Published in Biochem J on April 28, 2010
S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal (2011) 1.49
Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem (2010) 1.37
Glutathione and modulation of cell apoptosis. Biochim Biophys Acta (2012) 1.27
Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Biochim Biophys Acta (2011) 0.96
Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection. Methods Enzymol (2010) 0.94
Regulation of mitochondrial processes by protein S-nitrosylation. Biochim Biophys Acta (2011) 0.93
Nitrite as a mediator of ischemic preconditioning and cytoprotection. Nitric Oxide (2011) 0.88
Astrocytic metabolic and inflammatory changes as a function of age. Aging Cell (2014) 0.83
Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway. Chem Res Toxicol (2014) 0.82
Protein signatures of oxidative stress response in a patient specific cell line model for autism. Mol Autism (2014) 0.80
Proteome adaptations in Ethe1-deficient mice indicate a role in lipid catabolism and cytoskeleton organization via post-translational protein modifications. Biosci Rep (2013) 0.79
Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes. Free Radic Biol Med (2011) 0.76
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med (2001) 11.92
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol (2005) 7.25
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem (1991) 5.84
Nitrosylation. the prototypic redox-based signaling mechanism. Cell (2001) 5.38
Redefining oxidative stress. Antioxid Redox Signal (2006) 4.71
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature (2001) 4.33
Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell (2004) 3.98
Metabolism and functions of glutathione in brain. Prog Neurobiol (2000) 3.74
Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol (2002) 3.39
Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci U S A (1998) 3.10
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat Rev Neurosci (2007) 2.77
Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal (2008) 2.67
Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem (2003) 2.28
Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch Biochem Biophys (1996) 2.25
The biochemistry and physiology of S-nitrosothiols. Annu Rev Pharmacol Toxicol (2002) 2.23
Glutathione pathways in the brain. Biol Chem (2003) 2.01
Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis. Chem Res Toxicol (1997) 1.79
Molecular mechanisms and potential clinical significance of S-glutathionylation. Antioxid Redox Signal (2008) 1.78
Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem (1994) 1.67
Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J Neurosci (2002) 1.66
Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. J Neurochem (1995) 1.66
Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab (1993) 1.63
Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment. J Biol Chem (1996) 1.58
Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem (1999) 1.56
Paradoxical fate and biological action of peroxynitrite on human platelets. Proc Natl Acad Sci U S A (1994) 1.53
Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: convergences and divergences. Cardiovasc Res (2007) 1.50
S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels. J Biol Chem (2003) 1.47
c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons. J Neurochem (2007) 1.44
Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state. Free Radic Biol Med (2001) 1.36
Protein glutathiolation by nitric oxide: an intracellular mechanism regulating redox protein modification. FASEB J (2006) 1.34
Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection. Mol Immunol (2002) 1.21
Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons. Brain Res (1989) 1.21
Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione. Biochemistry (2005) 1.17
Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation. Biochem J (2001) 1.16
Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione. Free Radic Biol Med (1996) 1.14
Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med (2006) 1.11
Nitric oxide and neurological disorders. Mol Aspects Med (2005) 1.10
Novel application of S-nitrosoglutathione-Sepharose to identify proteins that are potential targets for S-nitrosoglutathione-induced mixed-disulphide formation. Biochem J (2000) 1.06
Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration? J Neurochem (2003) 1.03
Nitric oxide induces apoptosis via hydrogen peroxide, but necrosis via energy and thiol depletion. Free Radic Biol Med (2003) 1.02
Metabolism of S-nitrosoglutathione by endothelial cells. Am J Physiol Heart Circ Physiol (2001) 1.02
Cellular responses to nitric oxide: role of protein S-thiolation/dethiolation. Arch Biochem Biophys (1998) 0.92
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production. Free Radic Res (2009) 0.92
A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: the occurrence and regulation of protein S-nitrosylation is the checkpoint. J Neurochem (2007) 0.84
Modulation of astroglial energy metabolism by nitric oxide. Antioxid Redox Signal (2006) 0.83
Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem (2002) 2.94
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood (2009) 2.61
Mitochondrial nitric oxide synthase. Trends Pharmacol Sci (2005) 1.50
Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology (2008) 1.46
c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons. J Neurochem (2007) 1.44
Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem (2010) 1.37
Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal (2012) 1.32
Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis. Biol Chem (2002) 1.32
Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Biol Med (2006) 1.25
On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. Proc Natl Acad Sci U S A (2004) 1.23
c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J (2003) 1.22
Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr (2010) 1.20
Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione. Biochemistry (2005) 1.17
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One (2011) 1.14
(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. J Neurochem (2007) 1.13
Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression. PLoS One (2009) 1.07
Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions. Free Radic Biol Med (2002) 1.07
Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Biochim Biophys Acta (2010) 1.06
Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Mol Aspects Med (2011) 1.05
MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide. Neurobiol Aging (2002) 1.05
Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. FEBS Lett (2009) 1.03
Redox activation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase. Biochem J (2005) 1.00
Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem (2012) 0.99
H2O2 delivery to cells: steady-state versus bolus addition. Methods Enzymol (2013) 0.98
The energy-redox axis in aging and age-related neurodegeneration. Adv Drug Deliv Rev (2009) 0.98
Mitochondria: the cellular hub of the dynamic coordinated network. Antioxid Redox Signal (2015) 0.97
Dietary thioproline decreases spontaneous food intake and increases survival and neurological function in mice. Antioxid Redox Signal (2007) 0.97
Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid. Neurobiol Aging (2011) 0.97
Mitochondrial thiols in the regulation of cell death pathways. Antioxid Redox Signal (2012) 0.97
Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Biochim Biophys Acta (2011) 0.96
Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis. Biochem J (2007) 0.94
Hippocampal mitochondrial dysfunction in rat aging. Am J Physiol Regul Integr Comp Physiol (2007) 0.94
Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection. Methods Enzymol (2010) 0.94
The modulation of mitochondrial nitric-oxide synthase activity in rat brain development. J Biol Chem (2002) 0.93
Oxidants and antioxidants revisited. New concepts of oxidative stress. Free Radic Res (2007) 0.93
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production. Free Radic Res (2009) 0.92
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα). J Biol Chem (2013) 0.92
Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem (2012) 0.91
Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria. PLoS One (2008) 0.91
Free radicals and exercise: an introduction. Free Radic Biol Med (2007) 0.91
Short-term cigarette smoke exposure leads to metabolic alterations in lung alveolar cells. Am J Respir Cell Mol Biol (2014) 0.89
Mitochondrial superoxide anion production and release into intermembrane space. Methods Enzymol (2002) 0.88
Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs. Am J Physiol Lung Cell Mol Physiol (2012) 0.88
Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. PLoS One (2013) 0.88
Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor. Proc Natl Acad Sci U S A (2005) 0.87
Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology (2010) 0.87
Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling. Biochem Soc Trans (2013) 0.87
PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med (2013) 0.87
On the biologic role of the reaction of NO with oxidized cytochrome c oxidase. Antioxid Redox Signal (2007) 0.86
Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One (2012) 0.85
Astrocytic metabolic and inflammatory changes as a function of age. Aging Cell (2014) 0.83
Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem (2015) 0.83
Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450. Free Radic Biol Med (2011) 0.83
The mechanism of cytochrome C oxidase inhibition by nitric oxide. Front Biosci (2007) 0.83
Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone. Brain Res (2010) 0.83
Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway. Chem Res Toxicol (2014) 0.82
Kinetic analysis of thapsigargin-induced thymocyte apoptosis. Free Radic Biol Med (2004) 0.81
Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway. Aging Cell (2013) 0.81
Evidence for a pathway that facilitates nitric oxide diffusion in the brain. Neurochem Int (2011) 0.80
HNE and Further Lipid Peroxidation Products. Biofactors (2005) 0.80
Mitochondrial damage by nitric oxide is potentiated by dopamine in PC12 cells. Biochim Biophys Acta (2002) 0.80
In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus. Hippocampus (2010) 0.80
Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell (2014) 0.80
The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease. Free Radic Biol Med (2002) 0.79
Methods in Enzymology. Hydrogen peroxide and cell signaling, part C. Preface. Methods Enzymol (2013) 0.79
Compromised proteasome degradation elevates neuronal nitric oxide synthase levels and induces apoptotic cell death. Arch Biochem Biophys (2008) 0.78
The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway. Free Radic Biol Med (2006) 0.78
Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway. Arch Biochem Biophys (2007) 0.78
Impact of water-dispersible beadlets as a vehicle for the delivery of carotenoids to cultured cells. Biofactors (2002) 0.77
The cellular steady-state of H2O2: latency concepts and gradients. Methods Enzymol (2013) 0.77
Mitochondrial medicine and therapeutics, Part II. Preface. Adv Drug Deliv Rev (2009) 0.77
Dynamic and interacting profiles of *NO and O2 in rat hippocampal slices. Free Radic Biol Med (2010) 0.77
Methods in Enzymology. Hydrogen sulfide in redox biology, part B. Preface. Methods Enzymol (2015) 0.76
Metabolic shift in lung alveolar cell mitochondria following acrolein exposure. Am J Physiol Lung Cell Mol Physiol (2013) 0.76
Redox interactions of nitric oxide with dopamine and its derivatives. Toxicology (2005) 0.76
Methods in Enzymology. Hydrogen peroxide and cell signaling, part B. Preface. Methods Enzymol (2013) 0.75
Leucoisoprenochrome-o-semiquinone formation in freshly isolated adult rat cardiomyocytes. Chem Res Toxicol (2004) 0.75
Pathways of dopamine oxidation mediated by nitric oxide. Free Radic Biol Med (2002) 0.75
Mitochondrial medicine and mitochondrion-based therapeutics. Adv Drug Deliv Rev (2008) 0.75
Oxidation of DOPAC by nitric oxide: effect of superoxide dismutase. J Neurochem (2002) 0.75
Preface. Methods Enzymol (2015) 0.75
Preface. Hydrogen peroxide and cell signaling, part A. Methods Enzymol (2013) 0.75
Protein post-translational modifications in cell signalling and disease. Free Radic Res (2010) 0.75