Published in Development on July 17, 2013
Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling. Cell Rep (2014) 1.11
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. EMBO J (2016) 0.86
Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease. Neurobiol Dis (2014) 0.83
Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons. Stem Cell Reports (2014) 0.81
Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease. Cell Stem Cell (2016) 0.79
Directed differentiation of postnatal hippocampal neural stem cells generates nuclear receptor related‑1 protein‑ and tyrosine hydroxylase‑expressing cells. Mol Med Rep (2016) 0.78
Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform. Sci Rep (2017) 0.76
Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors. Mol Cell Neurosci (2015) 0.76
Dissecting the role of Engrailed in adult dopaminergic neurons - Insights into Parkinson disease pathogenesis. FEBS Lett (2015) 0.75
Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson's Disease. Sci Rep (2016) 0.75
Neuroprotective Transcription Factors in Animal Models of Parkinson Disease. Neural Plast (2015) 0.75
Neuronal survival in the brain: neuron type-specific mechanisms. Cell Death Dis (2017) 0.75
Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons. PLoS One (2015) 0.75
Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. PLoS One (2016) 0.75
Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function. Biol Open (2016) 0.75
A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons. Development (2017) 0.75
Mest/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset. Front Mol Neurosci (2017) 0.75
Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation. Nat Commun (2017) 0.75
Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets. Front Neuroanat (2017) 0.75
Embryonic development of selectively vulnerable neurons in Parkinson's disease. NPJ Parkinsons Dis (2017) 0.75
Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool. PLoS One (2017) 0.75
Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics (2007) 7.93
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J (2004) 3.92
Functional organization of the S. cerevisiae phosphorylation network. Cell (2009) 3.15
Genome-wide analyses reveal RNA polymerase II located upstream of genes poised for rapid response upon S. cerevisiae stationary phase exit. Mol Cell (2005) 3.15
Protein interaction verification and functional annotation by integrated analysis of genome-scale data. Mol Cell (2002) 3.07
An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet (2005) 3.04
U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice. J Nucl Med (2005) 3.01
Monitoring global messenger RNA changes in externally controlled microarray experiments. EMBO Rep (2003) 2.51
FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem (2003) 2.50
Poised RNA polymerase II gives pause for thought. Cell (2008) 2.48
Functional overlap and regulatory links shape genetic interactions between signaling pathways. Cell (2010) 2.29
Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets. Mol Cell (2005) 2.21
Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA. Mol Cell (2006) 2.16
A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res (2004) 2.15
The specificity and topology of chromatin interaction pathways in yeast. Mol Cell (2011) 2.04
From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II. Cell (2013) 1.87
Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development (2004) 1.86
A central role for TFIID in the pluripotent transcription circuitry. Nature (2013) 1.82
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain (2012) 1.82
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol (2007) 1.72
Insulin signaling in the central nervous system: learning to survive. Prog Neurobiol (2006) 1.69
Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Res Ther (2013) 1.57
Distinct promoter dynamics of the basal transcription factor TBP across the yeast genome. Nat Struct Mol Biol (2009) 1.56
In control: systematic assessment of microarray performance. EMBO Rep (2004) 1.55
Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr Patterns (2005) 1.52
In control of biology: of mice, men and Foxes. Biochem J (2006) 1.50
Regulation of FoxO activity by CBP/p300-mediated acetylation. Trends Biochem Sci (2005) 1.40
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity. Nat Chem Biol (2009) 1.40
Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome. Genes Dev (2008) 1.38
FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling. Biochem J (2005) 1.31
Multiple robust signatures for detecting lymph node metastasis in head and neck cancer. Cancer Res (2006) 1.27
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc Natl Acad Sci U S A (2006) 1.26
E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Nucleic Acids Res (2011) 1.26
Mot1p is essential for TBP recruitment to selected promoters during in vivo gene activation. EMBO J (2002) 1.25
Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. Eur J Neurosci (2003) 1.24
Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development (2009) 1.21
Predicting gene function through systematic analysis and quality assessment of high-throughput data. Bioinformatics (2004) 1.21
Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. PLoS Genet (2012) 1.21
Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. Nucleic Acids Res (2011) 1.20
A consensus of core protein complex compositions for Saccharomyces cerevisiae. Mol Cell (2010) 1.19
Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J Neurosci (2009) 1.19
Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency. Development (2007) 1.18
PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells. Neoplasia (2013) 1.11
Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities. PLoS One (2008) 1.10
Developmental origin and fate of meso-diencephalic dopamine neurons. Prog Neurobiol (2006) 1.10
Adaptable gene-specific dye bias correction for two-channel DNA microarrays. Mol Syst Biol (2009) 1.09
Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation. J Neuroinflammation (2012) 1.09
Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Development (2009) 1.08
Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification. Nucleic Acids Res (2008) 1.07
Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast. EMBO J (2011) 1.05
Critical roles for a genetic code alteration in the evolution of the genus Candida. EMBO J (2007) 1.04
Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function. Cell Rep (2013) 1.03
Possible role of the innate immunity in temporal lobe epilepsy. Epilepsia (2007) 1.03
Structure-system correlation identifies a gene regulatory Mediator submodule. Genes Dev (2008) 1.03
Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors. Blood (2009) 1.00
Maintenance of head and neck tumor gene expression profiles upon lymph node metastasis. Cancer Res (2006) 0.99
Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism. Physiol Genomics (2005) 0.98
Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons. Development (2011) 0.98
H2B ubiquitylation controls the formation of export-competent mRNP. Mol Cell (2012) 0.97
Molecular programming of stem cells into mesodiencephalic dopaminergic neurons. Trends Neurosci (2006) 0.95
Fibronectin is a hypoxia-independent target of the tumor suppressor VHL. FEBS Lett (2004) 0.94
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60. Nat Commun (2013) 0.94
Novel diagnostic modalities for assessment of the clinically node-negative neck in oral squamous-cell carcinoma. Lancet Oncol (2012) 0.93
En1 and Wnt signaling in midbrain dopaminergic neuronal development. Neural Dev (2011) 0.92
Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system. Mol Cell Neurosci (2005) 0.92
Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment. Hypertension (2004) 0.92
Prenatal fluoxetine exposure induces life-long serotonin 5-HT₃ receptor-dependent cortical abnormalities and anxiety-like behaviour. Neuropharmacology (2011) 0.92
S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci U S A (2013) 0.91
Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1 alpha-hydroxylase knockout mice. Kidney Int (2004) 0.91
Dissection of a metastatic gene expression signature into distinct components. Genome Biol (2006) 0.90
Validation of a gene expression signature for assessment of lymph node metastasis in oral squamous cell carcinoma. J Clin Oncol (2012) 0.90
Modulation of cellular activity and synaptic transmission in the ventral tegmental area. Eur J Pharmacol (2003) 0.90
Transcription factors in the development of midbrain dopamine neurons. Ann N Y Acad Sci (2003) 0.89
A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover. PLoS Genet (2011) 0.89
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mamm Genome (2009) 0.89
Elucidation of the distal convoluted tubule transcriptome identifies new candidate genes involved in renal Mg(2+) handling. Am J Physiol Renal Physiol (2013) 0.88
Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area. J Neurosci (2012) 0.88
Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases. PLoS One (2013) 0.88
Aberrant gene expression in dogs with portosystemic shunts. PLoS One (2013) 0.87
Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation. Cell Rep (2013) 0.87
Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II. PLoS Genet (2013) 0.87
Epigenetic mechanisms in the development and maintenance of dopaminergic neurons. Development (2013) 0.87
Nitric oxide donor induces temporal and dose-dependent reduction of gene expression in human endothelial cells. Am J Physiol Heart Circ Physiol (2004) 0.87
Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biol Open (2012) 0.86
Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein. Nucleic Acids Res (2014) 0.86