Published in J Immunol on May 01, 2006
FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol (2009) 2.81
Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med (2007) 2.58
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. Proc Natl Acad Sci U S A (2009) 1.61
Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol (2008) 1.59
The role of Toll-like receptors in renal diseases. Nat Rev Nephrol (2010) 1.42
The taming of the cell penetrating domain of the HIV Tat: myths and realities. J Control Release (2006) 1.30
Mechanisms and regulation of the gene-expression response to sepsis. Pediatrics (2010) 1.22
Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis. Crit Care (2008) 1.21
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Mol Cell (2015) 1.12
HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice. J Clin Invest (2008) 1.11
Biomarkers and molecular probes for cell death imaging and targeted therapeutics. Bioconjug Chem (2012) 1.10
Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent. J Immunol (2011) 1.03
Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages. Free Radic Biol Med (2007) 1.00
Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor. Biochim Biophys Acta (2008) 0.98
Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells. Cell Death Differ (2011) 0.94
Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections. Emerg Infect Dis (2007) 0.93
Revisiting caspases in sepsis. Cell Death Dis (2014) 0.91
Blocking p55PIK signaling inhibits proliferation and induces differentiation of leukemia cells. Cell Death Differ (2012) 0.89
Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathog (2012) 0.88
An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochem Biophys Res Commun (2009) 0.87
Sepsis induced immunosuppression: Implications for secondary infections and complications. Indian J Crit Care Med (2013) 0.87
Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma. Int J Cancer (2009) 0.86
Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. FASEB J (2007) 0.85
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
Identification of a novel cell-penetrating peptide from human phosphatidate phosphatase LPIN3. Mol Cells (2012) 0.83
Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury. PLoS One (2010) 0.83
Anti-apoptotic therapy with a Tat fusion protein protects against excitotoxic insults in vitro and in vivo. Exp Neurol (2007) 0.83
Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. J Biol Chem (2014) 0.83
Alterations of dendritic cells in sepsis: featured role in immunoparalysis. Biomed Res Int (2015) 0.82
Adoptive transfer of dying cells causes bystander-induced apoptosis. Biochem Biophys Res Commun (2006) 0.82
Role of Programmed Cell Death in the Immunopathogenesis of Sepsis. Drug Discov Today Dis Mech (2007) 0.80
Detrimental effects of antiapoptotic treatments in spinal cord injury. Exp Neurol (2007) 0.79
Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development. J Neurosci (2015) 0.78
Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C. PLoS One (2012) 0.75
Inhibition of regulated cell death by cell-penetrating peptides. Cell Mol Life Sci (2016) 0.75
Impaired hepatocellular regeneration in murine sepsis is dependent on regulatory protein levels. Shock (2011) 0.75
Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain. Sci Rep (2015) 0.75
Dying to protect: cell death and the control of T-cell homeostasis. Immunol Rev (2017) 0.75
Exploiting death: apoptotic immunity in microbial pathogenesis. Cell Death Differ (2016) 0.75
Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation. J Exp Med (2017) 0.75
The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60
Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature (2012) 8.03
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke (2009) 5.28
Cell death. N Engl J Med (2009) 4.75
CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res (2004) 4.53
The sepsis seesaw: tilting toward immunosuppression. Nat Med (2009) 3.95
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood (2008) 3.77
Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A (2004) 3.59
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol (2009) 3.50
Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49
Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol (2010) 2.81
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 2.81
Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell (2005) 2.74
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol (2005) 2.70
Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science (2002) 2.51
Bioluminescence imaging of myeloperoxidase activity in vivo. Nat Med (2009) 2.43
Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock (2007) 2.37
Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol Cell Neurosci (2004) 2.36
Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. J Virol (2002) 2.31
The surgical intensive care unit optimal mobility score predicts mortality and length of stay. Crit Care Med (2012) 2.30
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29
Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol (2002) 2.25
Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res (2012) 2.24
Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat Methods (2005) 2.22
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA (2002) 2.20
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med (2002) 2.20
Interrelation of inflammation and APP in sIBM: IL-1 beta induces accumulation of beta-amyloid in skeletal muscle. Brain (2008) 2.18
β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Ann Neurol (2013) 2.10
Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients. Crit Care Med (2005) 2.09
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
Imaging 26S proteasome activity and inhibition in living mice. Nat Med (2003) 2.04
Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems. PLoS One (2010) 2.02
An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis. Invest Ophthalmol Vis Sci (2012) 2.02
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol (2013) 1.93
Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe. J Am Chem Soc (2006) 1.93
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol (2009) 1.91
ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells. Brain (2007) 1.87
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86
Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med (2003) 1.83
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A (2006) 1.82
Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci U S A (2002) 1.81
Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol (2003) 1.76
Mitochondrial resuscitation with exogenous cytochrome c in the septic heart. Crit Care Med (2007) 1.76
Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun (2010) 1.76
Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res (2008) 1.75
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J (2007) 1.73
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock (2003) 1.73
Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med (2002) 1.72
Effects of aging on the immunopathologic response to sepsis. Crit Care Med (2009) 1.72
Prevalence and cost of full-time research fellowships during general surgery residency: a national survey. Ann Surg (2009) 1.71
Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc Natl Acad Sci U S A (2003) 1.71
Mechanisms of acute axonal degeneration in the optic nerve in vivo. Proc Natl Acad Sci U S A (2010) 1.70
Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med (2010) 1.68
Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock (2004) 1.68
The Accreditation Council for Graduate Medical Education resident duty hour new standards: history, changes, and impact on staffing of intensive care units. Crit Care Med (2011) 1.60
Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. J Neurochem (2007) 1.59
Prevention of lymphocyte apoptosis--a potential treatment of sepsis? Clin Infect Dis (2005) 1.58
Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation. J Neurophysiol (2005) 1.57
Tracheostomy protocol: experience with development and potential utility. Crit Care Med (2008) 1.56
Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci U S A (2004) 1.56
Advances in bioluminescence imaging of live animal models. Curr Opin Biotechnol (2009) 1.55
Effects of interferon-beta-1a on neuronal survival under autoimmune inflammatory conditions. Exp Neurol (2006) 1.55
High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit Care Med (2004) 1.54
Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol (2008) 1.54
Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2004) 1.54
A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Mol Cancer Ther (2010) 1.53
Recent advances in imaging the lungs of intact small animals. Am J Respir Cell Mol Biol (2004) 1.51
Patient safety event reporting in critical care: a study of three intensive care units. Crit Care Med (2007) 1.51
Current state of imaging protein-protein interactions in vivo with genetically encoded reporters. Annu Rev Biomed Eng (2007) 1.50
Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit Care Med (2005) 1.49