Published in J Biol Chem on January 27, 2005
Endocytosis and cancer. Cold Spring Harb Perspect Biol (2013) 1.40
Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol Cell Biol (2005) 1.23
Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J (2006) 1.21
Structural implication of splicing stochastics. Nucleic Acids Res (2009) 1.01
The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor. J Neurosci (2010) 0.93
Alternative splicing results in RET isoforms with distinct trafficking properties. Mol Biol Cell (2012) 0.91
Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment. Clin Cancer Res (2014) 0.90
Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2. Clinics (Sao Paulo) (2012) 0.89
CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. J Neurosci (2008) 0.88
Cbl exposes its RING finger. Nat Struct Mol Biol (2012) 0.87
Alternative splicing in oncogenic kinases: from physiological functions to cancer. J Nucleic Acids (2011) 0.83
Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field. Biomark Insights (2007) 0.82
Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. J Biol Chem (2010) 0.82
CD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains. J Biol Chem (2014) 0.80
Extended Synaptotagmin Interaction with the Fibroblast Growth Factor Receptor Depends on Receptor Conformation, Not Catalytic Activity. J Biol Chem (2015) 0.80
Cellular localization of GDNF and its GFRalpha1/RET receptor complex in the developing pancreas of cat. J Anat (2008) 0.79
Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A. PLoS One (2014) 0.78
Genetic and epigenetic factors affect RET gene expression in breast cancer cell lines and influence survival in patients. Oncotarget (2016) 0.76
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell Death Dis (2015) 0.75
The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell (2003) 3.09
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol (2003) 2.47
Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron (2009) 1.96
Target-derived GFRalpha1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of Cdk5. Neuron (2002) 1.92
Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem (2006) 1.72
GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Neuron (2005) 1.40
GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nat Neurosci (2007) 1.33
Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes. Curr Biol (2002) 1.26
Mouse embryonic stem cell-derived spheres with distinct neurogenic potentials. Stem Cells Dev (2008) 1.25
Synergistic interaction between Gdf1 and Nodal during anterior axis development. Dev Biol (2006) 1.24
Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity. Proc Natl Acad Sci U S A (2008) 1.22
Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J (2006) 1.21
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc Natl Acad Sci U S A (2008) 1.16
Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep (2006) 1.13
Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme. Curr Opin Neurobiol (2002) 1.12
Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol (2007) 1.12
Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival. J Biol Chem (2001) 1.11
ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol Cell Biol (2004) 1.06
GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream. Mol Cell Neurosci (2005) 1.00
Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Mol Cell Neurosci (2004) 0.99
Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor. J Cell Sci (2009) 0.99
Assembly and activation of neurotrophic factor receptor complexes. Dev Neurobiol (2010) 0.98
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. J Neurosci (2009) 0.97
Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem (2012) 0.96
Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET. Hum Mol Genet (2003) 0.96
Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET. J Biol Chem (2003) 0.88
Retrograde propagation of GDNF-mediated signals in sympathetic neurons. Mol Cell Neurosci (2004) 0.85
New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain. J Med Chem (2012) 0.84
Functional characterization of mutations in the GDNF gene of patients with Hirschsprung disease. Hum Mol Genet (2002) 0.83
Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor. Cell Rep (2012) 0.83
Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells. FEBS Lett (2005) 0.82
Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides. J Med Chem (2012) 0.82
Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. J Biol Chem (2010) 0.82
Catecholaminergic neuron survival: getting hooked on GDNF. Nat Neurosci (2008) 0.81
Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion. J Biol Chem (2007) 0.81
Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS. J Neurochem (2014) 0.80
Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands. Diabetologia (2013) 0.79
Neuroendocrine control of female reproductive function by the activin receptor ALK7. FASEB J (2012) 0.79
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq. Genome Biol (2014) 0.78
Insights into GFRalpha1 regulation of neural cell adhesion molecule (NCAM) function from structure-function analysis of the NCAM/GFRalpha1 receptor complex. J Biol Chem (2008) 0.78
Population PKPD modeling of BACE1 inhibitor-induced reduction in Aβ levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig. Pharm Res (2013) 0.77
Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production. FEBS J (2014) 0.76
MET signaling in GABAergic neuronal precursors of the medial ganglionic eminence restricts GDNF activity in cells that express GFRα1 and a new transmembrane receptor partner. J Cell Sci (2011) 0.76
Critical role of GFRα1 in the development and function of the main olfactory system. J Neurosci (2012) 0.76