Published in Proc Natl Acad Sci U S A on February 04, 2005
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res (2008) 2.97
Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. Hepatology (2010) 1.41
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The involvement of replication in single stranded oligonucleotide-mediated gene repair. Nucleic Acids Res (2006) 1.21
Subtle gene modification in mouse ES cells: evidence for incorporation of unmodified oligonucleotides without induction of DNA damage. Nucleic Acids Res (2010) 1.20
Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAs. Nucleic Acids Res (2005) 1.16
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Targeted correction of a thalassemia-associated beta-globin mutation induced by pseudo-complementary peptide nucleic acids. Nucleic Acids Res (2009) 0.93
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The potential of nucleic acid repair in functional genomics. Nat Biotechnol (2001) 0.95
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Modification of hepatic genomic DNA using RNA/DNA oligonucleotides. Gene Ther (2002) 0.89
Gene therapy. The strange case of chimeraplasty. Science (2002) 0.88
Targeted genetic repair: an emerging approach to genetic therapy. J Clin Invest (2003) 0.84
The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. Ann N Y Acad Sci (2003) 0.84
Targeted correction of the point mutations of beta-thalassemia and targeted mutagenesis of the nucleotide associated with HPFH by RNA/DNA oligonucleotides: potential for beta-thalassemia gene therapy. Blood Cells Mol Dis (2001) 0.83
Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay. Mol Ther (2003) 0.83
Gene repair validation. Nat Biotechnol (2001) 0.83
Nuclease activity of Saccharomyces cerevisiae Mre11 functions in targeted nucleotide alteration. Appl Environ Microbiol (2003) 0.82
Targeted gene repair and its application to neurodegenerative disorders. Neuron (2002) 0.80
Development of a dual-luciferase fusion gene as a sensitive marker for site-directed DNA repair strategies. J Gene Med (2003) 0.80
Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat Genet (2005) 10.03
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet (2005) 6.91
Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A (2006) 4.54
Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet (2004) 3.74
Sox2 is required for sensory organ development in the mammalian inner ear. Nature (2005) 3.58
Biological features of novel avian influenza A (H7N9) virus. Nature (2013) 3.24
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res (2008) 2.97
ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A (2009) 2.93
Sox18 induces development of the lymphatic vasculature in mice. Nature (2008) 2.91
WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nat Neurosci (2004) 2.86
Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell (2012) 2.84
Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci U S A (2010) 2.69
Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes (2008) 2.58
Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer (2011) 2.56
Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals. Spine (Phila Pa 1976) (2009) 2.56
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A (2008) 2.52
Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res (2009) 2.49
Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell (2005) 2.44
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell (2006) 2.29
MicroRNAs: key participants in gene regulatory networks. Curr Opin Chem Biol (2003) 2.28
Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data. BMC Genomics (2008) 2.27
Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell (2007) 2.14
Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatics (2003) 2.09
Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. J Virol (2009) 2.08
The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects. J Biochem Mol Toxicol (2014) 2.03
PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res (2006) 1.96
Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation (2007) 1.88
Unpaired structures in SCA10 (ATTCT)n.(AGAAT)n repeats. J Mol Biol (2003) 1.87
Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function. PLoS Biol (2007) 1.82
Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A (2006) 1.81
Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations. Genetics (2005) 1.80
Overexpression of myofibrillogenesis regulator-1 aggravates cardiac hypertrophy induced by angiotensin II in mice. Hypertension (2007) 1.79
SOX9 induces and maintains neural stem cells. Nat Neurosci (2010) 1.74
Active chromatin hub of the mouse alpha-globin locus forms in a transcription factory of clustered housekeeping genes. Mol Cell Biol (2006) 1.72
Identification of influenza A nucleoprotein as an antiviral target. Nat Biotechnol (2010) 1.71
How replicable are mRNA expression QTL? Mamm Genome (2006) 1.71
Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis. Proc Natl Acad Sci U S A (2003) 1.67
SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res (2010) 1.64
Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression. PLoS Genet (2008) 1.64
Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China. Microbes Infect (2013) 1.59
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One (2012) 1.58
Paraoxonase gene polymorphisms, oxidative stress, and diseases. J Mol Med (Berl) (2003) 1.57
Identification of factors influencing strand bias in oligonucleotide-mediated recombination in Escherichia coli. Nucleic Acids Res (2003) 1.56
Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proc Natl Acad Sci U S A (2002) 1.55
Oncogenicity of the developmental transcription factor Sox9. Cancer Res (2012) 1.55
Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mamm Genome (2004) 1.53
Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proc Natl Acad Sci U S A (2011) 1.53
Efficient and seamless DNA recombineering using a thymidylate synthase A selection system in Escherichia coli. Nucleic Acids Res (2005) 1.51
Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem (2005) 1.49
Blood pressure response to potassium supplementation is associated with genetic variation in endothelin 1 and interactions with E selectin in rural Chinese. J Hypertens (2010) 1.47
Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits. Hum Mol Genet (2005) 1.46
Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. Mol Vis (2009) 1.44
Sequential establishment of stripe patterns in an expanding cell population. Science (2011) 1.44
Inferring gene transcriptional modulatory relations: a genetical genomics approach. Hum Mol Genet (2005) 1.43
Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. Proc Natl Acad Sci U S A (2013) 1.43
Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur J Neurosci (2010) 1.42
The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. J Immunol (2007) 1.40
Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proc Natl Acad Sci U S A (2002) 1.40
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem (2009) 1.39
The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genet (2009) 1.38
Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proc Natl Acad Sci U S A (2009) 1.38
Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci (2009) 1.36
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun (2012) 1.36
High frequency of CD4+ CXCR5+ TFH cells in patients with immune-active chronic hepatitis B. PLoS One (2011) 1.36
Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese population. Hypertension (2007) 1.34
ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PLoS One (2011) 1.34
Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis. PLoS One (2008) 1.33
Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res (2011) 1.32
Positive regulation of hepatic miR-122 expression by HNF4α. J Hepatol (2011) 1.31
Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology (2007) 1.29
A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC. J Infect (2012) 1.28
Complete chloroplast genome sequence of Magnolia kwangsiensis (Magnoliaceae): implication for DNA barcoding and population genetics. Genome (2011) 1.26
Highly restricted expression of Cre recombinase in cerebellar Purkinje cells. Genesis (2004) 1.26
Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine (Phila Pa 1976) (2006) 1.24
The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine (Phila Pa 1976) (2005) 1.24
Association of the asporin D14 allele with lumbar-disc degeneration in Asians. Am J Hum Genet (2008) 1.22
The involvement of replication in single stranded oligonucleotide-mediated gene repair. Nucleic Acids Res (2006) 1.21
Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function. Genome Biol (2012) 1.20
Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. BMC Genomics (2010) 1.19
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Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell (2012) 1.16