Published in Am J Med Genet B Neuropsychiatr Genet on January 05, 2005
Genome-wide scan of copy number variation in late-onset Alzheimer's disease. J Alzheimers Dis (2010) 1.35
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. Pharmacol Rev (2009) 1.24
Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease. Neurobiol Aging (2005) 0.90
Involvement of ATP-binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease. Biomed Rep (2013) 0.79
Butyrylcholinesterase K variant and Alzheimer's disease risk: a meta-analysis. Med Sci Monit (2015) 0.78
Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer's Disease: A Meta-Analysis. Biomed Res Int (2016) 0.77
CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking. Sci Rep (2016) 0.76
Polymorphisms of CHAT but not TFAM or VR22 are Associated with Alzheimer Disease Risk. Med Sci Monit (2016) 0.75
Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer's Disease Risk: A Meta-Analysis. PLoS One (2016) 0.75
Identifying genetic variants for heart rate variability in the acetylcholine pathway. PLoS One (2014) 0.75
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 41.47
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 26.95
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med (2002) 24.07
Global prevalence of dementia: a Delphi consensus study. Lancet (2005) 23.30
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med (2012) 14.14
Empirical studies assessing the quality of health information for consumers on the world wide web: a systematic review. JAMA (2002) 13.61
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med (2004) 12.20
TREM2 variants in Alzheimer's disease. N Engl J Med (2012) 11.35
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature (2010) 8.78
A loss-of-function RNA interference screen for molecular targets in cancer. Nature (2006) 8.11
Health related virtual communities and electronic support groups: systematic review of the effects of online peer to peer interactions. BMJ (2004) 7.92
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Oncogenically active MYD88 mutations in human lymphoma. Nature (2010) 7.34
Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol (2006) 6.97
Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol (2007) 6.58
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56
Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol (2010) 6.41
Age, neuropathology, and dementia. N Engl J Med (2009) 6.36
Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35
IRF4 addiction in multiple myeloma. Nature (2008) 6.27
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell (2003) 6.11
UK health performance: findings of the Global Burden of Disease Study 2010. Lancet (2013) 6.11
Molecular diagnosis of Burkitt's lymphoma. N Engl J Med (2006) 6.10
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med (2003) 6.06
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol (2011) 6.00
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci U S A (2008) 5.90
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78
Why are health care interventions delivered over the internet? A systematic review of the published literature. J Med Internet Res (2006) 5.72
TDP-43 A315T mutation in familial motor neuron disease. Ann Neurol (2008) 5.58
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem (2006) 5.39
Alzheimer's disease. Lancet (2011) 5.35
Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med (2013) 5.29
Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol (2005) 5.21
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement (2012) 5.10
Protective variant for hippocampal atrophy identified by whole exome sequencing. Ann Neurol (2015) 5.10
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol (2007) 5.09
Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol (2011) 4.96
Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med (2011) 4.93
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol (2009) 4.73
Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol (2008) 4.73
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell (2009) 4.47
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature (2012) 4.33
In search of an "autophagomometer". Autophagy (2009) 4.31
The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement (2011) 4.25
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A (2009) 4.18
Epidemiology of Alzheimer disease. Nat Rev Neurol (2011) 4.13
The developmental dynamics of the maize leaf transcriptome. Nat Genet (2010) 4.02
Prevalence of autism-spectrum conditions: UK school-based population study. Br J Psychiatry (2009) 3.97
Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis. BMJ (2013) 3.93
The Alzheimer's disease neuroimaging initiative: progress report and future plans. Alzheimers Dement (2010) 3.85
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol (2012) 3.77
Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol (2014) 3.75
α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol (2010) 3.67
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
A library of gene expression signatures to illuminate normal and pathological lymphoid biology. Immunol Rev (2006) 3.49
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study. Lancet Neurol (2013) 3.46
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet (2005) 3.39
A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.38
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol (2012) 3.31
Conceptual framework for personal recovery in mental health: systematic review and narrative synthesis. Br J Psychiatry (2011) 3.29
A block of autophagy in lysosomal storage disorders. Hum Mol Genet (2007) 3.28
White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke (2006) 3.27
Reference genome sequence of the model plant Setaria. Nat Biotechnol (2012) 3.21
The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic (2008) 3.18
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive data. BMC Psychiatry (2009) 3.15
Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. Blood (2005) 3.12