Biomech (Bristol, Avon) (2001) 2.56
Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1985) 2.55
Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med (1982) 2.52
Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science (1969) 2.48
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Mol Cell Biol (1993) 2.48
Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor. J Biol Chem (1990) 2.47
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A (1997) 2.42
Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron (1998) 2.36
Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene (1995) 2.32
B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol (1997) 2.29
The role of protein kinase C in transmembrane signalling. Annu Rev Cell Biol (1986) 2.29
Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae. Oncogene (1998) 2.27
SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. J Biol Chem (1997) 2.23
Isolation and Characterization of an Enterobacter cloacae Strain That Reduces Hexavalent Chromium under Anaerobic Conditions. Appl Environ Microbiol (1989) 2.23
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. J Biol Chem (1971) 2.23
A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc Natl Acad Sci U S A (1991) 2.22
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene (1999) 2.22
Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease. J Biol Chem (1983) 2.20
Basic ADL disability and functional limitation rates among older AMERICANS from 2000-2005: the end of the decline? J Gerontol A Biol Sci Med Sci (2009) 2.14
Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance. J Exp Med (1987) 2.14
Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene (1986) 2.14
rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Mol Cell Biol (1994) 2.12
Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer. J Exp Med (1982) 2.11
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum. J Biol Chem (1977) 2.10
Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol Cell Biol (1995) 2.10
Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein. J Biol Chem (1990) 2.09
Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland. Science (1976) 2.08