Published in EMBO J on February 03, 2005
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J (2005) 2.62
Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab (2008) 2.57
Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast. J Lipid Res (2008) 1.95
Mammalian ceramide synthases. IUBMB Life (2010) 1.94
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev (2011) 1.93
Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans. Mol Biol Cell (2006) 1.69
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem (2009) 1.58
LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. Biochem J (2006) 1.54
Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. Biochim Biophys Acta (2006) 1.28
Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Mol Biol Cell (2008) 1.16
Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.12
Transmembrane topology of ceramide synthase in yeast. Biochem J (2006) 1.09
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast. J Cell Sci (2012) 1.09
Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins. Mol Biol Cell (2005) 1.08
Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2. Histochem Cell Biol (2007) 1.03
TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Mol Biol Cell (2013) 1.03
Modulation of ceramide synthase activity via dimerization. J Biol Chem (2012) 1.02
TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids. Elife (2014) 1.00
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem (2011) 0.98
Yeast sphingolipids do not need to contain very long chain fatty acids. Biochem J (2007) 0.97
Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Mol Biol Cell (2009) 0.92
Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. J Lipid Res (2011) 0.89
Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function. J Biol Chem (2008) 0.85
A split-ubiquitin two-hybrid screen for proteins physically interacting with the yeast amino acid transceptor Gap1 and ammonium transceptor Mep2. PLoS One (2011) 0.85
Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PLoS One (2011) 0.84
Recent advances in the immunobiology of ceramide. Exp Mol Pathol (2006) 0.83
Regulation of ceramide synthase by casein kinase 2-dependent phosphorylation in Saccharomyces cerevisiae. J Biol Chem (2014) 0.81
The yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranes. Mol Cell Biol (2012) 0.81
Yeast cells lacking all known ceramide synthases continue to make complex sphingolipids and to incorporate ceramides into glycosylphosphatidylinositol (GPI) anchors. J Biol Chem (2010) 0.81
Expression of the bacterial type III effector DspA/E in Saccharomyces cerevisiae down-regulates the sphingolipid biosynthetic pathway leading to growth arrest. J Biol Chem (2014) 0.80
Susceptibility of Phelipanche and Orobanche species to AAL-toxin. Planta (2009) 0.80
Action of multiple endoplasmic reticulum chaperon-like proteins is required for proper folding and polarized localization of Kre6 protein essential in yeast cell wall β-1,6-glucan synthesis. J Biol Chem (2012) 0.80
Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase. Biochim Biophys Acta (2012) 0.78
Following the flux of long-chain bases through the sphingolipid pathway in vivo using mass spectrometry. J Lipid Res (2016) 0.77
The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease. Enzyme Res (2011) 0.76
Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders. Clin Lipidol (2014) 0.75
Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae. PLoS One (2016) 0.75
Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. Mol Biochem Parasitol (2011) 0.75
Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Eukaryot Cell (2015) 0.75
T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 57.88
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature (2000) 47.15
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A (2001) 33.71
ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics (1999) 21.85
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature (1996) 5.48
The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem (2002) 4.52
ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J Biol Chem (1997) 3.38
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem (1991) 3.20
The complex life of simple sphingolipids. EMBO Rep (2004) 3.10
Ceramide in the eukaryotic stress response. Trends Cell Biol (2000) 2.98
Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. J Cell Biol (1999) 2.80
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem (2002) 2.79
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta (2002) 2.53
Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem (2002) 2.42
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem (1997) 2.21
Sphingolipid functions in Saccharomyces cerevisiae: comparison to mammals. Annu Rev Biochem (1998) 2.15
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem (2003) 2.06
Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. EMBO J (2000) 2.06
Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration. Science (2003) 2.02
Inositol phosphorylceramide, a novel substance and the chief member of a major group of yeast sphingolipids containing a single inositol phosphate. J Biol Chem (1974) 1.99
Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell (2001) 1.96
C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J (2001) 1.89
Sphingolipids with inositolphosphate-containing head groups. Adv Lipid Res (1993) 1.83
Sphingolipid functions in Saccharomyces cerevisiae. Biochim Biophys Acta (2002) 1.79
Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc Natl Acad Sci U S A (1998) 1.72
The role of ceramide in cell signaling. Biochim Biophys Acta (1998) 1.59
The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. J Biol Chem (1998) 1.56
Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. J Biol Chem (2000) 1.52
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (1999) 1.49
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. Biochem J (1993) 1.43
Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphingolipid structures. J Biol Chem (1993) 1.42
Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res (1998) 1.42
Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. J Biol Chem (2000) 1.39
Sec61p contributes to signal sequence orientation according to the positive-inside rule. Mol Biol Cell (2003) 1.35
Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. J Biol Chem (1995) 1.31
Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem (2003) 1.29
Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast. J Cell Biol (2001) 1.28
The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem J (1999) 1.27
Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. Mol Biol Cell (1999) 1.24
The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Producing organism, fermentation, isolation, and biological activity. J Antibiot (Tokyo) (1995) 1.23
Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells. J Biol Chem (2002) 1.21
A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. Proc Natl Acad Sci U S A (2000) 1.20
Specificity in ceramide biosynthesis from long chain bases and various fatty acyl coenzyme A's by brain microsomes. J Biol Chem (1970) 1.17
Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. J Biol Chem (2000) 1.14
Ceramide/long-chain base phosphate rheostat in Saccharomyces cerevisiae: regulation of ceramide synthesis by Elo3p and Cka2p. Eukaryot Cell (2003) 1.13
Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae. Biochemistry (2002) 1.11
FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. J Biol Chem (2004) 1.08
Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae. J Biol Chem (2002) 1.01
Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. Genes Cells (2003) 1.00
Reactions of serine palmitoyltransferase with serine and molecular mechanisms of the actions of serine derivatives as inhibitors. Biochemistry (2004) 1.00
Fungicidal action of aureobasidin A, a cyclic depsipeptide antifungal antibiotic, against Saccharomyces cerevisiae. Antimicrob Agents Chemother (1997) 0.98
Synthesis of ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids from lignoceroyl-CoA by rat brain microsomes. J Biol Chem (1979) 0.88
LAG1 puts the focus on ceramide signaling. Int J Biochem Cell Biol (2002) 0.86
Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science (2007) 6.65
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell (2007) 5.67
Conformational changes in the Arp2/3 complex leading to actin nucleation. Nat Struct Mol Biol (2004) 2.77
Sorting GPI-anchored proteins. Nat Rev Mol Cell Biol (2004) 2.77
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell (2003) 2.65
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell (2009) 2.17
The ins and outs of sphingolipid synthesis. Trends Cell Biol (2005) 1.95
Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science (2009) 1.75
Distinct acto/myosin-I structures associate with endocytic profiles at the plasma membrane. J Cell Biol (2008) 1.68
Concentration of GPI-anchored proteins upon ER exit in yeast. Traffic (2008) 1.64
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol (2012) 1.58
An essential function of sphingolipids in yeast cell division. Mol Microbiol (2012) 1.44
Multiple functions of sterols in yeast endocytosis. Mol Biol Cell (2002) 1.43
Loss of ceramide synthase 3 causes lethal skin barrier disruption. Hum Mol Genet (2011) 1.26
Ordering of compartments in the yeast endocytic pathway. Traffic (2002) 1.24
Where sterols are required for endocytosis. Biochim Biophys Acta (2004) 1.22
The Rab GTPase Ypt1p and tethering factors couple protein sorting at the ER to vesicle targeting to the Golgi apparatus. Dev Cell (2002) 1.21
Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. J Biol Chem (2007) 1.20
Survival strategies of a sterol auxotroph. Development (2010) 1.16
Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. Mol Biol Cell (2002) 1.16
Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Mol Biol Cell (2008) 1.16
Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. J Biol Chem (2002) 1.14
Yeast lipid analysis and quantification by mass spectrometry. Methods Enzymol (2010) 1.13
Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.12
Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae. Biochemistry (2002) 1.11
Increased ubiquitin-dependent degradation can replace the essential requirement for heat shock protein induction. EMBO J (2003) 1.10
Transmembrane topology of ceramide synthase in yeast. Biochem J (2006) 1.09
The yeast p24 complex is required for the formation of COPI retrograde transport vesicles from the Golgi apparatus. J Cell Biol (2008) 1.07
Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI. J Cell Biol (2011) 1.06
The yeast p24 complex regulates GPI-anchored protein transport and quality control by monitoring anchor remodeling. Mol Biol Cell (2011) 1.06
Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana. New Phytol (2011) 1.04
Distribution and functions of sterols and sphingolipids. Cold Spring Harb Perspect Biol (2011) 1.02
Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER. Cell (2004) 1.02
Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae. J Biol Chem (2002) 1.01
Rho1p mutations specific for regulation of beta(1-->3)glucan synthesis and the order of assembly of the yeast cell wall. Mol Microbiol (2002) 1.00
The ER v-SNAREs are required for GPI-anchored protein sorting from other secretory proteins upon exit from the ER. J Cell Biol (2003) 0.99
Differential ER exit in yeast and mammalian cells. Curr Opin Cell Biol (2004) 0.98
Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans. Dev Cell (2009) 0.96
Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure (2010) 0.94
Lipidomic profiling of Saccharomyces cerevisiae and Zygosaccharomyces bailii reveals critical changes in lipid composition in response to acetic acid stress. PLoS One (2013) 0.91
A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red. ACS Chem Biol (2014) 0.89
Two pathways of sphingolipid biosynthesis are separated in the yeast Pichia pastoris. J Biol Chem (2011) 0.89
Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. J Lipid Res (2011) 0.89
A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance. Metab Eng (2011) 0.87
TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p. J Biol Chem (2006) 0.87
TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy. Cell Rep (2013) 0.86
A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. PLoS Genet (2011) 0.84
Dynamic amphiphile libraries to screen for the "fragrant" delivery of siRNA into HeLa cells and human primary fibroblasts. J Am Chem Soc (2013) 0.84
Genetic and biochemical interactions between the Arp2/3 complex, Cmd1p, casein kinase II, and Tub4p in yeast. FEMS Yeast Res (2003) 0.84
Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PLoS One (2011) 0.84
Glycosylphosphatidylinositol anchors regulate glycosphingolipid levels. J Lipid Res (2012) 0.83
Sphingolipid signaling in yeast: potential implications for understanding disease. Front Biosci (Elite Ed) (2013) 0.83
Cell biology: the ubiquitin connection. Nature (2002) 0.82
Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro. J Biol Chem (2008) 0.82
Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast. J Cell Sci (2013) 0.81
The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids. Cell Rep (2013) 0.81
Yeast as a model system for studying lipid homeostasis and function. FEBS Lett (2012) 0.81
Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomyces cerevisiae COPI mutants. PLoS One (2012) 0.80
An efficient method for the production of isotopically enriched cholesterol for NMR. J Lipid Res (2011) 0.79
Lipid pickup and delivery. Nat Cell Biol (2004) 0.78
Conceptually new entries into cells. Chimia (Aarau) (2011) 0.78
The presence of an ER exit signal determines the protein sorting upon ER exit in yeast. Biochem J (2008) 0.77
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest (2017) 0.75
Chemical biology approaches to membrane homeostasis and function. Chimia (Aarau) (2011) 0.75
TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy. Cell Rep (2017) 0.75
The Biochemistry Department of the University of Geneva: Understanding the Molecular Basis and Function of Intracellular Organization. Chimia (Aarau) (2009) 0.75
Amphiphilic dynamic NDI and PDI probes: imaging microdomains in giant unilamellar vesicles. Org Biomol Chem (2012) 0.75
History of Biochemistry at the University of Geneva From the Boulevard des Philosophes to Quai Ernest-Ansermet. Chimia (Aarau) (2009) 0.75
NCCR Chemical Biology: Interdisciplinary Research Excellence, Outreach, Education, and New Tools for Switzerland. Chimia (Aarau) (2011) 0.75