Published in Trends Cell Biol on February 01, 2005
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat Rev Mol Cell Biol (2009) 4.16
Retromer. Curr Opin Cell Biol (2008) 3.89
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron (2008) 3.08
A gene ontology inferred from molecular networks. Nat Biotechnol (2013) 2.95
Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron (2006) 2.76
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol (2011) 2.68
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7. J Cell Biol (2008) 2.56
Differential degradation of PIN2 auxin efflux carrier by retromer-dependent vacuolar targeting. Proc Natl Acad Sci U S A (2008) 2.44
Wnt signaling from development to disease: insights from model systems. Cold Spring Harb Perspect Biol (2009) 2.42
Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. J Cell Sci (2009) 2.30
Functional architecture of the retromer cargo-recognition complex. Nature (2007) 2.26
Advances in the genetics of Parkinson disease. Nat Rev Neurol (2013) 2.21
C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless. Dev Cell (2007) 2.10
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A (2008) 2.09
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol (2006) 2.09
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol (2006) 2.05
The endosomal system of plants: charting new and familiar territories. Plant Physiol (2008) 2.01
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell (2009) 1.99
The march of the PINs: developmental plasticity by dynamic polar targeting in plant cells. EMBO J (2010) 1.94
PIKfyve: Partners, significance, debates and paradoxes. Cell Biol Int (2008) 1.87
Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol Cell Biol (2007) 1.70
The Arabidopsis AAA ATPase SKD1 is involved in multivesicular endosome function and interacts with its positive regulator LYST-INTERACTING PROTEIN5. Plant Cell (2007) 1.70
The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans. Mol Biol Cell (2006) 1.66
Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. J Cell Biol (2007) 1.65
Plant retromer, localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. Plant Cell (2006) 1.54
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol (2011) 1.50
SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting. Semin Cell Dev Biol (2009) 1.49
Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis. Clin Cancer Res (2010) 1.46
A retromerlike complex is a novel Rab7 effector that is involved in the transport of the virulence factor cysteine protease in the enteric protozoan parasite Entamoeba histolytica. Mol Biol Cell (2005) 1.41
PIKfyve regulation of endosome-linked pathways. Traffic (2009) 1.39
Golgi-mediated vacuolar sorting of the endoplasmic reticulum chaperone BiP may play an active role in quality control within the secretory pathway. Plant Cell (2005) 1.36
Regulation of Wnt protein secretion and its role in gradient formation. EMBO Rep (2008) 1.35
Wortmannin induces homotypic fusion of plant prevacuolar compartments. J Exp Bot (2009) 1.35
Amino acids regulate retrieval of the yeast general amino acid permease from the vacuolar targeting pathway. Mol Biol Cell (2006) 1.28
Targeting of the plant vacuolar sorting receptor BP80 is dependent on multiple sorting signals in the cytosolic tail. Plant Cell (2006) 1.22
Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol (2014) 1.21
Opposing activities of the Snx3-retromer complex and ESCRT proteins mediate regulated cargo sorting at a common endosome. Mol Biol Cell (2008) 1.21
Mechanisms and concepts paving the way towards a complete transport cycle of plant vacuolar sorting receptors. Plant Cell (2012) 1.19
Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease. Arch Neurol (2008) 1.19
The clathrin adaptor complex 1 directly binds to a sorting signal in Ste13p to reduce the rate of its trafficking to the late endosome of yeast. J Cell Biol (2006) 1.15
The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol Dis (2012) 1.14
SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. Cell Res (2011) 1.13
Screening for VPS35 mutations in Parkinson's disease. Neurobiol Aging (2011) 1.12
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet (2014) 1.10
A recycling-defective vacuolar sorting receptor reveals an intermediate compartment situated between prevacuoles and vacuoles in tobacco. Plant Cell (2010) 1.09
The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function. Biochim Biophys Acta (2012) 1.08
Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J (2010) 1.06
Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex. Biochem J (2007) 1.05
Rab GTPase regulation of retromer-mediated cargo export during endosome maturation. Mol Biol Cell (2012) 1.05
Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors. Cell Adh Migr (2009) 1.05
Overexpression of the Arabidopsis syntaxin PEP12/SYP21 inhibits transport from the prevacuolar compartment to the lytic vacuole in vivo. Plant Cell (2006) 1.04
Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. EMBO J (2010) 1.02
Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell (2011) 1.00
Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol (2008) 1.00
VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. PLoS One (2011) 0.99
Btn2, a Hook1 ortholog and potential Batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast. Mol Cell Biol (2006) 0.99
BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. J Biol Chem (2011) 0.98
Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. J Biol Chem (2013) 0.97
Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. Traffic (2012) 0.97
Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling. J Cell Biol (2013) 0.97
Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin. J Cell Sci (2011) 0.96
Dysregulation of protein trafficking in neurodegeneration. Mol Neurodegener (2014) 0.95
Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. EMBO J (2008) 0.94
Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. Traffic (2007) 0.94
COPI selectively drives maturation of the early Golgi. Elife (2015) 0.94
The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). J Biol Chem (2009) 0.92
VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1. Biol Open (2012) 0.91
Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol. Mol Biol Cell (2010) 0.91
Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Mol Biol Cell (2008) 0.90
The Golgi in cell migration: regulation by signal transduction and its implications for cancer cell metastasis. ScientificWorldJournal (2012) 0.90
Wntless in Wnt secretion: molecular, cellular and genetic aspects. Front Biol (Beijing) (2012) 0.89
The long and the short of Wnt signaling in C. elegans. Curr Opin Genet Dev (2008) 0.89
Molecular dissection of endosomal compartments in plants. Plant Physiol (2007) 0.89
Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor. Exp Cell Res (2006) 0.89
The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. Mol Biol Cell (2008) 0.89
Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer. J Cancer (2015) 0.88
Retromer guides STxB and CD8-M6PR from early to recycling endosomes, EHD1 guides STxB from recycling endosome to Golgi. Traffic (2012) 0.88
Loss-of-function mutations of retromer large subunit genes suppress the phenotype of an Arabidopsis zig mutant that lacks Qb-SNARE VTI11. Plant Cell (2010) 0.88
FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network. Mol Biol Cell (2010) 0.87
Multiple Roles of the Small GTPase Rab7. Cells (2016) 0.87
AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene. Mol Immunol (2007) 0.86
TNO1 is involved in salt tolerance and vacuolar trafficking in Arabidopsis. Plant Physiol (2011) 0.86
Updating the Wnt pathways. Biosci Rep (2014) 0.86
Retrograde traffic in the biosynthetic-secretory route. Histochem Cell Biol (2008) 0.85
Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast. Mol Biol Cell (2011) 0.84
The reconstructed ancestral subunit a functions as both V-ATPase isoforms Vph1p and Stv1p in Saccharomyces cerevisiae. Mol Biol Cell (2011) 0.84
Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast. PLoS One (2013) 0.83
Golgi phosphoprotein 3 regulates metastasis of prostate cancer via matrix metalloproteinase 9. Int J Clin Exp Pathol (2015) 0.83
Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome. Mol Biol Cell (2013) 0.82
Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response. EBioMedicine (2016) 0.82
Functional identification of sorting receptors involved in trafficking of soluble lytic vacuolar proteins in vegetative cells of Arabidopsis. Plant Physiol (2012) 0.81
SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein. Commun Integr Biol (2012) 0.81
Receptor-mediated transport of vacuolar proteins: a critical analysis and a new model. Protoplasma (2013) 0.81
Traffic into silence: endomembranes and post-transcriptional RNA silencing. EMBO J (2014) 0.81
Clathrin is not required for SNX-BAR-retromer-mediated carrier formation. J Cell Sci (2012) 0.81
Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments. Dev Biol (2011) 0.81
Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease. Neurotherapeutics (2015) 0.80
Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis. Mol Brain (2014) 0.80