Published in Trends Biochem Sci on February 01, 2005
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A (2005) 2.82
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab (2007) 2.42
Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer (2013) 2.02
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal (2010) 1.94
Adipocyte iron regulates adiponectin and insulin sensitivity. J Clin Invest (2012) 1.78
Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome. Cell Metab (2012) 1.77
The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J Clin Invest (2006) 1.62
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
In control of biology: of mice, men and Foxes. Biochem J (2006) 1.50
Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin Cancer Res (2011) 1.42
FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling. Biochem J (2005) 1.31
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab (2011) 1.18
FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochim Biophys Acta (2007) 1.13
p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle. Am J Physiol Cell Physiol (2011) 1.07
Regulation of Akt signaling by O-GlcNAc in euglycemia. Am J Physiol Endocrinol Metab (2008) 1.01
FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol (2011) 0.98
Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma. PLoS One (2011) 0.93
MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade. EMBO Mol Med (2013) 0.93
CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol Cancer Ther (2014) 0.93
FoxO1 and hepatic lipid metabolism. Curr Opin Lipidol (2009) 0.91
Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy. Acta Pharmacol Sin (2012) 0.88
Targeting mTOR for the treatment of B cell malignancies. Br J Clin Pharmacol (2016) 0.85
Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis. Arterioscler Thromb Vasc Biol (2011) 0.83
Role of transcription factor modifications in the pathogenesis of insulin resistance. Exp Diabetes Res (2011) 0.82
Acetylation and deacetylation--novel factors in muscle wasting. Metabolism (2012) 0.82
Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway. Sci Rep (2016) 0.82
New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder. Adv Exp Med Biol (2009) 0.81
Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol (2014) 0.80
Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: implication in hyperglycemia. J Leukoc Biol (2014) 0.79
The decay of stem cell nourishment at the niche. Rejuvenation Res (2013) 0.76
NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans. Cell Mol Life Sci (2012) 0.76
Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells. Mol Pharmacol (2015) 0.76
Role of transcription factor acetylation in the regulation of metabolic homeostasis. Protein Cell (2015) 0.76
Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a. Intrinsically Disord Proteins (2015) 0.75
Transcriptionally regulated cell adhesion network dictates distal tip cell directionality. Dev Dyn (2014) 0.75
FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical development. Proc Natl Acad Sci U S A (2016) 0.75
Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells. Hum Mol Genet (2017) 0.75
Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically? Oncol Lett (2017) 0.75
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells. Redox Biol (2017) 0.75
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology. Biochim Biophys Acta (2017) 0.75
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J (2004) 3.92
U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice. J Nucl Med (2005) 3.01
FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem (2003) 2.50
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol (2007) 1.72
Insulin signaling in the central nervous system: learning to survive. Prog Neurobiol (2006) 1.69
Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr Patterns (2005) 1.52
In control of biology: of mice, men and Foxes. Biochem J (2006) 1.50
FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling. Biochem J (2005) 1.31
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc Natl Acad Sci U S A (2006) 1.26
Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. Eur J Neurosci (2003) 1.24
Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development (2009) 1.21
Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J Neurosci (2009) 1.19
Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency. Development (2007) 1.18
Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities. PLoS One (2008) 1.10
Developmental origin and fate of meso-diencephalic dopamine neurons. Prog Neurobiol (2006) 1.10
Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Development (2009) 1.08
Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons. Development (2011) 0.98
Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development (2013) 0.96
Molecular programming of stem cells into mesodiencephalic dopaminergic neurons. Trends Neurosci (2006) 0.95
Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system. Mol Cell Neurosci (2005) 0.92
En1 and Wnt signaling in midbrain dopaminergic neuronal development. Neural Dev (2011) 0.92
Prenatal fluoxetine exposure induces life-long serotonin 5-HT₃ receptor-dependent cortical abnormalities and anxiety-like behaviour. Neuropharmacology (2011) 0.92
S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci U S A (2013) 0.91
Modulation of cellular activity and synaptic transmission in the ventral tegmental area. Eur J Pharmacol (2003) 0.90
Transcription factors in the development of midbrain dopamine neurons. Ann N Y Acad Sci (2003) 0.89
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mamm Genome (2009) 0.89
Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area. J Neurosci (2012) 0.88
Epigenetic mechanisms in the development and maintenance of dopaminergic neurons. Development (2013) 0.87
Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biol Open (2012) 0.86
CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systems. Mol Cell Neurosci (2002) 0.85
The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem (2004) 0.85
Molecular marker differences relate to developmental position and subsets of mesodiencephalic dopaminergic neurons. PLoS One (2013) 0.84
Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement components. Behav Brain Res (2007) 0.83
Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain. Brain Res (2005) 0.83
The serotonin 5-HT3 receptor: a novel neurodevelopmental target. Front Cell Neurosci (2013) 0.82
Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient mice. Eur J Neurosci (2008) 0.81
Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives. Cell Mol Life Sci (2014) 0.81
Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons. Eur J Neurosci (2012) 0.80
Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than rats. Brain Res Mol Brain Res (2004) 0.79
Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2. PLoS One (2013) 0.79
Decreased thalamic expression of the homeobox gene DLX1 in psychosis. Arch Gen Psychiatry (2003) 0.78
LMX1B is part of a transcriptional complex with PSPC1 and PSF. PLoS One (2013) 0.78
FoxK2 is required for cellular proliferation and survival. J Cell Physiol (2015) 0.78
Cloning and analysis of the murine Foxi2 transcription factor. Biochim Biophys Acta (2005) 0.77
Pitx3 deficiency in mice affects cholinergic modulation of GABAergic synapses in the nucleus accumbens. J Neurophysiol (2006) 0.77
Phox2b influences the development of a caudal dopaminergic subset. PLoS One (2012) 0.77
Development and engineering of dopamine neurons. Preface. Adv Exp Med Biol (2009) 0.77
The BCL2 code to dopaminergic development and Parkinson's disease. Trends Mol Med (2013) 0.76
Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice. Cerebellum (2014) 0.75