Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

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Published in Lancet Neurol on August 01, 2013

Authors

Joanna M Wardlaw1, Eric E Smith, Geert J Biessels, Charlotte Cordonnier, Franz Fazekas, Richard Frayne, Richard I Lindley, John T O'Brien, Frederik Barkhof, Oscar R Benavente, Sandra E Black, Carol Brayne, Monique Breteler, Hugues Chabriat, Charles Decarli, Frank-Erik de Leeuw, Fergus Doubal, Marco Duering, Nick C Fox, Steven Greenberg, Vladimir Hachinski, Ingo Kilimann, Vincent Mok, Robert van Oostenbrugge, Leonardo Pantoni, Oliver Speck, Blossom C M Stephan, Stefan Teipel, Anand Viswanathan, David Werring, Christopher Chen, Colin Smith, Mark van Buchem, Bo Norrving, Philip B Gorelick, Martin Dichgans, STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)

Author Affiliations

1: Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK. joanna.wardlaw@ed.ac.uk

Associated clinical trials:

Choline Alphoscerate-Nimodipine in Vascular Cognitive Impairment (CONIVAD) | NCT03228498

Association Between Gait Assessed by Intelligent System and Cognitive Function in Silent Cerebrovascular Disease (ACCURATE-2) | NCT04456348

The Effectiveness and Cost Effectiveness of Intelligent Assessment of Gait Disorder in Silent Cerebrovascular Disease (ACCURATE-1) | NCT04457908

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Weekends: a dangerous time for having a stroke? Stroke (2007) 4.47

The fugl-meyer assessment of motor recovery after stroke: a critical review of its measurement properties. Neurorehabil Neural Repair (2002) 4.47

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol (2013) 4.29

Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study. Lancet Neurol (2006) 4.19

Epidemiology of Alzheimer disease. Nat Rev Neurol (2011) 4.13

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Nat Genet (2009) 4.11

Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study. Hum Brain Mapp (2005) 4.11

Donepezil for the treatment of agitation in Alzheimer's disease. N Engl J Med (2007) 4.11

Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI. Proc Natl Acad Sci U S A (2002) 4.07

PML in a patient treated with dimethyl fumarate from a compounding pharmacy. N Engl J Med (2013) 4.02

Get With the Guidelines-Stroke is associated with sustained improvement in care for patients hospitalized with acute stroke or transient ischemic attack. Circulation (2008) 4.00

Prevalence of autism-spectrum conditions: UK school-based population study. Br J Psychiatry (2009) 3.97

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet (2008) 3.93

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93

Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis. BMJ (2013) 3.93

Cadasil. Lancet Neurol (2009) 3.88

Longitudinal stability of MRI for mapping brain change using tensor-based morphometry. Neuroimage (2006) 3.85

Long-term mortality after stroke among adults aged 18 to 50 years. JAMA (2013) 3.84

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol (2009) 3.82

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet (2011) 3.76

Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke. Ann Neurol (2008) 3.75

Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73

Vascular cognitive impairment. Lancet Neurol (2003) 3.73

Meningiomas. Lancet (2004) 3.69

Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation (2013) 3.57

MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study. Lancet Neurol (2007) 3.47

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol (2010) 3.47

A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch Neurol (2003) 3.44

Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial. Lancet Neurol (2009) 3.42

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40

Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet (2010) 3.38

Subcortical ischaemic vascular dementia. Lancet Neurol (2002) 3.32

Timeliness of tissue-type plasminogen activator therapy in acute ischemic stroke: patient characteristics, hospital factors, and outcomes associated with door-to-needle times within 60 minutes. Circulation (2011) 3.30

Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study. Lancet (2007) 3.29

White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke (2006) 3.27

Computer-assisted imaging to assess brain structure in healthy and diseased brains. Lancet Neurol (2003) 3.26

Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol (2007) 3.22

Fast free-form deformation using graphics processing units. Comput Methods Programs Biomed (2009) 3.18

Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study. Lancet Neurol (2011) 3.16

Distinguishing between stroke and mimic at the bedside: the brain attack study. Stroke (2006) 3.12

Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator. JAMA (2012) 3.07

Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias. Neuroimage (2002) 3.06

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement (2011) 3.05

Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann Neurol (2010) 3.05

Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up. BMJ (2008) 3.03

The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort. Brain (2009) 3.03