Published in Biol Open on October 11, 2012
VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function. Cell Rep (2015) 0.95
Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1. J Biol Chem (2013) 0.88
Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons. Cell Rep (2013) 0.86
Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response. EBioMedicine (2016) 0.82
Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease. Neurosci Biobehav Rev (2016) 0.78
VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation. Mol Brain (2015) 0.78
Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. J Neurosci (2016) 0.77
Cargo trafficking in Alzheimer’s disease: the possible role of retromer. Neurol Sci (2016) 0.77
Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2. Front Mol Neurosci (2017) 0.75
Role of the Retromer Complex in Neurodegenerative Diseases. Front Aging Neurosci (2016) 0.75
Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. Elife (2017) 0.75
Control of mitochondrial homeostasis by endocytic regulatory proteins. J Cell Sci (2017) 0.75
Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy. PLoS One (2017) 0.75
Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1. Neurobiol Aging (2017) 0.75
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell (2009) 4.89
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet (2011) 4.52
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol (2004) 4.24
VPS35 mutations in Parkinson disease. Am J Hum Genet (2011) 4.16
Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci (2009) 4.13
Retromer. Curr Opin Cell Biol (2008) 3.89
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron (2010) 3.49
Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells. Dev Cell (2007) 3.02
Recycle your receptors with retromer. Trends Cell Biol (2005) 3.02
Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol (2005) 3.01
The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev Cell (2007) 3.00
SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol (2011) 2.92
Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat Cell Biol (2008) 2.43
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex. Nat Cell Biol (2008) 2.38
C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless. Dev Cell (2007) 2.10
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A (2008) 2.09
Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nat Med (2004) 2.02
Focal adhesion kinase in netrin-1 signaling. Nat Neurosci (2004) 1.99
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell (2009) 1.99
Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev Cell (2010) 1.97
Retromer terminates the generation of cAMP by internalized PTH receptors. Nat Chem Biol (2011) 1.88
Activity-dependent development of callosal projections in the somatosensory cortex. J Neurosci (2007) 1.87
Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval. J Cell Sci (2007) 1.81
Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. Nat Cell Biol (2005) 1.74
Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Biochem J (2012) 1.74
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood (2010) 1.63
Myosin X regulates netrin receptors and functions in axonal path-finding. Nat Cell Biol (2007) 1.55
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol (2011) 1.50
SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting. Semin Cell Dev Biol (2009) 1.49
Recent advances in retromer biology. Traffic (2011) 1.43
Retromer retrieves wntless. Dev Cell (2008) 1.35
The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. Cell Res (2009) 1.33
Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Science (2010) 1.30
The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease. Alzheimers Res Ther (2011) 1.29
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol Neurodegener (2010) 1.25
AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes. Biochem Biophys Res Commun (2007) 1.22
Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. J Neurosci (2010) 1.08
Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J (2010) 1.06
BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. J Biol Chem (2011) 0.98
Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. Biochem Biophys Res Commun (2010) 0.95
Dendritic spine plasticity: new regulatory roles of dynamic microtubules. Neuroscientist (2010) 0.93
SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease. Rev Neurosci (2010) 0.86
Functional differences between and across different regions of the apical branch of hippocampal CA1 dendrites with respect to long-term depression induction and synaptic cross-tagging. J Neurosci (2010) 0.86
Vacuolar protein sorting receptor in Schizosaccharomyces pombe. Microbiology (2006) 0.84
Differential regulation of myosin X movements by its cargos, DCC and neogenin. J Cell Sci (2012) 0.82
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci (2008) 4.91
LRP4 serves as a coreceptor of agrin. Neuron (2008) 2.98
The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. Neuron (2007) 2.96
Neuregulin-1 enhances depolarization-induced GABA release. Neuron (2007) 2.89
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development (2002) 2.71
To build a synapse: signaling pathways in neuromuscular junction assembly. Development (2010) 2.65
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci U S A (2007) 2.65
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet (2011) 2.13
Retrograde regulation of motoneuron differentiation by muscle beta-catenin. Nat Neurosci (2008) 2.07
The in vivo degradation, absorption and excretion of PCL-based implant. Biomaterials (2005) 2.01
Focal adhesion kinase in netrin-1 signaling. Nat Neurosci (2004) 1.99
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A (2009) 1.98
Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev Cell (2010) 1.97
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron (2002) 1.96
Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem (2001) 1.87
Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. Nat Cell Biol (2005) 1.74
Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1. Neuron (2013) 1.73
Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci (2011) 1.72
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J Biol Chem (2003) 1.68
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood (2010) 1.63
Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos. Nat Neurosci (2004) 1.61
ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc Natl Acad Sci U S A (2010) 1.59
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A (2013) 1.57
Myosin X regulates netrin receptors and functions in axonal path-finding. Nat Cell Biol (2007) 1.55
Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability. Hum Mol Genet (2010) 1.52
Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine. J Bone Miner Res (2013) 1.52
Assessment of four DNA fragments (COI, 16S rDNA, ITS2, 12S rDNA) for species identification of the Ixodida (Acari: Ixodida). Parasit Vectors (2014) 1.51
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol (2011) 1.50
Generation of hepatocyte-like cells from human embryonic stem cells. Cell Transplant (2003) 1.49
Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis. Arch Neurol (2011) 1.47
ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. J Biol Chem (2008) 1.46
Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci (2011) 1.46
Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. J Neurosci (2003) 1.45
The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. J Neurosci (2009) 1.44
Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers. Biochemistry (2005) 1.39
Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Nat Neurosci (2011) 1.36
BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol (2004) 1.35
Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses. J Immunol (2003) 1.35
The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity. Nanomedicine (2009) 1.32
Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. J Biol Chem (2005) 1.28
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nat Cell Biol (2008) 1.27
Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2. J Biol Chem (2004) 1.24
Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J Cell Biol (2003) 1.24
Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats. J Neurosci (2010) 1.23
Erbin suppresses the MAP kinase pathway. J Biol Chem (2002) 1.23
HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE. J Bone Miner Res (2008) 1.23
ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. Neuroreport (2008) 1.22
Beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn. J Neurosci (2007) 1.22
Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel. Biomaterials (2009) 1.21
Regulation of osteoclast function and bone mass by RAGE. J Exp Med (2006) 1.21
A novel paclitaxel-loaded poly(epsilon-caprolactone)/Poloxamer 188 blend nanoparticle overcoming multidrug resistance for cancer treatment. Acta Biomater (2009) 1.21
Conserved N-terminal motifs of telomerase reverse transcriptase required for ribonucleoprotein assembly in vivo. J Biol Chem (2002) 1.20
Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Neuron (2007) 1.19
Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunit. J Neurosci (2007) 1.17
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J (2009) 1.16
Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors. Mol Cell Neurosci (2005) 1.15
Structural basis of agrin-LRP4-MuSK signaling. Genes Dev (2012) 1.15
HSP90 beta regulates rapsyn turnover and subsequent AChR cluster formation and maintenance. Neuron (2008) 1.15
Abatacept for Crohn's disease and ulcerative colitis. Gastroenterology (2012) 1.15
Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation. FASEB J (2004) 1.15
Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation. Neuron (2012) 1.14
Cholic acid-functionalized nanoparticles of star-shaped PLGA-vitamin E TPGS copolymer for docetaxel delivery to cervical cancer. Biomaterials (2013) 1.12
Implication of geranylgeranyltransferase I in synapse formation. Neuron (2003) 1.11
Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome. Am J Hum Genet (2010) 1.10
Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. J Biol Chem (2004) 1.10
N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth. Proc Natl Acad Sci U S A (2010) 1.09
Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering. J Neurosci (2006) 1.09
Paclitaxel drug delivery systems. Expert Opin Drug Deliv (2013) 1.09
Beta-catenin interacts with MyoD and regulates its transcription activity. Mol Cell Biol (2008) 1.06
Neuromuscular junction as Achilles' heel: yet another autoantibody? Neurology (2015) 1.05
A novel cellular defect in diabetes: membrane repair failure. Diabetes (2011) 1.05
Nanoparticles of Poly(Lactide-Co-Glycolide)-d-a-Tocopheryl Polyethylene Glycol 1000 Succinate Random Copolymer for Cancer Treatment. Nanoscale Res Lett (2010) 1.04
RANKL regulates Fas expression and Fas-mediated apoptosis in osteoclasts. J Bone Miner Res (2004) 1.04
Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis. J Clin Invest (2013) 1.03
Biglycan is an extracellular MuSK binding protein important for synapse stability. J Neurosci (2012) 1.02
Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J Neurosci (2008) 1.02
Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a beta-catenin-dependent manner. J Biol Chem (2011) 1.01