Published in Am J Physiol Cell Physiol on March 01, 2005
Life cycle of connexins in health and disease. Biochem J (2006) 3.44
Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential. J Physiol (2006) 2.68
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A (2008) 2.01
Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness. Proc Natl Acad Sci U S A (2007) 1.44
Gap junctions and cochlear homeostasis. J Membr Biol (2006) 1.41
Gap-junction channels dysfunction in deafness and hearing loss. Antioxid Redox Signal (2009) 1.39
Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions. Proc Natl Acad Sci U S A (2005) 1.39
The role of connexins in ear and skin physiology - functional insights from disease-associated mutations. Biochim Biophys Acta (2012) 1.34
Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs. J Comp Neurol (2006) 1.30
Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea. J Comp Neurol (2009) 1.25
Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models. Brain Res (2009) 1.20
Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice. PLoS One (2008) 1.16
Gap junctions couple astrocytes and oligodendrocytes. J Mol Neurosci (2008) 1.16
Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear. Proc Natl Acad Sci U S A (2008) 1.11
Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31. Hum Genet (2008) 1.08
The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Hum Mol Genet (2010) 1.07
Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues. FEBS Lett (2014) 1.04
Virally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice. Gene Ther (2013) 0.99
Connexin26 deafness associated mutations show altered permeability to large cationic molecules. Am J Physiol Cell Physiol (2008) 0.98
Permeation of calcium through purified connexin 26 hemichannels. J Biol Chem (2012) 0.98
Gap junctions in inherited human disease. Pflugers Arch (2010) 0.97
Dominant connexin26 mutants associated with human hearing loss have trans-dominant effects on connexin30. Neurobiol Dis (2010) 0.96
Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest (2014) 0.93
Dominant Cx26 mutants associated with hearing loss have dominant-negative effects on wild type Cx26. Mol Cell Neurosci (2010) 0.92
An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nat Commun (2016) 0.89
Pathological hemichannels associated with human Cx26 mutations causing Keratitis-Ichthyosis-Deafness syndrome. Biochim Biophys Acta (2011) 0.88
Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists. J Neurosci (2013) 0.87
Functional evaluation of GJB2 variants in nonsyndromic hearing loss. Mol Med (2011) 0.85
7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo. Biochem Biophys Res Commun (2012) 0.84
Pannexins are new molecular candidates for assembling gap junctions in the cochlea. Neuroreport (2008) 0.84
Early developmental expression of connexin26 in the cochlea contributes to its dominate functional role in the cochlear gap junctions. Biochem Biophys Res Commun (2011) 0.83
Mouse otocyst transuterine gene transfer restores hearing in mice with connexin 30 deletion-associated hearing loss. Mol Ther (2013) 0.83
TRPC3 ion channel subunit immunolocalization in the cochlea. Histochem Cell Biol (2009) 0.81
Analysis of connexin subunits required for the survival of vestibular hair cells. J Comp Neurol (2007) 0.81
Connexins and gap junctions in the inner ear--it's not just about K⁺ recycling. Cell Tissue Res (2014) 0.80
Reduced Connexin26 in the Mature Cochlea Increases Susceptibility to Noise-Induced Hearing Lossin Mice. Int J Mol Sci (2016) 0.79
Potential treatments for genetic hearing loss in humans: current conundrums. Gene Ther (2015) 0.78
Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6. Mol Ther Nucleic Acids (2012) 0.77
Clinical and biophysical characterization of 19 GJB1 mutations. Ann Clin Transl Neurol (2016) 0.75
In Vitro Models of GJB2-Related Hearing Loss Recapitulate Ca(2+) Transients via a Gap Junction Characteristic of Developing Cochlea. Stem Cell Reports (2016) 0.75
Single nucleotide polymorphisms of the GJB2 and GJB6 genes are associated with autosomal recessive nonsyndromic hearing loss. Biomed Res Int (2015) 0.75
Amplification mode differs along the length of the mouse cochlea as revealed by connexin 26 deletion from specific gap junctions. Sci Rep (2017) 0.75
Histochemistry and cell biology: the annual review 2010. Histochem Cell Biol (2011) 0.75
Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88
Overriding imatinib resistance with a novel ABL kinase inhibitor. Science (2004) 11.83
Suicide rates in China, 1995-99. Lancet (2002) 9.40
Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med (2013) 7.52
Risk factors for suicide in China: a national case-control psychological autopsy study. Lancet (2002) 7.00
Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey. Am J Respir Crit Care Med (2007) 4.82
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues. Science (2012) 4.52
Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet (2007) 3.79
Identification of new diamine scaffolds with activity against Mycobacterium tuberculosis. J Med Chem (2006) 3.75
Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science (2009) 3.69
Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study. Lancet (2008) 3.62
Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expr Patterns (2003) 3.42
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol Cell (2003) 3.42
Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Mol Cell Biol (2004) 3.31
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (2006) 2.96
miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest (2008) 2.87
Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85
Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. EMBO J (2004) 2.59
Identification of the immunodominant protein and other proteins of the Bacillus anthracis exosporium. J Bacteriol (2003) 2.48
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell (2007) 2.42
Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units. Science (2014) 2.37
Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol (2006) 2.37
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet (2005) 2.36
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines. J Antimicrob Chemother (2005) 2.08
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem (2002) 2.06
Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Mol Cancer Ther (2008) 2.04
Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. Neuron (2002) 1.95
Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme. Genome Med (2010) 1.94
Novel oligosaccharide side chains of the collagen-like region of BclA, the major glycoprotein of the Bacillus anthracis exosporium. J Biol Chem (2004) 1.92
Tumor microenvironments direct the recruitment and expansion of human Th17 cells. J Immunol (2009) 1.91
An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell (2010) 1.91
Risk factors for severe illness with 2009 pandemic influenza A (H1N1) virus infection in China. Clin Infect Dis (2011) 1.87
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Mol Cell Biol (2010) 1.86
Low-planned suicides in China. Psychol Med (2005) 1.81
Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med (2007) 1.77
Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. Mol Cell Biol (2006) 1.76
Orientation within the exosporium and structural stability of the collagen-like glycoprotein BclA of Bacillus anthracis. J Bacteriol (2005) 1.71
HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci U S A (2013) 1.70
Human regulatory T cells induce T-lymphocyte senescence. Blood (2012) 1.70
Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell (2008) 1.66
Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein. J Clin Oncol (2011) 1.65
The expression of CRM1 is associated with prognosis in human osteosarcoma. Oncol Rep (2009) 1.64
Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue. Stem Cells Dev (2008) 1.64
MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem (2009) 1.63
Synthesis and electromagnetic, microwave absorbing properties of core-shell Fe3O4-poly(3, 4-ethylenedioxythiophene) microspheres. ACS Appl Mater Interfaces (2011) 1.62
Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem (2006) 1.62
Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis (2012) 1.62
Asymptomatic patients of chronic obstructive pulmonary disease in China. Chin Med J (Engl) (2010) 1.62
Planar cell polarity signaling in vertebrates. Bioessays (2007) 1.62
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell (2012) 1.61
Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination. Mol Cell Biol (2003) 1.59
Validity of Asthma Control Test in Chinese patients. Chin Med J (Engl) (2007) 1.58
Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice. Biochem Biophys Res Commun (2003) 1.55
The seroprevalence of pandemic influenza H1N1 (2009) virus in China. PLoS One (2011) 1.54
Barriers to TB care for rural-to-urban migrant TB patients in Shanghai: a qualitative study. Trop Med Int Health (2009) 1.53
Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. J Pharmacol Exp Ther (2007) 1.53
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Chronic obstructive pulmonary disease in the absence of chronic bronchitis in China. Respirology (2010) 1.50
Results of trimodality therapy in patients with stage IIIA (N2-bulky) and stage IIIB non-small-cell lung cancer. Clin Lung Cancer (2009) 1.50
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun (2012) 1.49
Circadian, day-of-week, and age patterns of the occurrence of acute coronary syndrome in Beijing's emergency medical services system. Am J Emerg Med (2010) 1.46
Substrate-friendly synthesis of metal oxide nanostructures using a hotplate. Small (2006) 1.45
Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. J Comp Neurol (2004) 1.45
Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness. Proc Natl Acad Sci U S A (2007) 1.44
Analytical and clinical evaluation of CYFRA 21-1 by electrochemiluminescent immunoassay in head and neck squamous cell carcinoma. J Laryngol Otol (2003) 1.44
ER-alpha36, a novel variant of ER-alpha, is expressed in ER-positive and -negative human breast carcinomas. Anticancer Res (2008) 1.43
Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo. J Neurosci (2012) 1.43
Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions. Cell Cycle (2007) 1.43
Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A (2010) 1.43
Applications of targeted gene capture and next-generation sequencing technologies in studies of human deafness and other genetic disabilities. Hear Res (2012) 1.43
miR-135a Suppresses Calcification in Senescent VSMCs by Regulating KLF4/STAT3 Pathway. Curr Vasc Pharmacol (2016) 1.42
Attenuation of late-stage disease in mice infected by the Mycobacterium tuberculosis mutant lacking the SigF alternate sigma factor and identification of SigF-dependent genes by microarray analysis. Infect Immun (2004) 1.41
Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus. Clin Infect Dis (2013) 1.40
Retracted Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR-127 in human bladder cancer. Eur J Med Res (2013) 1.39
Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions. Proc Natl Acad Sci U S A (2005) 1.39
Venomous auger snail Hastula (Impages) hectica (Linnaeus, 1758): molecular phylogeny, foregut anatomy and comparative toxinology. J Exp Zool B Mol Dev Evol (2007) 1.39
Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer. J Immunol (2012) 1.38
Development of form and function in the mammalian cochlea. Curr Opin Neurobiol (2009) 1.36
A novel mechanism for connexin 26 mutation linked deafness: cell death caused by leaky gap junction hemichannels. Laryngoscope (2006) 1.36
Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. Cancer Res (2009) 1.35
History and evolution of alpine plants endemic to the Qinghai-Tibetan Plateau: Aconitum gymnandrum (Ranunculaceae). Mol Ecol (2009) 1.34