Published in J Leukoc Biol on November 24, 2014
GM-CSF: An immune modulatory cytokine that can suppress autoimmunity. Cytokine (2015) 1.09
FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype. Oncotarget (2016) 0.80
Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis. Scientifica (Cairo) (2015) 0.79
GM-CSF Grown Bone Marrow Derived Cells Are Composed of Phenotypically Different Dendritic Cells and Macrophages. Mol Cells (2016) 0.77
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med (1992) 22.13
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab (2006) 6.44
Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol (2011) 6.34
The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med (2012) 5.63
Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol (2008) 5.61
Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature (2013) 5.44
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol (2011) 5.11
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab (2008) 5.10
"Re-educating" tumor-associated macrophages by targeting NF-kappaB. J Exp Med (2008) 4.38
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science (2010) 4.15
Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity (2004) 3.98
FoxO proteins in insulin action and metabolism. Trends Endocrinol Metab (2005) 3.47
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A (2003) 3.28
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes (2009) 3.27
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol (2014) 3.12
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol (2011) 2.92
Fox's in development and disease. Trends Genet (2003) 2.80
FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem (2003) 2.50
FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem (2009) 2.40
Macrophages and tissue injury: agents of defense or destruction? Annu Rev Pharmacol Toxicol (2011) 2.28
Stimulation of macrophage plasminogen activator activity by colony-stimulating factors. J Cell Physiol (1980) 2.15
High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes (2003) 2.14
Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem (2010) 2.14
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem (2009) 2.05
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes (2009) 2.00
GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling. J Leukoc Biol (2009) 2.00
Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol (2008) 1.93
Orchestration of metabolism by macrophages. Cell Metab (2012) 1.92
The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol (2009) 1.91
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A (2012) 1.91
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med (2012) 1.87
Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice. Exerc Immunol Rev (2010) 1.82
Increased CD36 protein as a response to defective insulin signaling in macrophages. J Clin Invest (2004) 1.76
Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation. Blood (2013) 1.75
Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation. Diabetes (2003) 1.73
Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. Chem Res Toxicol (2009) 1.70
Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci U S A (2013) 1.69
Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest (2012) 1.63
FOXO transcription factors throughout T cell biology. Nat Rev Immunol (2012) 1.60
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J (2010) 1.60
Association of low interleukin-10 levels with the metabolic syndrome in obese women. J Clin Endocrinol Metab (2003) 1.50
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab (2006) 1.50
Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. J Biol Chem (2014) 1.48
Regulation of FoxO activity by CBP/p300-mediated acetylation. Trends Biochem Sci (2005) 1.40
Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol (2010) 1.38
Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10. J Immunol (2011) 1.36
Foxo: in command of T lymphocyte homeostasis and tolerance. Trends Immunol (2010) 1.35
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med (2014) 1.31
The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ Res (2010) 1.29
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes (2008) 1.26
A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis. Am J Pathol (2008) 1.24
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes (2009) 1.22
FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem (2009) 1.19
IRF5 is required for late-phase TNF secretion by human dendritic cells. Blood (2010) 1.15
From phagocyte diversity and activation to probiotics: back to Metchnikoff. Eur J Immunol (2008) 1.11
Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. J Immunol (2009) 1.11
Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal (2010) 1.08
Role and function of macrophages in the metabolic syndrome. Biochem J (2012) 1.05
FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells. J Immunol (2013) 1.03
Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia. Blood (2011) 1.03
Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression. J Immunol (2012) 1.00
Macrophage lineage phenotypes and osteoclastogenesis--complexity in the control by GM-CSF and TGF-beta. Bone (2006) 1.00
FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J Biol Chem (2012) 0.99
Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature. Pigment Cell Melanoma Res (2012) 0.95
Flow cytometry analyses of adipose tissue macrophages. Methods Enzymol (2014) 0.95
Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice. Circ Res (2013) 0.91
NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs. PLoS One (2011) 0.86
Adiponectin, IL-10 and metabolic syndrome in obese children and adolescents. Acta Biomed (2009) 0.85
Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance. Diabetes (2012) 0.84
Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis. Arterioscler Thromb Vasc Biol (2011) 0.83