PubRank

Yusuke Nakamura

Author PubWeight™ 925.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A second generation human haplotype map of over 3.1 million SNPs. Nature 2007 85.39
2 International network of cancer genome projects. Nature 2010 20.35
3 Genome-wide detection and characterization of positive selection in human populations. Nature 2007 17.27
4 Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008 9.39
5 SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008 8.63
6 Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet 2009 8.11
7 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet 2003 7.98
8 Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 2003 7.04
9 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 2008 6.75
10 Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 2002 6.46
11 Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet 2004 6.15
12 Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet 2005 5.35
13 A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 2009 5.29
14 Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet 2007 4.99
15 Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet 2012 4.84
16 SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol 2004 4.72
17 An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet 2003 4.61
18 Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat Genet 2010 4.36
19 A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet 2007 4.31
20 HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Cell 2009 3.94
21 Seven new loci associated with age-related macular degeneration. Nat Genet 2013 3.81
22 Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med 2011 3.80
23 Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet 2012 3.71
24 Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature 2008 3.62
25 Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 2007 3.24
26 Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J Clin Oncol 2010 3.21
27 Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet 2013 3.21
28 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nat Genet 2012 3.19
29 Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. Nat Genet 2011 3.19
30 Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 2011 3.18
31 A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet 2005 3.15
32 New gene functions in megakaryopoiesis and platelet formation. Nature 2011 3.14
33 Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies. Am J Hum Genet 2008 3.12
34 Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. Gastroenterology 2009 3.04
35 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 2012 3.04
36 Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. J Clin Oncol 2010 3.02
37 An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet 2005 3.00
38 Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. Hepatology 2010 3.00
39 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nat Genet 2010 2.92
40 Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet 2008 2.89
41 A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 2010 2.81
42 Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker. Biochem Biophys Res Commun 2003 2.78
43 ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet 2007 2.77
44 DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway. Oncogene 2004 2.73
45 Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet 2012 2.70
46 Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer 2011 2.42
47 Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. J Hum Genet 2006 2.41
48 JSNP: a database of common gene variations in the Japanese population. Nucleic Acids Res 2002 2.35
49 A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet 2010 2.34
50 Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 2012 2.31
51 ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene 2004 2.30
52 A SNP in the ABCC11 gene is the determinant of human earwax type. Nat Genet 2006 2.29
53 A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nat Genet 2009 2.26
54 Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J Hum Genet 2004 2.20
55 Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. Diabetes 2005 2.12
56 Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism. J Hum Genet 2002 2.11
57 Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet 2011 2.10
58 Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. Nat Genet 2011 2.09
59 Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. Nat Genet 2010 2.08
60 A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. Nat Genet 2005 2.08
61 Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet 2012 2.05
62 Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet 2008 2.03
63 Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility. Cancer Sci 2010 2.03
64 A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet 2011 1.96
65 Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy. Cancer Sci 2008 1.95
66 Expression profiles of non-small cell lung cancers on cDNA microarrays: identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs. Oncogene 2003 1.91
67 A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese. Hum Mol Genet 2011 1.91
68 Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet 2012 1.90
69 Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Sci 2006 1.90
70 Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet 2010 1.90
71 Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. J Hum Genet 2002 1.88
72 Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor. Clin Cancer Res 2013 1.87
73 Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet 2010 1.86
74 When good drugs go bad. Nature 2007 1.85
75 HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy. Gut 2010 1.85
76 HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. Gastroenterology 2011 1.83
77 Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. Hum Mol Genet 2010 1.83
78 An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines. Cancer Res 2002 1.82
79 Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer 2011 1.81
80 Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene 2004 1.77
81 A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E. Hum Genet 2010 1.75
82 Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene 2002 1.75
83 Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). PLoS Genet 2011 1.75
84 A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population. Nat Genet 2006 1.73
85 Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs. Cancer Res 2004 1.73
86 Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. Nat Genet 2008 1.73
87 Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Breast Cancer Res 2007 1.72
88 A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet 2005 1.69
89 Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. Cancer Res 2007 1.68
90 Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat Genet 2003 1.68
91 Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. Nature 2004 1.68
92 A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum Mol Genet 2005 1.67
93 Predicting response to methotrexate, vinblastine, doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide gene expression profiling. Clin Cancer Res 2005 1.66
94 p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol 2003 1.65
95 Multiple loci are associated with white blood cell phenotypes. PLoS Genet 2011 1.65
96 Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics 2013 1.65
97 Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer 2010 1.64
98 Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles. Cancer Res 2007 1.61
99 Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2008 1.60
100 Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. Nat Genet 2012 1.59
101 A genome-wide association study identifies three new risk loci for Kawasaki disease. Nat Genet 2012 1.58
102 Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat Genet 2012 1.58
103 Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis. Cancer Sci 2007 1.57
104 A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction. Nat Genet 2007 1.57
105 Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Cancer Sci 2011 1.57
106 A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet 2010 1.57
107 Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet 2007 1.55
108 Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Cancer Res 2007 1.55
109 Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53. Oncogene 2002 1.55
110 HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients. Pharmacogenet Genomics 2009 1.55
111 Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Cancer Res 2002 1.53
112 A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet 2012 1.51
113 PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer. Cancer Res 2006 1.51
114 Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum 2008 1.51
115 Genome-wide association study of pancreatic cancer in Japanese population. PLoS One 2010 1.50
116 A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. Clin Cancer Res 2012 1.50
117 Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci 2007 1.50
118 The p53 family member genes are involved in the Notch signal pathway. J Biol Chem 2001 1.50
119 Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancer. Cancer Sci 2009 1.49
120 A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Hum Mol Genet 2010 1.49
121 Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes. Am J Hum Genet 2004 1.49
122 Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens. J Transl Med 2012 1.47
123 Comparison of gene-expression profiles between diffuse- and intestinal-type gastric cancers using a genome-wide cDNA microarray. Oncogene 2004 1.46
124 Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial. J Natl Cancer Inst 2012 1.46
125 Genome-wide analysis of gene expression in intestinal-type gastric cancers using a complementary DNA microarray representing 23,040 genes. Cancer Res 2002 1.46
126 Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS Genet 2011 1.45
127 High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet 2007 1.44
128 The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population. Arthritis Rheum 2010 1.43
129 Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Nat Genet 2011 1.43
130 Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma. Hepatology 2005 1.43
131 ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients. Gastroenterology 2010 1.42
132 Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer Res 2009 1.42
133 Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas. Oncogene 2002 1.42
134 Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. Cancer Res 2007 1.42
135 A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. Nat Genet 2010 1.42
136 Genome-wide association meta-analysis identifies new endometriosis risk loci. Nat Genet 2012 1.42
137 Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. J Allergy Clin Immunol 2007 1.42
138 Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors. Cancer Biol Ther 2005 1.41
139 Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma. Hepatology 2006 1.40
140 Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex. Cancer Res 2003 1.40
141 Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients. Breast Cancer Res Treat 2011 1.39
142 A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. Gastroenterology 2009 1.39
143 Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues. Am J Hum Genet 2002 1.39
144 Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma. Am J Respir Cell Mol Biol 2010 1.39
145 Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer. Int J Oncol 2006 1.38
146 Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genet 2011 1.38
147 A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet 2010 1.38
148 Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Res 2012 1.37
149 Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nat Genet 2008 1.37
150 Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res 2002 1.37
151 A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. Nat Genet 2012 1.37
152 Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Cancer Res 2005 1.37
153 Genome-wide cDNA microarray screening to correlate gene expression profiles with sensitivity of 85 human cancer xenografts to anticancer drugs. Cancer Res 2002 1.37
154 Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. Arthritis Rheum 2004 1.36
155 Genome-wide profiling of gene expression in 29 normal human tissues with a cDNA microarray. DNA Res 2002 1.36
156 RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. Neoplasia 2012 1.36
157 Multiplex PCR-based real-time invader assay (mPCR-RETINA): a novel SNP-based method for detecting allelic asymmetries within copy number variation regions. Hum Mutat 2008 1.36
158 Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. Int J Oncol 2004 1.35
159 Identification of human leukocyte antigen-A24-restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy. Cancer Sci 2007 1.35
160 Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). Hum Mol Genet 2004 1.35
161 Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics. Pharmacogenet Genomics 2012 1.34
162 EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK. Oncogene 2003 1.34
163 IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C. J Infect Dis 2011 1.33
164 Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit. Cancer Res 2007 1.33
165 The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Cancer Res 2007 1.32
166 Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis. Cancer Res 2010 1.32
167 IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy. J Hepatol 2011 1.32
168 Mouse homologue of a novel human oncofetal antigen, glypican-3, evokes T-cell-mediated tumor rejection without autoimmune reactions in mice. Clin Cancer Res 2004 1.32
169 Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J Biol Chem 2003 1.31
170 Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients. J Hepatol 2010 1.31
171 A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. Nat Genet 2011 1.31
172 Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy. Cancer Res 2010 1.31
173 A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. Int J Oncol 2004 1.31
174 Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget 2012 1.30
175 Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. Hum Mol Genet 2010 1.30
176 Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabetes 2010 1.30
177 A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12. J Hum Genet 2006 1.30
178 Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Am J Hum Genet 2012 1.29
179 SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nat Genet 2009 1.29
180 Validation study of the prediction system for clinical response of M-VAC neoadjuvant chemotherapy. Cancer Sci 2007 1.28
181 Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. Cancer Res 2003 1.28
182 Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun 2012 1.27
183 New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. PLoS One 2010 1.27
184 Fukutin is required for maintenance of muscle integrity, cortical histiogenesis and normal eye development. Hum Mol Genet 2003 1.27
185 A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin Cancer Res 2011 1.26
186 Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Hum Mol Genet 2010 1.25
187 Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. Hum Genet 2007 1.25
188 Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell. Cancer Res 2005 1.24
189 A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. Hum Mol Genet 2012 1.24
190 Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers. Cancer Res 2005 1.24
191 hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. Cancer Sci 2003 1.24
192 A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet 2012 1.23
193 Association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphisms. Diabetes 2003 1.23
194 Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. Am J Respir Cell Mol Biol 2006 1.23
195 Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy. Clin Cancer Res 2012 1.22
196 ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. Cancer Res 2005 1.22
197 Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Res 2010 1.22
198 Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. Oncogene 2003 1.22
199 Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J Hum Genet 2005 1.21
200 Association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirements in Japanese patients. J Hum Genet 2006 1.21
201 Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Hum Mol Genet 2010 1.21
202 Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer. Cancer Res 2007 1.20
203 FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling. J Immunol 2009 1.20
204 Regulation of histone modification and chromatin structure by the p53-PADI4 pathway. Nat Commun 2012 1.20
205 Common variants in CASP3 confer susceptibility to Kawasaki disease. Hum Mol Genet 2010 1.20
206 Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis. Int J Oncol 2004 1.20
207 Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease. J Hum Genet 2004 1.20
208 Regulation of protein Citrullination through p53/PADI4 network in DNA damage response. Cancer Res 2009 1.19
209 Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. PLoS One 2011 1.19
210 CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection. Clin Chem 2009 1.19
211 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Gastroenterology 2012 1.19
212 Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. J Hepatol 2010 1.19
213 Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer Res 2005 1.18
214 A functional polymorphism in IL-18 is associated with severity of bronchial asthma. Am J Respir Crit Care Med 2009 1.18
215 A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Hum Mol Genet 2010 1.17
216 A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese. PLoS Genet 2012 1.17
217 A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. Gastroenterology 2010 1.17
218 Identification of a novel tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric, and colorectal cancers. Clin Cancer Res 2008 1.17
219 Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex. Cancer Res 2002 1.17
220 Common variation in GPC5 is associated with acquired nephrotic syndrome. Nat Genet 2011 1.17
221 Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss. J Hum Genet 2003 1.16
222 p53AIP1 regulates the mitochondrial apoptotic pathway. Cancer Res 2002 1.16
223 A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. Cancer Res 2005 1.16
224 IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations. J Gen Virol 2011 1.16
225 The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population. Hum Mol Genet 2011 1.16
226 Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J Hum Genet 2009 1.16
227 Cancer peptide vaccine therapy developed from oncoantigens identified through genome-wide expression profile analysis for bladder cancer. Jpn J Clin Oncol 2012 1.15
228 The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. Oncogene 2002 1.15
229 Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. Neoplasia 2011 1.15
230 Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma. PLoS One 2012 1.15
231 Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci 2008 1.14
232 Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Hum Genet 2005 1.14
233 Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol 2009 1.14
234 Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis. J Hum Genet 2012 1.14
235 Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count. Hum Mol Genet 2010 1.13
236 Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression. Breast Cancer Res 2012 1.13
237 Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). J Biol Chem 2013 1.12
238 Classification of sensitivity or resistance of cervical cancers to ionizing radiation according to expression profiles of 62 genes selected by cDNA microarray analysis. Neoplasia 2002 1.12
239 Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. Cancer Res 2009 1.12
240 Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy. Clin Cancer Res 2005 1.12
241 Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir. Hepatology 2011 1.12
242 Population-genetic nature of copy number variations in the human genome. Hum Mol Genet 2009 1.12
243 Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention. Cancer Discov 2013 1.12
244 p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Oncogene 2003 1.12
245 Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis. Cancer Res 2006 1.12
246 Identification of Epstein-Barr virus-induced gene 3 as a novel serum and tissue biomarker and a therapeutic target for lung cancer. Clin Cancer Res 2011 1.11
247 Detection of novel cancer-testis antigen-specific T-cell responses in TIL, regional lymph nodes, and PBL in patients with esophageal squamous cell carcinoma. Cancer Sci 2008 1.11
248 A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma. J Hum Genet 2009 1.11
249 High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet 2013 1.11
250 Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Hum Mol Genet 2007 1.11
251 Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. Int J Oncol 2006 1.10
252 Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Hum Mol Genet 2002 1.10
253 HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL. Int J Cancer 2008 1.10
254 ADAM8 as a novel serological and histochemical marker for lung cancer. Clin Cancer Res 2004 1.10
255 INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. J Hum Genet 2008 1.10
256 Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 2011 1.10
257 Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. J Hum Genet 2002 1.10
258 The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene. Int J Cancer 2011 1.09
259 Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma. Oncol Rep 2005 1.09
260 Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. Clin Cancer Res 2009 1.09
261 Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci 2009 1.09
262 EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth. Cancer Sci 2006 1.09
263 Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation. Cell Microbiol 2007 1.09
264 Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet 2012 1.09
265 Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. Oncogene 2005 1.08
266 Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet 2009 1.08
267 Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer. Cancer Sci 2009 1.08
268 Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. Genes Chromosomes Cancer 2007 1.08
269 Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet 2002 1.08
270 Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. Neoplasia 2011 1.08
271 Prediction of outcome of advanced cervical cancer to thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray analysis. Int J Radiat Oncol Biol Phys 2004 1.08
272 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Cancer Epidemiol Biomarkers Prev 2012 1.08
273 Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. Proc Natl Acad Sci U S A 2011 1.08
274 Genome-wide gene expression profile analysis of esophageal squamous cell carcinomas. Int J Oncol 2006 1.08
275 Prevalence of allergic rhinitis and sensitization to common aeroallergens in a Japanese population. Int Arch Allergy Immunol 2009 1.08
276 Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis. Cancer Sci 2009 1.08
277 Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP Maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs. Am J Hum Genet 2004 1.07
278 Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS One 2011 1.07
279 Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin. Neoplasia 2011 1.07
280 Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles. Int J Oncol 2004 1.07
281 Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. Gastroenterology 2009 1.06
282 Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. Cancer Res 2010 1.06
283 Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. Cancer Res 2005 1.05
284 Implication of allelic polymorphism of osteopontin in the development of lupus nephritis in MRL/lpr mice. Eur J Immunol 2005 1.05
285 Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. Hum Mol Genet 2012 1.05
286 Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer. Mol Cancer 2011 1.05
287 Ring finger protein 43 as a new target for cancer immunotherapy. Clin Cancer Res 2004 1.05
288 Comparative profiling of serum glycoproteome by sequential purification of glycoproteins and 2-nitrobenzensulfenyl (NBS) stable isotope labeling: a new approach for the novel biomarker discovery for cancer. J Proteome Res 2007 1.05
289 Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression. Jpn J Cancer Res 2002 1.05
290 Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis. Clin Cancer Res 2004 1.04
291 Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer. Clin Cancer Res 2007 1.04
292 Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4. Cancer Sci 2006 1.04
293 Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. PLoS One 2013 1.04
294 Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians. Int J Cancer 2014 1.03
295 Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays. Pharmacogenet Genomics 2010 1.03
296 Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. Hum Mol Genet 2007 1.03
297 Critical roles of T-LAK cell-originated protein kinase in cytokinesis. Cancer Sci 2009 1.02
298 Stanniocalcin 2 overexpression in castration-resistant prostate cancer and aggressive prostate cancer. Cancer Sci 2009 1.02
299 Identification of CDCA1-derived long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients. Int J Cancer 2014 1.02
300 The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. Cancer Prev Res (Phila) 2011 1.02
301 Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome. Hum Mol Genet 2004 1.02
302 Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genet 2013 1.02
303 TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression. Mol Endocrinol 2013 1.02
304 An algorithm for inferring complex haplotypes in a region of copy-number variation. Am J Hum Genet 2008 1.02
305 Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients. Clin Cancer Res 2008 1.01
306 Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers. Oncol Rep 2004 1.01
307 Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity. FEBS Lett 2003 1.01
308 Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. Int J Oncol 2005 1.01
309 Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. Mol Cancer Ther 2007 1.01
310 The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis. Genes Chromosomes Cancer 2012 1.00
311 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci 2013 1.00
312 Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition. Cancer Lett 2013 1.00
313 Combined hepatocellular/cholangiocellular carcinoma with sarcomatoid features: genetic analysis for histogenesis. Hepatol Res 2001 1.00
314 Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas. Oncogene 2005 1.00
315 p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. Cancer Res 2005 1.00
316 Prediction of chemosensitivity for patients with acute myeloid leukemia, according to expression levels of 28 genes selected by genome-wide complementary DNA microarray analysis. Mol Cancer Ther 2002 1.00
317 Association between HLA-B*4001 and lipodystrophy among HIV-infected patients from Thailand who received a stavudine-containing antiretroviral regimen. Clin Infect Dis 2010 0.99
318 Association study of 71 European Crohn's disease susceptibility loci in a Japanese population. Inflamm Bowel Dis 2013 0.99
319 ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations. PLoS One 2012 0.99
320 The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer. Cancer Res 2006 0.99
321 A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome. J Transl Med 2014 0.99
322 Pharmacogenomics of tamoxifen: roles of drug metabolizing enzymes and transporters. Drug Metab Pharmacokinet 2011 0.99
323 A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression. Hum Mol Genet 2010 0.99
324 Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR. J Hum Genet 2002 0.99
325 Genome-wide analysis of gene-expression profiles in chronic myeloid leukemia cells using a cDNA microarray. Int J Oncol 2003 0.99
326 Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters. J Assist Reprod Genet 2014 0.99
327 Inhibition of tumor growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma. Oncol Rep 2007 0.99
328 Temporary umbilical loop colostomy for anorectal malformations. Pediatr Surg Int 2012 0.99
329 Development of serum glycoproteomic profiling technique; simultaneous identification of glycosylation sites and site-specific quantification of glycan structure changes. Mol Cell Proteomics 2010 0.98
330 Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. J Biol Chem 2007 0.98
331 Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. Am J Hum Genet 2002 0.98
332 Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials. Clin Cancer Res 2011 0.98
333 Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients. J Hum Genet 2003 0.98
334 Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis. Cancer Res 2007 0.98
335 Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory function. Stem Cells 2007 0.98
336 Genome-wide gene expression profiles of thyroid carcinoma: Identification of molecular targets for treatment of thyroid carcinoma. Oncol Rep 2008 0.98
337 Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand. Hum Genet 2010 0.97
338 Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. Oncogene 2004 0.97
339 Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. Cancer Res 2009 0.97
340 Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Cancer Res 2002 0.97
341 A genome-wide association study identifies novel susceptibility genetic variation for thyrotoxic hypokalemic periodic paralysis. J Hum Genet 2012 0.97
342 Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus. Hum Mol Genet 2010 0.97
343 Activation of an oncogenic TBC1D7 (TBC1 domain family, member 7) protein in pulmonary carcinogenesis. Genes Chromosomes Cancer 2010 0.97
344 Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase. BMC Cancer 2010 0.96
345 Construction and characterization of a vestibular-specific cDNA library using T7-based RNA amplification. J Hum Genet 2003 0.96
346 Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese. PLoS One 2012 0.96
347 Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 2002 0.96
348 A phase ΙI study of five peptides combination with oxaliplatin-based chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study). J Transl Med 2014 0.96
349 Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Cancer Sci 2005 0.95
350 Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population. PLoS One 2012 0.95
351 Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. Oncol Rep 2009 0.95
352 Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1. Arthritis Rheum 2009 0.95
353 Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. Cancer Res 2007 0.95
354 MOCSphaser: a haplotype inference tool from a mixture of copy number variation and single nucleotide polymorphism data. Bioinformatics 2008 0.95
355 IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility. Hum Mol Genet 2012 0.95
356 Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. J Hum Genet 2010 0.95
357 Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis. Mol Cell Biol 2002 0.95
358 Successful outcomes using combination therapy of interleukin-2 and interferon-alpha for renal cell carcinoma patients with lung metastasis. Jpn J Clin Oncol 2010 0.95
359 Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Int J Oncol 2003 0.95
360 Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. Clin Infect Dis 2011 0.95
361 Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics. Mol Endocrinol 2014 0.94
362 Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. Clin Exp Nephrol 2011 0.94
363 Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer. Cancer Sci 2009 0.94
364 Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells. Clin Cancer Res 2006 0.94
365 A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese. J Hum Genet 2012 0.94
366 Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes. Eur J Endocrinol 2009 0.94
367 Lack of association between variations of PDE4D and ischemic stroke in the Japanese population. Stroke 2009 0.94
368 Similarity of the allele frequency and linkage disequilibrium pattern of single nucleotide polymorphisms in drug-related gene loci between Thai and northern East Asian populations: implications for tagging SNP selection in Thais. J Hum Genet 2006 0.94
369 No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations. BMC Med Genet 2012 0.94
370 Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration. World J Surg Oncol 2009 0.94
371 Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus. Hepatology 2011 0.94
372 Serum REG4 level is a predictive biomarker for the response to preoperative chemoradiotherapy in patients with pancreatic cancer. Pancreas 2009 0.94
373 A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. J Hepatol 2013 0.94
374 Cyclin K as a direct transcriptional target of the p53 tumor suppressor. Neoplasia 2002 0.93
375 An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes. Rheumatology (Oxford) 2013 0.93
376 Contribution of the 7β-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon. J Lipid Res 2013 0.93
377 Genome-wide screening by cDNA microarray of genes associated with matrix mineralization by human mesenchymal stem cells in vitro. Biochem Biophys Res Commun 2002 0.93
378 Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. J Hum Genet 2011 0.93
379 Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells. Int J Oncol 2009 0.93
380 A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells. Int J Oncol 2006 0.93
381 Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production. Proc Jpn Acad Ser B Phys Biol Sci 2011 0.93
382 Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells. Cancer Sci 2007 0.93
383 The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination. Neoplasia 2013 0.93
384 Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat. Clin Exp Pharmacol Physiol 2005 0.93
385 Megakaryocyte potentiating factor as a tumor marker of malignant pleural mesothelioma: evaluation in comparison with mesothelin. Lung Cancer 2008 0.93
386 C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage. Genes Chromosomes Cancer 2011 0.92
387 Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas. Oncogene 2002 0.92
388 Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese. PLoS One 2011 0.92
389 Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains. Arthritis Rheum 2002 0.92
390 PADI4 polymorphism predisposes male smokers to rheumatoid arthritis. Ann Rheum Dis 2010 0.91
391 CYP2B6 genotype is a strong predictor of systemic exposure to efavirenz in HIV-infected Zimbabweans. Eur J Clin Pharmacol 2011 0.91
392 MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells. Cell Cycle 2013 0.91
393 Phase I/II study of S-1 plus cisplatin combined with peptide vaccines for human vascular endothelial growth factor receptor 1 and 2 in patients with advanced gastric cancer. Int J Oncol 2012 0.91
394 Identification of semaphorin3B as a direct target of p53. Neoplasia 2002 0.91
395 Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway. Mol Cancer Res 2010 0.91
396 Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One 2013 0.91
397 Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis. Int J Oncol 2012 0.91
398 Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection. Hepatol Res 2009 0.91
399 Analysis of gene-expression profiles after gamma irradiation of normal human fibroblasts. Int J Radiat Oncol Biol Phys 2005 0.91
400 Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma. Int J Oncol 2002 0.91
401 Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy. J Hum Genet 2002 0.91
402 A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. Hum Mol Genet 2008 0.91
403 Combinational effect of genes for the renin-angiotensin system in conferring susceptibility to diabetic nephropathy. J Hum Genet 2006 0.90
404 An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway. J Hum Genet 2006 0.90
405 Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk. PLoS One 2013 0.90
406 Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. Cancer Sci 2006 0.90
407 Correlation of allelic losses and clinicopathological factors in 504 primary breast cancers. Breast Cancer 2002 0.90
408 Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population. J Hum Genet 2010 0.90
409 The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental retardation. Am J Hum Genet 2002 0.90
410 Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. Clin Cancer Res 2006 0.90
411 Expression profiles of metastatic brain tumor from lung adenocarcinomas on cDNA microarray. Int J Oncol 2006 0.90
412 Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Cancer Res 2010 0.90
413 Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients. J Hum Genet 2009 0.90
414 Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma. J Gastroenterol 2009 0.90
415 Oncogenic role of NALP7 in testicular seminomas. Cancer Sci 2004 0.90
416 A healthier Japan. Interview by David Cyranoski. Nature 2011 0.90
417 Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis. Cancer Res 2012 0.89
418 Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese. PLoS Genet 2012 0.89
419 Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas. Int J Oncol 2004 0.89
420 CLCA2 as a p53-inducible senescence mediator. Neoplasia 2012 0.89
421 Genome-wide analysis of organ-preferential metastasis of human small cell lung cancer in mice. Mol Cancer Res 2003 0.89
422 A single nucleotide polymorphism in KCNQ1 is associated with susceptibility to diabetic nephropathy in japanese subjects with type 2 diabetes. Diabetes Care 2010 0.89
423 A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T-lymphocytes reactive to tumor cells. Cancer Sci 2011 0.89
424 Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells. Genes Chromosomes Cancer 2010 0.89
425 From cancer genomics to thoracic oncology: discovery of new biomarkers and therapeutic targets for lung and esophageal carcinoma. Gen Thorac Cardiovasc Surg 2008 0.89
426 Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma. Hum Mol Genet 2005 0.89
427 Pharmacogenomics and patient care: one size does not fit all. Sci Transl Med 2012 0.89
428 Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer. Cancer Sci 2006 0.89
429 Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response. Pharmacogenet Genomics 2010 0.88
430 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun 2002 0.88
431 Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes. Oncogene 2005 0.88
432 Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet 2013 0.88
433 Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state. J Med Virol 2011 0.88
434 HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis. Ann Rheum Dis 2009 0.88
435 A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. PLoS Genet 2012 0.88
436 Novel deletion mutations of OPTN in amyotrophic lateral sclerosis in Japanese. Neurobiol Aging 2012 0.88
437 Amino acid substitution in HCV core region and genetic variation near the IL28B gene affect viral dynamics during telaprevir, peginterferon and ribavirin treatment. Intervirology 2012 0.88
438 Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells. Cancer Res 2010 0.88
439 Functional haplotypes of IL-12B are associated with childhood atopic asthma. J Allergy Clin Immunol 2005 0.88
440 Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. Cancer Sci 2008 0.88
441 Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8. J Hum Genet 2002 0.88
442 The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data. PLoS One 2010 0.87
443 Genome-wide association study of breast cancer in the Japanese population. PLoS One 2013 0.87
444 Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke. Hum Mol Genet 2009 0.87
445 Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. J Clin Endocrinol Metab 2007 0.87
446 Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population. J Hum Genet 2011 0.87
447 SLC22A4 polymorphism and rheumatoid arthritis susceptibility: a replication study in a Japanese population and a metaanalysis. J Rheumatol 2008 0.87
448 Pathway analysis of genome-wide data improves warfarin dose prediction. BMC Genomics 2013 0.87
449 Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers. Cancer Sci 2012 0.87
450 Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population. J Hum Genet 2002 0.87
451 Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. Int J Cancer 2008 0.87
452 Tumor budding is a significant indicator of a poor prognosis in lung squamous cell carcinoma patients. Mol Med Rep 2012 0.87
453 Identification of HLA-A24-restricted novel T Cell epitope peptides derived from P-cadherin and kinesin family member 20A. J Biomed Biotechnol 2012 0.87
454 Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. Int J Oncol 2003 0.87
455 The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1). PLoS One 2013 0.86
456 Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer. Clin Cancer Res 2011 0.86
457 Prediction of sensitivity to STI571 among chronic myeloid leukemia patients by genome-wide cDNA microarray analysis. Jpn J Cancer Res 2002 0.86
458 Small bowel perforation resulting from blunt abdominal trauma: interval change of radiological characteristics. Radiat Med 2006 0.86
459 High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population. J Hum Genet 2007 0.86
460 Establishment of a standardized system to perform population structure analyses with limited sample size or with different sets of SNP genotypes. J Hum Genet 2010 0.86
461 Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy. Intervirology 2011 0.86
462 A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese. Hum Mol Genet 2011 0.86
463 Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. Cancer Sci 2004 0.86
464 Quantitative structural characterization of local N-glycan microheterogeneity in therapeutic antibodies by energy-resolved oxonium ion monitoring. Anal Chem 2012 0.86
465 Prostate cancer genomics, biology, and risk assessment through genome-wide association studies. Cancer Sci 2012 0.86
466 Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice. Am J Physiol Gastrointest Liver Physiol 2005 0.86
467 Identification of the interleukin 4 receptor alpha gene as a direct target for p73. Cancer Res 2003 0.86
468 Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells. Nat Commun 2013 0.86
469 WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation. Neoplasia 2005 0.86
470 Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients. J Transl Med 2014 0.86
471 Characterization of a VNTR polymorphism in the coding region of the CEL gene. J Hum Genet 2002 0.85
472 Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer. Cancer Sci 2009 0.85
473 Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy. J Med Virol 2011 0.85
474 Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays. Proteomics 2009 0.85
475 Serum tumor antigen REG4 as a useful diagnostic biomarker in gastric cancer. Hepatogastroenterology 2011 0.85
476 ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. Cancer Sci 2007 0.85
477 Non-transmissible Sendai virus encoding granulocyte macrophage colony-stimulating factor is a novel and potent vector system for producing autologous tumor vaccines. Cancer Sci 2008 0.85
478 Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth. Cancer Sci 2008 0.85
479 CD40 ligand gene and Kawasaki disease. Eur J Hum Genet 2004 0.85
480 The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapy. Int J Cancer 2010 0.85
481 New correction algorithms for multiple comparisons in case-control multilocus association studies based on haplotypes and diplotype configurations. J Hum Genet 2008 0.85
482 Genetic basis of tissue specificity of vasculitis in MRL/lpr mice. Arthritis Rheum 2003 0.85
483 A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. Pharmacogenet Genomics 2012 0.85
484 Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity. J Med Chem 2015 0.85
485 Genome-wide gene expression profiles of clear cell renal cell carcinoma: identification of molecular targets for treatment of renal cell carcinoma. Int J Oncol 2006 0.85
486 Genome wide association study of age at menarche in the Japanese population. PLoS One 2013 0.85
487 Molecular cloning and characterization of a novel gene, EMILIN-5, and its possible involvement in skeletal development. Biochem Biophys Res Commun 2004 0.85
488 Toward the establishment of a prediction system for the personalized treatment of chronic hepatitis C. J Infect Dis 2011 0.84
489 Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b. J Med Virol 2011 0.84
490 Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. PLoS One 2012 0.84
491 Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells. Clin Cancer Res 2008 0.84
492 Pharmacogenomics and drug toxicity. N Engl J Med 2008 0.84
493 Label-free DNA sensors using ultrasensitive diamond field-effect transistors in solution. Phys Rev E Stat Nonlin Soft Matter Phys 2006 0.84
494 Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis. Clin Cancer Res 2009 0.84
495 Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors. Cancer Sci 2008 0.84
496 Characterization of a cleavage stimulation factor, 3' pre-RNA, subunit 2, 64 kDa (CSTF2) as a therapeutic target for lung cancer. Clin Cancer Res 2011 0.84
497 Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. J Hum Genet 2011 0.84
498 Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor. Circulation 2003 0.84
499 Important and critical scientific aspects in pharmacogenomics analysis: lessons from controversial results of tamoxifen and CYP2D6 studies. J Hum Genet 2013 0.84
500 PlatinumCNV: a Bayesian Gaussian mixture model for genotyping copy number polymorphisms using SNP array signal intensity data. Genet Epidemiol 2011 0.83
501 Characterization of an Opa interacting protein 5 involved in lung and esophageal carcinogenesis. Cancer Sci 2012 0.83
502 Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. Br J Clin Pharmacol 2014 0.83
503 Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population. J Atheroscler Thromb 2010 0.83
504 Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer. Oncogene 2004 0.83
505 Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population. Int J Hematol 2011 0.83
506 Radioimmunotherapy of solid tumors targeting a cell-surface protein, FZD10: therapeutic efficacy largely depends on radiosensitivity. Ann Nucl Med 2009 0.83
507 Predicting response to docetaxel neoadjuvant chemotherapy for advanced breast cancers through genome-wide gene expression profiling. Int J Oncol 2009 0.83
508 Identification of SPARC as a candidate target antigen for immunotherapy of various cancers. Int J Cancer 2010 0.83
509 Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. J Affect Disord 2009 0.83
510 In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy. Cancer Immunol Immunother 2012 0.83
511 Large-scale screening of TARDBP mutation in amyotrophic lateral sclerosis in Japanese. Neurobiol Aging 2010 0.83
512 SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population. J Hum Genet 2010 0.82
513 Reevaluation of a lectin antibody ELISA kit for measuring fucosylated haptoglobin in various conditions. Clin Chim Acta 2012 0.82
514 Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma. Mol Med Rep 2011 0.82
515 Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population. J Bone Miner Metab 2010 0.82
516 DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas. Cancer Res 2012 0.82
517 Catalog of 178 variations in the Japanese population among eight human genes encoding G protein-coupled receptors (GPCRs). J Hum Genet 2003 0.82
518 Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer. Proteome Sci 2011 0.82
519 SMYD3 interacts with HTLV-1 Tax and regulates subcellular localization of Tax. Cancer Sci 2010 0.82
520 pH-sensitive diamond field-effect transistors (FETs) with directly aminated channel surface. Anal Chim Acta 2006 0.82
521 PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. Cancer Res 2005 0.82
522 Japanese single nucleotide polymorphism database for 267 possible drug-related genes. Cancer Sci 2006 0.82
523 Induction of tenascin-C by tumor-specific EWS-ETS fusion genes. Genes Chromosomes Cancer 2003 0.82
524 A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction. J Hum Genet 2007 0.82
525 DNA micropatterning on polycrystalline diamond via one-step direct amination. Langmuir 2006 0.82
526 Determination of splice-site mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer) patients using functional splicing assay. Fam Cancer 2009 0.82
527 Recombination rates of genes expressed in human tissues. Hum Mol Genet 2007 0.81
528 Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma. Clin Cancer Res 2006 0.81
529 A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients. J Hepatol 2010 0.81
530 Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression. J Hum Genet 2009 0.81
531 Linkage disequilibrium of evolutionarily conserved regions in the human genome. BMC Genomics 2006 0.81
532 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Breast Cancer Res 2013 0.81
533 High-resolution SNP map of ASPN, a susceptibility gene for osteoarthritis. J Hum Genet 2005 0.81
534 Histidine augments the suppression of hepatic glucose production by central insulin action. Diabetes 2013 0.81
535 Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer. Clin Cancer Res 2007 0.81
536 A replication study for three nephrolithiasis loci at 5q35.3, 7p14.3 and 13q14.1 in the Japanese population. J Hum Genet 2013 0.81
537 High-density SNP map of human ITR, a gene associated with vascular remodeling. J Hum Genet 2003 0.81
538 HLA-A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese. Int J Cancer 2014 0.81
539 Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis. Cancer Sci 2006 0.81
540 Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians. Neurobiol Aging 2011 0.80
541 Combined immunotherapy with low-dose IL-2 plus IFN-alpha for metastatic renal cell carcinoma: survival benefit for selected patients with lung metastasis and serum sodium level. Jpn J Clin Oncol 2011 0.80
542 Expression profiles of two types of human knee-joint cartilage. J Hum Genet 2003 0.80
543 Involvement of C12orf32 overexpression in breast carcinogenesis. Int J Oncol 2010 0.80
544 Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study. Clin Cancer Res 2013 0.80
545 Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. Int J Oncol 2003 0.80
546 A functional polymorphism in MMP-9 is associated with childhood atopic asthma. Biochem Biophys Res Commun 2006 0.80
547 Predicting response of bladder cancers to gemcitabine and carboplatin neoadjuvant chemotherapy through genome-wide gene expression profiling. Exp Ther Med 2010 0.80
548 A comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinoma. PLoS One 2011 0.80
549 Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Sci 2007 0.80
550 Identification of a functional variant in SPLUNC1 associated with nasopharyngeal carcinoma susceptibility among Malaysian Chinese. Mol Carcinog 2011 0.80
551 Serial analysis of gene expression in progressing and regressing mouse tumors implicates the involvement of RANTES and TARC in antitumor immune responses. Mol Ther 2006 0.80
552 Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: a combined analysis of independent samples. Am J Med Genet B Neuropsychiatr Genet 2011 0.80
553 Identification of COX17 as a therapeutic target for non-small cell lung cancer. Cancer Res 2003 0.80
554 A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population. J Hum Genet 2008 0.80
555 Characterization of T-cell Receptor Repertoire in Inflamed Tissues of Patients with Crohn's Disease Through Deep Sequencing. Inflamm Bowel Dis 2016 0.80
556 Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. J Hum Genet 2007 0.79
557 Gene expression patterns as marker for 5-year postoperative prognosis of primary breast cancers. J Cancer Res Clin Oncol 2004 0.79
558 PKIB expression strongly correlated with phosphorylated Akt expression in breast cancers and also with triple-negative breast cancer subtype. Med Mol Morphol 2012 0.79
559 Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125). J Med Chem 2013 0.79
560 Gene-expression profiles of human tumor xenografts in nude mice treated orally with the EGFR tyrosine kinase inhibitor ZD1839. Int J Oncol 2003 0.79
561 Two replication regions in the pJM1 virulence plasmid of the marine pathogen Vibrio anguillarum. Plasmid 2012 0.79
562 Association of a single-nucleotide polymorphism in the immunoglobulin mu-binding protein 2 gene with immunoglobulin A nephropathy. J Hum Genet 2004 0.79
563 A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. J Hum Genet 2012 0.79
564 Retraction. Cloning and expression of soluble recombinant human esophageal cancer-related gene 4 protein and its inhibitory effect on tumor growth in vitro and in vivo in esophageal carcinoma. Cancer Sci 2011 0.79
565 Molecular target therapy for synovial sarcoma. Future Oncol 2005 0.79
566 Twenty single-nucleotide polymorphisms in four genes encoding cardiac ion channels. J Hum Genet 2002 0.78
567 Expression of Apc2 during mouse development. Brain Res Gene Expr Patterns 2002 0.78
568 VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Res 2014 0.78
569 Association of PTEN mutation with HPV-negative adenocarcinoma of the uterine cervix. Cancer Lett 2004 0.78
570 Structural and functional analysis of native peroxiredoxin 2 in human red blood cells. Int J Biochem Cell Biol 2012 0.78
571 Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors. Mol Cell Neurosci 2010 0.78
572 Identification of 46 novel SNPs in the 130-kb region containing a myocardial infarction susceptibility gene on chromosomal band 6p21. J Hum Genet 2003 0.78
573 Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy. Oncol Lett 2010 0.78
574 Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy. Int J Oncol 2007 0.78
575 Adenovirus-mediated p53AIP1 gene transfer as a new strategy for treatment of p53-resistant tumors. Cancer Sci 2004 0.78
576 Fine-scale SNP map of an 11-kb genomic region at 22q13.1 containing the galectin-1 gene. J Hum Genet 2004 0.78
577 Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors. J Hum Genet 2004 0.78
578 Impact of PSCA variation on gastric ulcer susceptibility. PLoS One 2013 0.78
579 Optineurin mutations in Japanese amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2011 0.78
580 Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis: case-control studies. PLoS One 2011 0.78
581 Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. Cancer Sci 2008 0.78
582 A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2. Breast Cancer Res Treat 2015 0.78
583 Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas. Oncogene 2004 0.78
584 Over expression of hypoxia-inducible protein 2, hypoxia-inducible factor-1alpha and nuclear factor kappaB is putatively involved in acquired renal cyst formation and subsequent tumor transformation in patients with end stage renal failure. J Urol 2008 0.78
585 Inference from the relationships between linkage disequilibrium and allele frequency distributions of 240 candidate SNPs in 109 drug-related genes in four Asian populations. J Hum Genet 2004 0.78
586 Genetic differences in the two main groups of the Japanese population based on autosomal SNPs and haplotypes. J Hum Genet 2012 0.78
587 Catalog of 668 SNPs detected among 31 genes encoding potential drug targets on the cell surface. J Hum Genet 2003 0.78
588 Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population. J Dermatol Sci 2013 0.78
589 Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia. Blood 2013 0.78
590 Institutional Profile: University of Chicago Center for Personalized Therapeutics: research, education and implementation science. Pharmacogenomics 2013 0.77
591 Association of allelic loss at 8p22 with poor prognosis among breast cancer cases treated with high-dose adjuvant chemotherapy. Cancer Lett 2002 0.77
592 Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C. J Gen Virol 2012 0.77
593 Herpes simplex virus-induced, death receptor-dependent apoptosis and regression of transplanted human cancers. Cancer Sci 2004 0.77
594 Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines. Cancer Sci 2003 0.77
595 Functional impact of IgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction. Immunogenetics 2006 0.77
596 [Possible role of genetic factors on reduced risk for gastric cancer among duodenal ulcer patients]. Nihon Rinsho 2013 0.77
597 New pharmacogenetic test for detecting an HLA-A*31: 01 allele using the InvaderPlus assay. Pharmacogenet Genomics 2012 0.77
598 Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. Pharmacogenomics 2011 0.77
599 Distinct pattern of gene expression in pyothorax-associated lymphoma (PAL), a lymphoma developing in long-standing inflammation. Cancer Sci 2004 0.77
600 Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway. J Biol Chem 2003 0.77
601 Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma. J Hum Genet 2004 0.77
602 Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats. J Pharmacol Sci 2010 0.77
603 Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis. Inflamm Bowel Dis 2013 0.77
604 Plasma low-molecular-weight proteome profiling identified neuropeptide-Y as a prostate cancer biomarker polypeptide. J Proteome Res 2013 0.77
605 Mutation analysis of COL9A3, a gene highly expressed in the cochlea, in hearing loss patients. Auris Nasus Larynx 2005 0.77
606 Maternal isodisomy for 14q21-q24 in a man with diabetes mellitus. Am J Med Genet 2002 0.77
607 A model of prediction system for adverse cardiovascular reactions by calcineurin inhibitors among patients with renal transplants using gene-based single-nucleotide polymorphisms. J Hum Genet 2005 0.77
608 Host molecular defense mechanisms against Chlamydophila pneumoniae and genetic studies of immune-response-related genes in asthma. Recent Pat Inflamm Allergy Drug Discov 2009 0.77
609 906 variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde dehydrogenases (ALDHs) in the Japanese population. J Hum Genet 2002 0.77
610 Association of the RIP2 gene with childhood atopic asthma. Allergol Int 2006 0.77
611 Genome-wide association study of epirubicin-induced leukopenia in Japanese patients. Pharmacogenet Genomics 2011 0.77
612 hzAnalyzer: detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets. Genome Biol 2011 0.77
613 Identification of a set of genes associated with response to interleukin-2 and interferon-α combination therapy for renal cell carcinoma through genome-wide gene expression profiling. Exp Ther Med 2010 0.77
614 Should CYP2D6 inhibitors be administered in conjunction with tamoxifen? Expert Rev Anticancer Ther 2011 0.77
615 MRG-binding protein contributes to colorectal cancer development. Cancer Sci 2011 0.76
616 Catalog of 77 single-nucleotide polymorphisms (SNPs) in the carbohydrate sulfotransferase 1 (CHST1) and carbohydrate sulfotransferase 3 (CHST3) genes. J Hum Genet 2002 0.76
617 Recent advances in active specific cancer vaccine treatment for colorectal cancer. Curr Pharm Biotechnol 2012 0.76
618 5alphaDH-DOC (5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer. Cancer Sci 2010 0.76
619 Understanding the functional significance of ghrelin processing and degradation. Peptides 2011 0.76
620 Criterion values for multiplex SNP genotyping by the invader assay. Forensic Sci Int Genet 2009 0.76
621 Suppression of rice immunity by Xanthomonas oryzae type III effector Xoo2875. Biosci Biotechnol Biochem 2013 0.76
622 Isolation and characterization of the mouse ortholog of the Fukuyama-type congenital muscular dystrophy gene. Genomics 2002 0.76
623 Retraction: Curcumin targets Akt cell survival signaling pathway in HTLV-I-infected T-cell lines. Cancer Sci 2010 0.76
624 Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. Int J Oncol 2010 0.76
625 Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. J Hum Genet 2003 0.76
626 Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome. J Hum Genet 2009 0.76
627 Host cell-specific effects of lentiviral accessory proteins on the eukaryotic cell cycle progression. Microbes Infect 2009 0.76
628 Effect of taurine supplementation on the alterations in amino Acid content in skeletal muscle with exercise in rat. J Sports Sci Med 2011 0.76
629 [Phase I study of combination therapy with peptide vaccine and anti-cancer drug for colorectal cancer]. Gan To Kagaku Ryoho 2008 0.76
630 High-resolution SNP map in the 55-kb region containing the selectin gene family on chromosome 1q24-q25. J Hum Genet 2003 0.76
631 Prediction of response to imatinib by cDNA microarray analysis. Semin Hematol 2003 0.76
632 Impact of four loci on serum tamsulosin hydrochloride concentration. J Hum Genet 2012 0.76
633 Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. Psychiatr Genet 2013 0.76
634 Oxygen consumption rate of early pre-antral follicles from vitrified human ovarian cortical tissue. J Reprod Dev 2014 0.75
635 Synthesis of encephalomyocarditis virus in a cell-free system: from DNA to RNA virus in one tube. Biotechnol Lett 2011 0.75
636 Guidance for peptide vaccines for the treatment of cancer. Cancer Sci 2014 0.75
637 [BioBank Japan project]. Nihon Rinsho 2005 0.75
638 [A phase I study of combination-therapy with gemcitabine and epitope peptides derived from human vascular endothelial growth factor receptor for unresectable or recurrent pancreas cancer]. Gan To Kagaku Ryoho 2008 0.75
639 Accurate automated clustering of two-dimensional data for single-nucleotide polymorphism genotyping by a combination of clustering methods: evaluation by large-scale real data. Bioinformatics 2007 0.75
640 Colorectal cancer metastasis to the thyroid. Osaka City Med J 2012 0.75
641 A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats. Clin Exp Pharmacol Physiol 2004 0.75
642 Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis. Int J Oncol 2012 0.75
643 Potential involvement of p53 in ischemia/reperfusion-induced osteonecrosis. J Bone Miner Metab 2008 0.75
644 Aberrant splicing caused by a MLH1 splice donor site mutation found in a young Japanese patient with Lynch syndrome. Fam Cancer 2012 0.75
645 Retracted: Modulation of p53 /Akt / phosphatase and tensin homolog expression by esculetin potentiates the anticancer activity of cisplatin and prevents its nephrotoxicity. Cancer Sci 2011 0.75
646 Optimal phenology of annual plants under grazing pressure. J Theor Biol 2007 0.75
647 Retraction: Epstein-Barr virus-encoded latent membrane protein 1 activates β-catenin signaling in B lymphocytes. Cancer Sci 2010 0.75
648 [Gene expression analysis of AML cells using cDNA microarray]. Rinsho Ketsueki 2002 0.75
649 Retraction: Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene). Cancer Sci 2010 0.75
650 [Therapeutic cancer vaccines against gastro-intestinal cancer]. Nihon Shokakibyo Gakkai Zasshi 2010 0.75
651 Thirteen single-nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4 (ADH4) gene locus. J Hum Genet 2002 0.75
652 Development of new HLA-B*3505 genotyping method using Invader assay. Pharmacogenet Genomics 2010 0.75
653 Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus. J Hum Genet 2004 0.75
654 Effect of Saiko-ka-ryukotsu-borei-to on amylase activity in mice. Biol Pharm Bull 2004 0.75
655 [Spinal epidural hematoma: relationship between imaging findings and neurological outcomes]. Nihon Igaku Hoshasen Gakkai Zasshi 2003 0.75
656 Temporal Changes of Inflammatory Cytokine Profiles in Epithelial Lining Fluid in a Canine Lung Transplant Model. Tokai J Exp Clin Med 2017 0.75
657 [Genomic medicine]. Nihon Naika Gakkai Zasshi 2002 0.75
658 [SNP collection, pharmacogenomics, and the future of drug therapy]. Gan To Kagaku Ryoho 2002 0.75
659 Automated SNPs typing system based on the Invader assay. Leg Med (Tokyo) 2009 0.75
660 RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. Mol Cancer Res 2013 0.75
661 Making a haplotype catalog with estimated frequencies based on SNP homozygotes. J Hum Genet 2010 0.75
662 Identification of 156 novel SNPs in 29 genes encoding G-protein coupled receptors. J Hum Genet 2005 0.75
663 Personalizing carbamazepine therapy. Genome Med 2011 0.75
664 [A case of inoperable gastric small cell carcinoma effectively treated by chemotherapy and radiotherapy]. Gan To Kagaku Ryoho 2006 0.75
665 [Early diagnosis of metastatic spinal tumor is a key for effective palliative radiotherapy in patients with lung cancer]. Gan To Kagaku Ryoho 2011 0.75
666 Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population. J Rheumatol 2010 0.75
667 Fatal case of clinically amyopathic dermatomyositis: cotton-wool spots as a sign of an aggressive subtype of dermatomyositis. J Dermatol 2014 0.75
668 [A case with an ovarian cancer patient who could receive anti-cancer therapy and palliative care simultaneously at home through seamless collaboration in healthcare linkage]. Gan To Kagaku Ryoho 2010 0.75
669 Identification of CAG repeat-containing genes expressed in human brain as candidate genes for autosomal dominant spinocerebellar ataxias and other neurodegenerative diseases. J Hum Genet 2002 0.75
670 Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays. Int J Oncol 2002 0.75
671 Plagiarism. Cancer Sci 2009 0.75
672 Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13. J Hum Genet 2004 0.75