1
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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
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Nature
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2005
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14.65
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2
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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
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Nature
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2006
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11.76
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3
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Genomic instability--an evolving hallmark of cancer.
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Nat Rev Mol Cell Biol
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2010
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7.11
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4
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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.
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Nature
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2004
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6.72
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5
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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.
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Nat Cell Biol
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2002
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4.45
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6
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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.
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Nat Genet
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2011
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3.10
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7
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Break-induced replication repair of damaged forks induces genomic duplications in human cells.
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Science
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2013
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1.90
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8
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Emerging common themes in regulation of PIKKs and PI3Ks.
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EMBO J
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2009
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1.88
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9
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53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
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Cancer Res
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2003
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1.87
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10
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53BP1, an activator of ATM in response to DNA damage.
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DNA Repair (Amst)
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2004
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1.84
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11
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Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
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J Cell Biol
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2004
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1.82
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12
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Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
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Cancer Res
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2007
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1.79
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13
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Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
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Structure
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2002
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1.77
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14
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Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.
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EMBO J
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2004
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1.63
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15
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Oncogene-induced senescence: the bright and dark side of the response.
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Curr Opin Cell Biol
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2010
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1.58
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16
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The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.
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Oncogene
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2003
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1.55
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17
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Human LATS1 is a mitotic exit network kinase.
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Cancer Res
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2005
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1.50
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18
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TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.
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EMBO J
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2010
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1.46
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19
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An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks.
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Mol Cell Biol
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2008
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1.45
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20
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Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
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Nat Cell Biol
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2013
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1.36
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21
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Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress.
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Mol Oncol
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2011
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1.26
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22
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DNA replication stress as a hallmark of cancer.
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Annu Rev Pathol
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2015
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1.22
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23
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The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus.
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Oncogene
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2005
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1.21
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24
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A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.
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Cancer Res
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2012
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1.19
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25
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Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells.
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Nat Commun
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2013
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1.17
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26
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Valosin-containing protein phosphorylation at Ser784 in response to DNA damage.
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Cancer Res
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2005
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1.16
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27
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ATM signaling and 53BP1.
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Radiother Oncol
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2005
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1.15
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28
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Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
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Carcinogenesis
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2003
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1.13
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29
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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
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EMBO J
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2011
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1.10
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30
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Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction.
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Acta Crystallogr D Biol Crystallogr
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2009
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1.07
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31
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Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.
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Cancer Res
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2007
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1.06
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32
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Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.
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Structure
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2004
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1.06
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33
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The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.
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Carcinogenesis
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2012
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0.98
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34
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Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas.
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Am J Pathol
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2009
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0.97
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35
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DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.
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J Cell Biol
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2010
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0.96
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36
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Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element.
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Mol Cancer Res
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2011
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0.94
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37
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Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network.
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Mol Cancer Res
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2007
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0.94
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38
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Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.
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Cancer Res
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2003
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0.93
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39
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p53 and stress in the ER.
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Genes Dev
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2004
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0.89
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40
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Nbs1 moving up in the world.
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Nat Cell Biol
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2005
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0.86
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41
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Microcollimator for micrometer-wide stripe irradiation of cells using 20-30 keV X rays.
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Radiat Res
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2009
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0.86
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42
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Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.
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PLoS Genet
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2012
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0.83
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43
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Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium.
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DNA Repair (Amst)
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2006
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0.81
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44
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Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein.
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Acta Crystallogr Sect F Struct Biol Cryst Commun
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2010
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0.79
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45
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Chk2 leaves the PML depot.
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Nat Cell Biol
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2002
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0.78
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46
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SAHF, to senesce or not to senesce?
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Cell Cycle
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2011
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0.76
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47
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Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168.
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Cell Cycle
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2015
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0.76
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