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Intercellular coupling confers robustness against mutations in the SCN circadian clock network.
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3
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Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia.
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Dynamic flux balance analysis of diauxic growth in Escherichia coli.
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A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9.
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Detection of a meal using continuous glucose monitoring: implications for an artificial beta-cell.
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2007
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Feasibility of outpatient fully integrated closed-loop control: first studies of wearable artificial pancreas.
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2013
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2.26
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9
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Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension.
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2010
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Safety constraints in an artificial pancreatic beta cell: an implementation of model predictive control with insulin on board.
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Bolus calculator: a review of four "smart" insulin pumps.
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Identification of small molecule activators of cryptochrome.
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Iterative approach to model identification of biological networks.
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Sensitivity analysis of discrete stochastic systems.
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Clinical evaluation of a personalized artificial pancreas.
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Real-Time hypoglycemia prediction suite using continuous glucose monitoring: a safety net for the artificial pancreas.
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Model-based blood glucose control for Type 1 diabetes via parametric programming.
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2006
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Zone model predictive control: a strategy to minimize hyper- and hypoglycemic events.
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Pilot studies of wearable outpatient artificial pancreas in type 1 diabetes.
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Control to range for diabetes: functionality and modular architecture.
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A molecular model for intercellular synchronization in the mammalian circadian clock.
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Biophys J
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A model of the cell-autonomous mammalian circadian clock.
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25
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Run-to-run control of blood glucose concentrations for people with Type 1 diabetes mellitus.
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IEEE Trans Biomed Eng
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2006
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Prandial insulin dosing using run-to-run control: application of clinical data and medical expertise to define a suitable performance metric.
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2007
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A Run-to-Run Control Strategy to Adjust Basal Insulin Infusion Rates in Type 1 Diabetes.
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J Process Control
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In silico evaluation platform for artificial pancreatic beta-cell development--a dynamic simulator for closed-loop control with hardware-in-the-loop.
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Diabetes Technol Ther
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2009
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Control-relevant models for glucose control using a priori patient characteristics.
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IEEE Trans Biomed Eng
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Enhanced 911/global position system wizard: a telemedicine application for the prevention of severe hypoglycemia--monitor, alert, and locate.
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J Diabetes Sci Technol
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2009
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In silico preclinical trials: methodology and engineering guide to closed-loop control in type 1 diabetes mellitus.
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A neuropeptide speeds circadian entrainment by reducing intercellular synchrony.
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Design of the health monitoring system for the artificial pancreas: low glucose prediction module.
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J Diabetes Sci Technol
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Glucose estimation and prediction through meal responses using ambulatory subject data for advisory mode model predictive control.
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Energy-efficient pulse-coupled synchronization strategy design for wireless sensor networks through reduced idle listening.
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Isochron-based phase response analysis of circadian rhythms.
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Use of continuous glucose monitoring to estimate insulin requirements in patients with type 1 diabetes mellitus during a short course of prednisone.
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2008
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Wavelet measurement suggests cause of period instability in mammalian circadian neurons.
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Quantitative performance metrics for robustness in circadian rhythms.
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Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and post-traumatic stress disorder (PTSD) in humans.
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PLoS Comput Biol
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2012
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43
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Closed-loop control of artificial pancreatic Beta -cell in type 1 diabetes mellitus using model predictive iterative learning control.
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Calculating the insulin to carbohydrate ratio using the hyperinsulinaemic-euglycaemic clamp-a novel use for a proven technique.
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Coordinated basal-bolus infusion for tighter postprandial glucose control in insulin pump therapy.
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46
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Experimental evaluation of a recursive model identification technique for type 1 diabetes.
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2009
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1.02
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Decreased protein expression and intermittent recoveries in BiP levels result from cellular stress during heterologous protein expression in Saccharomyces cerevisiae.
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Biotechnol Prog
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2002
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1.01
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Proposed clinical application for tuning fuzzy logic controller of artificial pancreas utilizing a personalization factor.
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2010
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1.00
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49
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Optimal phase response functions for fast pulse-coupled synchronization in wireless sensor networks.
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IEEE Trans Signal Process
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2012
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0.99
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50
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Multicenter closed-loop insulin delivery study points to challenges for keeping blood glucose in a safe range by a control algorithm in adults and adolescents with type 1 diabetes from various sites.
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Diabetes Technol Ther
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2014
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0.99
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51
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Synchrony and entrainment properties of robust circadian oscillators.
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2014
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Dynamic energy budgets in syntrophic symbiotic relationships between heterotrophic hosts and photoautotrophic symbionts.
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2009
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55
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Weakly circadian cells improve resynchrony.
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2012
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Collagen cross-linking using rose bengal and green light to increase corneal stiffness.
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2013
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A novel adaptive basal therapy based on the value and rate of change of blood glucose.
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2009
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Modeling the effects of subcutaneous insulin administration and carbohydrate consumption on blood glucose.
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Analysis of unfolded protein response during single-chain antibody expression in Saccaromyces cerevisiae reveals different roles for BiP and PDI in folding.
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Multicenter closed-loop/hybrid meal bolus insulin delivery with type 1 diabetes.
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Core modular blood and brain biomarkers in social defeat mouse model for post traumatic stress disorder.
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Predicting subcutaneous glucose concentration using a latent-variable-based statistical method for type 1 diabetes mellitus.
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Velocity response curves support the role of continuous entrainment in circadian clocks.
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Multi-objective blood glucose control for type 1 diabetes.
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2009
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Circadian phase resetting via single and multiple control targets.
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2008
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70
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Identifying fragilities in biochemical networks: robust performance analysis of Fas signaling-induced apoptosis.
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Continuous-time identification of gene expression models.
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Phase sensitivity analysis of circadian rhythm entrainment.
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Core module biomarker identification with network exploration for breast cancer metastasis.
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Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology.
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Modeling the Drosophila melanogaster circadian oscillator via phase optimization.
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Clinically relevant hypoglycemia prediction metrics for event mitigation.
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Multiple feedback loop design in the tryptophan regulatory network of Escherichia coli suggests a paradigm for robust regulation of processes in series.
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Cybernetic model predictive control of a continuous bioreactor with cell recycle.
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Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling.
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Confidence from uncertainty--a multi-target drug screening method from robust control theory.
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Estimating confidence intervals in predicted responses for oscillatory biological models.
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Why is rose bengal more phototoxic to fibroblasts in vitro than in vivo?
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A physiological systems approach to modeling and resetting of mouse thermoregulation under heat stress.
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A detailed modular analysis of heat-shock protein dynamics under acute and chronic stress and its implication in anxiety disorders.
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Modeling the intra- and extracellular cytokine signaling pathway under heat stroke in the liver.
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Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk.
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Computational modeling of glucose transport in pancreatic β-cells identifies metabolic thresholds and therapeutic targets in diabetes.
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Dynamic insulin on board: incorporation of circadian insulin sensitivity variation.
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