Published in Mol Cell Biol on November 01, 2004
Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity. Proc Natl Acad Sci U S A (2008) 1.22
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc Natl Acad Sci U S A (2008) 1.16
Nodal signaling via an autocrine pathway promotes proliferation of mouse spermatogonial stem/progenitor cells through Smad2/3 and Oct-4 activation. Stem Cells (2009) 1.15
Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep (2006) 1.13
Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction. J Cell Biol (2008) 1.01
Activin B can signal through both ALK4 and ALK7 in gonadotrope cells. Reprod Biol Endocrinol (2006) 1.00
Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Dev Dyn (2008) 0.89
Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex. Mol Endocrinol (2013) 0.85
Activin/Nodal signalling before implantation: setting the stage for embryo patterning. Philos Trans R Soc Lond B Biol Sci (2014) 0.84
Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation. J Biol Chem (2014) 0.82
Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway. Biomed Res Int (2014) 0.80
Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation. Mol Endocrinol (2015) 0.80
Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife (2014) 0.79
Follistatin is critical for mouse uterine receptivity and decidualization. Proc Natl Acad Sci U S A (2017) 0.75
Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature (1996) 3.42
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature (1998) 3.16
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development (1994) 3.12
Nodal signaling in vertebrate development. Annu Rev Cell Dev Biol (2003) 3.09
Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell (2001) 2.58
Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature (1993) 2.45
The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes Dev (2001) 2.17
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev (1997) 2.09
Genetic dissection of nodal function in patterning the mouse embryo. Development (2001) 2.07
Nodal activity in the node governs left-right asymmetry. Genes Dev (2002) 1.95
Activin receptor patterning of foregut organogenesis. Genes Dev (2000) 1.91
Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev (1999) 1.74
Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev (2002) 1.68
The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. Genes Dev (1998) 1.52
The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol (1999) 1.51
A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis. Development (1997) 1.43
A role of the cryptic gene in the correct establishment of the left-right axis. Curr Biol (1999) 1.33
A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system. J Biol Chem (1996) 1.17
The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds. Development (1997) 1.14
Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain. Eur J Biochem (2003) 1.07
The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line. J Biol Chem (2000) 0.93
Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain. Mol Cell Neurosci (1996) 0.91
The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals. Biochem Biophys Res Commun (1999) 0.85
Habrec1, a novel serine/threonine kinase TGF-beta type I-like receptor, has a specific cellular expression suggesting function in the developing organism and adult brain. Exp Neurol (1996) 0.84
The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell (2003) 3.09
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol (2003) 2.47
Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron (2009) 1.96
Target-derived GFRalpha1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of Cdk5. Neuron (2002) 1.92
Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem (2006) 1.72
Relationship between diurnal blood pressure variation and diurnal blood glucose levels in type 2 diabetic patients. Am J Hypertens (2007) 1.52
GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Neuron (2005) 1.40
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol (2012) 1.39
GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nat Neurosci (2007) 1.33
Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes. Curr Biol (2002) 1.26
Mouse embryonic stem cell-derived spheres with distinct neurogenic potentials. Stem Cells Dev (2008) 1.25
Synergistic interaction between Gdf1 and Nodal during anterior axis development. Dev Biol (2006) 1.24
Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity. Proc Natl Acad Sci U S A (2008) 1.22
Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J (2006) 1.21
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc Natl Acad Sci U S A (2008) 1.16
Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep (2006) 1.13
Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme. Curr Opin Neurobiol (2002) 1.12
Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol (2007) 1.12
Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival. J Biol Chem (2001) 1.11
Suppression of Alk8-mediated Bmp signaling cell-autonomously induces pancreatic beta-cells in zebrafish. Proc Natl Acad Sci U S A (2009) 1.10
Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase. J Biol Chem (2005) 1.02
Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction. J Cell Biol (2008) 1.01
GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream. Mol Cell Neurosci (2005) 1.00
Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Mol Cell Neurosci (2004) 0.99
Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor. J Cell Sci (2009) 0.99
Assembly and activation of neurotrophic factor receptor complexes. Dev Neurobiol (2010) 0.98
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. J Neurosci (2009) 0.97
Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET. Hum Mol Genet (2003) 0.96
Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET. J Biol Chem (2003) 0.88
Retrograde propagation of GDNF-mediated signals in sympathetic neurons. Mol Cell Neurosci (2004) 0.85
Functional characterization of mutations in the GDNF gene of patients with Hirschsprung disease. Hum Mol Genet (2002) 0.83
Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor. Cell Rep (2012) 0.83
Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. J Biol Chem (2010) 0.82
Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells. FEBS Lett (2005) 0.82
Catecholaminergic neuron survival: getting hooked on GDNF. Nat Neurosci (2008) 0.81
Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion. J Biol Chem (2007) 0.81
Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands. Diabetologia (2013) 0.79
Neuroendocrine control of female reproductive function by the activin receptor ALK7. FASEB J (2012) 0.79
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq. Genome Biol (2014) 0.78
Insights into GFRalpha1 regulation of neural cell adhesion molecule (NCAM) function from structure-function analysis of the NCAM/GFRalpha1 receptor complex. J Biol Chem (2008) 0.78
MET signaling in GABAergic neuronal precursors of the medial ganglionic eminence restricts GDNF activity in cells that express GFRα1 and a new transmembrane receptor partner. J Cell Sci (2011) 0.76
Critical role of GFRα1 in the development and function of the main olfactory system. J Neurosci (2012) 0.76