Published in Structure on July 01, 2004
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A (2006) 3.35
p63 and p73, the ancestors of p53. Cold Spring Harb Perspect Biol (2010) 2.16
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
The tumor suppressor p53: from structures to drug discovery. Cold Spring Harb Perspect Biol (2010) 1.64
Structural evolution of C-terminal domains in the p53 family. EMBO J (2007) 1.32
The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity. EMBO J (2006) 1.26
Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harb Perspect Biol (2010) 1.19
Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC Genomics (2008) 1.11
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. EMBO J (2011) 1.10
Biochemical and functional evidence of p53 homology is inconsistent with molecular phylogenetics for distant sequences. J Mol Evol (2008) 0.88
CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants. PLoS Genet (2014) 0.87
Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans. Free Radic Biol Med (2014) 0.85
Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics. PLoS One (2013) 0.84
Tracing the protectors path from the germ line to the genome. Proc Natl Acad Sci U S A (2010) 0.84
Structural basis for ASPP2 recognition by the tumor suppressor p73. J Mol Biol (2012) 0.83
Regulation of Fertility by the p53 Family Members. Genes Cancer (2011) 0.82
Structure and stability insights into tumour suppressor p53 evolutionary related proteins. PLoS One (2013) 0.78
An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells. Nucleic Acids Res (2013) 0.78
Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay. PLoS One (2015) 0.76
Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions. Cancer Inform (2016) 0.75
Analysis of the p53/CEP-1 regulated non-coding transcriptome in C. elegans by an NSR-seq strategy. Protein Cell (2014) 0.75
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
Genomic instability--an evolving hallmark of cancer. Nat Rev Mol Cell Biol (2010) 7.11
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature (2004) 6.72
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science (2002) 6.32
Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures. Nature (2008) 5.85
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res (2005) 5.44
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell (2003) 5.31
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell (2005) 4.73
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol (2002) 4.45
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature (2005) 4.08
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol Cell (2007) 3.97
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science (2002) 3.86
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat Genet (2011) 3.10
Structure of the protein phosphatase 2A holoenzyme. Cell (2006) 3.07
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol (2006) 3.00
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature (2007) 2.97
mTOR kinase structure, mechanism and regulation. Nature (2013) 2.80
Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74
Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell (2006) 2.48
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell (2008) 2.47
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev (2002) 2.26
Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54. Nat Struct Mol Biol (2005) 2.25
A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell (2009) 2.24
Making worm guts: the gene regulatory network of the Caenorhabditis elegans endoderm. Dev Biol (2002) 2.24
Structure of a site-2 protease family intramembrane metalloprotease. Science (2007) 2.08
Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Mol Cell (2008) 1.93
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell (2005) 1.90
Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science (2013) 1.90
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell (2006) 1.88
Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J (2009) 1.88
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res (2003) 1.87
53BP1, an activator of ATM in response to DNA damage. DNA Repair (Amst) (2004) 1.84
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol (2004) 1.82
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res (2007) 1.79
Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J (2003) 1.78
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate. Structure (2002) 1.77
The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis. Mol Cell (2003) 1.68
Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell (2008) 1.67
ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans. Curr Biol (2008) 1.64
Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature (2008) 1.64
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J (2004) 1.63
Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62
Oncogene-induced senescence: the bright and dark side of the response. Curr Opin Cell Biol (2010) 1.58
Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Science (2011) 1.58
C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline. Curr Biol (2006) 1.57
The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. Oncogene (2003) 1.55
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev (2010) 1.55
Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev Biol (2005) 1.50
Human LATS1 is a mitotic exit network kinase. Cancer Res (2005) 1.50
The Wnt effector POP-1 and the PAL-1/Caudal homeoprotein collaborate with SKN-1 to activate C. elegans endoderm development. Dev Biol (2005) 1.48
A strategy for antagonizing quorum sensing. Mol Cell (2011) 1.47
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. EMBO J (2010) 1.46
An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol Cell Biol (2008) 1.45
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. Structure (2002) 1.42
Mechanism of procaspase-8 activation by c-FLIPL. Proc Natl Acad Sci U S A (2009) 1.39
Structure and conformational change of a replication protein A heterotrimer bound to ssDNA. Genes Dev (2012) 1.38
Dynamics of a developmental switch: recursive intracellular and intranuclear redistribution of Caenorhabditis elegans POP-1 parallels Wnt-inhibited transcriptional repression. Dev Biol (2002) 1.37
Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat Struct Mol Biol (2009) 1.36
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36
Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proc Natl Acad Sci U S A (2009) 1.30
Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. J Biol Chem (2011) 1.26
The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat Chem Biol (2009) 1.26
Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans. Nature (2003) 1.26
Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress. Mol Oncol (2011) 1.26
Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling. J Biol Chem (2005) 1.25
DNA replication stress as a hallmark of cancer. Annu Rev Pathol (2015) 1.22
The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus. Oncogene (2005) 1.21
A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Res (2012) 1.19
Maternal deployment of the embryonic SKN-1-->MED-1,2 cell specification pathway in C. elegans. Dev Biol (2006) 1.19
Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. Proc Natl Acad Sci U S A (2011) 1.18
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40. Nat Struct Mol Biol (2007) 1.18
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase. Mol Cell (2009) 1.18
Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells. Nat Commun (2013) 1.17
Valosin-containing protein phosphorylation at Ser784 in response to DNA damage. Cancer Res (2005) 1.16
ATM signaling and 53BP1. Radiother Oncol (2005) 1.15
The noncanonical binding site of the MED-1 GATA factor defines differentially regulated target genes in the C. elegans mesendoderm. Dev Cell (2005) 1.14
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis (2003) 1.13
The structural basis for tight control of PP2A methylation and function by LCMT-1. Mol Cell (2011) 1.13
High-level expression and purification of recombinant SCF ubiquitin ligases. Methods Enzymol (2005) 1.11
Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J Biol Chem (2003) 1.11
Caenorhabditis elegans as a model for stem cell biology. Dev Dyn (2010) 1.11
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. EMBO J (2011) 1.10