Published in Oncogene on April 14, 2005
Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis. J Cell Biol (2010) 1.89
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene (2008) 1.20
ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis. PLoS One (2007) 1.20
Ubiquitin and SUMO systems in the regulation of mitotic checkpoints. Trends Biochem Sci (2006) 1.15
The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr. J Cell Sci (2011) 1.04
Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint. Neoplasia (2008) 1.04
Safeguarding entry into mitosis: the antephase checkpoint. Mol Cell Biol (2010) 1.03
FHA-RING ubiquitin ligases in cell division cycle control. Cell Mol Life Sci (2008) 1.00
CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC. Clin Cancer Res (2013) 0.99
Physiological and oncogenic Aurora-A pathway. Int J Biol Sci (2009) 0.97
Functional interaction between Chfr and Kif22 controls genomic stability. J Biol Chem (2009) 0.95
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Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer. Br J Cancer (2011) 0.92
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The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain. PLoS One (2008) 0.88
Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry. J Biol Chem (2012) 0.87
The auto-ubiquitylation of E3 ubiquitin-protein ligase Chfr at G2 phase is required for accumulation of polo-like kinase 1 and mitotic entry in mammalian cells. J Biol Chem (2011) 0.86
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest (2009) 0.85
Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Mol Cell Biol (2014) 0.85
TOPK and PTEN participate in CHFR mediated mitotic checkpoint. Cell Signal (2013) 0.84
Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach. Virchows Arch (2011) 0.83
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy. J Transl Med (2015) 0.81
The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. Clin Epigenetics (2016) 0.81
Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer. Oncotarget (2015) 0.79
Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem (2013) 0.78
Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast. Mol Biol Cell (2012) 0.76
Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR. Nucleic Acids Res (2017) 0.75
Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nat Commun (2016) 0.75
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76
Genomic instability--an evolving hallmark of cancer. Nat Rev Mol Cell Biol (2010) 7.11
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature (2004) 6.72
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol (2002) 4.45
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat Genet (2011) 3.10
Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science (2013) 1.90
Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J (2009) 1.88
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res (2003) 1.87
53BP1, an activator of ATM in response to DNA damage. DNA Repair (Amst) (2004) 1.84
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol (2004) 1.82
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res (2007) 1.79
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate. Structure (2002) 1.77
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J (2004) 1.63
Oncogene-induced senescence: the bright and dark side of the response. Curr Opin Cell Biol (2010) 1.58
The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. Oncogene (2003) 1.55
Human LATS1 is a mitotic exit network kinase. Cancer Res (2005) 1.50
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. EMBO J (2010) 1.46
An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol Cell Biol (2008) 1.45
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36
Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress. Mol Oncol (2011) 1.26
DNA replication stress as a hallmark of cancer. Annu Rev Pathol (2015) 1.22
A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Res (2012) 1.19
Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells. Nat Commun (2013) 1.17
Valosin-containing protein phosphorylation at Ser784 in response to DNA damage. Cancer Res (2005) 1.16
ATM signaling and 53BP1. Radiother Oncol (2005) 1.15
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis (2003) 1.13
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. EMBO J (2011) 1.10
Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Structure (2003) 1.07
Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction. Acta Crystallogr D Biol Crystallogr (2009) 1.07
Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function. Cancer Res (2007) 1.06
Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. Structure (2004) 1.06
The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation. Carcinogenesis (2012) 0.98
Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Am J Pathol (2009) 0.97
DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken. J Cell Biol (2010) 0.96
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element. Mol Cancer Res (2011) 0.94
Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network. Mol Cancer Res (2007) 0.94
Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer. Cancer Res (2003) 0.93
Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies. Clin Cancer Res (2014) 0.90
p53 and stress in the ER. Genes Dev (2004) 0.89
Microcollimator for micrometer-wide stripe irradiation of cells using 20-30 keV X rays. Radiat Res (2009) 0.86
Nbs1 moving up in the world. Nat Cell Biol (2005) 0.86
Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1. PLoS Genet (2012) 0.83
Population pharmacokinetic analysis from phase I and phase II studies of the humanized monovalent antibody, onartuzumab (MetMAb), in patients with advanced solid tumors. J Clin Pharmacol (2013) 0.82
Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium. DNA Repair (Amst) (2006) 0.81
Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.79
Chk2 leaves the PML depot. Nat Cell Biol (2002) 0.78
Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168. Cell Cycle (2015) 0.76
SAHF, to senesce or not to senesce? Cell Cycle (2011) 0.76