Published in J Clin Invest on February 01, 2005
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52
Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest (2005) 8.45
The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol (2007) 5.59
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol (2008) 4.10
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J (2005) 3.92
Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol (2006) 3.31
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene (2012) 2.82
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab (2009) 2.52
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell (2009) 2.47
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A (2012) 2.45
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet (2005) 2.33
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J (2011) 2.08
gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A (2009) 2.00
Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress. Mol Biol Cell (2006) 1.94
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. Cell Metab (2012) 1.90
Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol (2011) 1.80
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab (2008) 1.75
Reovirus induces and benefits from an integrated cellular stress response. J Virol (2006) 1.74
Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One (2010) 1.52
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal (2010) 1.52
Protein homeostasis in models of aging and age-related conformational disease. Adv Exp Med Biol (2010) 1.48
Unfolded protein response signaling and metabolic diseases. J Biol Chem (2013) 1.48
Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK. Blood (2014) 1.45
Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. EMBO J (2008) 1.41
Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response. PLoS One (2010) 1.41
The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells. Mol Immunol (2007) 1.39
Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature (2016) 1.37
Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL. Blood (2005) 1.34
Identification of a consensus element recognized and cleaved by IRE1 alpha. Nucleic Acids Res (2010) 1.32
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. J Exp Med (2012) 1.30
A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress. PLoS One (2010) 1.29
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo. Methods Enzymol (2008) 1.28
CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells. Mol Immunol (2009) 1.26
Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol Life Sci (2009) 1.24
HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. PLoS One (2008) 1.23
Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell (2014) 1.23
IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level. PLoS One (2010) 1.21
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. EMBO J (2012) 1.17
Emerging roles for XBP1, a sUPeR transcription factor. Gene Expr (2010) 1.17
Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response. Cell Stress Chaperones (2009) 1.16
IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin. Mol Biol Cell (2012) 1.15
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J (2013) 1.15
Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells. Clin Cancer Res (2010) 1.14
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol (2009) 1.11
Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation. J Leukoc Biol (2013) 1.10
Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem (2012) 1.10
Druggable sensors of the unfolded protein response. Nat Chem Biol (2014) 1.09
Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection. J Immunol (2008) 1.08
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis. Ann N Y Acad Sci (2009) 1.08
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLoS One (2011) 1.07
The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathol (2015) 1.05
Endoplasmic reticulum stress in the kidney. Clin Exp Nephrol (2008) 1.04
SUMO modification regulates the transcriptional activity of XBP1. Biochem J (2010) 1.03
Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? Exp Diabetes Res (2012) 1.02
Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma. Leukemia (2011) 1.01
Negative feedback by IRE1β optimizes mucin production in goblet cells. Proc Natl Acad Sci U S A (2013) 1.00
Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2014) 0.95
ER stress: Autophagy induction, inhibition and selection. Autophagy (2015) 0.95
Detecting and quantitating physiological endoplasmic reticulum stress. Methods Enzymol (2011) 0.93
Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA. J Biol Chem (2008) 0.91
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences. Front Genet (2013) 0.90
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol (2011) 0.89
Stress, genomic adaptation, and the evolutionary trade-off. Front Genet (2014) 0.89
The role of endoplasmic reticulum stress in maintaining and targeting multiple myeloma: a double-edged sword of adaptation and apoptosis. Front Genet (2013) 0.89
Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response. J Biol Chem (2010) 0.88
Novel function of PERK as a mediator of force-induced apoptosis. J Biol Chem (2008) 0.88
Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells. Cancer Res (2016) 0.87
The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells. Mol Immunol (2012) 0.87
The unfolded protein response in immunity and inflammation. Nat Rev Immunol (2016) 0.86
Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells. Exp Mol Med (2009) 0.86
Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint. J Immunol (2015) 0.86
The role of endoplasmic reticulum stress in autoimmune-mediated beta-cell destruction in type 1 diabetes. Exp Diabetes Res (2012) 0.85
ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. BMC Cancer (2012) 0.83
Endoplasmic reticulum quality control in cancer: Friend or foe. Semin Cancer Biol (2015) 0.83
Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity. Int Rev Cell Mol Biol (2015) 0.83
GNRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line. Mol Endocrinol (2008) 0.82
The case for therapeutic proteostasis modulators. Expert Opin Ther Targets (2011) 0.82
The role of the unfolded protein response in diabetes mellitus. Semin Immunopathol (2013) 0.81
In vitro replication phenotype of a novel (-1G) hepatitis B virus variant associated with HIV co-infection. J Med Virol (2012) 0.81
Translational control of gene expression in the gonadotrope. Mol Cell Endocrinol (2013) 0.80
UPR-Mediated Membrane Biogenesis in B Cells. Biochem Res Int (2011) 0.80
IRE1α is essential for Xenopus pancreas development. J Biomed Res (2013) 0.78
Engineering of chaperone systems and of the unfolded protein response. Cytotechnology (2008) 0.78
The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production. MBio (2015) 0.78
Target identification of grape seed extract in colorectal cancer using drug affinity responsive target stability (DARTS) technique: role of endoplasmic reticulum stress response proteins. Curr Cancer Drug Targets (2014) 0.78
Birth pangs: the stressful origins of lymphocytes. J Clin Invest (2005) 0.78
Inositol-requiring enzyme 1α is required for gut development in Xenopus lavies embryos. World J Gastroenterol (2013) 0.77
Synthetic embryonic lethality upon deletion of the ER cochaperone p58(IPK) and the ER stress sensor ATF6α. Biochem Biophys Res Commun (2013) 0.76
The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development. Cell Rep (2016) 0.76
IRE1α knockdown rescues tunicamycin-induced developmental defects and apoptosis in Xenopus laevis. J Biomed Res (2014) 0.75
Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies. Environ Dis (2016) 0.75
Ire1 supports normal ER differentiation in developing Drosophila photoreceptors. J Cell Sci (2016) 0.75
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell (1992) 17.50
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52
A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev (1999) 13.24
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62
Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell (2001) 11.21
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell (1993) 9.84
Plasma cell differentiation requires the transcription factor XBP-1. Nature (2001) 9.72
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (1990) 9.33
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell (2000) 9.13
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell (1999) 9.05
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell (1996) 8.17
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell (2002) 6.95
B cell development pathways. Annu Rev Immunol (2001) 6.94
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell (1993) 6.82
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol (2002) 6.48
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev (2002) 6.37
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity (1997) 6.15
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A (2002) 6.09
Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J (1998) 5.96
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev (1998) 5.88
Definitive hematopoiesis is autonomously initiated by the AGM region. Cell (1996) 5.75
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell (1980) 5.59
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J (1996) 5.46
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell (2001) 5.39
Generation of high-titer pseudotyped retroviral vectors with very broad host range. Methods Cell Biol (1994) 5.17
A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell (2003) 4.99
Development of hematopoietic stem cell activity in the mouse embryo. Immunity (1994) 3.91
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem (2003) 3.89
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A (1993) 3.65
Quality control in the endoplasmic reticulum protein factory. Nature (2003) 3.58
The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med (1993) 3.57
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science (2003) 3.48
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem (2000) 3.40
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin. Science (2003) 3.28
Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol Biol Cell (1997) 2.91
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J Exp Med (1991) 2.88
Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science (1993) 2.80
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev (2000) 2.72
Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity (2003) 2.40
IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae. Mol Microbiol (1992) 2.38
Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J Biol Chem (2002) 2.38
The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation. J Biol Chem (1996) 2.36
Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity (1999) 2.35
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev (2003) 2.20
Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo. Immunity (1996) 2.08
Antibody regulation of B cell development. Nat Immunol (2000) 2.00
A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J Exp Med (1996) 1.86
Plasma cells: finding new light at the end of B cell development. Nat Immunol (2001) 1.74
B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames. Cell (1991) 1.63
Transcription factors in lymphocyte development--T and B cells get together. Cell (1999) 1.41
Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p. Proc Natl Acad Sci U S A (1997) 1.28
In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region. Immunity (1998) 1.16
Gene rearrangement and B-cell development. Curr Opin Immunol (1993) 1.14
Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes. Proc Natl Acad Sci U S A (1990) 1.06
Expression of CD43 on murine and human pluripotent hematopoietic stem cells. J Immunol (1994) 1.04
Differential surrogate light chain expression governs B-cell differentiation. Blood (2002) 1.03
The stressful road to antibody secretion. Nat Immunol (2003) 0.98
PCR screening of transgenic RAG-2 "knockout" immunodeficient mice. Biotechniques (1995) 0.93
Transcriptional regulation of early B-lymphocyte differentiation. Immunol Rev (2000) 0.92
The mammalian unfolded protein response. Annu Rev Biochem (2005) 16.31
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol (2005) 9.25
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
A trip to the ER: coping with stress. Trends Cell Biol (2004) 7.67
From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 6.45
ER stress and the unfolded protein response. Mutat Res (2005) 6.43
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev (2002) 6.37
The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol (2007) 5.59
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A (2001) 5.59
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal (2007) 5.17
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell (2006) 5.10
A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell (2003) 4.99
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol (2003) 4.77
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell (2007) 4.39
The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem (2003) 3.89
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol (2013) 3.84
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J (2004) 3.77
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci U S A (2008) 3.58
The unfolded protein response in nutrient sensing and differentiation. Nat Rev Mol Cell Biol (2002) 3.56
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology (2006) 3.46
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol (2006) 3.31
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab (2009) 3.28
That which does not kill me makes me stronger: adapting to chronic ER stress. Trends Biochem Sci (2007) 3.20
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature (2004) 3.18
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol (2003) 3.01
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A (2006) 2.90
Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem (2004) 2.87
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem (2005) 2.85
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. Mol Biol Cell (2006) 2.84
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med (2005) 2.83
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J Cell Biol (2006) 2.76
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem (2004) 2.62
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol (2006) 2.58
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell (2003) 2.50
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J (2006) 2.41
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet (2005) 2.33
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem (2004) 2.29
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell (2005) 2.27
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods (2005) 2.25
The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell (2007) 2.20
PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis (2012) 2.20
ER stress controls iron metabolism through induction of hepcidin. Science (2009) 2.18
Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem (2012) 2.10
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J (2011) 2.08
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem (2008) 1.89
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nat Genet (2003) 1.82
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A (2009) 1.78
Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem (2006) 1.78
Bioengineering of coagulation factor VIII for improved secretion. Blood (2004) 1.76
Inhibition of the ubiquitin-proteasome system induces stress granule formation. Mol Biol Cell (2007) 1.75
Reovirus induces and benefits from an integrated cellular stress response. J Virol (2006) 1.74
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci U S A (2009) 1.68
The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum. J Chem Neuroanat (2004) 1.63
The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J Biol Chem (2002) 1.63
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem (2003) 1.61
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J Cell Sci (2009) 1.57
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metab (2012) 1.56
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe (2010) 1.56
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem (2006) 1.53
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal (2010) 1.52
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. J Biol Chem (2006) 1.52
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
Divergent roles of IRE1alpha and PERK in the unfolded protein response. Curr Mol Med (2006) 1.50
Uncoupling stress granule assembly and translation initiation inhibition. Mol Biol Cell (2009) 1.49
Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity. Blood (2012) 1.49