Published in Toxicology on March 15, 2005
The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. Int J Mol Sci (2011) 0.80
Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects. Front Physiol (2015) 0.75
Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems. Recent Pat CNS Drug Discov (2012) 0.75
Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem (2002) 2.94
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood (2009) 2.61
Mitochondrial nitric oxide synthase. Trends Pharmacol Sci (2005) 1.50
Red wine-dependent reduction of nitrite to nitric oxide in the stomach. Free Radic Biol Med (2007) 1.48
Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology (2008) 1.46
c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons. J Neurochem (2007) 1.44
Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem (2010) 1.37
Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal (2012) 1.32
Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis. Biol Chem (2002) 1.32
Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Biol Med (2006) 1.25
On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. Proc Natl Acad Sci U S A (2004) 1.23
c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J (2003) 1.22
Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr (2010) 1.20
Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione. Biochemistry (2005) 1.17
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One (2011) 1.14
(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. J Neurochem (2007) 1.13
NO-mediated apoptosis in yeast. J Cell Sci (2007) 1.11
Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression. PLoS One (2009) 1.07
Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions. Free Radic Biol Med (2002) 1.07
Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Biochim Biophys Acta (2010) 1.06
Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Mol Aspects Med (2011) 1.05
MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide. Neurobiol Aging (2002) 1.05
Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. FEBS Lett (2009) 1.03
Redox activation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase. Biochem J (2005) 1.00
Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem (2012) 0.99
H2O2 delivery to cells: steady-state versus bolus addition. Methods Enzymol (2013) 0.98
The energy-redox axis in aging and age-related neurodegeneration. Adv Drug Deliv Rev (2009) 0.98
Mitochondria: the cellular hub of the dynamic coordinated network. Antioxid Redox Signal (2015) 0.97
Dietary thioproline decreases spontaneous food intake and increases survival and neurological function in mice. Antioxid Redox Signal (2007) 0.97
Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production. J Occup Med Toxicol (2010) 0.97
Mitochondrial thiols in the regulation of cell death pathways. Antioxid Redox Signal (2012) 0.97
Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid. Neurobiol Aging (2011) 0.97
Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Biochim Biophys Acta (2011) 0.96
Role of nitric oxide-mediated glutathionylation in neuronal function: potential regulation of energy utilization. Biochem J (2010) 0.95
Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection. Methods Enzymol (2010) 0.94
Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis. Biochem J (2007) 0.94
Hippocampal mitochondrial dysfunction in rat aging. Am J Physiol Regul Integr Comp Physiol (2007) 0.94
The modulation of mitochondrial nitric-oxide synthase activity in rat brain development. J Biol Chem (2002) 0.93
Oxidants and antioxidants revisited. New concepts of oxidative stress. Free Radic Res (2007) 0.93
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production. Free Radic Res (2009) 0.92
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα). J Biol Chem (2013) 0.92
Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria. PLoS One (2008) 0.91
Free radicals and exercise: an introduction. Free Radic Biol Med (2007) 0.91
Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem (2012) 0.91
Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human intestinal cells: comparison with 5-aminosalicylic acid. PLoS One (2013) 0.90
Nitric oxide signaling is disrupted in the yeast model for Batten disease. Mol Biol Cell (2007) 0.90
Intragastric nitration by dietary nitrite: implications for modulation of protein and lipid signaling. Free Radic Biol Med (2011) 0.89
Short-term cigarette smoke exposure leads to metabolic alterations in lung alveolar cells. Am J Respir Cell Mol Biol (2014) 0.89
Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs. Am J Physiol Lung Cell Mol Physiol (2012) 0.88
Mitochondrial superoxide anion production and release into intermembrane space. Methods Enzymol (2002) 0.88
Identification of the first germline HRPT2 whole-gene deletion in a patient with primary hyperparathyroidism. Clin Endocrinol (Oxf) (2012) 0.88
Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. PLoS One (2013) 0.88
Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor. Proc Natl Acad Sci U S A (2005) 0.87
Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology (2010) 0.87
PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med (2013) 0.87
Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling. Biochem Soc Trans (2013) 0.87
In vivo real-time measurement of nitric oxide in anesthetized rat brain. Methods Enzymol (2008) 0.87
On the biologic role of the reaction of NO with oxidized cytochrome c oxidase. Antioxid Redox Signal (2007) 0.86
Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One (2012) 0.85
Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregions. Mol Aspects Med (2004) 0.84
Self-mixing microprobe for monitoring microvascular perfusion in rat brain. Med Biol Eng Comput (2012) 0.83
Astrocytic metabolic and inflammatory changes as a function of age. Aging Cell (2014) 0.83
Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem (2015) 0.83
Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone. Brain Res (2010) 0.83
The mechanism of cytochrome C oxidase inhibition by nitric oxide. Front Biosci (2007) 0.83
Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450. Free Radic Biol Med (2011) 0.83
Carob pulp as raw material for production of the biocontrol agent P. agglomerans PBC-1. J Ind Microbiol Biotechnol (2010) 0.82
Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway. Chem Res Toxicol (2014) 0.82
Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology (2009) 0.81
Antero-medialisation of the tibial tubercle for patellar instability. Int Orthop (2005) 0.81
Kinetic analysis of thapsigargin-induced thymocyte apoptosis. Free Radic Biol Med (2004) 0.81
Simultaneous production of superoxide radical and singlet oxygen by sulphonated chloroaluminum phthalocyanine incorporated in human low-density lipoproteins: implications for photodynamic therapy. Photochem Photobiol (2004) 0.81
Nitric oxide and DOPAC-induced cell death: from GSH depletion to mitochondrial energy crisis. Mol Cell Neurosci (2011) 0.81
A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue. Biosens Bioelectron (2008) 0.81
The redox interplay between nitrite and nitric oxide: From the gut to the brain. Redox Biol (2013) 0.81
Dietary nitrite in nitric oxide biology: a redox interplay with implications for pathophysiology and therapeutics. Curr Drug Targets (2011) 0.81
Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway. Aging Cell (2013) 0.81
Mitochondrial damage by nitric oxide is potentiated by dopamine in PC12 cells. Biochim Biophys Acta (2002) 0.80
Evidence for a pathway that facilitates nitric oxide diffusion in the brain. Neurochem Int (2011) 0.80
In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus. Hippocampus (2010) 0.80
Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell (2014) 0.80
Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells. Food Funct (2012) 0.80
Estimating the incidence of adverse events in Portuguese hospitals: a contribution to improving quality and patient safety. BMC Health Serv Res (2014) 0.80
HNE and Further Lipid Peroxidation Products. Biofactors (2005) 0.80
Prevalence of scoliosis in southern Portugal adolescents. Pediatr Endocrinol Rev (2014) 0.79
Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration. Int J Cell Biol (2012) 0.79
The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease. Free Radic Biol Med (2002) 0.79
Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: a novel interaction between dietary nitrate and gut proteins. Free Radic Biol Med (2012) 0.79
Dietary flavonoids with a catechol structure increase alpha-tocopherol in rats and protect the vitamin from oxidation in vitro. J Lipid Res (2006) 0.79
Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC). Implications for Parkinson's disease. Neurochem Int (2005) 0.79
Methods in Enzymology. Hydrogen peroxide and cell signaling, part C. Preface. Methods Enzymol (2013) 0.79
Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway. Arch Biochem Biophys (2007) 0.78
Glutamate induces release of glutathione from cultured rat astrocytes--a possible neuroprotective mechanism? J Neurochem (2008) 0.78
Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: physiological impact. Nitric Oxide (2010) 0.78
Nitric oxide monitoring in hippocampal brain slices using electrochemical methods. Methods Enzymol (2002) 0.78
The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway. Free Radic Biol Med (2006) 0.78
Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain. Biosens Bioelectron (2013) 0.78