|
1
|
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.
|
J Cell Biol
|
2005
|
9.25
|
|
2
|
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
|
Science
|
2005
|
7.98
|
|
3
|
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
|
Proc Natl Acad Sci U S A
|
2001
|
5.59
|
|
4
|
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
|
J Clin Invest
|
2008
|
4.30
|
|
5
|
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.
|
EMBO J
|
2005
|
3.79
|
|
6
|
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.
|
EMBO J
|
2004
|
3.77
|
|
7
|
The unfolded protein response in nutrient sensing and differentiation.
|
Nat Rev Mol Cell Biol
|
2002
|
3.56
|
|
8
|
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
|
Cell Metab
|
2009
|
3.28
|
|
9
|
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.
|
J Clin Invest
|
2005
|
3.16
|
|
10
|
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.
|
Mol Cell Biol
|
2003
|
3.01
|
|
11
|
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2.
|
Mol Cell Biol
|
2004
|
3.00
|
|
12
|
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.
|
J Biol Chem
|
2005
|
2.85
|
|
13
|
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.
|
Cell
|
2003
|
2.50
|
|
14
|
Activation of GCN2 in UV-irradiated cells inhibits translation.
|
Curr Biol
|
2002
|
2.02
|
|
15
|
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.
|
Proc Natl Acad Sci U S A
|
2009
|
1.68
|
|
16
|
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.
|
Cell Host Microbe
|
2010
|
1.56
|
|
17
|
Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis.
|
J Biol Chem
|
2004
|
1.36
|
|
18
|
eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.
|
J Biol Chem
|
2010
|
1.28
|
|
19
|
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.
|
Mol Biol Cell
|
2010
|
1.25
|
|
20
|
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression.
|
Cell Metab
|
2005
|
1.23
|
|
21
|
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
|
Sci Signal
|
2009
|
1.11
|
|
22
|
Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.
|
Mol Cell Biol
|
2009
|
1.10
|
|
23
|
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.
|
Endocrinology
|
2006
|
1.07
|
|
24
|
In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation.
|
J Virol
|
2003
|
0.89
|
|
25
|
Novel function of PERK as a mediator of force-induced apoptosis.
|
J Biol Chem
|
2008
|
0.88
|