Published in J Biol Chem on January 28, 2005
Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer (2010) 11.16
COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. Br J Cancer (2006) 1.39
Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes. Mol Metab (2014) 1.31
Reduced glioma infiltration in Src-deficient mice. J Neurooncol (2006) 1.29
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling. J Cell Sci (2008) 1.26
Beta3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy. FASEB J (2009) 1.19
Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies. Genes Cancer (2011) 1.06
Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma. Oncogene (2012) 1.03
Tumor-stromal interactions in pancreatic cancer. Crit Rev Oncog (2013) 1.01
Lack of beta3 integrin signaling contributes to calpain-mediated myocardial cell loss in pressure-overloaded myocardium. J Cardiovasc Pharmacol (2010) 0.92
The integrin alpha2beta1 agonist, aggretin, promotes proliferation and migration of VSMC through NF-kB translocation and PDGF production. Br J Pharmacol (2009) 0.89
Integrin inhibition promotes atypical anoikis in glioma cells. Cell Death Dis (2014) 0.88
Tumor suppressive protein gene associated with retinoid-interferon-induced mortality (GRIM)-19 inhibits src-induced oncogenic transformation at multiple levels. Am J Pathol (2007) 0.86
VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation. Proc Natl Acad Sci U S A (2011) 0.86
Matricellular proteins produced by melanocytes and melanomas: in search for functions. Cancer Microenviron (2008) 0.84
Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models. Breast Cancer Res (2015) 0.83
Disintegrins from snake venoms and their applications in cancer research and therapy. Curr Protein Pept Sci (2015) 0.83
The thyroid hormone-αvβ3 integrin axis in ovarian cancer: regulation of gene transcription and MAPK-dependent proliferation. Oncogene (2015) 0.83
An inducible, ligand-independent receptor activator of NF-κB gene to control osteoclast differentiation from monocytic precursors. PLoS One (2013) 0.82
Integrins and p53 pathways in glioblastoma resistance to temozolomide. Front Oncol (2012) 0.80
Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation. J Oncol (2011) 0.79
Inflammatory Th17 Cells Express Integrin αvβ3 for Pathogenic Function. Cell Rep (2016) 0.77
In vitro and in vivo drug disposition of cilengitide in animals and human. Pharmacol Res Perspect (2016) 0.75
Targeted approach to metastatic colorectal cancer: what comes beyond epidermal growth factor receptor antibodies and bevacizumab? Ther Adv Med Oncol (2013) 0.75
PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility. Biol Open (2015) 0.75
αVβ3 Integrin regulates astrocyte reactivity. J Neuroinflammation (2017) 0.75
Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circ Res (2006) 3.97
Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res (2009) 3.53
Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol (2007) 3.13
Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol (2005) 3.01
Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res (2011) 2.56
Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int (2004) 2.25
Smooth muscle cell plasticity: fact or fiction? Circ Res (2012) 2.18
Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells. Arterioscler Thromb Vasc Biol (2005) 2.18
The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am J Pathol (2004) 1.88
Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol (2002) 1.88
Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice. Arterioscler Thromb Vasc Biol (2006) 1.86
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int (2012) 1.82
BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis (2008) 1.80
Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int (2009) 1.77
Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med (2002) 1.67
Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney Int (2013) 1.66
The role of osteopontin in inflammatory processes. J Cell Commun Signal (2009) 1.57
VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering. Arterioscler Thromb Vasc Biol (2009) 1.57
Effects of cyclosporine in osteopontin null mice. Kidney Int (2002) 1.47
Regulation of cardiovascular calcification. Cardiovasc Pathol (2004) 1.46
Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis. J Cell Biochem (2010) 1.29
Vascular calcification: an update on mechanisms and challenges in treatment. Calcif Tissue Int (2013) 1.29
Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro. Cardiovasc Res (2005) 1.28
PEG-cross-linked heparin is an affinity hydrogel for sustained release of vascular endothelial growth factor. J Biomater Sci Polym Ed (2006) 1.20
Mechanisms of vascular calcification. Adv Chronic Kidney Dis (2007) 1.18
Direct effects of phosphate on vascular cell function. Adv Chronic Kidney Dis (2011) 1.17
Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression. Biomaterials (2007) 1.17
Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study. Cardiovasc Res (2012) 1.16
Immunohistologic labeling of murine endothelium. Cardiovasc Pathol (2003) 1.15
Rat aorta-derived mural precursor cells express the Tie2 receptor and respond directly to stimulation by angiopoietins. J Cell Sci (2003) 1.15
Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering. Biomaterials (2008) 1.14
Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. Am J Pathol (2011) 1.14
A fibrinogen-based precision microporous scaffold for tissue engineering. Biomaterials (2007) 1.12
Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells. J Mol Cell Cardiol (2005) 1.11
Osteoprotegerin and RANKL differentially regulate angiogenesis and endothelial cell function. Angiogenesis (2008) 1.09
Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts. Biotechnol Bioeng (2012) 1.09
Development of an esophagus acellular matrix tissue scaffold. Tissue Eng (2006) 1.08
Sodium-dependent phosphate cotransporters and vascular calcification. Curr Opin Nephrol Hypertens (2007) 1.07
Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2. Arterioscler Thromb Vasc Biol (2013) 1.04
Mimicking cell-cell interactions at the biomaterial-cell interface for control of stem cell differentiation. J Biomed Mater Res A (2006) 1.04
Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1. Genesis (2009) 1.03
The role of osteopontin in foreign body giant cell formation. Biomaterials (2005) 1.03
Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion. J Biomed Mater Res A (2005) 1.00
Biomimetic peptides that engage specific integrin-dependent signaling pathways and bind to calcium phosphate surfaces. J Biomed Mater Res A (2003) 0.97
RANKL enhances macrophage paracrine pro-calcific activity in high phosphate-treated smooth muscle cells: dependence on IL-6 and TNF-α. J Vasc Res (2012) 0.96
Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures. J Dermatol (2006) 0.94
Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1. Thromb Haemost (2010) 0.94
Characterization and analysis of osteopontin-immobilized poly(2-hydroxyethyl methacrylate) surfaces. J Biomed Mater Res A (2003) 0.93
Matrix remodeling in vascular calcification associated with chronic kidney disease. J Am Soc Nephrol (2010) 0.92
Esophageal epithelial cell interaction with synthetic and natural scaffolds for tissue engineering. Biomaterials (2005) 0.92
Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin. J Cell Biochem (2013) 0.90
Prevascularized microtemplated fibrin scaffolds for cardiac tissue engineering applications. Tissue Eng Part A (2013) 0.90
Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin. Calcif Tissue Int (2005) 0.90
Molecular mediators of alphavbeta3-induced endothelial cell survival. J Vasc Res (2006) 0.89
Vitamin D receptor activators induce an anticalcific paracrine program in macrophages: requirement of osteopontin. Arterioscler Thromb Vasc Biol (2009) 0.89
Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization. Am J Pathol (2009) 0.89
Characterization of mandibular bone in a mouse model of chronic kidney disease. J Periodontol (2010) 0.87
Arteriosclerosis, calcium phosphate deposition and cardiovascular disease in uremia: current concepts at the bench. Curr Opin Nephrol Hypertens (2005) 0.86
Heparin-regulated delivery of osteoprotegerin promotes vascularization of implanted hydrogels. J Biomater Sci Polym Ed (2008) 0.86
Immobilization of alkaline phosphatase on microporous nanofibrous fibrin scaffolds for bone tissue engineering. Biomaterials (2009) 0.86
Hyaluronic acid grafting mitigates calcification of glutaraldehyde-fixed bovine pericardium. J Biomed Mater Res A (2004) 0.85
Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model. J Biomed Mater Res A (2009) 0.84
Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-kappaB activation. Metabolism (2002) 0.83
The influence of surface mineral and osteopontin on the formation and function of murine bone marrow-derived osteoclasts. J Mater Sci Mater Med (2008) 0.83
Enhancing the biological activity of immobilized osteopontin using a type-1 collagen affinity coating. J Biomed Mater Res A (2004) 0.83
Increased calcification in osteoprotegerin-deficient smooth muscle cells: Dependence on receptor activator of NF-κB ligand and interleukin 6. J Vasc Res (2014) 0.81
Crosslinking of an oesophagus acellular matrix tissue scaffold. J Tissue Eng Regen Med (2008) 0.81
Expression and function of the integrin alpha9beta1 in bovine aortic valve interstitial cells. J Heart Valve Dis (2003) 0.79
Proangiogenic microtemplated fibrin scaffolds containing aprotinin promote improved wound healing responses. Angiogenesis (2013) 0.79
Adhesive protein interactions with chitosan: consequences for valve endothelial cell growth on tissue-engineering materials. J Biomed Mater Res A (2003) 0.78
Combination of Sleeping Beauty transposition and chemically induced dimerization selection for robust production of engineered cells. Nucleic Acids Res (2012) 0.77
High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease. Nephrol Dial Transplant (2012) 0.77
Role of carbonic anhydrase II in ectopic calcification. Cardiovasc Pathol (2008) 0.76