Thanos D Halazonetis

Author PubWeight™ 96.05‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005 14.65
2 Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006 11.76
3 Genomic instability--an evolving hallmark of cancer. Nat Rev Mol Cell Biol 2010 7.11
4 Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 2004 6.72
5 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol 2002 4.45
6 Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat Genet 2011 3.10
7 Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science 2013 1.90
8 Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J 2009 1.88
9 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res 2003 1.87
10 53BP1, an activator of ATM in response to DNA damage. DNA Repair (Amst) 2004 1.84
11 Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 2004 1.82
12 Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res 2007 1.79
13 Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate. Structure 2002 1.77
14 Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J 2004 1.63
15 Oncogene-induced senescence: the bright and dark side of the response. Curr Opin Cell Biol 2010 1.58
16 The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. Oncogene 2003 1.55
17 Human LATS1 is a mitotic exit network kinase. Cancer Res 2005 1.50
18 TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. EMBO J 2010 1.46
19 An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol Cell Biol 2008 1.45
20 Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol 2013 1.36
21 Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress. Mol Oncol 2011 1.26
22 DNA replication stress as a hallmark of cancer. Annu Rev Pathol 2015 1.22
23 The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus. Oncogene 2005 1.21
24 A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Res 2012 1.19
25 Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells. Nat Commun 2013 1.17
26 Valosin-containing protein phosphorylation at Ser784 in response to DNA damage. Cancer Res 2005 1.16
27 ATM signaling and 53BP1. Radiother Oncol 2005 1.15
28 Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis 2003 1.13
29 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. EMBO J 2011 1.10
30 Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction. Acta Crystallogr D Biol Crystallogr 2009 1.07
31 Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function. Cancer Res 2007 1.06
32 Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. Structure 2004 1.06
33 The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation. Carcinogenesis 2012 0.98
34 Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Am J Pathol 2009 0.97
35 DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken. J Cell Biol 2010 0.96
36 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element. Mol Cancer Res 2011 0.94
37 Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network. Mol Cancer Res 2007 0.94
38 Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer. Cancer Res 2003 0.93
39 p53 and stress in the ER. Genes Dev 2004 0.89
40 Nbs1 moving up in the world. Nat Cell Biol 2005 0.86
41 Microcollimator for micrometer-wide stripe irradiation of cells using 20-30 keV X rays. Radiat Res 2009 0.86
42 Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1. PLoS Genet 2012 0.83
43 Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium. DNA Repair (Amst) 2006 0.81
44 Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.79
45 Chk2 leaves the PML depot. Nat Cell Biol 2002 0.78
46 SAHF, to senesce or not to senesce? Cell Cycle 2011 0.76
47 Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168. Cell Cycle 2015 0.76