Published in J Biol Chem on February 04, 2005
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci (2012) 3.49
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell (2011) 3.32
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet (2010) 2.57
Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology (2008) 1.78
The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. Mol Cell Biol (2008) 1.70
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem (2011) 1.59
Notch and the skeleton. Mol Cell Biol (2009) 1.49
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J Biol Chem (2008) 1.48
A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol (2009) 1.30
Hes1 is required for pituitary growth and melanotrope specification. Dev Biol (2006) 1.20
Communications between bone cells and hematopoietic stem cells. Arch Biochem Biophys (2008) 1.18
BMP9 signaling in stem cell differentiation and osteogenesis. Am J Stem Cells (2013) 1.17
Notch signaling and the bone marrow hematopoietic stem cell niche. Bone (2009) 1.14
Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. PLoS Genet (2010) 1.09
Involvement of Notch signaling in initiation of prechondrogenic condensation and nodule formation in limb bud micromass cultures. J Bone Miner Metab (2006) 1.02
Notch signaling in cardiovascular disease and calcification. Curr Cardiol Rev (2008) 1.01
Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and nuclear factor-κB activation. Arterioscler Thromb Vasc Biol (2013) 0.98
The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathways. Am J Pathol (2009) 0.97
Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells. Dev Biol (2010) 0.91
Hematopoietic niche and bone meet. Curr Opin Support Palliat Care (2008) 0.89
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res (2016) 0.88
Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts. J Biol Chem (2012) 0.86
Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab (2010) 0.86
Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med (2013) 0.86
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics (2006) 0.85
Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. J Bone Miner Res (2010) 0.84
JAG1 and COL1A1 polymorphisms and haplotypes in relation to bone mineral density variations in postmenopausal Mexican-Mestizo Women. Age (Dordr) (2011) 0.84
Notch signaling and bone remodeling. Curr Osteoporos Rep (2013) 0.83
Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1. Br J Cancer (2009) 0.83
Regulatory circuits controlling vascular cell calcification. Cell Mol Life Sci (2012) 0.83
Notch Signaling and the Skeleton. Endocr Rev (2016) 0.82
Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2. Calcif Tissue Int (2015) 0.82
Notch signaling and neurogenesis in normal and stroke brain. Int J Physiol Pathophysiol Pharmacol (2009) 0.82
Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization. BMC Syst Biol (2011) 0.81
Jagged1 is essential for osteoblast development during maxillary ossification. Bone (2014) 0.81
A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Metab (2012) 0.81
Notch signaling: mediator and therapeutic target of bone metastasis. Bonekey Rep (2012) 0.80
Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage. Bone (2014) 0.80
Reciprocal upregulation of Notch signaling molecules in hematopoietic progenitor and mesenchymal stromal cells. J Stem Cells Regen Med (2011) 0.79
Notch: A multi-functional integrating system of microenvironmental signals. Dev Biol (2016) 0.78
Cell fate mediators Notch and Twist in mouse mandibular condylar cartilage. Arch Oral Biol (2010) 0.78
Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women. BMC Musculoskelet Disord (2014) 0.78
Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer. Oncotarget (2016) 0.77
Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway. PLoS One (2014) 0.77
Essential role for Pbx1 in corneal morphogenesis. Invest Ophthalmol Vis Sci (2009) 0.77
Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord. Dev Dyn (2014) 0.76
Icariin improves osteoporosis, inhibits the expression of PPARγ, C/EBPα, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats. Exp Ther Med (2017) 0.75
An Unbalanced Rearrangement of Chromosomes 4:20 is Associated with Childhood Osteoporosis and Reduced Caspase-3 Levels. J Pediatr Genet (2016) 0.75
Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation. Bone Joint Res (2017) 0.75
Relation of JAGGED 1 and collagen type 1 alpha 1 polymorphisms with bone mineral density in Chinese postmenopausal women. Int J Clin Exp Pathol (2014) 0.75
Notch signaling pathway promotes osteogenic differentiation of mesenchymal stem cells by enhancing BMP9/Smad signaling. Int J Mol Med (2017) 0.75
Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling. J Cell Physiol (2016) 0.75
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63
Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol (2003) 3.02
Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk. J Bone Miner Res (2005) 2.36
BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem (2008) 2.12
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med (2006) 1.93
The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. Mol Cell Biol (2008) 1.70
Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem (2004) 1.64
Predicting soil erosion for alternative land uses. J Environ Qual (2006) 1.58
Establishment of a novel B-cell lymphoma cell line with suppressed growth by gamma-secretase inhibitors. Leuk Res (2006) 1.57
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol Biol Cell (2007) 1.57
Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dyn (2007) 1.56
Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. J Clin Invest (2010) 1.54
The Notch ligand, Delta-1, alters retinoic acid (RA)-induced neutrophilic differentiation into monocytic and reduces RA-induced apoptosis in NB4 cells. Leuk Res (2005) 1.41
Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells. Blood (2002) 1.38
Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer. Clin Cancer Res (2005) 1.35
Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein. Stem Cells (2006) 1.35
A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes. Mol Cell Biol (2005) 1.30
Comparison of the prevalence of radiographic osteoarthritis of the knee and hand between Japan and the United States. J Rheumatol (2002) 1.28
BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J Cell Physiol (2007) 1.21
Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus epidermidis biofilms isolated from infected total hip arthroplasty cases. J Orthop Sci (2006) 1.20
Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur J Immunol (2005) 1.18
CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways. Biochem Biophys Res Commun (2007) 1.17
Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2. J Cell Physiol (2002) 1.16
Role of CCN, a vertebrate specific gene family, in development. Dev Growth Differ (2009) 1.16
Neuronal and glial accumulation of alpha- and beta-synucleins in human lipidoses. Acta Neuropathol (2007) 1.16
A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest (2006) 1.15
The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue. Biomaterials (2007) 1.15
Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model. Neuroreport (2003) 1.14
Bone morphogenetic protein-2 induces differentiation of multipotent C3H10T1/2 cells into osteoblasts, chondrocytes, and adipocytes in vivo and in vitro. J Orthop Sci (2004) 1.12
Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling. Exp Cell Res (2003) 1.10
Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development. Dev Biol (2006) 1.08
Comprehensive keratin profiling reveals different histopathogenesis of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst. Hum Pathol (2010) 1.07
Multiinstitutional epidemiological study regarding osteoarthritis of the hip in Japan. J Orthop Sci (2010) 1.06
Osteoarthritis hip joints in Japan: involvement of acetabular dysplasia. J Orthop Sci (2011) 1.05
Outcome of rotational acetabular osteotomy for early hip osteoarthritis secondary to dysplasia related to femoral head shape: 49 hips followed for 10-17 years. Acta Orthop (2008) 1.05
Revision with impacted bone allografts and the Kerboull cross plate for massive bone defect of the acetabulum. J Arthroplasty (2009) 1.02
Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest (2012) 1.02
Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions. J Biol Chem (2005) 1.02
A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. Biochem Biophys Res Commun (2002) 1.02
Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells. Biomaterials (2007) 1.01
Distinct roles of EGF repeats for the Notch signaling system. Exp Cell Res (2005) 1.00
Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1. Biochem Biophys Res Commun (2008) 1.00
Long-term outcome of Ludloff's medial approach for open reduction of developmental dislocation of the hip in relation to the age at operation. Int Orthop (2009) 0.99
Fast magnetization tunneling in tetranickel(II) single-molecule magnets. Inorg Chem (2006) 0.99
Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells. Am J Pathol (2009) 0.99
The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein. Oncogene (2004) 0.99
Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis. Histopathology (2011) 0.98
Enhanced expression of insulin-like growth factor-binding proteins in human osteoarthritic cartilage detected by immunohistochemistry and in situ hybridization. Osteoarthritis Cartilage (2005) 0.98
Modulation of mouse RANKL gene expression by Runx2 and PKA pathway. J Cell Biochem (2006) 0.98
Use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified poly-DL-lactic-co-glycolic acid (PLGA)-collagen sponge. J Cell Physiol (2003) 0.96
Osteonecrosis in stroke-prone spontaneously hypertensive rats: effect of glucocorticoid. J Orthop Sci (2007) 0.96
Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15. J Immunol (2009) 0.96
Functional domains of paired-like homeoprotein Cart1 and the relationship between dimerization and transcription activity. Genes Cells (2002) 0.95
Diverse effects of the Notch ligands Jagged1 and Delta1 on the growth and differentiation of primary acute myeloblastic leukemia cells. Exp Hematol (2005) 0.95
Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem (2012) 0.94
Analysis of interobserver reliability for radiographic staging of coxarthrosis and indexes of acetabular dysplasia: a preliminary study. J Orthop Sci (2010) 0.94
Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition. Clin Oral Implants Res (2008) 0.94
Measurement of advanced glycation endproducts in skin of patients with rheumatoid arthritis, osteoarthritis, and dialysis-related spondyloarthropathy using non-invasive methods. Rheumatol Int (2007) 0.93
Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels. J Cell Biochem (2008) 0.92
Structural differences in the osteocyte network between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting distinct mechano-adaptations and sensitivities. Biochem Biophys Res Commun (2011) 0.92
Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer. Mod Pathol (2005) 0.92
Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Bone (2011) 0.92
Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts. Hypertension (2002) 0.91
Modulation of mouse RANKL gene expression by Runx2 and vitamin D3. J Cell Biochem (2008) 0.91
Notch ligands potentiate IL-7-driven proliferation and survival of human thymocyte precursors. Eur J Immunol (2009) 0.91
Enhanced initial cell responses to chemically modified anodized titanium. Clin Implant Dent Relat Res (2008) 0.91
CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction. Biochem Biophys Res Commun (2012) 0.91
Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells. J Cell Sci (2008) 0.91
Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts. J Biol Chem (2010) 0.91
The slow resorption with replacement by bone of a hydrothermally synthesized pure calcium-deficient hydroxyapatite. Biomaterials (2008) 0.91
Effect of intermittent parathyroid hormone (1-34) treatment on the bone response after placement of titanium implants into the tibia of ovariectomized rats. J Oral Maxillofac Surg (2003) 0.90
Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts. Biomaterials (2009) 0.90
Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features. PLoS One (2013) 0.90
Frequent promoter hypermethylation of RASSF1A and p16INK4a and infrequent allelic loss other than 9p21 in betel-associated oral carcinoma in a Vietnamese non-smoking/non-drinking female population. J Oral Pathol Med (2005) 0.90
Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrent oral cancer. Cancer Sci (2010) 0.90
Recombinant motor domain constructs of Chara corallina myosin display fast motility and high ATPase activity. Biochem Biophys Res Commun (2003) 0.90
Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies. Histol Histopathol (2012) 0.89
Nanoporous waveguide sensor with optimized nanoarchitectures for highly sensitive label-free biosensing. ACS Nano (2012) 0.89
Bone marrow adipocytes support dexamethasone-induced osteoclast differentiation. Biochem Biophys Res Commun (2009) 0.89
Quantitative analysis of Staphylococcus epidermidis biofilm on the surface of biomaterial. J Orthop Sci (2009) 0.89
SP7 inhibits osteoblast differentiation at a late stage in mice. PLoS One (2012) 0.89
Identification of estrogen receptor beta-positive intraepithelial lymphocytes and their possible roles in normal and tubal pregnancy oviducts. Hum Reprod (2006) 0.89
The soluble Notch ligand, Jagged-1, inhibits proliferation of CD34+ macrophage progenitors. Int J Hematol (2002) 0.89
Effects of insulin-like growth factor I on transforming growth factor beta1 induced chondrogenesis of synovium-derived mesenchymal stem cells cultured in a polyglycolic acid scaffold. Cells Tissues Organs (2006) 0.89
Immunohistological localization of Notch receptors and their ligands Delta and Jagged in synovial tissues of rheumatoid arthritis. J Orthop Sci (2005) 0.89
Autocrine/paracrine role of the angiopoietin-1 and -2/Tie2 system in cell proliferation and chemotaxis of cultured fibroblastic synoviocytes in rheumatoid arthritis. Hum Pathol (2004) 0.88
Primary human bone marrow adipocytes support TNF-α-induced osteoclast differentiation and function through RANKL expression. Cytokine (2011) 0.88
Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ. Genes Cells (2004) 0.88
Organic-inorganic mesoporous silica nanostrands for ultrafine filtration of spherical nanoparticles. Chem Commun (Camb) (2010) 0.88
Feasibility and effectiveness of a nurse-led community exercise programme for prevention of falls among frail elderly people: a multi-centre controlled trial. J Rehabil Med (2007) 0.88
Bone morphogenetic proteins are involved in the pathobiology of synovial chondromatosis. Biochem Biophys Res Commun (2009) 0.88
Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells. Biochem Biophys Res Commun (2004) 0.88