Published in J Biol Chem on May 20, 1994
Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst (2004) 14.97
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology (1999) 3.06
DNA methylation and genetic instability in colorectal cancer cells. Proc Natl Acad Sci U S A (1997) 3.03
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc Natl Acad Sci U S A (1995) 2.93
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proc Natl Acad Sci U S A (1996) 2.57
DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev (2008) 2.40
Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 2.29
Replication slippage between distant short repeats in Saccharomyces cerevisiae depends on the direction of replication and the RAD50 and RAD52 genes. Mol Cell Biol (1995) 2.21
APC mutations in colorectal tumors with mismatch repair deficiency. Proc Natl Acad Sci U S A (1996) 2.18
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med (1998) 2.00
The mutation rate and cancer. Genetics (1998) 1.88
The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs. Mol Cell Biol (1996) 1.86
Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. Mol Cell Biol (1997) 1.79
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination. Gynecol Oncol (2012) 1.71
Functional overlap in mismatch repair by human MSH3 and MSH6. Genetics (1998) 1.70
Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A (2000) 1.63
Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli. Proc Natl Acad Sci U S A (1996) 1.58
DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. Proc Natl Acad Sci U S A (1997) 1.58
Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. Am J Pathol (1998) 1.55
Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine. J Clin Invest (1996) 1.49
Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta}. Proc Natl Acad Sci U S A (2010) 1.45
Triple-helix formation induces recombination in mammalian cells via a nucleotide excision repair-dependent pathway. Mol Cell Biol (2000) 1.40
Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases. Proc Natl Acad Sci U S A (1995) 1.40
A polymerase chain reaction assay for non-random X chromosome inactivation identifies monoclonal endometrial cancers and precancers. Am J Pathol (1995) 1.30
A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition. Proc Natl Acad Sci U S A (2003) 1.30
Mismatch repair activity in mammalian mitochondria. Nucleic Acids Res (2003) 1.24
Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Cancer Res (2006) 1.24
Cell cycle control, checkpoint mechanisms, and genotoxic stress. Environ Health Perspect (1999) 1.22
Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides. Proc Natl Acad Sci U S A (2000) 1.19
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. DNA Repair (Amst) (2009) 1.18
Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability. Neoplasia (2002) 1.12
Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis. Mol Cell Biol (1999) 1.12
A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype. Proc Natl Acad Sci U S A (1994) 1.11
Systematic review and meta-analysis of ovarian cancers: estimation of microsatellite-high frequency and characterization of mismatch repair deficient tumor histology. Clin Cancer Res (2008) 1.09
Measurement of DNA mismatch repair activity in live cells. Nucleic Acids Res (2004) 1.09
Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro. Br J Cancer (1996) 1.08
Microsatellite instability in ovarian neoplasms. Br J Cancer (1995) 1.06
Transcriptional mutagenesis induced by 8-oxoguanine in mammalian cells. PLoS Genet (2009) 1.00
High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. PLoS One (2011) 0.98
A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory. J Cell Mol Med (2009) 0.96
Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants. Gut (2002) 0.91
Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction. DNA Repair (Amst) (2013) 0.90
Construction and characterization of mismatch-containing circular DNA molecules competent for assessment of nick-directed human mismatch repair in vitro. Nucleic Acids Res (2002) 0.88
Mature microsatellites: mechanisms underlying dinucleotide microsatellite mutational biases in human cells. G3 (Bethesda) (2013) 0.87
DNA mismatch repair gene mutations in human cancer. Environ Health Perspect (1997) 0.85
Extracolonic features of familial adenomatous polyposis in patients with sporadic colorectal cancer. Br J Cancer (1996) 0.85
Modeling variation in tumors in vivo. Proc Natl Acad Sci U S A (2005) 0.84
Molecular pathogenesis of sporadic duodenal cancer. Br J Cancer (1998) 0.83
High-fidelity correction of genomic uracil by human mismatch repair activities. BMC Mol Biol (2008) 0.82
Prophylactic surgery in Lynch syndrome. Tech Coloproctol (2011) 0.82
A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair. DNA Repair (Amst) (2015) 0.82
Effects of mutation and growth rates on patterns of microsatellite instability. Am J Pathol (1996) 0.81
Characterization of homologous DNA recombination activity in normal and immortal mammalian cells. Nucleic Acids Res (1996) 0.81
Decoding the histone code: Role of H3K36me3 in mismatch repair and implications for cancer susceptibility and therapy. Cancer Res (2013) 0.80
Altered spectra of hypermutation in DNA repair-deficient mice. Philos Trans R Soc Lond B Biol Sci (2001) 0.79
In vitro expansion of mammalian telomere repeats by DNA polymerase alpha-primase. Nucleic Acids Res (2000) 0.79
Deficiency of a novel mismatch repair activity in a bladder tumor cell line. Nucleic Acids Res (2002) 0.78
Molecular tumor clocks to study the evolution of drug resistance. Mol Pharm (2011) 0.77
Retracted Risk factors for ovarian cancers with and without microsatellite instability. Int J Gynecol Cancer (2013) 0.77
hMSH2 and GTBP expression in advanced stage epithelial ovarian cancer. Br J Cancer (1999) 0.77
Study of the synthesis, antiproliferative properties, and interaction with DNA and polynucleotides of cisplatin-like Pt(II) complexes containing carcinogenic polyaromatic amines. J Biol Inorg Chem (2013) 0.76
Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status. Cancer Cell Int (2015) 0.76
Initiation of strand incision at G:T and O(6)-methylguanine:T base mismatches in DNA by human cell extracts. Nucleic Acids Res (2001) 0.76
The genetics of inherited colon cancer. Clin Mol Pathol (1996) 0.75
Genetics of endometrial cancer. Fam Cancer (2014) 0.75
Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A (1985) 68.48
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (1993) 12.74
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell (1988) 10.29
Mutation detection and single-molecule counting using isothermal rolling-circle amplification. Nat Genet (1998) 9.84
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. Biochemistry (1988) 9.66
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
The accuracy of reverse transcriptase from HIV-1. Science (1988) 8.24
Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol (1991) 7.94
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1. N Engl J Med (1996) 7.09
Haplotype sharing analysis using mantel statistics. Hum Hered (2005) 6.76
Genetic and physical linkage of exogenous sequences in transformed cells. Cell (1980) 6.67
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med (1994) 6.59
Fidelity of DNA synthesis. Annu Rev Biochem (1982) 6.54
Mutational specificity of depurination. Proc Natl Acad Sci U S A (1984) 6.51
The Y-family of DNA polymerases. Mol Cell (2001) 6.49
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst (1997) 5.68
Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature (1987) 5.46
The problem of multiple inference in studies designed to generate hypotheses. Am J Epidemiol (1985) 4.76
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell (1996) 4.47
The somatic replication of DNA methylation. Cell (1981) 4.42
Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature (1980) 4.37
DNA polymerase fidelity and the polymerase chain reaction. PCR Methods Appl (1991) 4.31
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature (1982) 4.30
The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation. J Biol Chem (1986) 4.25
Evidence of improving prognosis in heart failure: trends in case fatality in 66 547 patients hospitalized between 1986 and 1995. Circulation (2000) 4.16
Deoxynucleoside [1-thio]triphosphates prevent proofreading during in vitro DNA synthesis. Proc Natl Acad Sci U S A (1981) 4.14
High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. Nucleic Acids Res (1990) 4.12
The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. J Biol Chem (1985) 3.98
Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nat Struct Biol (1996) 3.91
Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. J Biol Chem (1989) 3.80
A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. Am J Respir Crit Care Med (1999) 3.71
Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res (1994) 3.63
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat Immunol (2001) 3.60
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A (1983) 3.52
A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. Biochemistry (1990) 3.51
Exposure to residential electric and magnetic fields and risk of childhood leukemia. Am J Epidemiol (1991) 3.49
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity. Proc Natl Acad Sci U S A (1991) 3.44
Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A (1980) 3.39
Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs. Am J Epidemiol (1999) 3.31
A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells. Proc Natl Acad Sci U S A (1985) 3.29
On the need for the rare disease assumption in case-control studies. Am J Epidemiol (1982) 3.28
Biological models and statistical interactions: an example from multistage carcinogenesis. Int J Epidemiol (1981) 3.21
The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell (1992) 3.20
A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med (1999) 3.18
Heteroduplex repair in extracts of human HeLa cells. J Biol Chem (1991) 3.13
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. Mol Cell Biol (1989) 3.00
Infidelity of DNA synthesis associated with bypass of apurinic sites. Proc Natl Acad Sci U S A (1983) 2.95
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet (1994) 2.95
Low fidelity DNA synthesis by human DNA polymerase-eta. Nature (2000) 2.85
The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis. J Biol Chem (1985) 2.66
Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nat Genet (1994) 2.66
Simultaneously modelling censored survival data and repeatedly measured covariates: a Gibbs sampling approach. Stat Med (1996) 2.66
Passing the baton in base excision repair. Nat Struct Biol (2000) 2.65
Effect of DNA polymerase I and DNA helicase II on the turnover rate of UvrABC excision nuclease. Proc Natl Acad Sci U S A (1985) 2.62
A cohort study of thyroid disease in relation to fallout from nuclear weapons testing. JAMA (1993) 2.62
Nucleotide repeats. Slippery DNA and diseases. Nature (1993) 2.56
Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med (1997) 2.52
Analyzing fidelity of DNA polymerases. Methods Enzymol (1995) 2.52
Trends in case-fatality in 117 718 patients admitted with acute myocardial infarction in Scotland. Eur Heart J (2000) 2.50
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res (1997) 2.40
Frameshift mutagenesis by eucaryotic DNA polymerases in vitro. J Biol Chem (1986) 2.40
Depurination-induced infidelity of deoxyribonucleic acid synthesis with purified deoxyribonucleic acid replication proteins in vitro. Biochemistry (1983) 2.38
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. J Biol Chem (1990) 2.36
Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res (1995) 2.35
Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins. Nature (1986) 2.35
Structural similarity between the p17 matrix protein of HIV-1 and interferon-gamma. Nature (1994) 2.35
Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas. J Natl Cancer Inst (1993) 2.34
Structural determinants of protein dynamics: analysis of 15N NMR relaxation measurements for main-chain and side-chain nuclei of hen egg white lysozyme. Biochemistry (1995) 2.31
Measuring outcomes: one month survival after acute myocardial infarction in Scotland. Heart (1996) 2.30
Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations. Mol Cell Biol (1999) 2.26
"I don't like Mondays"-day of the week of coronary heart disease deaths in Scotland: study of routinely collected data. BMJ (2000) 2.25
Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood (1988) 2.24
Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase. Cell (1993) 2.20
Genetic instability of microsatellites in endometrial carcinoma. Cancer Res (1993) 2.20
On the fidelity of DNA replication. Effect of divalent metal ion activators and deoxyrionucleoside triphosphate pools on in vitro mutagenesis. J Biol Chem (1979) 2.20
DNA loop repair by human cell extracts. Science (1994) 2.19
Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res (1995) 2.17
Gender and survival: a population-based study of 201,114 men and women following a first acute myocardial infarction. J Am Coll Cardiol (2001) 2.17
Fidelity of mammalian DNA polymerases. Science (1981) 2.17
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci U S A (2001) 2.16
Amplification and purification of UvrA, UvrB, and UvrC proteins of Escherichia coli. J Biol Chem (1985) 2.11
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. J Biol Chem (2000) 2.06
Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. J Biol Chem (1990) 2.06
Sequences of Escherichia coli uvrA gene and protein reveal two potential ATP binding sites. J Biol Chem (1986) 2.06
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. J Biol Chem (1993) 2.04
Mutagenesis in vitro by DNA polymerase from an RNA tumour virus. Nature (1979) 2.00
Fractionation of hemagglutinating and bacterial binding adhesins of Bacteroides gingivalis. Infect Immun (1984) 1.99
Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes. J Biol Chem (2000) 1.99
Air pollution and bronchitic symptoms in Southern California children with asthma. Environ Health Perspect (1999) 1.98
Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase delta. Curr Biol (2006) 1.98
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res (1997) 1.96