Published in J Biol Chem on January 31, 2005
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. Antimicrob Agents Chemother (2010) 1.49
Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni. J Bacteriol (2007) 1.07
Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori. FEBS J (2009) 1.01
NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel. Antimicrob Agents Chemother (2012) 0.93
Characterization of a pseudomonad 2-nitrobenzoate nitroreductase and its catabolic pathway-associated 2-hydroxylaminobenzoate mutase and a chemoreceptor involved in 2-nitrobenzoate chemotaxis. J Bacteriol (2007) 0.92
Enzymatic activation of nitro-aryl fluorogens in live bacterial cells for enzymatic turnover-activated localization microscopy† Chem Sci (2013) 0.91
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. Antimicrob Agents Chemother (2012) 0.87
E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954. Br J Cancer (2009) 0.87
Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruzi. Parasit Vectors (2011) 0.82
Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase. J Am Chem Soc (2015) 0.79
Escherichia coli YafP protein modulates DNA damaging property of the nitroaromatic compounds. Nucleic Acids Res (2011) 0.78
Understanding the broad substrate repertoire of nitroreductase based on its kinetic mechanism. J Biol Chem (2014) 0.77
Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci Rep (2011) 0.77
Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae. BMC Microbiol (2009) 0.76
Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme. Mem Inst Oswaldo Cruz (2014) 0.76
"On demand" redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor. Chem Sci (2017) 0.75
Empirical power laws for the radii of gyration of protein oligomers. Acta Crystallogr D Struct Biol (2016) 0.75
Azoreductases in drug metabolism. Br J Pharmacol (2016) 0.75
Crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae. Protein Sci (2015) 0.75
Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole. Nitric Oxide (2016) 0.75
Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. PLoS One (2017) 0.75
Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase. Structure (2017) 0.75
Molecular modeling study on the disassembly of dendrimers designed as potential antichagasic and antileishmanial prodrugs. J Mol Model (2011) 0.75
Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol (2010) 4.23
The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol (2004) 2.96
Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res (2008) 2.21
Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol (2004) 2.10
Response of key soil parameters during compost-assisted phytostabilization in extremely acidic tailings: effect of plant species. Environ Sci Technol (2012) 2.05
Massive and submassive pulmonary embolism: experience with an algorithm for catheter-directed mechanical thrombectomy. Ann Vasc Surg (2011) 1.98
Beta-lactam antibiotic resistance: a current structural perspective. Curr Opin Microbiol (2005) 1.89
Viral gene therapy strategies: from basic science to clinical application. J Pathol (2006) 1.88
Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. Am J Physiol Gastrointest Liver Physiol (2004) 1.86
Percutaneous angioplasty and stenting of the superficial femoral artery. J Vasc Surg (2005) 1.77
Carotid artery stenting in elderly patients: importance of case selection. Catheter Cardiovasc Interv (2008) 1.61
Hemodynamic benefits of regional anesthesia for carotid endarterectomy. J Vasc Surg (2002) 1.61
Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer. J Clin Oncol (2004) 1.54
International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors. Neuro Oncol (2011) 1.53
One-year clinical outcomes, midterm survival, and predictors of mortality after carotid stenting in elderly patients. Circulation (2009) 1.50
Standards of practice: carotid angioplasty and stenting. J Vasc Surg (2004) 1.49
Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res (2004) 1.40
Endoleak management following endovascular aneurysm repair. J Vasc Interv Radiol (2008) 1.36
Vectors based on reducible polycations facilitate intracellular release of nucleic acids. J Gene Med (2003) 1.30
Structural and biochemical identification of a novel bacterial oxidoreductase. J Biol Chem (2004) 1.30
Safety of anticoagulation use and bevacizumab in patients with glioma. Neuro Oncol (2008) 1.25
Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. J Hepatol (2004) 1.19
A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984]. Mol Ther (2009) 1.16
Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. J Biol Chem (2003) 1.15
An oncolytic adenovirus vector combining enhanced cell-to-cell spreading, mediated by the ADP cytolytic protein, with selective replication in cancer cells with deregulated wnt signaling. Cancer Res (2004) 1.12
Pentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial. Ann Hepatol (2011) 1.11
Rosette-forming glioneuronal tumor: a pineal region case with IDH1 and IDH2 mutation analyses and literature review of 43 cases. J Neurooncol (2010) 1.11
Correlating carotid artery stenosis detected by panoramic radiography with clinically relevant carotid artery stenosis determined by duplex ultrasound. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2002) 1.09
Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis. Liver Int (2006) 1.07
Rotational muscle flap closure for acute groin wound infections following vascular surgery. Ann Vasc Surg (2004) 1.06
Changes in lead and zinc lability during weathering-induced acidification of desert mine tailings: Coupling chemical and micro-scale analyses. Appl Geochem (2009) 1.05
The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis. Mutat Res (2008) 1.04
Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. PLoS One (2009) 1.03
Transcription activation at the Escherichia coli melAB promoter: interactions of MelR with its DNA target site and with domain 4 of the RNA polymerase sigma subunit. Mol Microbiol (2004) 1.03
Minimal RB-responsive E1A promoter modification to attain potency, selectivity, and transgene-arming capacity in oncolytic adenoviruses. Mol Ther (2010) 1.02
Internal carotid artery pseudoaneurysms: treatment with the Wallgraft endoprosthesis. J Endovasc Ther (2003) 1.01
NASH--hepatic metabolism and not simply the metabolic syndrome. Hepatology (2003) 1.01
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis. Hepatology (2011) 1.00
Nitroreductase: a prodrug-activating enzyme for cancer gene therapy. Clin Exp Pharmacol Physiol (2004) 0.99
Binding of the Escherichia coli MelR protein to the melAB promoter: orientation of MelR subunits and investigation of MelR-DNA contacts. Mol Microbiol (2003) 0.99
The crystal structure of the cytosolic exopolyphosphatase from Saccharomyces cerevisiae reveals the basis for substrate specificity. J Mol Biol (2007) 0.99
Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol. J Biol Chem (2004) 0.97
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis. J Biol Chem (2009) 0.96
Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954. J Mol Biol (2007) 0.96
DNA binding of the transcription activator protein MelR from Escherichia coli and its C-terminal domain. Nucleic Acids Res (2002) 0.95
Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954. Cancer Res (2003) 0.94
A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice. J Lipid Res (2010) 0.94
Optimal operative strategies in repair of juxtarenal abdominal aortic aneurysms. Ann Vasc Surg (2003) 0.93
Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells. Int Immunol (2007) 0.93
Initial treatment patterns over time for anaplastic oligodendroglial tumors. Neuro Oncol (2012) 0.92
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase. Glycobiology (2010) 0.92
Differential specific radiation damage in the Cu II-bound and Pd II-bound forms of an alpha-helical foldamer: a case study of crystallographic phasing by RIP and SAD. Acta Crystallogr D Biol Crystallogr (2008) 0.91
Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs. Bioorg Med Chem Lett (2011) 0.91
The unfolded protein response in fatty liver disease. Semin Liver Dis (2013) 0.91
Accelerated weathering of biosolid-amended copper mine tailings. J Environ Qual (2005) 0.90
Dimerization and DNA-dependent aggregation of the Escherichia coli nucleoid protein and chaperone CbpA. Mol Microbiol (2010) 0.90
Specialized peptidoglycan hydrolases sculpt the intra-bacterial niche of predatory Bdellovibrio and increase population fitness. PLoS Pathog (2012) 0.90
Technical considerations for late removal of aortic endografts. J Vasc Surg (2002) 0.89
Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling. PLoS One (2013) 0.89
Hemodynamics of distal revascularization-interval ligation. Ann Vasc Surg (2005) 0.89
4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol (2009) 0.89
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Microbiology (2010) 0.89
Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet. Am J Physiol Gastrointest Liver Physiol (2005) 0.88
Kinetic and mutational analyses of the major cytosolic exopolyphosphatase from Saccharomyces cerevisiae. J Biol Chem (2007) 0.88
Management of complex groin wounds: preferred use of the rectus femoris muscle flap. Plast Reconstr Surg (2005) 0.88
Use of computer simulation for determining endovascular skill levels in a carotid stenting model. J Vasc Surg (2004) 0.88
Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells. DNA Repair (Amst) (2009) 0.87
Transcription activation at the Escherichia coli melAB promoter: interactions of MelR with the C-terminal domain of the RNA polymerase alpha subunit. Mol Microbiol (2004) 0.87
Secondary structure and DNA binding by the C-terminal domain of the transcriptional activator NifA from Klebsiella pneumoniae. Nucleic Acids Res (2002) 0.87
X-ray structure of methanol dehydrogenase from Paracoccus denitrificans and molecular modeling of its interactions with cytochrome c-551i. J Biol Inorg Chem (2003) 0.87
Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Am J Physiol Gastrointest Liver Physiol (2009) 0.86
Atraumatic subclavian vein thrombosis in a collegiate baseball player: a case report. J Athl Train (2006) 0.85
Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones. Mamm Genome (2005) 0.85
A single aromatic residue in transcriptional repressor protein KorA is critical for cooperativity with its co-regulator KorB. Mol Microbiol (2008) 0.85
Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954. Biochemistry (2009) 0.85
Endovascular management of central venous stenoses in the hemodialysis patient: results of percutaneous therapy. Vasc Endovascular Surg (2004) 0.84
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. J Hepatol (2005) 0.84
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. Am J Physiol Gastrointest Liver Physiol (2012) 0.84
The homodimeric GBS1074 from Streptococcus agalactiae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.84
The alternating site, binding change mechanism for proton translocation by transhydrogenase. Biochemistry (2002) 0.84
Free-tissue transfer in patients with peripheral vascular disease: a 10-year experience. Plast Reconstr Surg (2002) 0.83
Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2. ACS Chem Biol (2013) 0.83
Long-term proliferation of functional human NK cells, with conversion of CD56(dim) NK cells to a CD56 (bright) phenotype, induced by carcinoma cells co-expressing 4-1BBL and IL-12. Cancer Immunol Immunother (2011) 0.83
Percutaneous therapy for renal artery fibromuscular dysplasia. Ann Vasc Surg (2003) 0.83
Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression. Mutagenesis (2007) 0.82
Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy. J Med Chem (2003) 0.82