Published in N Engl J Med on May 28, 2009
Longitudinal Early-onset Alzheimer's Disease Study Protocol (LEADS) | NCT03507257
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol (2010) 19.42
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Hearing loss and incident dementia. Arch Neurol (2011) 4.65
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Amyloid-β associated cortical thinning in clinically normal elderly. Ann Neurol (2011) 2.57
The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis (2009) 2.54
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The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol (2010) 2.31
The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain (2010) 2.29
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Dementia from Alzheimer disease and mixed pathologies in the oldest old. JAMA (2012) 1.40
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The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta (2013) 1.34
Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment. Neuroimage (2011) 1.34
Age and diagnostic performance of Alzheimer disease CSF biomarkers. Neurology (2012) 1.31
A population-based clinicopathological study in the oldest-old: the 90+ study. Curr Alzheimer Res (2012) 1.31
Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment. Neuroimage (2011) 1.30
Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. Brain (2011) 1.29
Type 2 diabetes and cognitive impairment: linking mechanisms. J Alzheimers Dis (2012) 1.28
Aβ Deposition in aging is associated with increases in brain activation during successful memory encoding. Cereb Cortex (2011) 1.26
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The aging brain and cognition: contribution of vascular injury and aβ to mild cognitive dysfunction. JAMA Neurol (2013) 1.25
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The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects. Cereb Cortex (2011) 1.23
Cognitive reserve, presynaptic proteins and dementia in the elderly. Transl Psychiatry (2012) 1.22
Vascular risk factors: imaging and neuropathologic correlates. J Alzheimers Dis (2010) 1.22
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J Neural Transm (Vienna) (2009) 1.22
Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimers Dement (2011) 1.19
Cognition, glucose metabolism and amyloid burden in Alzheimer's disease. Neurobiol Aging (2010) 1.19
Improved DTI registration allows voxel-based analysis that outperforms tract-based spatial statistics. Neuroimage (2014) 1.19
Developmental aspects of the intracerebral microvasculature and perivascular spaces: insights into brain response to late-life diseases. J Neuropathol Exp Neurol (2011) 1.17
Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches. Neuroimage (2013) 1.17
In vivo assessment of amyloid-β deposition in nondemented very elderly subjects. Ann Neurol (2013) 1.17
Neuropathologic features associated with Alzheimer disease diagnosis: age matters. Neurology (2011) 1.15
Ischemic stroke in the elderly: an overview of evidence. Nat Rev Neurol (2010) 1.15
Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes? J Int Neuropsychol Soc (2013) 1.14
Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals. PLoS One (2009) 1.12
Alzheimer disease pathology and longitudinal cognitive performance in the oldest-old with no dementia. Neurology (2012) 1.12
Prevalence of mixed pathologies in the aging brain. Alzheimers Res Ther (2014) 1.11
Suspected non-Alzheimer disease pathophysiology - concept and controversy. Nat Rev Neurol (2016) 1.10
Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology (2014) 1.10
Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques. Neurology (2010) 1.07
Update on the pharmacological treatment of Alzheimer's disease. Curr Neuropharmacol (2010) 1.07
Rates of decline in Alzheimer disease decrease with age. PLoS One (2012) 1.07
Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications. Alzheimers Res Ther (2011) 1.07
Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study. Neurology (2015) 1.05
The MAPT H1 haplotype is associated with tangle-predominant dementia. Acta Neuropathol (2012) 1.05
Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease. Neurobiol Aging (2012) 1.04
Effects of age on the glucose metabolic changes in mild cognitive impairment. AJNR Am J Neuroradiol (2010) 1.04
Treatment of cardiovascular risk factors to prevent cognitive decline and dementia: a systematic review. Vasc Health Risk Manag (2010) 1.04
Selected findings from the Religious Orders Study and Rush Memory and Aging Project. J Alzheimers Dis (2013) 1.03
Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease. Ann Neurol (2015) 1.03
Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease. Neuroimage Clin (2013) 1.02
Conceptual evolution in Alzheimer's disease: implications for understanding the clinical phenotype of progressive neurodegenerative disease. J Alzheimers Dis (2010) 1.02
The Framingham Brain Donation Program: neuropathology along the cognitive continuum. Curr Alzheimer Res (2012) 1.02
Disentangling the effects of age and APOE on neuropathology and late life cognitive decline. Neurobiol Aging (2013) 1.00
Deconstructing mitochondrial dysfunction in Alzheimer disease. Oxid Med Cell Longev (2013) 0.99
Alzheimer disease pathology in subjects without dementia in 2 studies of aging: the Nun Study and the Adult Changes in Thought Study. J Neuropathol Exp Neurol (2011) 0.99
Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Sci Rep (2011) 0.99
BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease. PLoS One (2013) 0.98
Integrative Understanding of Emergent Brain Properties, Quantum Brain Hypotheses, and Connectome Alterations in Dementia are Key Challenges to Conquer Alzheimer's Disease. Front Neurol (2010) 0.96
The influence of multimorbidity on clinical progression of dementia in a population-based cohort. PLoS One (2013) 0.95
Interactive effects of vascular risk burden and advanced age on cerebral blood flow. Front Aging Neurosci (2014) 0.95
Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults. Neurobiol Aging (2013) 0.94
Cool with plaques and tangles. N Engl J Med (2009) 0.93
Cerebral amyloid PET imaging in Alzheimer's disease. Acta Neuropathol (2013) 0.93
Diagnosing dementia in the oldest-old. Maturitas (2011) 0.93
Resilient brain aging: characterization of discordance between Alzheimer's disease pathology and cognition. Curr Alzheimer Res (2013) 0.93
MRI parcellation of ex vivo medial temporal lobe. Neuroimage (2013) 0.93
Current application of neurochemical biomarkers in the prediction and differential diagnosis of Alzheimer's disease and other neurodegenerative dementias. Eur Arch Psychiatry Clin Neurosci (2012) 0.93
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 41.47
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 26.95
Global prevalence of dementia: a Delphi consensus study. Lancet (2005) 23.30
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol (2007) 8.10
The cervical cancer epidemic that screening has prevented in the UK. Lancet (2004) 7.72
Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol (2006) 6.97
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol (2007) 6.58
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
UK health performance: findings of the Global Burden of Disease Study 2010. Lancet (2013) 6.11
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
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Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol (2009) 4.73
Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol (2008) 4.73
Epidemiology of Alzheimer disease. Nat Rev Neurol (2011) 4.13
Prevalence of autism-spectrum conditions: UK school-based population study. Br J Psychiatry (2009) 3.97
Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis. BMJ (2013) 3.93
White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke (2006) 3.27
A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies. J Clin Epidemiol (2005) 3.04
Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up. BMJ (2008) 3.03
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort. Brain (2009) 3.03
Anticholinergic medication use and cognitive impairment in the older population: the medical research council cognitive function and ageing study. J Am Geriatr Soc (2011) 2.88
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Hum Mol Genet (2007) 2.73
A systematic review of prevalence studies of dementia in Parkinson's disease. Mov Disord (2005) 2.70
Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study. Brain (2012) 2.64
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One (2010) 2.57
Controversies and priorities in amyotrophic lateral sclerosis. Lancet Neurol (2013) 2.52
The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain (2010) 2.29
Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72. Brain (2012) 2.28
Analysis of longitudinal studies with death and drop-out: a case study. Stat Med (2004) 2.24
Inability to get up after falling, subsequent time on floor, and summoning help: prospective cohort study in people over 90. BMJ (2008) 2.23
The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort. J Neurol Neurosurg Psychiatry (2013) 2.20
The natural history of treated Parkinson's disease in an incident, community based cohort. J Neurol Neurosurg Psychiatry (2011) 2.08
The burden of diseases on disability-free life expectancy in later life. J Gerontol A Biol Sci Med Sci (2007) 1.98
Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation. BMC Public Health (2004) 1.97
What sleep characteristics predict cognitive decline in the elderly? Sleep Med (2012) 1.96
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clin Cancer Res (2005) 1.95
Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls. Arch Intern Med (2006) 1.94
Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry (2009) 1.91
Trachoma survey methods: a literature review. Bull World Health Organ (2009) 1.90
Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement. BMJ (2009) 1.89
Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection. J Immunol (2003) 1.88
The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study. PLoS Med (2005) 1.86
Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain Pathol (2008) 1.85
Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). Int J Epidemiol (2007) 1.82
A global model for effective use and evaluation of e-learning in health. Telemed J E Health (2013) 1.82
Multiple biological pathways link cognitive lifestyle to protection from dementia. Biol Psychiatry (2011) 1.79
Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree? J Am Geriatr Soc (2008) 1.74
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet (2006) 1.73
Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med (2009) 1.72
Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts. PLoS Med (2011) 1.71
What do we mean by Alzheimer's disease? BMJ (2010) 1.69
Education, the brain and dementia: neuroprotection or compensation? Brain (2010) 1.68
Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci (2004) 1.65
Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS). Int J Epidemiol (2006) 1.61
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. J Neurochem (2009) 1.61
Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology. Acta Neuropathol (2011) 1.58
Prevalence and causes of blindness and low vision in southern Sudan. PLoS Med (2006) 1.54
Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study. J Alzheimers Dis (2009) 1.53
Associations between active trachoma and community intervention with Antibiotics, Facial cleanliness, and Environmental improvement (A,F,E). PLoS Negl Trop Dis (2008) 1.52
Does depression predict adverse outcomes for older medical inpatients? A prospective cohort study of individuals screened for a trial. Age Ageing (2008) 1.52
Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study. Am J Clin Nutr (2006) 1.52
Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. J Neurol Neurosurg Psychiatry (2007) 1.52
Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: findings from the Medical Research Council Cognitive Function and Ageing Study. J Gerontol A Biol Sci Med Sci (2005) 1.50
Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study. Age Ageing (2006) 1.49
An investigation of whether factors associated with short-term attrition change or persist over ten years: data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). BMC Public Health (2006) 1.49
On the success of the successful aging paradigm. J Appl Gerontol (2013) 1.48
Primary care and dementia: 1. diagnosis, screening and disclosure. Int J Geriatr Psychiatry (2009) 1.44
Prevalence studies of dementia in mainland china, Hong Kong and taiwan: a systematic review and meta-analysis. PLoS One (2013) 1.44
A systematic review of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing (2005) 1.43
What is the evidence for a premorbid parkinsonian personality: a systematic review. Mov Disord (2006) 1.42
Blinding trachoma in postconflict southern Sudan. PLoS Med (2006) 1.42
A genome wide linkage disequilibrium screen in Parkinson's disease. J Neurol (2005) 1.41
The CAST (Childhood Asperger Syndrome Test): test accuracy. Autism (2005) 1.41
The CAST (Childhood Asperger Syndrome Test): preliminary development of a UK screen for mainstream primary-school-age children. Autism (2002) 1.40
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