Published in Cancer Cell on October 01, 2007
Modes of p53 regulation. Cell (2009) 9.31
Signaling to p53: ribosomal proteins find their way. Cancer Cell (2009) 3.84
MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer (2013) 3.60
The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol (2010) 3.08
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell (2010) 2.47
Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A (2009) 2.00
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res (2009) 1.87
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell (2012) 1.79
The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66
The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci U S A (2011) 1.66
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A (2011) 1.51
Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem (2008) 1.43
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms. Cell Death Differ (2011) 1.39
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J (2011) 1.38
Explaining oscillations and variability in the p53-Mdm2 system. BMC Syst Biol (2008) 1.31
Nucleoplasmic mobilization of nucleostemin stabilizes MDM2 and promotes G2-M progression and cell survival. J Cell Sci (2008) 1.28
MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. J Biol Chem (2011) 1.27
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol Cell (2011) 1.27
Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget (2012) 1.24
Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24
The regulation of the p53-mediated stress response by MDM2 and MDM4. Cold Spring Harb Perspect Biol (2010) 1.23
Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin. Dev Biol (2011) 1.13
The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Front Biosci (Landmark Ed) (2012) 1.12
Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets. Cancer Invest (2012) 1.12
The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev (2013) 1.11
Limiting the power of p53 through the ubiquitin proteasome pathway. Genes Dev (2014) 1.10
The PIDDosome activates p53 in response to supernumerary centrosomes. Genes Dev (2017) 1.07
New insights into p53 activation. Cell Res (2010) 1.06
MTA1 coregulator regulates p53 stability and function. J Biol Chem (2009) 1.04
Translational approaches targeting the p53 pathway for anti-cancer therapy. Br J Pharmacol (2012) 1.04
XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J (2013) 1.02
A function for the RING finger domain in the allosteric control of MDM2 conformation and activity. J Biol Chem (2009) 1.01
MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy. Oncogene (2010) 1.00
Role of Pirh2 in mediating the regulation of p53 and c-Myc. PLoS Genet (2011) 0.99
Stress-specific response of the p53-Mdm2 feedback loop. BMC Syst Biol (2010) 0.99
Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. J Biol Chem (2010) 0.99
Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. Biochim Biophys Acta (2009) 0.98
Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction. Oncotarget (2010) 0.98
Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage. Cancer Cell (2014) 0.98
Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1. Mol Cell Biol (2010) 0.97
p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation. J Biol Chem (2011) 0.95
Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. J Cell Biol (2014) 0.95
p53 -Dependent and -Independent Nucleolar Stress Responses. Cells (2012) 0.95
Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov (2011) 0.94
A role for Numb in p53 stabilization. Genome Biol (2008) 0.91
Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53. Br J Cancer (2010) 0.91
Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. J Clin Invest (2010) 0.91
Abnormal MDMX degradation in tumor cells due to ARF deficiency. Oncogene (2011) 0.90
Does control of mutant p53 by Mdm2 complicate cancer therapy? Genes Dev (2008) 0.90
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget (2012) 0.88
CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation. Cell Death Differ (2014) 0.87
Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis. Genes Cancer (2012) 0.86
Towards an understanding of the role of p53 in adrenocortical carcinogenesis. Mol Cell Endocrinol (2011) 0.86
Targeting p53-MDM2-MDMX loop for cancer therapy. Subcell Biochem (2014) 0.85
Making sense of ubiquitin ligases that regulate p53. Cancer Biol Ther (2010) 0.85
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1. World J Biol Chem (2014) 0.84
MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4. Pigment Cell Melanoma Res (2013) 0.84
Guardian of corpulence: a hypothesis on p53 signaling in the fat cell. Clin Lipidol (2009) 0.84
Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy. Curr Pharm Des (2013) 0.84
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol (2015) 0.83
FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. Cancer Res (2014) 0.83
Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2. PLoS One (2013) 0.83
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53. Genes Cancer (2012) 0.83
The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization. J Biol Chem (2015) 0.83
F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proc Natl Acad Sci U S A (2015) 0.83
Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops. Genes Cancer (2012) 0.83
Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene (2012) 0.82
p53 Regulation Goes Live-Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling. Genes Cancer (2012) 0.81
NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep (2016) 0.81
Peroxisome Proliferator-Activated Receptor γ-Mediated Inhibition on Hypoxia-Triggered Store-Operated Calcium Entry. A Caveolin-1-Dependent Mechanism. Am J Respir Cell Mol Biol (2015) 0.80
Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction. PLoS One (2012) 0.80
Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity. J Biol Chem (2013) 0.79
Therapeutic considerations for Mdm2: not just a one trick pony. Expert Opin Drug Discov (2008) 0.79
Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish. Oncogene (2015) 0.78
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. Oncogene (2013) 0.78
Ubp2 regulates Rsp5 ubiquitination activity in vivo and in vitro. PLoS One (2013) 0.78
Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Elife (2014) 0.77
Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D. Cell Cycle (2008) 0.77
Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection. Cell Cycle (2012) 0.77
Autoantibody response to murine double minute 2 protein in immunodiagnosis of hepatocellular carcinoma. J Immunol Res (2014) 0.77
Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell Death Dis (2015) 0.76
MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity. PLoS One (2013) 0.76
Distinct downstream targets manifest p53-dependent pathologies in mice. Oncogene (2016) 0.76
MDM2 oligomers: antagonizers of the guardian of the genome. Oncogene (2016) 0.76
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis. Transl Cancer Res (2016) 0.76
Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase. Proc Natl Acad Sci U S A (2015) 0.75
Characterization of cancer-associated missense mutations in MDM2. Mol Cell Oncol (2015) 0.75
Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE. J Biol Chem (2016) 0.75
Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Elife (2016) 0.75
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog (2016) 0.75
The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2. Cell Cycle (2014) 0.75
Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. Cell Rep (2016) 0.75
Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4. Cell Cycle (2017) 0.75
Dysfunction of the MDM2/p53 axis is linked to premature aging. J Clin Invest (2017) 0.75
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nat Struct Mol Biol (2017) 0.75
Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12
Suicide rates in China, 1995-99. Lancet (2002) 9.40
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med (2013) 7.52
Risk factors for suicide in China: a national case-control psychological autopsy study. Lancet (2002) 7.00
Modeling the therapeutic efficacy of p53 restoration in tumors. Cell (2006) 5.95
Modelling Myc inhibition as a cancer therapy. Nature (2008) 5.81
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell (2002) 5.29
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol (2003) 4.61
Distinct thresholds govern Myc's biological output in vivo. Cancer Cell (2008) 4.16
Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology (2003) 4.10
A matter of life and death. Cancer Cell (2002) 4.07
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol Cell (2003) 3.42
Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Mol Cell Biol (2004) 3.31
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med (2007) 3.11
p53--a Jack of all trades but master of none. Nat Rev Cancer (2009) 2.96
Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. EMBO J (2004) 2.59
Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature (2010) 2.51
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet (2005) 2.36
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell (2006) 2.32
Temporal dissection of p53 function in vitro and in vivo. Nat Genet (2005) 2.19
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol (2007) 2.16
Endogenous Myc maintains the tumor microenvironment. Genes Dev (2011) 2.16
Tumor microenvironments direct the recruitment and expansion of human Th17 cells. J Immunol (2009) 1.91
An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell (2010) 1.91
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev (2006) 1.87
Risk factors for severe illness with 2009 pandemic influenza A (H1N1) virus infection in China. Clin Infect Dis (2011) 1.87
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Mol Cell Biol (2010) 1.86
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology. Blood (2011) 1.84
Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet (2007) 1.82
Low-planned suicides in China. Psychol Med (2005) 1.81
MYC-dependent regulation and prognostic role of CIP2A in gastric cancer. J Natl Cancer Inst (2009) 1.80
Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res (2003) 1.78
Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. Mol Cell Biol (2006) 1.76
The ups and downs of Myc biology. Curr Opin Genet Dev (2009) 1.70
Human regulatory T cells induce T-lymphocyte senescence. Blood (2012) 1.70
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med (2005) 1.70
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci U S A (2003) 1.68
Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes (2007) 1.67
Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell (2008) 1.66
Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis. Cancer Res (2006) 1.64
MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem (2009) 1.63
Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis (2012) 1.62
Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem (2006) 1.62
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. Genes Dev (2013) 1.60
Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination. Mol Cell Biol (2003) 1.59
Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol (2003) 1.58
The seroprevalence of pandemic influenza H1N1 (2009) virus in China. PLoS One (2011) 1.54
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts. Am J Physiol Cell Physiol (2005) 1.49
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res (2004) 1.48
Circadian, day-of-week, and age patterns of the occurrence of acute coronary syndrome in Beijing's emergency medical services system. Am J Emerg Med (2010) 1.46
Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions. Cell Cycle (2007) 1.43
PDGF and PDGF receptors in glioma. Ups J Med Sci (2012) 1.43
Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res (2006) 1.42
Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer. J Immunol (2012) 1.38
Biodegradation of Inion fast-absorbing biodegradable plates and screws. J Craniofac Surg (2008) 1.35
Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression. Clin Cancer Res (2004) 1.33
Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells. Cancer Res (2004) 1.33
Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia. Oncogene (2004) 1.32
Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. Mol Cell Biol (2006) 1.29
E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A (2009) 1.28
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem (2002) 1.27
Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol (2004) 1.26
Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem (2003) 1.25
Nuclear import of the stem-loop binding protein and localization during the cell cycle. Mol Biol Cell (2005) 1.25
Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. J Biol Chem (2008) 1.24
Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget (2012) 1.24
The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer Cell (2002) 1.24
The RP-Mdm2-p53 pathway and tumorigenesis. Oncotarget (2011) 1.23
Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. Toxicol Sci (2005) 1.21
Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation. Mol Cell Biol (2009) 1.21
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife (2013) 1.20
Overexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Res (2007) 1.20
Proteome reference map and comparative proteomic analysis between a wild type Clostridium acetobutylicum DSM 1731 and its mutant with enhanced butanol tolerance and butanol yield. J Proteome Res (2010) 1.19
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov (2013) 1.17
Role of estrogen receptor in the regulation of ecto-5'-nucleotidase and adenosine in breast cancer. Clin Cancer Res (2004) 1.17
Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo. J Biol Chem (2006) 1.16
Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol (2011) 1.16
Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans. Dev Cell (2006) 1.16
Unlocking the Mdm2-p53 loop: ubiquitin is the key. Cell Cycle (2007) 1.16
Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma. Neuro Oncol (2012) 1.16
Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies. J Soc Gynecol Investig (2005) 1.15
The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. J Gen Virol (2004) 1.14
Use of national pneumonia surveillance to describe influenza A(H7N9) virus epidemiology, China, 2004-2013. Emerg Infect Dis (2013) 1.14
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability. J Biol Chem (2006) 1.13
Spaceflight transcriptomes: unique responses to a novel environment. Astrobiology (2012) 1.12
Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage. J Biol Chem (2004) 1.11