Published in J Mol Biol on April 20, 1992
Influence of non-bonded parameters on the quality of NMR structures: a new force field for NMR structure calculation. J Biomol NMR (1999) 1.96
Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokines. Proc Natl Acad Sci U S A (1996) 1.62
Proposed three-dimensional structure for the cellular prion protein. Proc Natl Acad Sci U S A (1994) 1.35
A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain. Proc Natl Acad Sci U S A (1997) 1.28
The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors. Proc Natl Acad Sci U S A (1993) 1.27
More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology. PLoS Comput Biol (2010) 1.26
Origins of structural diversity within sequentially identical hexapeptides. Protein Sci (1993) 1.18
Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation. EMBO J (1993) 1.14
Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure. Proc Natl Acad Sci U S A (1993) 1.05
Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proc Natl Acad Sci U S A (1994) 1.00
A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor. BMC Biol (2006) 0.95
Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway. Immunol Rev (2012) 0.91
Cells transfected with human interleukin 6 cDNA acquire binding sites for the hepatitis B virus envelope protein. J Exp Med (1992) 0.89
Receptor binding properties of four-helix-bundle growth factors deduced from electrostatic analysis. Protein Sci (1994) 0.89
Young Investigator Award Lecture. Structures of larger proteins, protein-ligand and protein-DNA complexes by multidimensional heteronuclear NMR. Protein Sci (1994) 0.88
Homology model of human interferon-alpha 8 and its receptor complex. Protein Sci (1995) 0.81
Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors. Protein Sci (1995) 0.81
Resonance assignments, secondary structure and topology of leukaemia inhibitory factor in solution. J Biomol NMR (1997) 0.76
Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin. Proteins (2015) 0.75
Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1. N Engl J Med (1996) 7.09
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med (1994) 6.59
Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality. Cancer (2001) 6.16
Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis. Nature (1997) 5.47
Overlapping genes at the cheA locus of Escherichia coli. Proc Natl Acad Sci U S A (1980) 4.82
Designing conditions for in vitro formation of amyloid protofilaments and fibrils. Proc Natl Acad Sci U S A (1999) 4.71
Birth after the reimplantation of a human embryo. Lancet (1978) 4.69
The folding of hen lysozyme involves partially structured intermediates and multiple pathways. Nature (1992) 4.32
Evidence of improving prognosis in heart failure: trends in case fatality in 66 547 patients hospitalized between 1986 and 1995. Circulation (2000) 4.16
Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques. Biochemistry (1999) 4.12
Amyloid fibrils from muscle myoglobin. Nature (2001) 3.93
A novel method for prediction of long-term outcome of women with T1a, T1b, and 10-14 mm invasive breast cancers: a prospective study. Lancet (2000) 3.76
Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing. EMBO J (1999) 3.72
Two classes of PDGF receptor recognize different isoforms of PDGF. Science (1988) 3.59
Amyloid fibril formation by an SH3 domain. Proc Natl Acad Sci U S A (1998) 3.55
Efficacy of breast cancer screening by age. New results from the Swedish Two-County Trial. Cancer (1995) 3.32
The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell (1992) 3.20
The Swedish Two-County Trial twenty years later. Updated mortality results and new insights from long-term follow-up. Radiol Clin North Am (2000) 3.18
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem (2000) 3.12
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO J (1993) 3.11
Three key residues form a critical contact network in a protein folding transition state. Nature (2001) 3.09
Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int (1995) 2.97
American Cancer Society guidelines for screening and surveillance for early detection of colorectal polyps and cancer: update 1997. American Cancer Society Detection and Treatment Advisory Group on Colorectal Cancer. CA Cancer J Clin (1997) 2.89
Detection of transient protein folding populations by mass spectrometry. Science (1993) 2.85
Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem (1994) 2.82
Genomic 5-methyldeoxycytidine decreases with age. J Biol Chem (1987) 2.74
Understanding protein folding via free-energy surfaces from theory and experiment. Trends Biochem Sci (2000) 2.73
Penicillin-resistant Streptococcus pneumoniae in acute otitis media: risk factors, susceptibility patterns and antimicrobial management. Pediatr Infect Dis J (1995) 2.73
Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapy. Nature (1981) 2.71
Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nat Genet (1994) 2.66
Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med (1997) 2.52
Time to revolutionize the triggering of ovulation. Reprod Biomed Online (2004) 2.52
Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations. J Mol Biol (1996) 2.50
Trends in case-fatality in 117 718 patients admitted with acute myocardial infarction in Scotland. Eur Heart J (2000) 2.50
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med (2001) 2.47
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res (1997) 2.40
Structural similarity between the p17 matrix protein of HIV-1 and interferon-gamma. Nature (1994) 2.35
Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. Nat Struct Biol (1999) 2.34
Increasing physician productivity and the hospitalization characteristics of practices using Medex. A progress report. Northwest Med (1971) 2.34
Structural determinants of protein dynamics: analysis of 15N NMR relaxation measurements for main-chain and side-chain nuclei of hen egg white lysozyme. Biochemistry (1995) 2.31
Measuring outcomes: one month survival after acute myocardial infarction in Scotland. Heart (1996) 2.30
Early stages of fertilization in vitro of human oocytes matured in vitro. Nature (1969) 2.30
Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol (1980) 2.28
Quantifying the potential problem of overdiagnosis of ductal carcinoma in situ in breast cancer screening. Eur J Cancer (2003) 2.26
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. Neurology (2004) 2.26
The broad spectrum antiviral agent ribavirin inhibits capping of mRNA. Biochem Biophys Res Commun (1979) 2.26
"I don't like Mondays"-day of the week of coronary heart disease deaths in Scotland: study of routinely collected data. BMJ (2000) 2.25
The relative contributions of screen-detected in situ and invasive breast carcinomas in reducing mortality from the disease. Eur J Cancer (2003) 2.24
Cytodifferentiation and embryogenesis in cell colonies and tissue cultures derived from ova and blastocysts of the rabbit. Dev Biol (1966) 2.24
Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood (1988) 2.24
Benefit of screening mammography in women aged 40-49: a new meta-analysis of randomized controlled trials. J Natl Cancer Inst Monogr (1997) 2.24
Probing proton dynamics in molecules on an attosecond time scale. Science (2006) 2.24
Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy. Protein Sci (2000) 2.23
The cumulative embryo score: a predictive embryo scoring technique to select the optimal number of embryos to transfer in an in-vitro fertilization and embryo transfer programme. Hum Reprod (1992) 2.21
Lymphedema: current issues in research and management. CA Cancer J Clin (2000) 2.21
Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase. Cell (1993) 2.20
Genetic instability of microsatellites in endometrial carcinoma. Cancer Res (1993) 2.20
Gender and survival: a population-based study of 201,114 men and women following a first acute myocardial infarction. J Am Coll Cardiol (2001) 2.17
Effects of macromolecular crowding on protein folding and aggregation. EMBO J (1999) 2.15
Chiasma frequency and maternal age in mammals. Nature (1968) 2.15
Pressure support ventilation decreases inspiratory work of breathing during general anesthesia and spontaneous ventilation. Anesth Analg (1992) 2.14
Benefit of mammography screening in women ages 40 to 49 years. Current evidence from randomized controlled trials. Cancer (1995) 2.13
Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig alpha-lactalbumin. Biochemistry (1989) 2.11
On attempts at cloning in the human. Fertil Steril (1994) 2.10
Following protein folding in real time using NMR spectroscopy. Nat Struct Biol (1995) 2.04
Cumulative conception and livebirth rates after in-vitro fertilisation. Lancet (1992) 2.01
Fractionation of hemagglutinating and bacterial binding adhesins of Bacteroides gingivalis. Infect Immun (1984) 1.99
Ribonucleic acid-protein fractions of virulent Salmonella typhimurium as protective immunogens. Infect Immun (1972) 1.99
A study guided by the Health Belief Model of the predictors of breast cancer screening of women ages 40 and older. Public Health Rep (1991) 1.97
Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet (1976) 1.96
Age, sex, and social trends in out-of-hospital cardiac deaths in Scotland 1986-95: a retrospective cohort study. Lancet (2001) 1.96
Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the beta-domain. J Mol Biol (2000) 1.90
A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules. J Mol Biol (1997) 1.89
Determination of inorganic phosphate in the presence of labile organic phosphates. Anal Biochem (1969) 1.89
A refined solution structure of hen lysozyme determined using residual dipolar coupling data. Protein Sci (2001) 1.88
Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry. J Mol Biol (1998) 1.88
The active form of tumor necrosis factor is a trimer. J Biol Chem (1987) 1.86
Mutational analysis of the propensity for amyloid formation by a globular protein. EMBO J (2000) 1.86
Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res (1996) 1.84
Planning for the future: the experience of implementing a children's day assessment unit in a district general hospital. Arch Dis Child (1997) 1.83
Drug delivery to mitochondria: the key to mitochondrial medicine. Adv Drug Deliv Rev (2000) 1.82
Macromolecular crowding perturbs protein refolding kinetics: implications for folding inside the cell. EMBO J (2000) 1.81
Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes. Nature (1965) 1.81
Mutations of the E-cadherin gene in human gynecologic cancers. Nat Genet (1994) 1.81
Hydrogen exchange in native and denatured states of hen egg-white lysozyme. Proteins (1992) 1.79
The pressure reversal of general anesthesia and the critical volume hypothesis. Mol Pharmacol (1973) 1.79
The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population. Am J Hum Genet (2002) 1.77
A residue-specific NMR view of the non-cooperative unfolding of a molten globule. Nat Struct Biol (1997) 1.76
Twenty-year follow-up of the breast cancers diagnosed during the Breast Cancer Detection Demonstration Project. CA Cancer J Clin (1997) 1.75
Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea. Biochemistry (1997) 1.75
Specific binding of the diphtheria tox regulatory element DtxR to the tox operator requires divalent heavy metal ions and a 9-base-pair interrupted palindromic sequence. Proc Natl Acad Sci U S A (1992) 1.74
Breast conservation therapy for invasive breast cancer in Ashkenazi women with BRCA gene founder mutations. J Natl Cancer Inst (1999) 1.73
Temperature dependent molecular motion of a tyrosine residue of ferrocytochrome C. FEBS Lett (1976) 1.73
Intranasal Teeth. Report of two cases and review of the literature. Oral Surg Oral Med Oral Pathol (1979) 1.73
A magnetization-transfer nuclear magnetic resonance study of the folding of staphylococcal nuclease. Biochemistry (1989) 1.72